4-Methylumbelliferyl beta-D-xyloside

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  • Identifiers

    CAS number
    6734-33-4

    Molecular formula
    C15H16O7

    SMILES
    CC1=CC(=O)OC2=C1C=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H](CO3)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 53.36%
    Sweet 40.51%
    Vanilla 35.69%
    Phenolic 28.84%
    Creamy 25.01%
    Milky 23.37%
    Spicy 22.05%
    Powdery 21.46%
    Coconut 21.26%
    Caramellic 21.16%

     

    Flavor
    Bitter 80.6%
    Bland 27.55%
    Odorless 25.96%
    Sweet-like 24.23%
    Cedarleaf 20.55%
    Parsley 20.07%
    Eugenol 19.78%
    Lovage 19.65%
    Naphthalic 19.4%
    Fenugreek 19.25%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    6.62 (neutral)

    Molecular weight
    308.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1238°C

    Flash point

    • 238.61 ˚C est.

  • Synonyms

    • 6734-33-4
    • 4-Methylumbelliferyl beta-D-xyloside
    • Methylumbelliferyl-beta-D-xyloside
    • 766N8850JA
    • DTXSID10217687
    • 4-methylumbelliferyl-beta-xyloside
    • 2H-1-Benzopyran-2-one, 4-methyl-7-(beta-D-xylopyranosyloxy)-
    • Xyl-MU
    • RefChem:912706
    • DTXCID60140178
    • 4-Methylumbelliferyl-beta-D-xylopyranoside
    • 4-Methylumbelliferyl beta-D-xylopyranoside
    • 4-Methylumbelliferyl b-D-xylopyranoside
    • MFCD00037607
    • 4-Methylumbelliferyl-|A-D-xylopyranoside
    • 4-methyl-7-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxychromen-2-one
    • CHEMBL1938471
    • 2H-1-Benzopyran-2-one, 4-methyl-7-(b-D-xylopyranosyloxy)-
    • 4-Methyl-7-(beta-D-xylopyranosyloxy)-2H-1-benzopyran-2-one
    • 4-methyl-7-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one
    • 4'-Methylumbelliferyl-b-D-xylose
    • 4-MU-b-D-Xyl
    • 4-Methylumbelliferyl beta-xyloside
    • EINECS 229-784-4
    • 4-Methylumbelliferyl-beta-D-xyloside
    • 4-Methylumbelliferylb-D-xylopyranoside
    • SCHEMBL197177
    • orb1819215
    • UNII-766N8850JA
    • JWIYLOHVJDJZOQ-KAOXEZKKSA-N
    • 2H-1-Benzopyran-2-one,4-methyl-7-(b-D-xylopyranosyloxy)-
    • 2H-1-Benzopyran-2-one, 4-methyl-7-(.beta.-D-xylopyranosyloxy)-
    • BDBM50361734
    • AKOS005257904
    • AKOS015899834
    • EM03180
    • 4-methyl-7-{[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}-2H-chromen-2-one
    • s12045
    • AS-70369
    • PD171160
    • 4-Methylumbelliferyl I(2)-D-xylopyranoside
    • HY-137824
    • 4-Methylumbelliferyl- beta -D-xylopyranoside
    • NS00036114
    • (4-Methylumbelliferone)-beta-D-xylopyranoside
    • 4-METHYLUMBELLIFERONE-.BETA.-D-XYLOSIDE
    • M-6500
    • M04141
    • 734M334
    • 4-METHYLUMBELLIFERYL .BETA.-D-XYLOPYRANOSIDE
    • Q27894530
    • 4-Methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-xylopyranoside
    • 4-Methyl-7-(|A-D-xylopyranosyloxy)-2H-1-benzopyran-2-one
    • 4-METHYLUMBELLIFERYL .BETA.-D-XYLOPYRANOSIDE, (-)-
    • COUMARIN, 4-METHYL-7-(.BETA.-D-XYLOPYRANOSYLOXY)-
    • 7-(beta-D-Xylopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
    • 4-Methylumbelliferyl-beta-D-xylopyranoside, beta-xylosidase substrate
    • 4-METHYL-7-(.BETA.-D-XYLOPYRANOSYLOXY)-2H-1-BENZOPYRAN-2-ONE
    • 4-methyl-7-[(2S,3R,4S,5R)-3,4,5-trihydroxytetrahydropyran-2-yl]oxy-chromen-2-one
    • 6734-33-4

  • Applications

    4-Methylumbelliferyl beta-D-xyloside (CAS 6734-33-4) is a fluorogenic substrate used to assay β-xylosidase activity in biochemical research and enzyme screening. It is commonly employed in pharmaceutical and biotech R&D workflows for fluorescence-based detection of xylose release, including assay development and high-throughput screening. In academic and industrial laboratories, it functions as a model substrate for glycosidase profiling in microorganisms and plant extracts, and as a component in fluorescence-based analytical kits. It may also serve as a reference standard for analytical method validation in fluorescence-based detection. Use is typically limited to research and development contexts and is subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.31
    methanol 3.33
    isopropanol 1.62
    water 0.15
    ethyl acetate 0.26
    n-propanol 1.87
    acetone 1.22
    n-butanol 1.84
    acetonitrile 0.36
    DMF 23.99
    toluene 0.11
    isobutanol 1.04
    1,4-dioxane 2.63
    methyl acetate 0.44
    THF 9.85
    2-butanone 1.28
    n-pentanol 0.94
    sec-butanol 1.8
    n-hexane 0.01
    ethylene glycol 7.36
    NMP 17.48
    cyclohexane 0.02
    DMSO 143.23
    n-butyl acetate 0.27
    n-octanol 0.91
    chloroform 0.02
    n-propyl acetate 0.3
    acetic acid 6.91
    dichloromethane 0.05
    cyclohexanone 2.74
    propylene glycol 6.55
    isopropyl acetate 0.29
    DMAc 43.83
    2-ethoxyethanol 19.34
    isopentanol 1.61
    n-heptane 0.06
    ethyl formate 0.39
    1,2-dichloroethane 0.1
    n-hexanol 0.65
    2-methoxyethanol 47.43
    isobutyl acetate 0.21
    tetrachloromethane 0.01
    n-pentyl acetate 0.62
    transcutol 51.51
    n-heptanol 1.2
    ethylbenzene 0.07
    MIBK 0.87
    2-propoxyethanol 10.5
    tert-butanol 2.01
    MTBE 0.46
    2-butoxyethanol 6.64
    propionic acid 1.55
    o-xylene 0.14
    formic acid 20.83
    diethyl ether 0.38
    m-xylene 0.15
    p-xylene 0.11
    chlorobenzene 0.04
    dimethyl carbonate 1.01
    n-octane 0.03
    formamide 30.07
    cyclopentanone 4.29
    2-pentanone 0.96
    anisole 0.43
    cyclopentyl methyl ether 1.26
    gamma-butyrolactone 4.63
    1-methoxy-2-propanol 25.67
    pyridine 1.26
    3-pentanone 0.6
    furfural 5.81
    n-dodecane 0.03
    diethylene glycol 20.69
    diisopropyl ether 0.12
    tert-amyl alcohol 1.84
    acetylacetone 2.28
    n-hexadecane 0.03
    acetophenone 0.95
    methyl propionate 0.73
    isopentyl acetate 0.52
    trichloroethylene 0.16
    n-nonanol 1.1
    cyclohexanol 1.25
    benzyl alcohol 1.19
    2-ethylhexanol 0.51
    isooctanol 1.0
    dipropyl ether 0.72
    1,2-dichlorobenzene 0.07
    ethyl lactate 1.73
    propylene carbonate 1.06
    n-methylformamide 6.95
    2-pentanol 0.93
    n-pentane 0.02
    1-propoxy-2-propanol 5.85
    1-methoxy-2-propyl acetate 1.93
    2-(2-methoxypropoxy) propanol 9.26
    mesitylene 0.11
    ε-caprolactone 2.35
    p-cymene 0.17
    epichlorohydrin 3.71
    1,1,1-trichloroethane 0.03
    2-aminoethanol 9.17
    morpholine-4-carbaldehyde 23.95
    sulfolane 20.9
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 1.97
    n-hexyl acetate 1.02
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 13.25
    sec-butyl acetate 0.22
    tert-butyl acetate 0.77
    decalin 0.02
    glycerin 29.12
    diglyme 24.05
    acrylic acid 2.63
    isopropyl myristate 0.5
    n-butyric acid 1.52
    acetyl acetate 0.32
    di(2-ethylhexyl) phthalate 1.12
    ethyl propionate 0.32
    nitromethane 8.68
    1,2-diethoxyethane 2.64
    benzonitrile 0.37
    trioctyl phosphate 0.74
    1-bromopropane 0.06
    gamma-valerolactone 15.7
    n-decanol 0.82
    triethyl phosphate 0.78
    4-methyl-2-pentanol 0.59
    propionitrile 0.29
    vinylene carbonate 0.86
    1,1,2-trichlorotrifluoroethane 8.4
    DMS 0.97
    cumene 0.08
    2-octanol 0.63
    2-hexanone 0.65
    octyl acetate 0.75
    limonene 0.25
    1,2-dimethoxyethane 13.58
    ethyl orthosilicate 0.76
    tributyl phosphate 0.8
    diacetone alcohol 5.44
    N,N-dimethylaniline 0.57
    acrylonitrile 0.64
    aniline 0.57
    1,3-propanediol 15.31
    bromobenzene 0.03
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.2
    2-methyl-cyclohexyl acetate 0.85
    tetrabutyl urea 1.91
    diisobutyl methanol 0.46
    2-phenylethanol 1.06
    styrene 0.06
    dioctyl adipate 1.28
    dimethyl sulfate 3.67
    ethyl butyrate 0.48
    methyl lactate 4.65
    butyl lactate 1.8
    diethyl carbonate 0.36
    propanediol butyl ether 7.04
    triethyl orthoformate 0.93
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 3.29
    morpholine 7.09
    tert-butylamine 0.4
    n-dodecanol 0.56
    dimethoxymethane 9.55
    ethylene carbonate 0.63
    cyrene 10.04
    2-ethoxyethyl acetate 1.69
    2-ethylhexyl acetate 0.34
    1,2,4-trichlorobenzene 0.13
    4-methylpyridine 0.67
    dibutyl ether 0.65
    2,6-dimethyl-4-heptanol 0.46
    DEF 3.04
    dimethyl isosorbide 11.92
    tetrachloroethylene 0.16
    eugenol 4.1
    triacetin 2.7
    span 80 5.38
    1,4-butanediol 4.57
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.99
    methyl formate 3.15
    2-methyl-1-butanol 1.53
    n-decane 0.06
    butyronitrile 0.3
    3,7-dimethyl-1-octanol 0.85
    1-chlorooctane 0.19
    1-chlorotetradecane 0.09
    n-nonane 0.04
    undecane 0.04
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 1.83
    tetrahydropyran 0.98
    tert-amyl methyl ether 0.71
    2,5,8-trioxanonane 19.08
    1-hexene 0.05
    2-isopropoxyethanol 6.92
    2,2,2-trifluoroethanol 2.68
    methyl butyrate 0.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction