4-Nonanone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    4485-09-0

    Molecular formula
    C9H18O

    SMILES
    CCCCCC(=O)CCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fruity 86.39%
    Green 78.39%
    Herbal 72.51%
    Cheesy 55.87%
    Sweet 53.81%
    Earthy 53.21%
    Fatty 46.54%
    Ketonic 45.65%
    Oily 44.2%
    Mushroom 42.16%

    Scent© AI

  • Properties

    XLogP3-AA
    2.8

    Molecular weight
    142.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point

    • 188.00 °C. @ 760.00 mm Hg

    Flash point est.
    61.33 ˚C

  • Synonyms

    • 4-Nonanone
    • 4485-09-0
    • Nonan-4-one
    • Amyl Propyl Ketone
    • Propyl amyl ketone
    • Pentyl Propyl Ketone
    • EINECS 224-770-4
    • DTXSID5063493
    • n-Pentyl n-propyl ketone
    • Nonan4one
    • N-Amyl N-propylketone
    • SCHEMBL129432
    • DTXCID2040361
    • CHEBI:179604
    • LMFA12000148
    • MFCD00027286
    • AKOS009157392
    • DB-051253
    • CS-0362557
    • N0427
    • NS00022200
    • D91706
    • Q31838919
    • InChI=1/C9H18O/c1-3-5-6-8-9(10)7-4-2/h3-8H2,1-2H
    • 224-770-4

  • Applications

    4-Nonanone (CAS 4485-09-0) is a straight-chain, high-boiling ketone used mainly as a synthesis intermediate and as a solvent/co-solvent in specialty formulations: it undergoes selective reduction to 4-nonanol, reductive amination to secondary/tertiary C9 amines, addition of Grignard or organolithium reagents to give tertiary alcohols, and enolate formation for aldol/alkylation to extend carbon frameworks; its oxime/hydrazone derivatives assist purification/identification, and Baeyer–Villiger oxidation can yield propyl–pentyl esters valued in fragrance; owing to moderate polarity and slow evaporation, it is applied to tune drying rate, flow, and film formation in coatings, inks, and adhesives, to extract hydrophobic analytes, and as a processing aid in polymer synthesis; in research it serves as a model substrate for enolization and radical oxidation kinetics of medium-chain ketones and can act as a GC retention-index/calibration candidate or solvent benchmark; additionally, the balanced lipophilicity of the C9 scaffold makes 4-nonanone convenient for building surfactants, specialty lubricants, and ketal/acetal specialty solvents.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15488.1
    methanol 13990.8
    isopropanol 14886.68
    water 0.89
    ethyl acetate 8516.51
    n-propanol 12385.16
    acetone 14634.84
    n-butanol 11834.7
    acetonitrile 10147.87
    DMF 7459.93
    toluene 3131.09
    isobutanol 9708.66
    1,4-dioxane 9540.57
    methyl acetate 5506.99
    THF 12916.65
    2-butanone 8235.77
    n-pentanol 6721.15
    sec-butanol 10772.7
    n-hexane 6742.7
    ethylene glycol 985.5
    NMP 5140.24
    cyclohexane 6427.41
    DMSO 6543.74
    n-butyl acetate 10308.04
    n-octanol 3677.71
    chloroform 18391.09
    n-propyl acetate 5263.05
    acetic acid 7366.04
    dichloromethane 13995.4
    cyclohexanone 12653.13
    propylene glycol 2010.43
    isopropyl acetate 5266.92
    DMAc 3396.17
    2-ethoxyethanol 4141.28
    isopentanol 9124.41
    n-heptane 3407.12
    ethyl formate 5005.76
    1,2-dichloroethane 7972.84
    n-hexanol 9979.08
    2-methoxyethanol 7298.4
    isobutyl acetate 2885.8
    tetrachloromethane 3671.09
    n-pentyl acetate 4836.02
    transcutol 11715.79
    n-heptanol 3223.75
    ethylbenzene 1939.19
    MIBK 4049.79
    2-propoxyethanol 7243.14
    tert-butanol 13388.97
    MTBE 9805.57
    2-butoxyethanol 3554.79
    propionic acid 5987.18
    o-xylene 1548.66
    formic acid 1260.57
    diethyl ether 11682.63
    m-xylene 1737.12
    p-xylene 2563.95
    chlorobenzene 4748.19
    dimethyl carbonate 911.97
    n-octane 982.67
    formamide 1600.2
    cyclopentanone 9505.8
    2-pentanone 8151.14
    anisole 2633.66
    cyclopentyl methyl ether 6926.39
    gamma-butyrolactone 8121.89
    1-methoxy-2-propanol 5549.63
    pyridine 9569.98
    3-pentanone 4348.85
    furfural 5513.21
    n-dodecane 457.12
    diethylene glycol 2955.52
    diisopropyl ether 3182.98
    tert-amyl alcohol 8882.17
    acetylacetone 5015.5
    n-hexadecane 525.62
    acetophenone 2145.81
    methyl propionate 3945.36
    isopentyl acetate 7364.41
    trichloroethylene 13264.42
    n-nonanol 2826.65
    cyclohexanol 10004.03
    benzyl alcohol 2301.61
    2-ethylhexanol 5652.04
    isooctanol 2477.45
    dipropyl ether 7696.42
    1,2-dichlorobenzene 3286.29
    ethyl lactate 1221.69
    propylene carbonate 4503.49
    n-methylformamide 4289.12
    2-pentanol 8226.86
    n-pentane 4178.89
    1-propoxy-2-propanol 6393.91
    1-methoxy-2-propyl acetate 3916.68
    2-(2-methoxypropoxy) propanol 2110.82
    mesitylene 1158.88
    ε-caprolactone 8774.8
    p-cymene 1421.52
    epichlorohydrin 8075.26
    1,1,1-trichloroethane 9223.67
    2-aminoethanol 2967.11
    morpholine-4-carbaldehyde 5076.77
    sulfolane 6488.88
    2,2,4-trimethylpentane 889.65
    2-methyltetrahydrofuran 12022.37
    n-hexyl acetate 5860.96
    isooctane 830.18
    2-(2-butoxyethoxy)ethanol 3426.3
    sec-butyl acetate 3230.79
    tert-butyl acetate 4257.85
    decalin 1417.75
    glycerin 1811.08
    diglyme 5858.34
    acrylic acid 3669.18
    isopropyl myristate 1721.65
    n-butyric acid 12086.71
    acetyl acetate 3221.43
    di(2-ethylhexyl) phthalate 1107.2
    ethyl propionate 3571.69
    nitromethane 7962.39
    1,2-diethoxyethane 6441.92
    benzonitrile 5009.27
    trioctyl phosphate 962.55
    1-bromopropane 8602.88
    gamma-valerolactone 9277.51
    n-decanol 1836.16
    triethyl phosphate 1124.26
    4-methyl-2-pentanol 3359.25
    propionitrile 8341.35
    vinylene carbonate 3788.59
    1,1,2-trichlorotrifluoroethane 4872.65
    DMS 1898.75
    cumene 1228.61
    2-octanol 2693.66
    2-hexanone 6098.86
    octyl acetate 2080.95
    limonene 3041.84
    1,2-dimethoxyethane 8711.1
    ethyl orthosilicate 1260.99
    tributyl phosphate 1282.57
    diacetone alcohol 3376.71
    N,N-dimethylaniline 1677.8
    acrylonitrile 7203.58
    aniline 3908.46
    1,3-propanediol 4782.16
    bromobenzene 5012.15
    dibromomethane 11701.84
    1,1,2,2-tetrachloroethane 10780.34
    2-methyl-cyclohexyl acetate 2511.3
    tetrabutyl urea 1591.44
    diisobutyl methanol 2487.38
    2-phenylethanol 2791.45
    styrene 2746.39
    dioctyl adipate 1927.32
    dimethyl sulfate 1201.32
    ethyl butyrate 4954.53
    methyl lactate 1296.49
    butyl lactate 2553.65
    diethyl carbonate 2197.36
    propanediol butyl ether 3094.0
    triethyl orthoformate 2678.23
    p-tert-butyltoluene 1307.3
    methyl 4-tert-butylbenzoate 1705.6
    morpholine 12962.53
    tert-butylamine 10230.35
    n-dodecanol 1293.61
    dimethoxymethane 3779.28
    ethylene carbonate 3958.58
    cyrene 1261.79
    2-ethoxyethyl acetate 3622.89
    2-ethylhexyl acetate 5375.59
    1,2,4-trichlorobenzene 3353.24
    4-methylpyridine 8875.38
    dibutyl ether 6419.65
    2,6-dimethyl-4-heptanol 2487.38
    DEF 6746.5
    dimethyl isosorbide 2814.58
    tetrachloroethylene 7707.29
    eugenol 1666.85
    triacetin 2510.98
    span 80 2582.31
    1,4-butanediol 1681.08
    1,1-dichloroethane 11803.37
    2-methyl-1-pentanol 5092.24
    methyl formate 2684.59
    2-methyl-1-butanol 7939.1
    n-decane 988.02
    butyronitrile 11717.38
    3,7-dimethyl-1-octanol 3219.93
    1-chlorooctane 2805.39
    1-chlorotetradecane 873.72
    n-nonane 1221.69
    undecane 633.8
    tert-butylcyclohexane 1287.23
    cyclooctane 1412.65
    cyclopentanol 8620.56
    tetrahydropyran 16875.8
    tert-amyl methyl ether 5229.45
    2,5,8-trioxanonane 3143.88
    1-hexene 11506.52
    2-isopropoxyethanol 3222.68
    2,2,2-trifluoroethanol 1333.71
    methyl butyrate 6167.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Cymbopogon microstachys Cymbopogon microstachys (Hook. f.) S. Soenarko, fam. Poaceae (Gramineae) 0.4%
Lemongrass (India) 4 8007-02-1 Cymbopogon citratus (DC) Stapf (C. flexuosus), fam. Poaceae (Gramineae) 0.4%
Lemongrass (Bhuta) 8007-02-1 Cymbopogon citratus (DC) Stapf (C. flexuosus), fam. Poaceae (Gramineae) 0.01%
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.01%
Cassie absolute 1a extract 8023-82-3 Acacia farnesiana (L.) Willd., fam. Mimosaceae (Leguminosae) 0.5%