4-Methylquinoline

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  • Identifiers

    CAS number
    491-35-0

    Molecular formula
    C10H9N

    SMILES
    CC1=CC=NC2=CC=CC=C12

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Sweet 68.67%
    Herbal 67.47%
    Animal 66.94%
    Floral 65.31%
    Green 62.0%
    Tobacco 56.65%
    Leathery 49.48%
    Earthy 47.9%
    Oily 46.56%
    Musty 44.38%

    Scent© AI

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    4.81 (weak acid)

    Molecular weight
    143.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 9.5 °C

    Boiling point

    • 261-263 °C

    Flash point est.
    105.26 ˚C

    Solubility expt.

    • Slightly soluble in water
    • Soluble in ethanol, ether, and acetone.
    • Miscible with alcohol and benzene
    • Soluble in mineral acid; insoluble in alkali
    • In water, 783 mg/liter @ 25 °C

  • Synonyms

    • Lepidine
    • 4-METHYLQUINOLINE
    • 491-35-0
    • Quinoline, 4-methyl-
    • Cincholepidine
    • Lepidin
    • 4-Lepidine
    • p-Methylquinoline
    • 4-methyl-quinoline
    • gamma-Methylquinoline
    • CCRIS 2894
    • HSDB 7153
    • NSC 3412
    • AI3-24277
    • EINECS 207-734-2
    • MFCD00006784
    • BRN 0110926
    • DTXSID7047067
    • CHEBI:48983
    • .gamma.-Methylquinoline
    • LEPIDINE [MI]
    • NSC-3412
    • 116169T3O8
    • DTXCID5027067
    • 5-20-07-00389 (Beilstein Handbook Reference)
    • 4-methyl quinoline
    • Lepidine (4-Methylquinoline)
    • pMethylquinoline
    • 4Lepidine
    • 4-lepidin
    • gammaMethylquinoline
    • UNII-116169T3O8
    • Quinoline, 4methyl
    • Lepidine, 99%
    • methyl-4 isoquinoleine
    • CHEMBL9734
    • SCHEMBL31559
    • 4-Methylquinoline, >=99%
    • NSC3412
    • BCP27150
    • STR06140
    • Tox21_301829
    • AKOS000119150
    • FM35012
    • PS-3771
    • NCGC00184238-01
    • NCGC00184238-02
    • NCGC00184238-03
    • NCGC00184238-04
    • NCGC00184238-05
    • NCGC00184238-06
    • NCGC00184238-07
    • NCGC00184238-08
    • NCGC00184238-09
    • NCGC00184238-10
    • NCGC00256086-01
    • CAS-491-35-0
    • DB-013319
    • L0024
    • NS00012990
    • EN300-19081
    • A22510
    • H10212
    • Q6527408
    • F0001-1281
    • Z104472668
    • 207-734-2

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 132.99
    methanol 85.47
    isopropanol 110.69
    water 0.77
    ethyl acetate 424.17
    n-propanol 145.18
    acetone 463.75
    n-butanol 142.22
    acetonitrile 435.32
    DMF 462.19
    toluene 307.1
    isobutanol 123.25
    1,4-dioxane 1457.67
    methyl acetate 376.46
    THF 1055.45
    2-butanone 407.01
    n-pentanol 144.98
    sec-butanol 117.53
    n-hexane 104.55
    ethylene glycol 18.81
    NMP 503.0
    cyclohexane 94.7
    DMSO 624.9
    n-butyl acetate 533.02
    n-octanol 114.12
    chloroform 980.69
    n-propyl acetate 370.51
    acetic acid 153.48
    dichloromethane 1297.25
    cyclohexanone 705.95
    propylene glycol 14.17
    isopropyl acetate 232.45
    DMAc 252.05
    2-ethoxyethanol 199.0
    isopentanol 135.3
    n-heptane 78.75
    ethyl formate 239.57
    1,2-dichloroethane 974.01
    n-hexanol 227.82
    2-methoxyethanol 224.44
    isobutyl acetate 257.69
    tetrachloromethane 222.34
    n-pentyl acetate 243.76
    transcutol 681.29
    n-heptanol 114.67
    ethylbenzene 182.19
    MIBK 229.42
    2-propoxyethanol 340.66
    tert-butanol 150.39
    MTBE 242.9
    2-butoxyethanol 185.5
    propionic acid 133.08
    o-xylene 163.58
    formic acid 32.26
    diethyl ether 498.11
    m-xylene 195.29
    p-xylene 227.22
    chlorobenzene 377.84
    dimethyl carbonate 151.31
    n-octane 41.42
    formamide 80.04
    cyclopentanone 786.04
    2-pentanone 357.88
    anisole 296.51
    cyclopentyl methyl ether 555.97
    gamma-butyrolactone 878.13
    1-methoxy-2-propanol 165.83
    pyridine 690.74
    3-pentanone 331.89
    furfural 530.99
    n-dodecane 25.48
    diethylene glycol 166.29
    diisopropyl ether 139.97
    tert-amyl alcohol 131.87
    acetylacetone 372.38
    n-hexadecane 30.19
    acetophenone 240.27
    methyl propionate 304.37
    isopentyl acetate 347.95
    trichloroethylene 1249.18
    n-nonanol 103.83
    cyclohexanol 185.89
    benzyl alcohol 157.73
    2-ethylhexanol 162.25
    isooctanol 102.18
    dipropyl ether 333.66
    1,2-dichlorobenzene 284.45
    ethyl lactate 94.66
    propylene carbonate 382.96
    n-methylformamide 208.59
    2-pentanol 115.46
    n-pentane 61.07
    1-propoxy-2-propanol 230.48
    1-methoxy-2-propyl acetate 276.86
    2-(2-methoxypropoxy) propanol 147.43
    mesitylene 123.6
    ε-caprolactone 556.72
    p-cymene 105.16
    epichlorohydrin 1112.58
    1,1,1-trichloroethane 664.86
    2-aminoethanol 43.17
    morpholine-4-carbaldehyde 598.98
    sulfolane 796.37
    2,2,4-trimethylpentane 28.7
    2-methyltetrahydrofuran 797.49
    n-hexyl acetate 293.43
    isooctane 27.16
    2-(2-butoxyethoxy)ethanol 222.04
    sec-butyl acetate 214.68
    tert-butyl acetate 235.14
    decalin 58.62
    glycerin 31.62
    diglyme 472.91
    acrylic acid 113.91
    isopropyl myristate 119.97
    n-butyric acid 207.74
    acetyl acetate 214.29
    di(2-ethylhexyl) phthalate 80.87
    ethyl propionate 280.23
    nitromethane 474.64
    1,2-diethoxyethane 468.1
    benzonitrile 268.57
    trioctyl phosphate 68.99
    1-bromopropane 512.81
    gamma-valerolactone 848.66
    n-decanol 83.22
    triethyl phosphate 109.59
    4-methyl-2-pentanol 80.14
    propionitrile 307.87
    vinylene carbonate 362.98
    1,1,2-trichlorotrifluoroethane 279.97
    DMS 247.36
    cumene 119.62
    2-octanol 92.15
    2-hexanone 359.98
    octyl acetate 145.52
    limonene 154.13
    1,2-dimethoxyethane 619.82
    ethyl orthosilicate 107.05
    tributyl phosphate 91.51
    diacetone alcohol 186.17
    N,N-dimethylaniline 178.02
    acrylonitrile 339.47
    aniline 232.91
    1,3-propanediol 84.56
    bromobenzene 451.19
    dibromomethane 870.63
    1,1,2,2-tetrachloroethane 751.65
    2-methyl-cyclohexyl acetate 180.36
    tetrabutyl urea 119.59
    diisobutyl methanol 96.47
    2-phenylethanol 188.26
    styrene 215.36
    dioctyl adipate 136.02
    dimethyl sulfate 220.21
    ethyl butyrate 290.05
    methyl lactate 74.29
    butyl lactate 116.54
    diethyl carbonate 172.01
    propanediol butyl ether 104.21
    triethyl orthoformate 161.98
    p-tert-butyltoluene 97.37
    methyl 4-tert-butylbenzoate 158.91
    morpholine 935.77
    tert-butylamine 119.11
    n-dodecanol 67.57
    dimethoxymethane 437.88
    ethylene carbonate 353.07
    cyrene 146.72
    2-ethoxyethyl acetate 293.64
    2-ethylhexyl acetate 316.36
    1,2,4-trichlorobenzene 302.27
    4-methylpyridine 596.49
    dibutyl ether 271.7
    2,6-dimethyl-4-heptanol 96.47
    DEF 383.85
    dimethyl isosorbide 309.35
    tetrachloroethylene 565.98
    eugenol 156.88
    triacetin 187.12
    span 80 120.05
    1,4-butanediol 47.99
    1,1-dichloroethane 683.05
    2-methyl-1-pentanol 134.3
    methyl formate 208.82
    2-methyl-1-butanol 128.8
    n-decane 43.81
    butyronitrile 296.99
    3,7-dimethyl-1-octanol 104.01
    1-chlorooctane 150.77
    1-chlorotetradecane 58.87
    n-nonane 47.52
    undecane 32.65
    tert-butylcyclohexane 56.51
    cyclooctane 42.98
    cyclopentanol 208.13
    tetrahydropyran 924.15
    tert-amyl methyl ether 189.97
    2,5,8-trioxanonane 272.64
    1-hexene 251.67
    2-isopropoxyethanol 176.08
    2,2,2-trifluoroethanol 77.38
    methyl butyrate 357.83

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Genet absolute 2 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.03%