4-Methyl-5-thiazoleethanol

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  • Identifiers

    CAS number
    137-00-8

    Molecular formula
    C6H9NOS

    SMILES
    CC1=C(SC=N1)CCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Meaty 76.1%
    Nutty 75.88%
    Roasted 74.01%
    Sulfurous 54.42%
    Fatty 52.72%
    Beefy 47.12%
    Savory 41.74%
    Cooked 40.22%
    Coffee 38.81%
    Hazelnut 36.74%

     

    Flavor
    Fatty 51.05%
    Roasted 39.29%
    Coffee 36.91%
    Nutty 36.35%
    Vegetable 32.98%
    Bitter 31.12%
    Roast 29.59%
    Musty 29.34%
    Sulfur 28.8%
    Meaty 28.05%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    6.65 (neutral)

    Molecular weight
    143.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • < 25 °C

    Boiling point

    • 135.00 °C. @ 7.00 mm Hg

    Flash point

    • 104.99 ˚C est.

    Solubility expt.

    • Soluble in water, ether, benzene, chloroform
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • 4-METHYL-5-THIAZOLEETHANOL
    • 137-00-8
    • sulfurol
    • 5-(2-Hydroxyethyl)-4-methylthiazole
    • Hemineurine
    • 5-Thiazoleethanol, 4-methyl-
    • 2-(4-Methylthiazol-5-yl)ethanol
    • 2-(4-Methyl-1,3-thiazol-5-yl)ethanol
    • 4-Methyl-5-thiazolethanol
    • 4-Methyl-5-(2-hydroxyethyl)thiazole
    • 4-Methyl-5-thiazolylethanol
    • Thiamine thiozole
    • 2-(4-Methylthiazole-5-yl)ethanol
    • 4-Methyl-5-hydroxethylthiazole
    • 4-Methyl-5-hydroxyethylthiazole
    • Thiamine thiazole
    • MHT (VAN)
    • 2-(4-Methyl-1,3-Thiazol-5-Yl)Ethan-1-Ol
    • 5-(Hydroxyethyl)-4-methylthiazole
    • 4-methyl-5-thiazole ethanol
    • 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL
    • FEMA No. 3204
    • 5-(beta-Hydroxyethyl)-4-methylthiazole
    • CHEBI:17957
    • 2-(4-methyl-5-thiazolyl)ethanol
    • NSC 23262
    • 4-methyl-5-(2-hydroxyethyl)-thiazole
    • 4-methyl-5-(beta-hydroxyethyl)thiazole
    • 3XYV4I47I8
    • 4-Methyl-5-(2'-hydroxyethyl)-thiazole
    • DTXSID3044382
    • MHT
    • 4-Methyl-5-(.beta.-hydroxyethyl)thiazole
    • EINECS 205-272-6
    • MFCD00005339
    • NSC 41831
    • NSC-23262
    • NSC-41831
    • AI3-23391
    • HET
    • CHEMBL1236482
    • DTXCID1024382
    • Thiazole, 5-(2-hydroxyethyl)-4-methyl
    • 4-METHYL-5-THIAZOLEETHANOL [MI]
    • 4-METHYL-5-THIAZOLE ETHANOL [FCC]
    • 4-METHYL-5-THIAZOLEETHANOL [FHFI]
    • 5-(.BETA.-HYDROXYETHYL)-4-METHYLTHIAZOLE
    • TZE
    • 5-(2-Hydroxyethyl)-4-methylthiazole; MHT
    • 5-Hydroxyethyl-4-methylthiazole
    • UNII-3XYV4I47I8
    • 4-METHYLTHIAZOL-5YLETHANOL
    • Clomethiazole Impurity C
    • bmse000355
    • 4-METHYL-5-(beta-HYDROXYETHYL)-THIAZOLE
    • 4-methyl-5-thiazole-ethanol
    • SCHEMBL259480
    • FEMA 3204
    • 4-Methyl-5-thiazoleethanol, 9CI
    • 4-Methyl-5-thiazoleethanol, 98%
    • 2-(4-methylthiazol-5-yl) ethanol
    • 2-(4-methylthiazol-5-yl)-ethanol
    • 4-Methyl-5-thiazoleethanol (Bean)
    • HY-W015695R
    • NSC23262
    • NSC41831
    • STR05522
    • 4-Methyl-5-thiazoleethanol (Milky)
    • Thiazole, 4-methyl-5-hydroxyethyl-
    • Tox21_302187
    • 4-Methyl-5-thiazoleethanol (5-(2-Hydroxyethyl)-4-methylthiazole)
    • BDBM50016817
    • AKOS000119411
    • 4-Methyl-5-thiazoleethanol (Standard)
    • 4-Metyl-5-(beta-hydroxyethyl)thiazole
    • 5-(2-hydroxyethyl)-4-methyl-thiazole
    • AB00407
    • AC-7852
    • CS-W016411
    • DB02969
    • FH54860
    • HY-W015695
    • PS-4466
    • 4-METHYL-5-HYDROXYETHYL THIAZOLE
    • NCGC00257545-01
    • CAS-137-00-8
    • PD007492
    • 4-Methyl-5-thiazoleethanol, >=98%, FG
    • DB-003514
    • 2-(4-Methyl-1,3-thiazol-5-yl)ethanol #
    • 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole
    • H0527
    • NS00012994
    • EN300-20333
    • 4-Methyl-5-thiazoleethanol, analytical standard
    • C04294
    • D77790
    • 5-(2-Hydroxyethyl)-4-methylthiazole (sulfurol)
    • Q27093940
    • Z104477768
    • 48114B6F-A59B-4E5B-82B1-38B17D2A0B5A
    • InChI=1/C6H9NOS/c1-5-6(2-3-8)9-4-7-5/h4,8H,2-3H2,1H
    • 4-methyl-5-thiazoleethanol; sulfurol; 4-methyl-5-(2'-hydroxyethyl)-thiazole; 4-methyl-5-hydroxyethylthiazole; 5-(2-hydroxyethyl)-4-methylthiazole; 4-methyl-5-beta-hydroxyethyl thiazole
    • 860175-16-2
    • Sulfurol; 4-Methyl-5-(2-hydroxyethyl)-thiazole; 4-Methyl-5-hydroxyethyl-thiazole; 5-(2-Hydroxyethyl)-4-methylthiazole; 4-Methyl-5-beta-hydroxyethyl thiazole

  • Applications

    4-Methyl-5-thiazoleethanol (CAS number: 137-00-8) is primarily used as an intermediate in the synthesis of heterocyclic compounds bearing a thiazole ring. It serves as a building block for fragrance and flavor chemistry, enabling incorporation of a thiazole moiety into aroma and taste materials. In cosmetics and personal care, it is used as a precursor to fragrance ingredients that provide complex scent profiles. It is also employed as a synthetic intermediate in pharmaceutical development for thiazole-containing compounds. In agrochemicals, it may serve as a precursor for the synthesis of crop-protection chemicals. In industrial manufacturing, it can be used as a starting material for specialty chemicals and as a functional building block in coatings and inks or in polymer formulations, depending on formulation requirements and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 218.69
    methanol 376.29
    isopropanol 142.58
    water 45.66
    ethyl acetate 92.39
    n-propanol 170.39
    acetone 171.81
    n-butanol 120.26
    acetonitrile 129.43
    DMF 921.7
    toluene 52.85
    isobutanol 101.64
    1,4-dioxane 291.7
    methyl acetate 113.86
    THF 282.76
    2-butanone 123.06
    n-pentanol 77.61
    sec-butanol 101.13
    n-hexane 1.34
    ethylene glycol 232.28
    NMP 370.05
    cyclohexane 3.48
    DMSO 725.32
    n-butyl acetate 48.18
    n-octanol 44.59
    chloroform 253.61
    n-propyl acetate 43.94
    acetic acid 144.22
    dichloromethane 211.36
    cyclohexanone 171.27
    propylene glycol 144.81
    isopropyl acetate 51.74
    DMAc 452.6
    2-ethoxyethanol 233.79
    isopentanol 75.83
    n-heptane 4.09
    ethyl formate 103.61
    1,2-dichloroethane 142.79
    n-hexanol 79.38
    2-methoxyethanol 483.96
    isobutyl acetate 33.38
    tetrachloromethane 60.82
    n-pentyl acetate 45.79
    transcutol 237.29
    n-heptanol 49.44
    ethylbenzene 20.55
    MIBK 58.66
    2-propoxyethanol 208.74
    tert-butanol 136.77
    MTBE 60.92
    2-butoxyethanol 115.21
    propionic acid 115.09
    o-xylene 41.57
    formic acid 198.72
    diethyl ether 61.36
    m-xylene 39.77
    p-xylene 29.19
    chlorobenzene 88.43
    dimethyl carbonate 73.53
    n-octane 2.72
    formamide 258.66
    cyclopentanone 249.35
    2-pentanone 94.66
    anisole 84.59
    cyclopentyl methyl ether 99.85
    gamma-butyrolactone 256.36
    1-methoxy-2-propanol 283.66
    pyridine 190.41
    3-pentanone 74.93
    furfural 310.9
    n-dodecane 3.42
    diethylene glycol 289.33
    diisopropyl ether 17.66
    tert-amyl alcohol 94.45
    acetylacetone 134.38
    n-hexadecane 3.94
    acetophenone 84.97
    methyl propionate 103.37
    isopentyl acetate 44.41
    trichloroethylene 253.53
    n-nonanol 40.92
    cyclohexanol 89.29
    benzyl alcohol 89.74
    2-ethylhexanol 40.21
    isooctanol 39.13
    dipropyl ether 36.26
    1,2-dichlorobenzene 83.5
    ethyl lactate 53.49
    propylene carbonate 111.34
    n-methylformamide 385.85
    2-pentanol 63.03
    n-pentane 2.53
    1-propoxy-2-propanol 118.1
    1-methoxy-2-propyl acetate 85.24
    2-(2-methoxypropoxy) propanol 90.52
    mesitylene 26.64
    ε-caprolactone 124.03
    p-cymene 23.23
    epichlorohydrin 250.53
    1,1,1-trichloroethane 130.19
    2-aminoethanol 268.32
    morpholine-4-carbaldehyde 422.67
    sulfolane 369.46
    2,2,4-trimethylpentane 3.41
    2-methyltetrahydrofuran 143.2
    n-hexyl acetate 56.22
    isooctane 2.97
    2-(2-butoxyethoxy)ethanol 125.77
    sec-butyl acetate 30.79
    tert-butyl acetate 60.48
    decalin 4.35
    glycerin 295.91
    diglyme 216.96
    acrylic acid 127.5
    isopropyl myristate 28.31
    n-butyric acid 120.11
    acetyl acetate 56.67
    di(2-ethylhexyl) phthalate 36.98
    ethyl propionate 45.6
    nitromethane 296.25
    1,2-diethoxyethane 70.91
    benzonitrile 98.51
    trioctyl phosphate 29.3
    1-bromopropane 56.39
    gamma-valerolactone 344.51
    n-decanol 32.33
    triethyl phosphate 33.44
    4-methyl-2-pentanol 37.24
    propionitrile 107.68
    vinylene carbonate 125.79
    1,1,2-trichlorotrifluoroethane 267.76
    DMS 57.7
    cumene 18.93
    2-octanol 33.71
    2-hexanone 53.12
    octyl acetate 38.85
    limonene 30.68
    1,2-dimethoxyethane 243.82
    ethyl orthosilicate 31.76
    tributyl phosphate 29.29
    diacetone alcohol 110.47
    N,N-dimethylaniline 65.82
    acrylonitrile 164.95
    aniline 112.14
    1,3-propanediol 263.87
    bromobenzene 76.05
    dibromomethane 117.24
    1,1,2,2-tetrachloroethane 199.91
    2-methyl-cyclohexyl acetate 43.25
    tetrabutyl urea 46.64
    diisobutyl methanol 27.31
    2-phenylethanol 80.81
    styrene 28.99
    dioctyl adipate 40.39
    dimethyl sulfate 178.3
    ethyl butyrate 41.51
    methyl lactate 118.56
    butyl lactate 53.68
    diethyl carbonate 31.91
    propanediol butyl ether 91.68
    triethyl orthoformate 37.11
    p-tert-butyltoluene 24.69
    methyl 4-tert-butylbenzoate 82.6
    morpholine 291.66
    tert-butylamine 65.79
    n-dodecanol 25.4
    dimethoxymethane 287.67
    ethylene carbonate 97.03
    cyrene 116.01
    2-ethoxyethyl acetate 70.43
    2-ethylhexyl acetate 36.3
    1,2,4-trichlorobenzene 107.16
    4-methylpyridine 167.53
    dibutyl ether 29.56
    2,6-dimethyl-4-heptanol 27.31
    DEF 158.13
    dimethyl isosorbide 136.73
    tetrachloroethylene 155.61
    eugenol 98.49
    triacetin 60.12
    span 80 80.21
    1,4-butanediol 121.42
    1,1-dichloroethane 127.35
    2-methyl-1-pentanol 55.36
    methyl formate 253.89
    2-methyl-1-butanol 75.64
    n-decane 4.93
    butyronitrile 90.4
    3,7-dimethyl-1-octanol 38.31
    1-chlorooctane 24.07
    1-chlorotetradecane 11.26
    n-nonane 4.17
    undecane 4.03
    tert-butylcyclohexane 4.66
    cyclooctane 2.07
    cyclopentanol 122.39
    tetrahydropyran 131.52
    tert-amyl methyl ether 49.79
    2,5,8-trioxanonane 167.16
    1-hexene 8.57
    2-isopropoxyethanol 120.75
    2,2,2-trifluoroethanol 120.64
    methyl butyrate 61.25

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction