4-Methoxysalicylic Acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    2237-36-7

    Molecular formula
    C8H8O4

    SMILES
    COC1=CC(=C(C=C1)C(=O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 65.9%
    Sweet 51.87%
    Odorless 41.4%
    Vanilla 38.67%
    Balsamic 37.17%
    Aromatic 33.77%
    Medicinal 33.27%
    Nutty 30.7%
    Spicy 29.33%
    Smoky 28.03%

     

    Flavor
    Phenolic 52.56%
    Odorless 42.34%
    Mild 38.73%
    Nutty 33.96%
    Faint 32.06%
    Sour 25.63%
    Balsamic 23.07%
    Cadaverous 22.88%
    Urine 22.58%
    Powdery 22.07%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    7.23 (neutral)

    Molecular weight
    168.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    322°C

    Flash point

    • 159.5 ˚C est.

  • Synonyms

    • 4-Methoxysalicylic acid
    • 2-Hydroxy-4-methoxybenzoic acid
    • 2237-36-7
    • EINECS 218-801-0
    • DTXSID50176906
    • NSC 94304
    • RefChem:524846
    • DTXCID7099397
    • 218-801-0
    • MFCD00002450
    • 2-hydroxy-4-methoxy-benzoic acid
    • Benzoic acid, 2-hydroxy-4-methoxy-
    • 4-methoxy salicylic acid
    • 2-Hydroxy-p-anisic Acid
    • 2-Hydroxy-4-methoxybenzoicacid
    • OXYBENZONE_met012
    • 4-methoxy-salicylic acid
    • DIOXYBENZONE_met015
    • NCIOpen2_001552
    • MLS000517276
    • SCHEMBL483346
    • CHEMBL507095
    • orb1304754
    • SCHEMBL1804047
    • SCHEMBL6851855
    • 4-methoxy-2-hydroxobenzoic acid
    • WLZ4603
    • CHEBI:167809
    • HMS2269N04
    • ALBB-032509
    • NSC94304
    • STR06769
    • C2M882
    • EBC-47438
    • NSC-94304
    • s5160
    • SBB063950
    • STK065285
    • AKOS000120626
    • CCG-266345
    • FH71372
    • PS-3720
    • 2-Hydroxy-4-methoxybenzoic acid, 99%
    • NCGC00246993-01
    • AC-11620
    • AC-34348
    • HY-75625
    • PD088240
    • SMR000127395
    • ST094897
    • SY008083
    • DB-021179
    • CS-0006868
    • M1795
    • NS00014744
    • EN300-21485
    • AK-087/40343173
    • F227914
    • Z104499836
    • 2237-36-7

  • Applications

    4-Methoxysalicylic Acid (CAS 2237-36-7) is primarily used as an intermediate in the synthesis of pharmaceuticals and specialty chemicals, serving as a building block for polyphenol compounds and related aryl derivatives based on the benzene ring. It may be employed in fragrance and cosmetic chemistry as a precursor to aroma materials or aroma esters, and in coatings and plastics as a functional aryl building block rooted in the salicylic framework. It can also be explored as a precursor for agrochemical research and may act as a ligand or stabilizer in certain formulations. Where applicable, use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 66.19
    methanol 88.95
    isopropanol 47.54
    water 1.97
    ethyl acetate 33.38
    n-propanol 43.76
    acetone 74.28
    n-butanol 36.75
    acetonitrile 16.0
    DMF 276.7
    toluene 1.93
    isobutanol 24.9
    1,4-dioxane 31.9
    methyl acetate 36.1
    THF 226.48
    2-butanone 47.06
    n-pentanol 23.22
    sec-butanol 36.43
    n-hexane 0.87
    ethylene glycol 50.24
    NMP 282.26
    cyclohexane 0.33
    DMSO 642.43
    n-butyl acetate 20.17
    n-octanol 8.86
    chloroform 3.95
    n-propyl acetate 19.18
    acetic acid 42.58
    dichloromethane 5.77
    cyclohexanone 39.3
    propylene glycol 54.49
    isopropyl acetate 22.45
    DMAc 225.34
    2-ethoxyethanol 87.02
    isopentanol 29.48
    n-heptane 0.88
    ethyl formate 24.5
    1,2-dichloroethane 9.47
    n-hexanol 21.66
    2-methoxyethanol 180.45
    isobutyl acetate 7.49
    tetrachloromethane 2.27
    n-pentyl acetate 10.64
    transcutol 183.27
    n-heptanol 10.88
    ethylbenzene 2.01
    MIBK 31.04
    2-propoxyethanol 83.91
    tert-butanol 71.52
    MTBE 27.6
    2-butoxyethanol 33.67
    propionic acid 37.32
    o-xylene 3.45
    formic acid 76.44
    diethyl ether 25.53
    m-xylene 3.36
    p-xylene 2.01
    chlorobenzene 3.01
    dimethyl carbonate 41.71
    n-octane 0.23
    formamide 155.02
    cyclopentanone 97.96
    2-pentanone 48.51
    anisole 17.94
    cyclopentyl methyl ether 46.02
    gamma-butyrolactone 127.79
    1-methoxy-2-propanol 155.22
    pyridine 12.76
    3-pentanone 29.52
    furfural 78.3
    n-dodecane 0.22
    diethylene glycol 103.11
    diisopropyl ether 8.0
    tert-amyl alcohol 54.56
    acetylacetone 61.51
    n-hexadecane 0.25
    acetophenone 23.49
    methyl propionate 47.23
    isopentyl acetate 17.83
    trichloroethylene 15.02
    n-nonanol 8.12
    cyclohexanol 16.92
    benzyl alcohol 16.17
    2-ethylhexanol 11.0
    isooctanol 8.57
    dipropyl ether 13.86
    1,2-dichlorobenzene 5.13
    ethyl lactate 30.38
    propylene carbonate 49.48
    n-methylformamide 124.96
    2-pentanol 27.99
    n-pentane 0.84
    1-propoxy-2-propanol 56.47
    1-methoxy-2-propyl acetate 48.05
    2-(2-methoxypropoxy) propanol 55.93
    mesitylene 2.85
    ε-caprolactone 41.6
    p-cymene 3.7
    epichlorohydrin 93.01
    1,1,1-trichloroethane 6.49
    2-aminoethanol 70.94
    morpholine-4-carbaldehyde 143.14
    sulfolane 257.69
    2,2,4-trimethylpentane 0.96
    2-methyltetrahydrofuran 67.37
    n-hexyl acetate 16.63
    isooctane 0.74
    2-(2-butoxyethoxy)ethanol 59.19
    sec-butyl acetate 12.96
    tert-butyl acetate 37.89
    decalin 0.62
    glycerin 117.3
    diglyme 104.89
    acrylic acid 39.33
    isopropyl myristate 6.75
    n-butyric acid 34.69
    acetyl acetate 19.5
    di(2-ethylhexyl) phthalate 10.26
    ethyl propionate 25.29
    nitromethane 117.65
    1,2-diethoxyethane 23.65
    benzonitrile 8.26
    trioctyl phosphate 7.94
    1-bromopropane 4.31
    gamma-valerolactone 110.21
    n-decanol 5.72
    triethyl phosphate 15.93
    4-methyl-2-pentanol 16.43
    propionitrile 14.38
    vinylene carbonate 31.23
    1,1,2-trichlorotrifluoroethane 82.88
    DMS 23.92
    cumene 2.58
    2-octanol 6.3
    2-hexanone 24.96
    octyl acetate 9.48
    limonene 5.62
    1,2-dimethoxyethane 101.08
    ethyl orthosilicate 13.22
    tributyl phosphate 10.22
    diacetone alcohol 83.78
    N,N-dimethylaniline 16.37
    acrylonitrile 20.27
    aniline 10.11
    1,3-propanediol 74.34
    bromobenzene 1.88
    dibromomethane 3.58
    1,1,2,2-tetrachloroethane 14.86
    2-methyl-cyclohexyl acetate 16.87
    tetrabutyl urea 15.93
    diisobutyl methanol 7.91
    2-phenylethanol 17.07
    styrene 2.01
    dioctyl adipate 14.01
    dimethyl sulfate 117.98
    ethyl butyrate 19.56
    methyl lactate 67.84
    butyl lactate 20.55
    diethyl carbonate 15.29
    propanediol butyl ether 42.46
    triethyl orthoformate 17.17
    p-tert-butyltoluene 4.14
    methyl 4-tert-butylbenzoate 30.8
    morpholine 63.48
    tert-butylamine 25.54
    n-dodecanol 4.02
    dimethoxymethane 138.94
    ethylene carbonate 24.04
    cyrene 63.45
    2-ethoxyethyl acetate 22.79
    2-ethylhexyl acetate 12.65
    1,2,4-trichlorobenzene 7.2
    4-methylpyridine 15.45
    dibutyl ether 6.46
    2,6-dimethyl-4-heptanol 7.91
    DEF 65.77
    dimethyl isosorbide 89.62
    tetrachloroethylene 11.12
    eugenol 30.51
    triacetin 29.1
    span 80 31.01
    1,4-butanediol 27.0
    1,1-dichloroethane 5.59
    2-methyl-1-pentanol 18.74
    methyl formate 80.8
    2-methyl-1-butanol 27.61
    n-decane 0.37
    butyronitrile 14.11
    3,7-dimethyl-1-octanol 9.93
    1-chlorooctane 2.29
    1-chlorotetradecane 0.89
    n-nonane 0.33
    undecane 0.28
    tert-butylcyclohexane 0.77
    cyclooctane 0.25
    cyclopentanol 35.37
    tetrahydropyran 20.8
    tert-amyl methyl ether 28.43
    2,5,8-trioxanonane 80.75
    1-hexene 2.99
    2-isopropoxyethanol 47.06
    2,2,2-trifluoroethanol 33.28
    methyl butyrate 28.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction