4-Methoxypyridine

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  • Identifiers

    CAS number
    620-08-6

    Molecular formula
    C6H7NO

    SMILES
    COC1=CC=NC=C1

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 52.68%
    Spicy 51.28%
    Phenolic 47.96%
    Green 47.21%
    Smoky 46.78%
    Nutty 46.68%
    Earthy 42.13%
    Burnt 41.93%
    Aromatic 38.28%
    Tobacco 38.09%

     

    Flavor
    Sweet 68.96%
    Nutty 51.11%
    Bitter 39.34%
    Green 36.35%
    Musty 36.28%
    Earthy 31.68%
    Tobacco 30.64%
    Caramel 29.58%
    Balsam 28.78%
    Vanilla 28.78%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    4.97 (weak acid)

    Molecular weight
    109.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    179°C

    Flash point

    • 64.91 ˚C est.

  • Synonyms

    • 4-Methoxypyridine
    • 620-08-6
    • Pyridine, 4-methoxy-
    • .gamma.-Methoxypyridine
    • 4-methoxy-pyridine
    • MFCD00674049
    • EINECS 210-624-7
    • DTXSID10211029
    • gamma-Methoxypyridine;
    • p-methoxypyridine
    • methyl pyridin-4-yl ether
    • 4-methoxypyrdine
    • 4-methoxylpyridine
    • 4-methoxy pyridine
    • gamma-Methoxypyridine
    • 4-Methoxypyridine 95+%
    • 4-Methoxypyridine, 97%
    • SCHEMBL61315
    • SCHEMBL10297348
    • DTXCID60133520
    • BCP26365
    • AKOS002664334
    • AC-7005
    • CS-W007634
    • HY-W007634
    • PS-9280
    • SY003216
    • DB-006867
    • M1696
    • NS00022519
    • EN300-84486
    • AC-907/25004551
    • 210-624-7

  • Applications

    4-Methoxypyridine (CAS 620-08-6) is primarily used as an organic synthesis building block and intermediate. In pharmaceutical development, it serves as a precursor for constructing heterocyclic drug-like molecules and active pharmaceutical ingredients. In agrochemical research, it is used as a versatile intermediate in the synthesis of pyridine-containing candidates. It also serves as a starting material and ligand precursor for metal-catalyzed reactions, enabling cross-coupling and other catalytic processes. In polymer and coatings development, it can be used as a building block for pyridine-containing monomers or additives, and in organic synthesis workflows it may act as a specialty solvent or reaction medium under appropriate conditions. These applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 577.38
    methanol 650.91
    isopropanol 367.65
    water 16.73
    ethyl acetate 792.43
    n-propanol 441.24
    acetone 509.56
    n-butanol 331.86
    acetonitrile 869.34
    DMF 889.59
    toluene 427.42
    isobutanol 292.1
    1,4-dioxane 1214.06
    methyl acetate 697.93
    THF 793.37
    2-butanone 500.06
    n-pentanol 223.15
    sec-butanol 324.02
    n-hexane 24.97
    ethylene glycol 224.48
    NMP 687.49
    cyclohexane 74.79
    DMSO 1126.77
    n-butyl acetate 190.22
    n-octanol 48.48
    chloroform 1679.22
    n-propyl acetate 175.75
    acetic acid 774.7
    dichloromethane 1644.76
    cyclohexanone 487.9
    propylene glycol 196.07
    isopropyl acetate 224.88
    DMAc 998.12
    2-ethoxyethanol 466.64
    isopentanol 222.31
    n-heptane 29.39
    ethyl formate 406.1
    1,2-dichloroethane 889.88
    n-hexanol 161.17
    2-methoxyethanol 848.73
    isobutyl acetate 82.7
    tetrachloromethane 355.34
    n-pentyl acetate 93.97
    transcutol 715.64
    n-heptanol 60.97
    ethylbenzene 72.85
    MIBK 124.02
    2-propoxyethanol 321.81
    tert-butanol 442.56
    MTBE 358.67
    2-butoxyethanol 128.81
    propionic acid 540.79
    o-xylene 180.38
    formic acid 508.16
    diethyl ether 563.46
    m-xylene 159.98
    p-xylene 98.39
    chlorobenzene 410.36
    dimethyl carbonate 202.47
    n-octane 8.16
    formamide 738.75
    cyclopentanone 493.58
    2-pentanone 305.91
    anisole 228.33
    cyclopentyl methyl ether 420.35
    gamma-butyrolactone 728.44
    1-methoxy-2-propanol 430.49
    pyridine 1181.65
    3-pentanone 320.4
    furfural 760.34
    n-dodecane 6.34
    diethylene glycol 325.1
    diisopropyl ether 84.89
    tert-amyl alcohol 332.42
    acetylacetone 321.65
    n-hexadecane 7.19
    acetophenone 166.04
    methyl propionate 565.33
    isopentyl acetate 123.44
    trichloroethylene 1591.19
    n-nonanol 44.78
    cyclohexanol 319.81
    benzyl alcohol 209.42
    2-ethylhexanol 83.22
    isooctanol 46.94
    dipropyl ether 136.62
    1,2-dichlorobenzene 280.07
    ethyl lactate 81.86
    propylene carbonate 312.51
    n-methylformamide 722.07
    2-pentanol 205.7
    n-pentane 39.89
    1-propoxy-2-propanol 185.35
    1-methoxy-2-propyl acetate 191.76
    2-(2-methoxypropoxy) propanol 134.64
    mesitylene 74.7
    ε-caprolactone 464.1
    p-cymene 48.03
    epichlorohydrin 966.98
    1,1,1-trichloroethane 848.72
    2-aminoethanol 351.71
    morpholine-4-carbaldehyde 874.11
    sulfolane 607.56
    2,2,4-trimethylpentane 20.62
    2-methyltetrahydrofuran 799.62
    n-hexyl acetate 99.73
    isooctane 11.99
    2-(2-butoxyethoxy)ethanol 172.47
    sec-butyl acetate 99.78
    tert-butyl acetate 162.86
    decalin 22.71
    glycerin 301.12
    diglyme 390.27
    acrylic acid 480.43
    isopropyl myristate 40.3
    n-butyric acid 566.22
    acetyl acetate 365.72
    di(2-ethylhexyl) phthalate 44.68
    ethyl propionate 187.78
    nitromethane 1276.97
    1,2-diethoxyethane 272.05
    benzonitrile 299.1
    trioctyl phosphate 28.73
    1-bromopropane 490.35
    gamma-valerolactone 779.21
    n-decanol 33.77
    triethyl phosphate 68.05
    4-methyl-2-pentanol 77.91
    propionitrile 564.18
    vinylene carbonate 354.31
    1,1,2-trichlorotrifluoroethane 695.47
    DMS 139.77
    cumene 43.49
    2-octanol 36.91
    2-hexanone 144.83
    octyl acetate 52.88
    limonene 76.45
    1,2-dimethoxyethane 536.44
    ethyl orthosilicate 66.9
    tributyl phosphate 42.33
    diacetone alcohol 187.31
    N,N-dimethylaniline 127.1
    acrylonitrile 672.15
    aniline 558.89
    1,3-propanediol 428.05
    bromobenzene 425.71
    dibromomethane 986.73
    1,1,2,2-tetrachloroethane 1059.8
    2-methyl-cyclohexyl acetate 74.04
    tetrabutyl urea 57.06
    diisobutyl methanol 48.1
    2-phenylethanol 141.97
    styrene 124.05
    dioctyl adipate 63.63
    dimethyl sulfate 309.15
    ethyl butyrate 144.36
    methyl lactate 196.8
    butyl lactate 64.4
    diethyl carbonate 103.4
    propanediol butyl ether 91.0
    triethyl orthoformate 101.9
    p-tert-butyltoluene 47.62
    methyl 4-tert-butylbenzoate 98.02
    morpholine 1393.22
    tert-butylamine 263.45
    n-dodecanol 27.4
    dimethoxymethane 500.32
    ethylene carbonate 314.47
    cyrene 127.81
    2-ethoxyethyl acetate 180.46
    2-ethylhexyl acetate 102.35
    1,2,4-trichlorobenzene 370.51
    4-methylpyridine 852.96
    dibutyl ether 75.27
    2,6-dimethyl-4-heptanol 48.1
    DEF 539.15
    dimethyl isosorbide 202.76
    tetrachloroethylene 763.56
    eugenol 103.42
    triacetin 122.2
    span 80 93.64
    1,4-butanediol 152.04
    1,1-dichloroethane 964.72
    2-methyl-1-pentanol 165.11
    methyl formate 434.95
    2-methyl-1-butanol 254.31
    n-decane 10.01
    butyronitrile 441.29
    3,7-dimethyl-1-octanol 56.5
    1-chlorooctane 42.1
    1-chlorotetradecane 18.01
    n-nonane 10.07
    undecane 7.58
    tert-butylcyclohexane 19.55
    cyclooctane 21.65
    cyclopentanol 349.6
    tetrahydropyran 846.21
    tert-amyl methyl ether 246.51
    2,5,8-trioxanonane 272.11
    1-hexene 86.97
    2-isopropoxyethanol 227.96
    2,2,2-trifluoroethanol 314.18
    methyl butyrate 216.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction