4-Propyl-2,6-dimethoxyphenol

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  • Identifiers

    CAS number
    6766-82-1

    Molecular formula
    C11H16O3

    SMILES
    CCCC1=CC(=C(C(=C1)OC)O)OC

  • Odor profile

    Spicy 82.35%
    Phenolic 75.06%
    Smoky 65.46%
    Woody 54.32%
    Burnt 47.73%
    Clove 46.21%
    Vanilla 42.36%
    Balsamic 42.05%
    Medicinal 39.63%
    Leathery 36.08%

    Scent© AI

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    9.43 (weak base)

    Molecular weight
    196.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    305°C

    Flash point est.
    115.66 ˚C

    Solubility expt.

    • insoluble in water; soluble in fat
    • miscible (in ethanol)

  • Synonyms

    • 2,6-Dimethoxy-4-propylphenol
    • 6766-82-1
    • Phenol, 2,6-dimethoxy-4-propyl-
    • 4-Propylsyringol
    • 4-Propyl-2,6-dimethoxyphenol
    • syringylpropane
    • FEMA No. 3729
    • GM73K8R20X
    • DTXSID6075067
    • Phenol, 2,6-dimethoxy-4-propyl
    • 4-PROPYL-2,6-DIMETHOXYPHENOL [FHFI]
    • UNII-GM73K8R20X
    • 2,6-dimethoxy-4-propyl-phenol
    • SCHEMBL223826
    • DTXCID4044953
    • FEMA 3729
    • CHEBI:169375
    • GAA76682
    • AKOS028111454
    • LS-13989
    • DB-277399
    • NS00126915
    • EN300-263267
    • Q27279179
    • Z57234305
    • 3-Amino-7-[4-chlorophenylsulfonyl]-1,2,4-bezotriazine 1-oxide
    • 7-[(4-Chlorophenyl)sulfonyl]-1-oxido-1,2,4-benzotriazin-3-ylamine
    • 639-195-8

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 838.89
    methanol 1004.54
    isopropanol 475.88
    water 0.75
    ethyl acetate 786.63
    n-propanol 631.18
    acetone 1232.45
    n-butanol 462.14
    acetonitrile 815.18
    DMF 1541.93
    toluene 157.42
    isobutanol 357.97
    1,4-dioxane 1205.35
    methyl acetate 871.35
    THF 1200.54
    2-butanone 682.43
    n-pentanol 277.33
    sec-butanol 374.73
    n-hexane 12.92
    ethylene glycol 402.69
    NMP 703.58
    cyclohexane 67.81
    DMSO 1499.68
    n-butyl acetate 379.06
    n-octanol 115.03
    chloroform 1540.8
    n-propyl acetate 353.8
    acetic acid 1170.31
    dichloromethane 1895.39
    cyclohexanone 963.81
    propylene glycol 347.65
    isopropyl acetate 298.65
    DMAc 560.93
    2-ethoxyethanol 642.07
    isopentanol 293.71
    n-heptane 16.81
    ethyl formate 839.34
    1,2-dichloroethane 1367.59
    n-hexanol 286.44
    2-methoxyethanol 1396.17
    isobutyl acetate 182.17
    tetrachloromethane 251.63
    n-pentyl acetate 195.29
    transcutol 690.92
    n-heptanol 135.1
    ethylbenzene 89.02
    MIBK 208.23
    2-propoxyethanol 537.39
    tert-butanol 568.36
    MTBE 344.42
    2-butoxyethanol 282.86
    propionic acid 633.83
    o-xylene 114.4
    formic acid 402.9
    diethyl ether 399.54
    m-xylene 108.6
    p-xylene 117.34
    chlorobenzene 433.04
    dimethyl carbonate 314.97
    n-octane 11.08
    formamide 795.28
    cyclopentanone 1071.51
    2-pentanone 472.01
    anisole 246.96
    cyclopentyl methyl ether 383.66
    gamma-butyrolactone 1408.63
    1-methoxy-2-propanol 700.98
    pyridine 867.83
    3-pentanone 321.2
    furfural 1176.81
    n-dodecane 10.34
    diethylene glycol 573.11
    diisopropyl ether 74.95
    tert-amyl alcohol 391.75
    acetylacetone 563.46
    n-hexadecane 12.07
    acetophenone 256.38
    methyl propionate 587.59
    isopentyl acetate 271.38
    trichloroethylene 2150.62
    n-nonanol 101.12
    cyclohexanol 408.01
    benzyl alcohol 298.53
    2-ethylhexanol 150.72
    isooctanol 109.56
    dipropyl ether 138.68
    1,2-dichlorobenzene 387.48
    ethyl lactate 189.96
    propylene carbonate 770.31
    n-methylformamide 1090.91
    2-pentanol 222.85
    n-pentane 16.49
    1-propoxy-2-propanol 297.21
    1-methoxy-2-propyl acetate 284.5
    2-(2-methoxypropoxy) propanol 166.36
    mesitylene 70.78
    ε-caprolactone 711.53
    p-cymene 73.18
    epichlorohydrin 1588.87
    1,1,1-trichloroethane 901.47
    2-aminoethanol 523.34
    morpholine-4-carbaldehyde 813.84
    sulfolane 1262.57
    2,2,4-trimethylpentane 16.99
    2-methyltetrahydrofuran 670.64
    n-hexyl acetate 233.01
    isooctane 12.47
    2-(2-butoxyethoxy)ethanol 269.96
    sec-butyl acetate 166.1
    tert-butyl acetate 266.8
    decalin 27.03
    glycerin 495.13
    diglyme 628.68
    acrylic acid 658.07
    isopropyl myristate 82.87
    n-butyric acid 827.58
    acetyl acetate 453.64
    di(2-ethylhexyl) phthalate 97.4
    ethyl propionate 268.68
    nitromethane 1999.97
    1,2-diethoxyethane 257.82
    benzonitrile 416.72
    trioctyl phosphate 81.42
    1-bromopropane 424.75
    gamma-valerolactone 1210.05
    n-decanol 78.72
    triethyl phosphate 117.26
    4-methyl-2-pentanol 106.33
    propionitrile 532.73
    vinylene carbonate 772.73
    1,1,2-trichlorotrifluoroethane 1115.48
    DMS 238.95
    cumene 65.66
    2-octanol 89.72
    2-hexanone 262.34
    octyl acetate 119.77
    limonene 107.98
    1,2-dimethoxyethane 884.51
    ethyl orthosilicate 108.38
    tributyl phosphate 91.41
    diacetone alcohol 342.56
    N,N-dimethylaniline 133.32
    acrylonitrile 816.02
    aniline 340.61
    1,3-propanediol 753.66
    bromobenzene 410.53
    dibromomethane 1048.39
    1,1,2,2-tetrachloroethane 1494.86
    2-methyl-cyclohexyl acetate 169.21
    tetrabutyl urea 112.08
    diisobutyl methanol 83.17
    2-phenylethanol 253.77
    styrene 130.58
    dioctyl adipate 133.96
    dimethyl sulfate 418.33
    ethyl butyrate 237.19
    methyl lactate 304.51
    butyl lactate 157.42
    diethyl carbonate 186.56
    propanediol butyl ether 232.19
    triethyl orthoformate 147.8
    p-tert-butyltoluene 70.3
    methyl 4-tert-butylbenzoate 189.53
    morpholine 1302.45
    tert-butylamine 253.05
    n-dodecanol 60.67
    dimethoxymethane 765.18
    ethylene carbonate 665.73
    cyrene 243.38
    2-ethoxyethyl acetate 267.67
    2-ethylhexyl acetate 198.63
    1,2,4-trichlorobenzene 435.43
    4-methylpyridine 560.89
    dibutyl ether 110.73
    2,6-dimethyl-4-heptanol 83.17
    DEF 529.35
    dimethyl isosorbide 303.3
    tetrachloroethylene 1027.98
    eugenol 199.18
    triacetin 211.25
    span 80 170.11
    1,4-butanediol 276.86
    1,1-dichloroethane 990.25
    2-methyl-1-pentanol 210.78
    methyl formate 1059.59
    2-methyl-1-butanol 284.05
    n-decane 15.65
    butyronitrile 517.76
    3,7-dimethyl-1-octanol 101.34
    1-chlorooctane 80.36
    1-chlorotetradecane 34.47
    n-nonane 14.8
    undecane 12.42
    tert-butylcyclohexane 22.83
    cyclooctane 18.12
    cyclopentanol 469.45
    tetrahydropyran 866.17
    tert-amyl methyl ether 206.96
    2,5,8-trioxanonane 344.36
    1-hexene 63.86
    2-isopropoxyethanol 338.02
    2,2,2-trifluoroethanol 395.89
    methyl butyrate 432.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction