4-sec-Butyl-2,6-di-tert-butylphenol

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  • Identifiers

    CAS number
    17540-75-9

    Molecular formula
    C18H30O

    SMILES
    CCC(C)C1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 49.48%
    Woody 47.76%
    Leathery 44.04%
    Dry 36.12%
    Spicy 34.33%
    Camphoreous 33.46%
    Burnt 33.2%
    Vetiver 31.4%
    Medicinal 28.91%
    Smoky 28.15%

     

    Flavor
    Camphor 40.72%
    Phenolic 37.88%
    Musty 35.06%
    Woody 32.21%
    Mild 32.01%
    Spice 23.67%
    Leather 22.95%
    Creosote 22.77%
    Thymol 21.89%
    Green pepper 21.44%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.6

    pKa est.
    8.85 (weak base)

    Molecular weight
    262.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    290°C

    Flash point

    • 134.02 ˚C est.

  • Synonyms

    • 4-sec-Butyl-2,6-di-tert-butylphenol
    • 2,6-Di-tert-butyl-4-sec-butylphenol
    • Phenol, 2,6-bis(1,1-dimethylethyl)-4-(1-methylpropyl)-
    • Isonox 132
    • Vanox 1320
    • TYL476W27Y
    • EINECS 241-533-0
    • NSC 14460
    • NSC-14460
    • ISONOX(R) 132
    • Phenol, 4-sec-butyl-2,6-di-tert-butyl-
    • 2,6-di-tertiary-butyl-4-sec-butylphenol
    • 2,6-BIS(1,1-DIMETHYLETHYL)-4-(1-METHYLPROPYL)PHENOL
    • RefChem:526704
    • (+-)-4-SEC-BUTYL-2,6-DI-TERT-BUTYLPHENOL
    • 241-533-0
    • 17540-75-9
    • 4-(sec-Butyl)-2,6-di-tert-butylphenol
    • 4-(Butan-2-yl)-2,6-di-tert-butylphenol
    • 4-butan-2-yl-2,6-ditert-butylphenol
    • MFCD00075575
    • DTXSID8029315
    • UNII-TYL476W27Y
    • NSC14460
    • Di-t-butyl-4-butylphenol
    • SCHEMBL144821
    • DTXCID809315
    • CHEMBL3189073
    • SCHEMBL28079627
    • 2,6-di-t-butyl-4-s-butylphenol
    • Tox21_201062
    • 2,6-Di-t-butyl-4-sec-butyl phenol
    • 2,6-ditert-butyl-4-sec-butyl-phenol
    • AKOS022172766
    • 4-sec-butyl-2,6-di-tert-butyl-phenol
    • 4-Sec-butyl-2,6-ditert-butylphenol #
    • NCGC00248911-01
    • NCGC00258615-01
    • BS-15658
    • SY052475
    • CAS-17540-75-9
    • 4-sec-Butyl-2,6-di-tert-butylphenol, 96%
    • CS-0152627
    • NS00014255
    • NS00076530
    • E75725
    • (+/-)-4-SEC-BUTYL-2,6-DI-TERT-BUTYLPHENOL
    • Q27290486
    • Phenol,6-bis(1,1-dimethylethyl)-4-(1-methylpropyl)-
    • 17540-75-9

  • Applications

    4-sec-Butyl-2,6-di-tert-butylphenol (CAS 17540-75-9) is primarily used as a hindered phenol antioxidant and stabilizer to retard oxidation in polymers, rubbers, and coatings, helping to slow oxidative degradation and extend product life. Typical applications include stabilizing plastics and synthetic resins, polyolefins, and rubber formulations, protecting them during processing and in end products. It is also used as an antioxidant additive in lubricants and industrial oils to prevent oxidative degradation. In coatings and inks, it helps preserve color and film properties during storage and processing. Additionally, the compound may be used in adhesive formulations as a stabilizer and can serve as an intermediate in specialized chemical syntheses when required, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 200.51
    methanol 87.14
    isopropanol 254.16
    water 0.06
    ethyl acetate 346.31
    n-propanol 257.58
    acetone 412.14
    n-butanol 293.17
    acetonitrile 180.58
    DMF 575.01
    toluene 512.74
    isobutanol 269.17
    1,4-dioxane 729.06
    methyl acetate 323.52
    THF 1691.45
    2-butanone 546.3
    n-pentanol 269.2
    sec-butanol 350.73
    n-hexane 264.13
    ethylene glycol 14.4
    NMP 863.73
    cyclohexane 311.14
    DMSO 231.79
    n-butyl acetate 698.06
    n-octanol 312.26
    chloroform 1054.2
    n-propyl acetate 354.55
    acetic acid 139.64
    dichloromethane 730.18
    cyclohexanone 977.84
    propylene glycol 68.34
    isopropyl acetate 315.91
    DMAc 559.31
    2-ethoxyethanol 194.55
    isopentanol 317.52
    n-heptane 228.47
    ethyl formate 212.67
    1,2-dichloroethane 482.23
    n-hexanol 576.35
    2-methoxyethanol 222.31
    isobutyl acetate 344.33
    tetrachloromethane 180.56
    n-pentyl acetate 423.27
    transcutol 468.3
    n-heptanol 328.77
    ethylbenzene 372.19
    MIBK 354.34
    2-propoxyethanol 479.34
    tert-butanol 368.54
    MTBE 546.68
    2-butoxyethanol 337.24
    propionic acid 175.55
    o-xylene 326.64
    formic acid 18.39
    diethyl ether 408.78
    m-xylene 387.15
    p-xylene 516.47
    chlorobenzene 520.67
    dimethyl carbonate 134.38
    n-octane 109.77
    formamide 39.83
    cyclopentanone 1118.7
    2-pentanone 463.93
    anisole 430.54
    cyclopentyl methyl ether 727.5
    gamma-butyrolactone 847.79
    1-methoxy-2-propanol 283.74
    pyridine 770.67
    3-pentanone 364.84
    furfural 577.84
    n-dodecane 74.4
    diethylene glycol 141.95
    diisopropyl ether 220.85
    tert-amyl alcohol 415.82
    acetylacetone 397.64
    n-hexadecane 87.4
    acetophenone 409.92
    methyl propionate 301.82
    isopentyl acetate 726.75
    trichloroethylene 994.06
    n-nonanol 296.71
    cyclohexanol 428.8
    benzyl alcohol 287.32
    2-ethylhexanol 491.59
    isooctanol 294.78
    dipropyl ether 487.72
    1,2-dichlorobenzene 432.28
    ethyl lactate 156.3
    propylene carbonate 587.58
    n-methylformamide 155.43
    2-pentanol 297.8
    n-pentane 172.76
    1-propoxy-2-propanol 503.09
    1-methoxy-2-propyl acetate 498.6
    2-(2-methoxypropoxy) propanol 312.81
    mesitylene 272.14
    ε-caprolactone 779.43
    p-cymene 330.84
    epichlorohydrin 865.75
    1,1,1-trichloroethane 655.58
    2-aminoethanol 59.93
    morpholine-4-carbaldehyde 633.89
    sulfolane 825.33
    2,2,4-trimethylpentane 114.26
    2-methyltetrahydrofuran 1183.99
    n-hexyl acetate 596.81
    isooctane 94.39
    2-(2-butoxyethoxy)ethanol 362.65
    sec-butyl acetate 318.97
    tert-butyl acetate 425.16
    decalin 193.72
    glycerin 58.33
    diglyme 558.66
    acrylic acid 121.01
    isopropyl myristate 297.35
    n-butyric acid 320.39
    acetyl acetate 208.58
    di(2-ethylhexyl) phthalate 229.47
    ethyl propionate 308.41
    nitromethane 229.6
    1,2-diethoxyethane 393.76
    benzonitrile 360.91
    trioctyl phosphate 201.4
    1-bromopropane 511.92
    gamma-valerolactone 1059.68
    n-decanol 229.07
    triethyl phosphate 228.11
    4-methyl-2-pentanol 219.2
    propionitrile 265.71
    vinylene carbonate 423.53
    1,1,2-trichlorotrifluoroethane 368.22
    DMS 281.82
    cumene 283.34
    2-octanol 289.79
    2-hexanone 457.43
    octyl acetate 356.47
    limonene 454.57
    1,2-dimethoxyethane 500.22
    ethyl orthosilicate 238.77
    tributyl phosphate 207.05
    diacetone alcohol 376.05
    N,N-dimethylaniline 388.75
    acrylonitrile 229.83
    aniline 376.54
    1,3-propanediol 116.58
    bromobenzene 610.21
    dibromomethane 598.44
    1,1,2,2-tetrachloroethane 833.02
    2-methyl-cyclohexyl acetate 554.69
    tetrabutyl urea 290.48
    diisobutyl methanol 275.72
    2-phenylethanol 461.22
    styrene 365.8
    dioctyl adipate 366.59
    dimethyl sulfate 194.55
    ethyl butyrate 437.14
    methyl lactate 136.78
    butyl lactate 306.51
    diethyl carbonate 270.8
    propanediol butyl ether 296.42
    triethyl orthoformate 372.2
    p-tert-butyltoluene 360.28
    methyl 4-tert-butylbenzoate 438.31
    morpholine 880.88
    tert-butylamine 312.45
    n-dodecanol 181.57
    dimethoxymethane 345.43
    ethylene carbonate 362.1
    cyrene 373.06
    2-ethoxyethyl acetate 354.03
    2-ethylhexyl acetate 657.41
    1,2,4-trichlorobenzene 511.97
    4-methylpyridine 847.57
    dibutyl ether 404.91
    2,6-dimethyl-4-heptanol 275.72
    DEF 440.08
    dimethyl isosorbide 685.21
    tetrachloroethylene 414.01
    eugenol 368.83
    triacetin 325.72
    span 80 405.0
    1,4-butanediol 60.7
    1,1-dichloroethane 602.93
    2-methyl-1-pentanol 323.05
    methyl formate 135.91
    2-methyl-1-butanol 322.76
    n-decane 125.66
    butyronitrile 371.12
    3,7-dimethyl-1-octanol 309.69
    1-chlorooctane 309.0
    1-chlorotetradecane 148.18
    n-nonane 128.04
    undecane 95.06
    tert-butylcyclohexane 195.1
    cyclooctane 149.31
    cyclopentanol 455.52
    tetrahydropyran 1115.47
    tert-amyl methyl ether 449.91
    2,5,8-trioxanonane 381.1
    1-hexene 482.47
    2-isopropoxyethanol 207.59
    2,2,2-trifluoroethanol 46.59
    methyl butyrate 415.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction