4-Methylquinolin-2-ol

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  • Identifiers

    CAS number
    607-66-9

    Molecular formula
    C10H9NO

    SMILES
    CC1=CC(=O)NC2=CC=CC=C12

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Animal 45.89%
    Phenolic 37.87%
    Floral 34.36%
    Burnt 31.75%
    Musty 30.94%
    Bitter 29.47%
    Sweet 29.09%
    Fruity 28.38%
    Tobacco 27.84%
    Powdery 27.27%

     

    Flavor
    Bitter 75.95%
    Very strong 23.37%
    Indole 22.87%
    Nitrile 21.51%
    Moth ball 21.38%
    Naphthelene 21.28%
    Almond shell 21.03%
    Flat 20.96%
    Phenolic 20.81%
    Medical 20.66%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    7.67 (neutral)

    Molecular weight
    159.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    350°C

    Flash point

    • 176.23 ˚C est.

  • Synonyms

    • 4-Methylquinolin-2-ol
    • 2-Hydroxy-4-methylquinoline
    • 607-66-9
    • 84909-43-3
    • 4-methylquinolin-2(1H)-one
    • 4-Methyl-2-quinolinol
    • 4-Methylcarbostyril
    • 2-Hydroxylepidine
    • 4-Methyl-1H-quinolin-2-one
    • 4-Methyl-2-hydroxyquinoline
    • 4-Methyl-2-quinolone
    • 2(1H)-Lepidinone
    • 2-Lepidinol
    • 4-Methyl-2(1H)-quinolinone
    • 2(1H)-Quinolinone, 4-methyl-
    • 4-Methylquinolin-2-one
    • Carbostyril, 4-methyl-
    • NSC 2057
    • AI3-00843
    • EINECS 210-139-0
    • MFCD00006745
    • CHEBI:48986
    • DTXSID20976132
    • 4-methyl-quinolin-2-ol
    • NSC2057
    • AJ2
    • Lepidine, 2-hydroxy
    • 4-Methylquinol-2-one
    • 2-Quinolinol, 4-methyl-
    • Oprea1_272485
    • Oprea1_547052
    • Oprea1_780405
    • cid_69088
    • MLS000096591
    • SCHEMBL377555
    • Carbostyril, 4-methyl-(VAN)
    • CHEMBL424414
    • Carbostyril, 4-methyl- (VAN)
    • BDBM29214
    • DTXCID601403512
    • HMS1722B17
    • HMS2320G05
    • ALBB-026701
    • BCP33184
    • NSC-2057
    • 2-Hydroxy-4-methylquinoline, 97%
    • MFCD00790771
    • STK038061
    • STL304705
    • 1,2-Dihydro-4-methyl-2-oxoquinoline
    • AKOS000120372
    • AKOS001041007
    • 3N-601S
    • Carbostyril, 4-methyl-(VAN) (8CI)
    • DS-1525
    • FH35034
    • SB67458
    • SB67481
    • SDCCGMLS-0027272.P002
    • NCGC00036814-02
    • NCGC00036814-03
    • NCGC00036814-04
    • NCGC00036814-05
    • NCGC00036814-06
    • NCGC00036814-07
    • SMR000062448
    • SY057803
    • SY317482
    • 4-Methyl-2-quinolinol 4-Methylcarbostyril
    • DB-053698
    • CS-0097736
    • H0259
    • NS00043066
    • EN300-17147
    • F10377
    • O11270
    • AE-848/00959010
    • 4-Methylquinolin-2-ol;4-Methylquinolin-2(1H)-one
    • Q27121422
    • Z56893183
    • F0109-0047
    • F0183-0103
    • InChI=1/C10H9NO/c1-7-6-10(12)11-9-5-3-2-4-8(7)9/h2-6H,1H3,(H,11,12
    • 210-139-0

  • Applications

    4-Methylquinolin-2-ol (CAS 607-66-9) is primarily used as an intermediate for the synthesis of quinoline-based heterocycles and dyes, serving as a building block for pigments, coatings, and polymer materials. The 2-hydroxyquinoline core provides metal-coordination capability, so it is employed as a chelating ligand in analytical chemistry and catalytic systems. In pharmaceutical R&D, it is commonly evaluated as a scaffold for quinoline-derived compounds in medicinal chemistry programs. It can also be a precursor for fluorescent and luminescent materials intended for organic electronics and sensing applications. Additionally, it may function as a reactive intermediate or chelating additive in polymer or coating formulations where metal-binding properties influence performance. Overall, its applications span synthesis, coordination chemistry, and materials science, and are subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 27.75
    methanol 24.01
    isopropanol 19.49
    water 0.34
    ethyl acetate 28.04
    n-propanol 27.01
    acetone 62.89
    n-butanol 22.65
    acetonitrile 25.66
    DMF 122.61
    toluene 4.17
    isobutanol 18.73
    1,4-dioxane 115.36
    methyl acetate 32.23
    THF 260.86
    2-butanone 54.78
    n-pentanol 24.25
    sec-butanol 18.01
    n-hexane 1.2
    ethylene glycol 5.67
    NMP 114.33
    cyclohexane 0.24
    DMSO 274.85
    n-butyl acetate 38.45
    n-octanol 15.0
    chloroform 28.08
    n-propyl acetate 26.81
    acetic acid 29.52
    dichloromethane 43.56
    cyclohexanone 78.26
    propylene glycol 4.4
    isopropyl acetate 18.44
    DMAc 68.37
    2-ethoxyethanol 47.26
    isopentanol 23.75
    n-heptane 1.69
    ethyl formate 18.92
    1,2-dichloroethane 46.98
    n-hexanol 33.13
    2-methoxyethanol 71.89
    isobutyl acetate 20.01
    tetrachloromethane 3.88
    n-pentyl acetate 29.1
    transcutol 124.54
    n-heptanol 20.01
    ethylbenzene 4.94
    MIBK 29.96
    2-propoxyethanol 81.41
    tert-butanol 26.28
    MTBE 18.44
    2-butoxyethanol 45.35
    propionic acid 20.99
    o-xylene 4.27
    formic acid 12.13
    diethyl ether 23.23
    m-xylene 5.86
    p-xylene 8.32
    chlorobenzene 10.2
    dimethyl carbonate 15.71
    n-octane 0.96
    formamide 29.14
    cyclopentanone 144.77
    2-pentanone 43.72
    anisole 17.29
    cyclopentyl methyl ether 53.23
    gamma-butyrolactone 153.5
    1-methoxy-2-propanol 52.66
    pyridine 39.26
    3-pentanone 28.9
    furfural 70.03
    n-dodecane 0.98
    diethylene glycol 55.15
    diisopropyl ether 6.28
    tert-amyl alcohol 22.19
    acetylacetone 47.35
    n-hexadecane 1.11
    acetophenone 21.74
    methyl propionate 31.87
    isopentyl acetate 32.78
    trichloroethylene 68.17
    n-nonanol 14.7
    cyclohexanol 16.52
    benzyl alcohol 16.58
    2-ethylhexanol 19.65
    isooctanol 17.73
    dipropyl ether 22.69
    1,2-dichlorobenzene 12.32
    ethyl lactate 15.46
    propylene carbonate 41.33
    n-methylformamide 49.26
    2-pentanol 14.85
    n-pentane 0.5
    1-propoxy-2-propanol 46.66
    1-methoxy-2-propyl acetate 40.45
    2-(2-methoxypropoxy) propanol 38.69
    mesitylene 3.95
    ε-caprolactone 56.62
    p-cymene 7.48
    epichlorohydrin 189.56
    1,1,1-trichloroethane 22.5
    2-aminoethanol 14.49
    morpholine-4-carbaldehyde 110.37
    sulfolane 174.48
    2,2,4-trimethylpentane 0.75
    2-methyltetrahydrofuran 101.68
    n-hexyl acetate 34.69
    isooctane 0.76
    2-(2-butoxyethoxy)ethanol 54.45
    sec-butyl acetate 16.24
    tert-butyl acetate 24.81
    decalin 0.95
    glycerin 13.45
    diglyme 94.49
    acrylic acid 17.41
    isopropyl myristate 14.24
    n-butyric acid 29.6
    acetyl acetate 13.4
    di(2-ethylhexyl) phthalate 16.07
    ethyl propionate 22.68
    nitromethane 73.89
    1,2-diethoxyethane 39.77
    benzonitrile 18.48
    trioctyl phosphate 13.09
    1-bromopropane 18.4
    gamma-valerolactone 155.54
    n-decanol 11.69
    triethyl phosphate 15.41
    4-methyl-2-pentanol 12.04
    propionitrile 21.97
    vinylene carbonate 31.77
    1,1,2-trichlorotrifluoroethane 46.14
    DMS 27.62
    cumene 5.88
    2-octanol 13.94
    2-hexanone 39.05
    octyl acetate 19.33
    limonene 9.6
    1,2-dimethoxyethane 89.05
    ethyl orthosilicate 14.64
    tributyl phosphate 15.45
    diacetone alcohol 42.3
    N,N-dimethylaniline 16.0
    acrylonitrile 28.66
    aniline 10.88
    1,3-propanediol 26.06
    bromobenzene 8.19
    dibromomethane 22.88
    1,1,2,2-tetrachloroethane 45.64
    2-methyl-cyclohexyl acetate 23.98
    tetrabutyl urea 22.27
    diisobutyl methanol 11.65
    2-phenylethanol 24.51
    styrene 4.11
    dioctyl adipate 19.82
    dimethyl sulfate 39.6
    ethyl butyrate 22.28
    methyl lactate 16.81
    butyl lactate 24.25
    diethyl carbonate 15.36
    propanediol butyl ether 32.34
    triethyl orthoformate 17.66
    p-tert-butyltoluene 6.97
    methyl 4-tert-butylbenzoate 32.36
    morpholine 126.34
    tert-butylamine 12.38
    n-dodecanol 8.89
    dimethoxymethane 86.59
    ethylene carbonate 26.98
    cyrene 37.67
    2-ethoxyethyl acetate 41.28
    2-ethylhexyl acetate 25.53
    1,2,4-trichlorobenzene 16.52
    4-methylpyridine 33.71
    dibutyl ether 17.01
    2,6-dimethyl-4-heptanol 11.65
    DEF 42.4
    dimethyl isosorbide 69.81
    tetrachloroethylene 24.52
    eugenol 36.04
    triacetin 28.43
    span 80 28.86
    1,4-butanediol 12.82
    1,1-dichloroethane 24.49
    2-methyl-1-pentanol 23.41
    methyl formate 33.21
    2-methyl-1-butanol 20.36
    n-decane 1.48
    butyronitrile 23.79
    3,7-dimethyl-1-octanol 15.43
    1-chlorooctane 8.66
    1-chlorotetradecane 3.53
    n-nonane 1.3
    undecane 1.21
    tert-butylcyclohexane 1.5
    cyclooctane 0.17
    cyclopentanol 30.3
    tetrahydropyran 63.72
    tert-amyl methyl ether 16.46
    2,5,8-trioxanonane 61.61
    1-hexene 6.97
    2-isopropoxyethanol 35.8
    2,2,2-trifluoroethanol 15.15
    methyl butyrate 30.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction