4-Methyl-2,6-dimethoxyphenol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    6638-05-7

    Molecular formula
    C9H12O3

    SMILES
    CC1=CC(=C(C(=C1)OC)O)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 79.85%
    Spicy 77.36%
    Smoky 70.06%
    Woody 67.1%
    Vanilla 56.85%
    Burnt 49.68%
    Clove 47.99%
    Medicinal 47.03%
    Balsamic 44.2%
    Sweet 42.01%

     

    Flavor
    Phenolic 70.1%
    Smoky 58.83%
    Spice 56.79%
    Woody 55.66%
    Bacon 51.82%
    Smoke 50.75%
    Medicinal 46.71%
    Vanilla 41.71%
    Clove 39.11%
    Spicy 34.52%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    9.79 (weak base)

    Molecular weight
    168.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 36 °C

    Boiling point

    • 145.00 to 146.00 °C. @ 14.00 mm Hg

    Flash point

    • 104.22 ˚C est.

    Solubility expt.

    • insoluble in water; soluble in fat
    • moderately soluble (in ethanol)

  • Synonyms

    • 2,6-Dimethoxy-4-methylphenol
    • 6638-05-7
    • 4-Methyl-2,6-dimethoxyphenol
    • 4-Methylsyringol
    • Phenol, 2,6-dimethoxy-4-methyl-
    • 2,6-Dimethoxy-p-cresol
    • 3,5-Dimethoxy-4-hydroxytoluene
    • p-Cresol, 2,6-dimethoxy-
    • 4-Hydroxy-3,5-dimethoxytoluene
    • FJJ5MYE75W
    • FEMA No. 3704
    • UNII-FJJ5MYE75W
    • MFCD00017289
    • NSC-47901
    • 1-Methyl-3,5-dimethoxy-4-hydroxybenzene
    • 2,6-DIMETHOXY-4-CRESOL
    • DTXSID10216599
    • EINECS 229-641-6
    • NSC 47901
    • 4-METHYL-2,6-DIMETHOXYPHENOL [FHFI]
    • 2,6-dimethoxy-4-methyl-phenol
    • Syringol, 4-methyl
    • SCHEMBL562147
    • CHEMBL205268
    • FEMA 3704
    • DTXCID90139090
    • 3,5-Dimethoxy-4-hydroxy-toluene
    • CHEBI:172423
    • Phenol, 4-methyl-2,6-dimethoxy
    • NSC47901
    • 2,6-Dimethoxy-4-methylphenol, 9CI
    • 4-Methyl-2,6-dimethoxyphenol, 97%
    • AKOS000120559
    • FD41549
    • HY-W100715
    • 4-Methyl-2,6-dimethoxyphenol, >=97%
    • AS-17263
    • SY035503
    • DB-020219
    • CS-0153357
    • D2591
    • NS00022641
    • EN300-18157
    • 4-Methyl-2,6-dimethoxyphenol (4-methylsyringol)
    • Q27278026
    • Z57234306
    • UB9

  • Applications

    4-Methyl-2,6-dimethoxyphenol (CAS 6638-05-7) is primarily used as an aroma-chemical building block in fragrance and flavor chemistry, serving as an intermediate for the synthesis of aromatic compounds used in perfumery and flavor applications; in cosmetics and personal care, it may be employed as a fragrance ingredient or scent component. In household and cleaning products, it can contribute aroma notes as part of odorant formulations. It is also evaluated as a potential antioxidant or processing stabilizer in polymer formulations, helping improve oxidative stability of plastics and coatings. Additionally, it may be used as a precursor in coatings and inks formulations where an aromatic phenolic building block is required, subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 353.53
    methanol 447.55
    isopropanol 225.89
    water 4.41
    ethyl acetate 225.87
    n-propanol 239.28
    acetone 457.0
    n-butanol 173.1
    acetonitrile 366.17
    DMF 858.67
    toluene 55.48
    isobutanol 144.13
    1,4-dioxane 633.2
    methyl acetate 343.5
    THF 609.48
    2-butanone 283.22
    n-pentanol 142.25
    sec-butanol 175.05
    n-hexane 10.09
    ethylene glycol 493.59
    NMP 334.88
    cyclohexane 26.57
    DMSO 843.56
    n-butyl acetate 129.01
    n-octanol 105.46
    chloroform 583.97
    n-propyl acetate 153.56
    acetic acid 394.43
    dichloromethane 669.96
    cyclohexanone 306.42
    propylene glycol 242.21
    isopropyl acetate 107.96
    DMAc 343.55
    2-ethoxyethanol 406.91
    isopentanol 107.82
    n-heptane 19.9
    ethyl formate 366.75
    1,2-dichloroethane 425.36
    n-hexanol 158.63
    2-methoxyethanol 758.18
    isobutyl acetate 88.29
    tetrachloromethane 124.66
    n-pentyl acetate 92.43
    transcutol 285.95
    n-heptanol 105.42
    ethylbenzene 52.08
    MIBK 96.72
    2-propoxyethanol 345.47
    tert-butanol 257.19
    MTBE 138.01
    2-butoxyethanol 196.61
    propionic acid 267.11
    o-xylene 55.55
    formic acid 258.59
    diethyl ether 159.42
    m-xylene 50.36
    p-xylene 73.11
    chlorobenzene 134.08
    dimethyl carbonate 159.98
    n-octane 13.41
    formamide 437.69
    cyclopentanone 420.76
    2-pentanone 178.75
    anisole 149.46
    cyclopentyl methyl ether 168.3
    gamma-butyrolactone 570.2
    1-methoxy-2-propanol 397.15
    pyridine 284.25
    3-pentanone 136.12
    furfural 510.31
    n-dodecane 13.05
    diethylene glycol 444.11
    diisopropyl ether 40.36
    tert-amyl alcohol 177.84
    acetylacetone 243.62
    n-hexadecane 14.76
    acetophenone 147.11
    methyl propionate 223.31
    isopentyl acetate 103.09
    trichloroethylene 686.58
    n-nonanol 89.97
    cyclohexanol 155.62
    benzyl alcohol 161.0
    2-ethylhexanol 94.13
    isooctanol 80.73
    dipropyl ether 91.94
    1,2-dichlorobenzene 150.31
    ethyl lactate 148.43
    propylene carbonate 306.8
    n-methylformamide 577.63
    2-pentanol 101.26
    n-pentane 11.81
    1-propoxy-2-propanol 189.1
    1-methoxy-2-propyl acetate 151.37
    2-(2-methoxypropoxy) propanol 125.33
    mesitylene 38.97
    ε-caprolactone 256.66
    p-cymene 53.18
    epichlorohydrin 608.31
    1,1,1-trichloroethane 306.38
    2-aminoethanol 369.02
    morpholine-4-carbaldehyde 469.65
    sulfolane 625.89
    2,2,4-trimethylpentane 10.8
    2-methyltetrahydrofuran 294.72
    n-hexyl acetate 129.6
    isooctane 9.05
    2-(2-butoxyethoxy)ethanol 182.35
    sec-butyl acetate 76.66
    tert-butyl acetate 115.58
    decalin 19.04
    glycerin 386.48
    diglyme 397.2
    acrylic acid 288.17
    isopropyl myristate 57.44
    n-butyric acid 250.78
    acetyl acetate 155.16
    di(2-ethylhexyl) phthalate 66.82
    ethyl propionate 119.47
    nitromethane 780.74
    1,2-diethoxyethane 127.73
    benzonitrile 184.97
    trioctyl phosphate 61.6
    1-bromopropane 144.84
    gamma-valerolactone 515.77
    n-decanol 71.52
    triethyl phosphate 73.84
    4-methyl-2-pentanol 57.3
    propionitrile 219.25
    vinylene carbonate 327.4
    1,1,2-trichlorotrifluoroethane 529.75
    DMS 117.89
    cumene 45.57
    2-octanol 76.04
    2-hexanone 135.45
    octyl acetate 81.04
    limonene 68.14
    1,2-dimethoxyethane 578.18
    ethyl orthosilicate 64.33
    tributyl phosphate 60.55
    diacetone alcohol 185.61
    N,N-dimethylaniline 99.04
    acrylonitrile 335.72
    aniline 118.42
    1,3-propanediol 398.87
    bromobenzene 130.68
    dibromomethane 388.29
    1,1,2,2-tetrachloroethane 538.69
    2-methyl-cyclohexyl acetate 96.64
    tetrabutyl urea 78.67
    diisobutyl methanol 58.71
    2-phenylethanol 152.89
    styrene 62.18
    dioctyl adipate 90.94
    dimethyl sulfate 245.86
    ethyl butyrate 110.54
    methyl lactate 195.94
    butyl lactate 93.33
    diethyl carbonate 95.45
    propanediol butyl ether 182.0
    triethyl orthoformate 85.21
    p-tert-butyltoluene 52.91
    methyl 4-tert-butylbenzoate 136.44
    morpholine 579.75
    tert-butylamine 125.4
    n-dodecanol 57.93
    dimethoxymethane 460.24
    ethylene carbonate 262.37
    cyrene 168.0
    2-ethoxyethyl acetate 125.11
    2-ethylhexyl acetate 78.43
    1,2,4-trichlorobenzene 171.28
    4-methylpyridine 203.89
    dibutyl ether 76.53
    2,6-dimethyl-4-heptanol 58.71
    DEF 217.67
    dimethyl isosorbide 207.24
    tetrachloroethylene 393.44
    eugenol 145.13
    triacetin 131.36
    span 80 115.64
    1,4-butanediol 206.95
    1,1-dichloroethane 299.98
    2-methyl-1-pentanol 99.58
    methyl formate 630.56
    2-methyl-1-butanol 110.92
    n-decane 19.53
    butyronitrile 199.54
    3,7-dimethyl-1-octanol 76.74
    1-chlorooctane 68.1
    1-chlorotetradecane 31.28
    n-nonane 19.03
    undecane 15.56
    tert-butylcyclohexane 17.47
    cyclooctane 11.69
    cyclopentanol 219.4
    tetrahydropyran 318.96
    tert-amyl methyl ether 95.94
    2,5,8-trioxanonane 239.79
    1-hexene 37.68
    2-isopropoxyethanol 224.26
    2,2,2-trifluoroethanol 206.51
    methyl butyrate 185.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Boronia megastigma 91771-36-7 Boronia megastigma Nees., fam. Rutaceae 0.02%