4-Methylpyrrolo[1,2-a]pyrazine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    64608-60-2

    Molecular formula
    C8H8N2

    SMILES
    CC1=CN=CC2=CC=CN12

    Safety labels

  • Odor profile

    Fragrance
    Roasted 76.67%
    Nutty 66.88%
    Burnt 55.88%
    Coffee 54.13%
    Hazelnut 49.38%
    Earthy 46.46%
    Musty 45.67%
    Potato 39.27%
    Fruity 38.86%
    Meaty 38.03%

     

    Flavor
    Nutty 51.8%
    Roasted 48.76%
    Coffee 47.74%
    Bitter 45.73%
    Cocoa 43.16%
    Corn 37.1%
    Musty 36.44%
    Peanut 34.25%
    Hazelnut 32.12%
    Roast 31.93%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    4.84 (weak acid)

    Molecular weight
    132.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    302°C

    Flash point

    • 109.55 ˚C est.

  • Synonyms

    • 4-Methylpyrrolo[1,2-a]pyrazine
    • 64608-60-2
    • LL8VB7BF3K
    • 4-Methylpyrrolo(1,2-a)pyrazine
    • Pyrrolo(1,2-a)pyrazine, 4-methyl-
    • RefChem:99940
    • GCXGRZISVBCADH-UHFFFAOYSA-N
    • UNII-LL8VB7BF3K
    • SCHEMBL18237882
    • CHEBI:173356
    • DTXSID501305878
    • Pyrrolo[1,2-a]pyrazine,4-methyl-(9ci)
    • NS00113934
    • 64608-60-2

  • Applications

    4-Methylpyrrolo[1,2-a]pyrazine (CAS 64608-60-2) is used primarily as an aroma scaffold and intermediate in the fragrance and flavor industries. In perfumery it contributes roasty to nutty notes and serves as a building block for the synthesis of more complex odorants. In flavor formulations it is evaluated as an aroma intermediate to support roasted or savory character in formulations where permitted. In cosmetics and personal care, it can function as a fragrance ingredient for scented products. In industrial manufacturing, it serves as an intermediate in the synthesis of heterocyclic aroma compounds and related fragrance and flavor products. Its use is typically as an odorant or fragrance-building block and is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 293.98
    methanol 467.71
    isopropanol 178.95
    water 31.95
    ethyl acetate 183.02
    n-propanol 246.74
    acetone 258.27
    n-butanol 230.4
    acetonitrile 248.24
    DMF 274.87
    toluene 117.95
    isobutanol 202.1
    1,4-dioxane 256.23
    methyl acetate 158.32
    THF 521.02
    2-butanone 207.78
    n-pentanol 191.36
    sec-butanol 179.76
    n-hexane 34.42
    ethylene glycol 118.21
    NMP 273.57
    cyclohexane 36.55
    DMSO 284.57
    n-butyl acetate 102.61
    n-octanol 41.92
    chloroform 418.44
    n-propyl acetate 76.92
    acetic acid 276.1
    dichloromethane 532.68
    cyclohexanone 234.28
    propylene glycol 92.37
    isopropyl acetate 78.23
    DMAc 206.45
    2-ethoxyethanol 246.42
    isopentanol 172.5
    n-heptane 25.98
    ethyl formate 147.01
    1,2-dichloroethane 281.02
    n-hexanol 132.08
    2-methoxyethanol 357.06
    isobutyl acetate 54.12
    tetrachloromethane 92.26
    n-pentyl acetate 62.06
    transcutol 408.84
    n-heptanol 49.62
    ethylbenzene 37.65
    MIBK 83.22
    2-propoxyethanol 209.0
    tert-butanol 140.13
    MTBE 123.49
    2-butoxyethanol 95.01
    propionic acid 149.97
    o-xylene 59.26
    formic acid 287.43
    diethyl ether 239.35
    m-xylene 66.02
    p-xylene 50.2
    chlorobenzene 139.36
    dimethyl carbonate 68.3
    n-octane 8.99
    formamide 260.47
    cyclopentanone 278.0
    2-pentanone 171.66
    anisole 83.54
    cyclopentyl methyl ether 222.36
    gamma-butyrolactone 288.69
    1-methoxy-2-propanol 185.45
    pyridine 266.65
    3-pentanone 156.36
    furfural 267.42
    n-dodecane 6.16
    diethylene glycol 186.03
    diisopropyl ether 51.61
    tert-amyl alcohol 137.16
    acetylacetone 123.31
    n-hexadecane 6.74
    acetophenone 72.82
    methyl propionate 154.35
    isopentyl acetate 81.58
    trichloroethylene 409.79
    n-nonanol 38.29
    cyclohexanol 151.36
    benzyl alcohol 97.76
    2-ethylhexanol 68.61
    isooctanol 42.1
    dipropyl ether 98.47
    1,2-dichlorobenzene 104.29
    ethyl lactate 45.57
    propylene carbonate 131.83
    n-methylformamide 235.06
    2-pentanol 132.47
    n-pentane 40.85
    1-propoxy-2-propanol 115.31
    1-methoxy-2-propyl acetate 85.45
    2-(2-methoxypropoxy) propanol 88.47
    mesitylene 36.69
    ε-caprolactone 173.16
    p-cymene 30.93
    epichlorohydrin 390.59
    1,1,1-trichloroethane 190.18
    2-aminoethanol 177.22
    morpholine-4-carbaldehyde 241.99
    sulfolane 259.15
    2,2,4-trimethylpentane 16.5
    2-methyltetrahydrofuran 368.17
    n-hexyl acetate 69.08
    isooctane 9.89
    2-(2-butoxyethoxy)ethanol 118.63
    sec-butyl acetate 50.42
    tert-butyl acetate 63.44
    decalin 15.98
    glycerin 124.23
    diglyme 188.78
    acrylic acid 139.34
    isopropyl myristate 33.24
    n-butyric acid 201.26
    acetyl acetate 77.41
    di(2-ethylhexyl) phthalate 40.75
    ethyl propionate 74.92
    nitromethane 305.64
    1,2-diethoxyethane 155.87
    benzonitrile 112.79
    trioctyl phosphate 28.36
    1-bromopropane 204.65
    gamma-valerolactone 298.0
    n-decanol 30.37
    triethyl phosphate 38.29
    4-methyl-2-pentanol 62.69
    propionitrile 190.79
    vinylene carbonate 135.69
    1,1,2-trichlorotrifluoroethane 167.57
    DMS 70.59
    cumene 31.38
    2-octanol 32.58
    2-hexanone 97.94
    octyl acetate 41.55
    limonene 47.83
    1,2-dimethoxyethane 245.1
    ethyl orthosilicate 38.62
    tributyl phosphate 39.11
    diacetone alcohol 82.57
    N,N-dimethylaniline 59.68
    acrylonitrile 183.43
    aniline 156.19
    1,3-propanediol 205.29
    bromobenzene 131.92
    dibromomethane 340.73
    1,1,2,2-tetrachloroethane 242.72
    2-methyl-cyclohexyl acetate 55.2
    tetrabutyl urea 46.75
    diisobutyl methanol 36.47
    2-phenylethanol 79.0
    styrene 50.68
    dioctyl adipate 45.07
    dimethyl sulfate 85.71
    ethyl butyrate 70.18
    methyl lactate 64.29
    butyl lactate 48.76
    diethyl carbonate 51.22
    propanediol butyl ether 64.94
    triethyl orthoformate 52.02
    p-tert-butyltoluene 27.44
    methyl 4-tert-butylbenzoate 59.73
    morpholine 307.16
    tert-butylamine 103.27
    n-dodecanol 25.15
    dimethoxymethane 221.7
    ethylene carbonate 116.47
    cyrene 92.22
    2-ethoxyethyl acetate 99.91
    2-ethylhexyl acetate 68.71
    1,2,4-trichlorobenzene 110.81
    4-methylpyridine 219.35
    dibutyl ether 64.31
    2,6-dimethyl-4-heptanol 36.47
    DEF 159.46
    dimethyl isosorbide 134.37
    tetrachloroethylene 195.13
    eugenol 68.42
    triacetin 61.71
    span 80 65.93
    1,4-butanediol 124.23
    1,1-dichloroethane 245.94
    2-methyl-1-pentanol 150.44
    methyl formate 182.42
    2-methyl-1-butanol 186.86
    n-decane 9.58
    butyronitrile 205.98
    3,7-dimethyl-1-octanol 47.69
    1-chlorooctane 31.45
    1-chlorotetradecane 14.24
    n-nonane 9.87
    undecane 7.4
    tert-butylcyclohexane 14.26
    cyclooctane 14.05
    cyclopentanol 198.82
    tetrahydropyran 286.71
    tert-amyl methyl ether 105.68
    2,5,8-trioxanonane 145.13
    1-hexene 87.57
    2-isopropoxyethanol 137.51
    2,2,2-trifluoroethanol 112.69
    methyl butyrate 93.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction