4-Methyl-2-propyl-1,3-dioxolane

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  • Identifiers

    CAS number
    4352-99-2

    Molecular formula
    C7H14O2

    SMILES
    CCCC1OCC(O1)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 90.9%
    Green 83.01%
    Ethereal 79.18%
    Fermented 56.58%
    Sweet 54.28%
    Alcoholic 46.58%
    Winey 39.95%
    Fresh 38.25%
    Cognac 38.15%
    Rummy 37.9%

     

    Flavor
    Green 52.39%
    Sweet 46.25%
    Vegetable 45.14%
    Caramel 40.93%
    Nutty 34.79%
    Earthy 34.39%
    Herbal 28.41%
    Potato 27.39%
    Roasted 26.88%
    Tropical 26.55%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    7.51 (neutral)

    Molecular weight
    130.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    149°C

    Flash point

    • 37.71 ˚C est.

  • Synonyms

    • 4-Methyl-2-propyl-1,3-dioxolane
    • 4352-99-2
    • 2-Propyl-4-methyl-1,3-dioxolane
    • 1,3-Dioxolane, 4-methyl-2-propyl-
    • 2-Propyl-4-methyl-1,3-dioxoolane
    • EINECS 224-420-0
    • AI3-22812
    • DTXSID80863372
    • NSC 89713
    • NSC89713
    • SCHEMBL1838332
    • DTXCID20812001
    • butyraldehyde propylene glycol acetal
    • NSC-89713
    • AKOS024319088
    • 1,3-Dioxolane, 4-methyl-2-propyl, cis
    • 1,3-Dioxolane, 4-methyl-2-propyl, trans
    • NS00045905
    • 224-420-0

  • Applications

    4-Methyl-2-propyl-1,3-dioxolane (CAS 4352-99-2) is primarily used as an organic synthesis intermediate and as an acetal protecting group for carbonyl functionalities, enabling protection of carbonyl groups in complex synthetic sequences. It may function as a solvent or co-solvent in industrial manufacturing and in formulations for coatings, inks, and adhesives. Additionally, it is viewed as a building block for specialty chemicals and related processing, with its use and handling governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2023.13
    methanol 2580.2
    isopropanol 1566.34
    water 16.42
    ethyl acetate 792.87
    n-propanol 1471.14
    acetone 978.14
    n-butanol 1395.85
    acetonitrile 1535.25
    DMF 979.81
    toluene 529.63
    isobutanol 1114.61
    1,4-dioxane 1475.43
    methyl acetate 728.25
    THF 1793.87
    2-butanone 762.09
    n-pentanol 985.3
    sec-butanol 1331.8
    n-hexane 307.87
    ethylene glycol 577.7
    NMP 934.73
    cyclohexane 492.01
    DMSO 1273.35
    n-butyl acetate 755.74
    n-octanol 729.63
    chloroform 5086.06
    n-propyl acetate 542.51
    acetic acid 1920.04
    dichloromethane 3877.0
    cyclohexanone 1211.91
    propylene glycol 760.24
    isopropyl acetate 502.44
    DMAc 788.42
    2-ethoxyethanol 1043.85
    isopentanol 998.65
    n-heptane 281.39
    ethyl formate 682.3
    1,2-dichloroethane 1343.71
    n-hexanol 1212.34
    2-methoxyethanol 1402.8
    isobutyl acetate 398.76
    tetrachloromethane 867.31
    n-pentyl acetate 502.24
    transcutol 1855.15
    n-heptanol 573.05
    ethylbenzene 331.28
    MIBK 433.47
    2-propoxyethanol 1166.08
    tert-butanol 1526.99
    MTBE 851.8
    2-butoxyethanol 713.26
    propionic acid 1179.7
    o-xylene 358.02
    formic acid 612.02
    diethyl ether 886.64
    m-xylene 353.84
    p-xylene 477.93
    chlorobenzene 949.29
    dimethyl carbonate 250.77
    n-octane 106.39
    formamide 550.61
    cyclopentanone 1158.56
    2-pentanone 644.64
    anisole 590.22
    cyclopentyl methyl ether 851.21
    gamma-butyrolactone 1363.81
    1-methoxy-2-propanol 1035.08
    pyridine 1346.45
    3-pentanone 490.34
    furfural 1298.33
    n-dodecane 99.02
    diethylene glycol 859.29
    diisopropyl ether 285.29
    tert-amyl alcohol 1166.64
    acetylacetone 628.18
    n-hexadecane 106.54
    acetophenone 537.7
    methyl propionate 555.42
    isopentyl acetate 605.22
    trichloroethylene 2583.4
    n-nonanol 559.92
    cyclohexanol 1128.85
    benzyl alcohol 637.82
    2-ethylhexanol 650.69
    isooctanol 443.33
    dipropyl ether 634.15
    1,2-dichlorobenzene 812.43
    ethyl lactate 329.15
    propylene carbonate 864.62
    n-methylformamide 718.83
    2-pentanol 920.29
    n-pentane 330.54
    1-propoxy-2-propanol 841.99
    1-methoxy-2-propyl acetate 511.05
    2-(2-methoxypropoxy) propanol 592.18
    mesitylene 245.28
    ε-caprolactone 1100.78
    p-cymene 295.97
    epichlorohydrin 1430.07
    1,1,1-trichloroethane 1611.41
    2-aminoethanol 985.88
    morpholine-4-carbaldehyde 1036.06
    sulfolane 1393.31
    2,2,4-trimethylpentane 150.35
    2-methyltetrahydrofuran 1367.13
    n-hexyl acetate 808.32
    isooctane 110.89
    2-(2-butoxyethoxy)ethanol 762.1
    sec-butyl acetate 371.87
    tert-butyl acetate 462.71
    decalin 179.81
    glycerin 820.86
    diglyme 1226.85
    acrylic acid 1016.38
    isopropyl myristate 342.7
    n-butyric acid 1453.23
    acetyl acetate 581.86
    di(2-ethylhexyl) phthalate 321.04
    ethyl propionate 445.8
    nitromethane 1471.11
    1,2-diethoxyethane 628.12
    benzonitrile 1025.26
    trioctyl phosphate 247.78
    1-bromopropane 1156.33
    gamma-valerolactone 1250.72
    n-decanol 383.77
    triethyl phosphate 265.53
    4-methyl-2-pentanol 474.62
    propionitrile 1182.28
    vinylene carbonate 898.59
    1,1,2-trichlorotrifluoroethane 1297.64
    DMS 422.6
    cumene 264.64
    2-octanol 444.47
    2-hexanone 583.97
    octyl acetate 418.65
    limonene 452.25
    1,2-dimethoxyethane 1296.04
    ethyl orthosilicate 256.27
    tributyl phosphate 284.67
    diacetone alcohol 543.32
    N,N-dimethylaniline 428.66
    acrylonitrile 1275.24
    aniline 741.62
    1,3-propanediol 1028.14
    bromobenzene 1025.96
    dibromomethane 2635.85
    1,1,2,2-tetrachloroethane 2091.04
    2-methyl-cyclohexyl acetate 428.7
    tetrabutyl urea 336.2
    diisobutyl methanol 321.98
    2-phenylethanol 606.08
    styrene 451.97
    dioctyl adipate 457.9
    dimethyl sulfate 397.61
    ethyl butyrate 518.81
    methyl lactate 396.23
    butyl lactate 410.87
    diethyl carbonate 364.34
    propanediol butyl ether 727.43
    triethyl orthoformate 383.6
    p-tert-butyltoluene 271.7
    methyl 4-tert-butylbenzoate 506.7
    morpholine 1585.49
    tert-butylamine 1166.62
    n-dodecanol 296.34
    dimethoxymethane 692.0
    ethylene carbonate 727.42
    cyrene 470.75
    2-ethoxyethyl acetate 478.63
    2-ethylhexyl acetate 474.92
    1,2,4-trichlorobenzene 943.62
    4-methylpyridine 1211.34
    dibutyl ether 605.8
    2,6-dimethyl-4-heptanol 321.98
    DEF 740.98
    dimethyl isosorbide 775.35
    tetrachloroethylene 1456.55
    eugenol 498.46
    triacetin 630.35
    span 80 630.82
    1,4-butanediol 592.16
    1,1-dichloroethane 1693.67
    2-methyl-1-pentanol 793.9
    methyl formate 551.99
    2-methyl-1-butanol 976.96
    n-decane 157.94
    butyronitrile 1335.62
    3,7-dimethyl-1-octanol 581.96
    1-chlorooctane 460.24
    1-chlorotetradecane 187.39
    n-nonane 163.95
    undecane 118.66
    tert-butylcyclohexane 172.78
    cyclooctane 150.97
    cyclopentanol 1264.89
    tetrahydropyran 1463.86
    tert-amyl methyl ether 596.42
    2,5,8-trioxanonane 855.91
    1-hexene 714.89
    2-isopropoxyethanol 700.38
    2,2,2-trifluoroethanol 510.48
    methyl butyrate 650.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction