4-Methylphenyl salicylate

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  • Identifiers

    CAS number
    607-88-5

    Molecular formula
    C14H12O3

    SMILES
    CC1=CC=C(C=C1)OC(=O)C2=CC=CC=C2O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 71.1%
    Sweet 63.34%
    Phenolic 57.44%
    Balsamic 54.59%
    Herbal 49.24%
    Fruity 45.79%
    Aromatic 37.93%
    Medicinal 36.11%
    Woody 35.61%
    Animal 35.4%

     

    Flavor
    Bitter 47.19%
    Phenolic 46.26%
    Sweet 41.47%
    Herbal 38.37%
    Balsam 37.51%
    Wintergreen 30.86%
    Powdery 27.72%
    Balsamic 26.87%
    Medicinal 26.44%
    Tobacco 26.24%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    4.1

    pKa est.
    9.28 (weak base)

    Molecular weight
    228.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    318°C

    Flash point

    • 157.59 ˚C est.

  • Synonyms

    • p-Tolyl salicylate
    • 607-88-5
    • p-tolyl 2-hydroxybenzoate
    • Salicylic Acid p-Tolyl Ester
    • p-Cresyl salicylate
    • 4-Methylphenyl salicylate
    • Salicylic acid, p-tolyl ester
    • 4-Methylphenyl 2-hydroxybenzoate
    • Benzoic acid, 2-hydroxy-, 4-methylphenyl ester
    • (4-methylphenyl) 2-hydroxybenzoate
    • EINECS 210-144-8
    • NSC 60999
    • BRN 2114441
    • 8S7I019XJF
    • AI3-19491
    • NSC-60999
    • TOLYL SALICYLATE, P-
    • DTXSID3047508
    • 3-10-00-00132 (Beilstein Handbook Reference)
    • UNII-8S7I019XJF
    • MFCD00059616
    • para-cresyl salicylate
    • p-tolyl2-hydroxybenzoate
    • SCHEMBL1603005
    • CHEMBL2260698
    • DTXCID1027508
    • NSC60999
    • Salicylic Acid 4-Methylphenyl Ester
    • Tox21_302616
    • AKOS015838936
    • NCGC00256803-01
    • AS-87560
    • CAS-607-88-5
    • CS-0435540
    • NS00012141
    • D92213
    • Q27270959
    • 210-144-8

  • Applications

    4-Methylphenyl salicylate (CAS 607-88-5) is primarily used as a fragrance ingredient in perfumery, serving as an odorant and potentially helping to impart lasting notes in formulations. It is also employed in cosmetics and personal care products as a fragrance component, contributing to the scent profile of items such as shampoos and lotions. In coatings, inks, and certain polymer systems, it may function as a fragrance-related additive or scent carrier to enhance formulation stability and odor persistence. In industrial manufacturing, 4-Methylphenyl salicylate can be considered an intermediate or additive in specialty polymer and plastic formulations. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 783.63
    methanol 806.8
    isopropanol 384.6
    water 0.02
    ethyl acetate 842.57
    n-propanol 755.16
    acetone 566.79
    n-butanol 564.97
    acetonitrile 574.92
    DMF 739.1
    toluene 242.41
    isobutanol 341.17
    1,4-dioxane 890.19
    methyl acetate 811.4
    THF 1507.35
    2-butanone 1123.6
    n-pentanol 229.6
    sec-butanol 616.04
    n-hexane 1.71
    ethylene glycol 43.91
    NMP 329.44
    cyclohexane 3.69
    DMSO 1133.86
    n-butyl acetate 264.61
    n-octanol 35.77
    chloroform 417.21
    n-propyl acetate 241.46
    acetic acid 182.57
    dichloromethane 368.88
    cyclohexanone 551.79
    propylene glycol 191.71
    isopropyl acetate 299.38
    DMAc 971.31
    2-ethoxyethanol 379.35
    isopentanol 303.53
    n-heptane 1.58
    ethyl formate 204.36
    1,2-dichloroethane 504.45
    n-hexanol 157.03
    2-methoxyethanol 1192.35
    isobutyl acetate 125.14
    tetrachloromethane 10.57
    n-pentyl acetate 76.7
    transcutol 1431.52
    n-heptanol 47.27
    ethylbenzene 78.73
    MIBK 247.37
    2-propoxyethanol 410.62
    tert-butanol 357.2
    MTBE 352.61
    2-butoxyethanol 149.98
    propionic acid 230.46
    o-xylene 73.11
    formic acid 59.14
    diethyl ether 517.82
    m-xylene 79.21
    p-xylene 68.74
    chlorobenzene 165.61
    dimethyl carbonate 189.04
    n-octane 0.75
    formamide 293.29
    cyclopentanone 668.57
    2-pentanone 635.27
    anisole 285.08
    cyclopentyl methyl ether 388.4
    gamma-butyrolactone 613.03
    1-methoxy-2-propanol 811.61
    pyridine 761.52
    3-pentanone 413.84
    furfural 389.81
    n-dodecane 1.59
    diethylene glycol 251.76
    diisopropyl ether 59.02
    tert-amyl alcohol 386.5
    acetylacetone 503.07
    n-hexadecane 1.94
    acetophenone 203.74
    methyl propionate 661.12
    isopentyl acetate 226.4
    trichloroethylene 802.36
    n-nonanol 36.75
    cyclohexanol 245.23
    benzyl alcohol 198.25
    2-ethylhexanol 74.11
    isooctanol 42.85
    dipropyl ether 98.97
    1,2-dichlorobenzene 114.48
    ethyl lactate 102.81
    propylene carbonate 254.78
    n-methylformamide 489.06
    2-pentanol 253.7
    n-pentane 1.54
    1-propoxy-2-propanol 247.01
    1-methoxy-2-propyl acetate 288.36
    2-(2-methoxypropoxy) propanol 208.66
    mesitylene 33.23
    ε-caprolactone 428.93
    p-cymene 28.51
    epichlorohydrin 1174.45
    1,1,1-trichloroethane 200.39
    2-aminoethanol 235.93
    morpholine-4-carbaldehyde 470.22
    sulfolane 558.34
    2,2,4-trimethylpentane 4.07
    2-methyltetrahydrofuran 839.31
    n-hexyl acetate 117.32
    isooctane 3.41
    2-(2-butoxyethoxy)ethanol 324.48
    sec-butyl acetate 175.43
    tert-butyl acetate 284.85
    decalin 5.04
    glycerin 185.15
    diglyme 596.88
    acrylic acid 154.22
    isopropyl myristate 50.6
    n-butyric acid 331.63
    acetyl acetate 225.6
    di(2-ethylhexyl) phthalate 45.33
    ethyl propionate 256.21
    nitromethane 642.78
    1,2-diethoxyethane 326.77
    benzonitrile 202.2
    trioctyl phosphate 28.77
    1-bromopropane 215.08
    gamma-valerolactone 751.08
    n-decanol 29.22
    triethyl phosphate 63.12
    4-methyl-2-pentanol 99.6
    propionitrile 494.51
    vinylene carbonate 203.81
    1,1,2-trichlorotrifluoroethane 373.45
    DMS 165.93
    cumene 34.94
    2-octanol 26.81
    2-hexanone 275.67
    octyl acetate 61.75
    limonene 42.58
    1,2-dimethoxyethane 619.07
    ethyl orthosilicate 56.69
    tributyl phosphate 44.43
    diacetone alcohol 395.91
    N,N-dimethylaniline 106.17
    acrylonitrile 547.87
    aniline 329.04
    1,3-propanediol 419.06
    bromobenzene 160.55
    dibromomethane 222.33
    1,1,2,2-tetrachloroethane 651.91
    2-methyl-cyclohexyl acetate 97.56
    tetrabutyl urea 59.56
    diisobutyl methanol 43.4
    2-phenylethanol 160.27
    styrene 116.37
    dioctyl adipate 79.95
    dimethyl sulfate 222.16
    ethyl butyrate 166.56
    methyl lactate 210.4
    butyl lactate 81.15
    diethyl carbonate 107.66
    propanediol butyl ether 142.12
    triethyl orthoformate 94.33
    p-tert-butyltoluene 27.73
    methyl 4-tert-butylbenzoate 109.41
    morpholine 1511.76
    tert-butylamine 127.88
    n-dodecanol 23.41
    dimethoxymethane 822.4
    ethylene carbonate 168.17
    cyrene 133.59
    2-ethoxyethyl acetate 180.16
    2-ethylhexyl acetate 150.92
    1,2,4-trichlorobenzene 162.08
    4-methylpyridine 638.11
    dibutyl ether 77.63
    2,6-dimethyl-4-heptanol 43.4
    DEF 535.42
    dimethyl isosorbide 309.6
    tetrachloroethylene 214.23
    eugenol 118.91
    triacetin 123.96
    span 80 116.05
    1,4-butanediol 73.33
    1,1-dichloroethane 327.49
    2-methyl-1-pentanol 191.42
    methyl formate 220.31
    2-methyl-1-butanol 369.81
    n-decane 2.12
    butyronitrile 400.33
    3,7-dimethyl-1-octanol 61.56
    1-chlorooctane 20.32
    1-chlorotetradecane 9.49
    n-nonane 1.55
    undecane 1.83
    tert-butylcyclohexane 5.52
    cyclooctane 1.19
    cyclopentanol 245.11
    tetrahydropyran 874.0
    tert-amyl methyl ether 279.54
    2,5,8-trioxanonane 402.46
    1-hexene 30.86
    2-isopropoxyethanol 216.57
    2,2,2-trifluoroethanol 39.34
    methyl butyrate 298.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction