(4-Methyl-1,3-thiazol-5-yl)methanol

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  • Identifiers

    CAS number
    1977-06-6

    Molecular formula
    C5H7NOS

    SMILES
    CC1=C(SC=N1)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 73.22%
    Meaty 69.72%
    Roasted 69.47%
    Sulfurous 50.93%
    Beefy 40.96%
    Coffee 40.76%
    Vegetable 37.15%
    Fatty 36.51%
    Hazelnut 36.18%
    Savory 35.49%

     

    Flavor
    Nutty 50.25%
    Coffee 47.05%
    Roasted 46.64%
    Fatty 45.19%
    Roast 38.92%
    Musty 35.34%
    Burnt 33.39%
    Sulfur 32.73%
    Chocolate 32.25%
    Vegetable 32.1%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    6.05 (neutral)

    Molecular weight
    129.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    321°C

    Flash point

    • 97.61 ˚C est.

  • Synonyms

    • (4-methyl-1,3-thiazol-5-yl)methanol
    • 1977-06-6
    • DTXSID00438102
    • RefChem:208900
    • DTXCID30388924
    • 818-896-4
    • (4-Methylthiazol-5-yl)methanol
    • 5-Thiazolemethanol, 4-methyl-
    • 4-Methyl-5-thiazolyl methanol
    • MFCD09032911
    • 4-methyl-5-(hydroxymethyl)thiazole
    • 4-Methyl-5-thiazolemethanol
    • SCHEMBL858586
    • SCHEMBL2441506
    • SCHEMBL5265018
    • (4-Methyl-5-thiazolyl)methanol
    • 4-methyl-5-hydroxymethyl thiazole
    • ALBB-030274
    • 4-methyl-5-(hydroxymethyl)-thiazole
    • SBB085738
    • AKOS005073587
    • MD-0707
    • SY122994
    • (4-methyl-1,3-thiazol-5-yl)methan-1-ol
    • DB-021764
    • EN300-65576
    • F217920
    • Z397587526
    • 1977-06-6

  • Applications

    (4-Methyl-1,3-thiazol-5-yl)methanol (CAS 1977-06-6) is commonly used as an important intermediate in the synthesis of thiazole-containing heterocycles for pharmaceuticals and agrochemicals; it provides a flexible building block to access thiazole derivatives and related functionalities, supporting the development of drug candidates and crop-protection products. It is also employed as a precursor to fragrance and flavor components, and can be transformed into compounds for cosmetics and personal care applications. Additionally, due to the hydroxymethyl (-CH2OH) group, it can be converted into precursors for polymers and coating systems, enabling the incorporation of thiazole functionality into polymer chains or plastics and coatings. These features make the compound a valuable synthetic building block across multiple industrial pathways.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 92.37
    methanol 137.34
    isopropanol 64.4
    water 20.79
    ethyl acetate 42.74
    n-propanol 80.29
    acetone 63.02
    n-butanol 66.56
    acetonitrile 46.2
    DMF 275.57
    toluene 13.32
    isobutanol 52.74
    1,4-dioxane 151.15
    methyl acetate 52.63
    THF 193.31
    2-butanone 61.69
    n-pentanol 46.58
    sec-butanol 57.26
    n-hexane 1.07
    ethylene glycol 63.74
    NMP 198.43
    cyclohexane 2.47
    DMSO 238.02
    n-butyl acetate 30.87
    n-octanol 22.58
    chloroform 72.46
    n-propyl acetate 27.72
    acetic acid 111.55
    dichloromethane 61.68
    cyclohexanone 97.16
    propylene glycol 57.39
    isopropyl acetate 27.76
    DMAc 174.67
    2-ethoxyethanol 120.93
    isopentanol 48.34
    n-heptane 3.52
    ethyl formate 46.93
    1,2-dichloroethane 46.53
    n-hexanol 45.58
    2-methoxyethanol 222.94
    isobutyl acetate 19.91
    tetrachloromethane 20.01
    n-pentyl acetate 29.26
    transcutol 213.41
    n-heptanol 29.55
    ethylbenzene 6.02
    MIBK 37.17
    2-propoxyethanol 107.81
    tert-butanol 76.67
    MTBE 32.72
    2-butoxyethanol 71.48
    propionic acid 70.68
    o-xylene 14.89
    formic acid 141.2
    diethyl ether 38.81
    m-xylene 14.56
    p-xylene 10.41
    chlorobenzene 28.6
    dimethyl carbonate 30.92
    n-octane 1.61
    formamide 209.31
    cyclopentanone 133.19
    2-pentanone 51.07
    anisole 34.21
    cyclopentyl methyl ether 66.43
    gamma-butyrolactone 146.45
    1-methoxy-2-propanol 140.87
    pyridine 78.51
    3-pentanone 38.85
    furfural 156.68
    n-dodecane 1.55
    diethylene glycol 126.4
    diisopropyl ether 11.57
    tert-amyl alcohol 60.22
    acetylacetone 61.41
    n-hexadecane 1.75
    acetophenone 40.64
    methyl propionate 48.77
    isopentyl acetate 28.34
    trichloroethylene 99.93
    n-nonanol 22.23
    cyclohexanol 52.34
    benzyl alcohol 40.27
    2-ethylhexanol 25.69
    isooctanol 24.38
    dipropyl ether 25.88
    1,2-dichlorobenzene 30.65
    ethyl lactate 28.73
    propylene carbonate 64.03
    n-methylformamide 143.78
    2-pentanol 39.93
    n-pentane 2.14
    1-propoxy-2-propanol 69.81
    1-methoxy-2-propyl acetate 52.04
    2-(2-methoxypropoxy) propanol 67.24
    mesitylene 11.02
    ε-caprolactone 77.73
    p-cymene 11.07
    epichlorohydrin 133.84
    1,1,1-trichloroethane 48.0
    2-aminoethanol 110.12
    morpholine-4-carbaldehyde 206.18
    sulfolane 197.48
    2,2,4-trimethylpentane 2.41
    2-methyltetrahydrofuran 103.41
    n-hexyl acetate 32.96
    isooctane 2.0
    2-(2-butoxyethoxy)ethanol 90.98
    sec-butyl acetate 19.14
    tert-butyl acetate 37.48
    decalin 2.12
    glycerin 128.27
    diglyme 153.97
    acrylic acid 74.99
    isopropyl myristate 17.41
    n-butyric acid 70.93
    acetyl acetate 28.41
    di(2-ethylhexyl) phthalate 22.07
    ethyl propionate 24.3
    nitromethane 175.58
    1,2-diethoxyethane 54.47
    benzonitrile 39.31
    trioctyl phosphate 17.34
    1-bromopropane 20.16
    gamma-valerolactone 195.8
    n-decanol 17.15
    triethyl phosphate 21.34
    4-methyl-2-pentanol 24.89
    propionitrile 41.1
    vinylene carbonate 64.59
    1,1,2-trichlorotrifluoroethane 141.41
    DMS 30.07
    cumene 7.33
    2-octanol 18.97
    2-hexanone 35.16
    octyl acetate 23.24
    limonene 17.5
    1,2-dimethoxyethane 121.92
    ethyl orthosilicate 20.95
    tributyl phosphate 18.53
    diacetone alcohol 73.3
    N,N-dimethylaniline 29.17
    acrylonitrile 59.92
    aniline 45.12
    1,3-propanediol 120.37
    bromobenzene 20.75
    dibromomethane 34.23
    1,1,2,2-tetrachloroethane 80.25
    2-methyl-cyclohexyl acetate 30.22
    tetrabutyl urea 27.18
    diisobutyl methanol 17.24
    2-phenylethanol 41.04
    styrene 7.67
    dioctyl adipate 27.42
    dimethyl sulfate 70.82
    ethyl butyrate 27.9
    methyl lactate 51.75
    butyl lactate 32.87
    diethyl carbonate 20.51
    propanediol butyl ether 55.25
    triethyl orthoformate 26.97
    p-tert-butyltoluene 11.39
    methyl 4-tert-butylbenzoate 50.33
    morpholine 169.64
    tert-butylamine 38.13
    n-dodecanol 13.44
    dimethoxymethane 112.79
    ethylene carbonate 53.08
    cyrene 77.68
    2-ethoxyethyl acetate 47.12
    2-ethylhexyl acetate 23.34
    1,2,4-trichlorobenzene 42.66
    4-methylpyridine 63.45
    dibutyl ether 19.23
    2,6-dimethyl-4-heptanol 17.24
    DEF 72.87
    dimethyl isosorbide 108.75
    tetrachloroethylene 60.97
    eugenol 58.34
    triacetin 44.37
    span 80 55.07
    1,4-butanediol 54.64
    1,1-dichloroethane 41.75
    2-methyl-1-pentanol 37.05
    methyl formate 90.32
    2-methyl-1-butanol 46.74
    n-decane 2.42
    butyronitrile 38.75
    3,7-dimethyl-1-octanol 22.46
    1-chlorooctane 10.76
    1-chlorotetradecane 5.1
    n-nonane 2.05
    undecane 1.87
    tert-butylcyclohexane 2.42
    cyclooctane 1.23
    cyclopentanol 74.97
    tetrahydropyran 81.81
    tert-amyl methyl ether 31.26
    2,5,8-trioxanonane 128.14
    1-hexene 5.15
    2-isopropoxyethanol 74.52
    2,2,2-trifluoroethanol 85.3
    methyl butyrate 34.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction