4-Methoxypicolinamide

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  • Identifiers

    CAS number
    90151-10-3

    Molecular formula
    C7H8N2O2

    SMILES
    COC1=CC(=NC=C1)C(=O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 45.6%
    Roasted 38.49%
    Nutty 31.62%
    Popcorn 28.92%
    Burnt 23.08%
    Meaty 22.66%
    Savory 22.6%
    Cooked 21.98%
    Grape 21.21%
    Caramellic 21.03%

     

    Flavor
    Bitter 39.37%
    Odorless 34.65%
    Nutty 33.43%
    Popcorn 29.13%
    Roast 26.1%
    Roasted 25.95%
    Mild 23.52%
    Bread crust 22.74%
    Roasted peanuts 21.87%
    Taco 21.59%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.04 (weak acid)

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    305°C

    Flash point

    • 149.62 ˚C est.

  • Synonyms

    • 4-Methoxypicolinamide
    • 90151-10-3
    • 4-methoxypyridine-2-carboxamide
    • 4-Methoxy-pyridine-2-carboxylic acid amide
    • MFCD00955999
    • 9014-93-1
    • 4-Methoxypyridine-2-carboxylic acid amide
    • 2-Pyridinecarboxamide,4-methoxy-
    • SCHEMBL2624147
    • SCHEMBL3355639
    • 4-methoxy-2-pyridinecarboxamide
    • CHEMBL4517269
    • DYHMIVKBJSIOCH-UHFFFAOYSA-N
    • A1I13
    • QDA15110
    • SBB070042
    • AKOS006343714
    • AB07772
    • SY143623
    • DB-057185
    • CS-0082331
    • D74452
    • EN300-120989
    • 4-Methoxy-pyridine-2-carboxylic acid amide, AldrichCPR
    • Z1201620706
    • 9014-93-1

  • Applications

    4-Methoxypicolinamide (CAS 90151-10-3) is primarily used as a chemical intermediate and building block in medicinal chemistry and organic synthesis. It functions as a versatile ligand in coordination chemistry and catalysis, enabling the preparation of metal complexes and serving as a precursor to functionalized heterocycles. In research contexts, it is explored as a lead-like scaffold in pharmaceutical discovery and in materials science as a precursor to functional materials, including coordination polymers or metal–organic frameworks (MOFs). It may also have potential in analytical chemistry as a coordinating ligand for metal-ion detection.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.34
    methanol 11.92
    isopropanol 3.26
    water 10.67
    ethyl acetate 2.96
    n-propanol 4.23
    acetone 4.58
    n-butanol 3.31
    acetonitrile 6.72
    DMF 63.21
    toluene 1.94
    isobutanol 3.18
    1,4-dioxane 16.09
    methyl acetate 5.74
    THF 17.57
    2-butanone 3.99
    n-pentanol 2.68
    sec-butanol 2.58
    n-hexane 0.08
    ethylene glycol 11.2
    NMP 85.42
    cyclohexane 0.38
    DMSO 101.49
    n-butyl acetate 2.61
    n-octanol 2.02
    chloroform 3.0
    n-propyl acetate 2.04
    acetic acid 14.91
    dichloromethane 7.63
    cyclohexanone 14.29
    propylene glycol 5.41
    isopropyl acetate 1.66
    DMAc 96.61
    2-ethoxyethanol 11.73
    isopentanol 3.24
    n-heptane 0.32
    ethyl formate 8.72
    1,2-dichloroethane 4.34
    n-hexanol 3.15
    2-methoxyethanol 27.61
    isobutyl acetate 1.49
    tetrachloromethane 0.95
    n-pentyl acetate 2.07
    transcutol 14.26
    n-heptanol 2.54
    ethylbenzene 1.28
    MIBK 1.83
    2-propoxyethanol 12.08
    tert-butanol 5.45
    MTBE 1.79
    2-butoxyethanol 8.35
    propionic acid 7.37
    o-xylene 3.2
    formic acid 36.36
    diethyl ether 1.01
    m-xylene 1.98
    p-xylene 2.38
    chlorobenzene 3.15
    dimethyl carbonate 4.93
    n-octane 0.15
    formamide 39.11
    cyclopentanone 16.37
    2-pentanone 2.14
    anisole 4.57
    cyclopentyl methyl ether 4.89
    gamma-butyrolactone 26.71
    1-methoxy-2-propanol 11.5
    pyridine 14.07
    3-pentanone 2.43
    furfural 39.74
    n-dodecane 0.17
    diethylene glycol 19.54
    diisopropyl ether 0.45
    tert-amyl alcohol 3.86
    acetylacetone 4.86
    n-hexadecane 0.2
    acetophenone 6.84
    methyl propionate 4.74
    isopentyl acetate 2.93
    trichloroethylene 7.54
    n-nonanol 2.14
    cyclohexanol 4.87
    benzyl alcohol 6.97
    2-ethylhexanol 2.65
    isooctanol 2.29
    dipropyl ether 2.06
    1,2-dichlorobenzene 4.4
    ethyl lactate 4.12
    propylene carbonate 13.51
    n-methylformamide 25.74
    2-pentanol 1.21
    n-pentane 0.09
    1-propoxy-2-propanol 6.48
    1-methoxy-2-propyl acetate 5.34
    2-(2-methoxypropoxy) propanol 9.83
    mesitylene 1.38
    ε-caprolactone 13.84
    p-cymene 1.97
    epichlorohydrin 18.77
    1,1,1-trichloroethane 2.33
    2-aminoethanol 11.74
    morpholine-4-carbaldehyde 55.6
    sulfolane 50.56
    2,2,4-trimethylpentane 0.13
    2-methyltetrahydrofuran 9.43
    n-hexyl acetate 2.76
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 10.64
    sec-butyl acetate 1.38
    tert-butyl acetate 2.24
    decalin 0.29
    glycerin 18.71
    diglyme 20.24
    acrylic acid 10.81
    isopropyl myristate 1.57
    n-butyric acid 7.2
    acetyl acetate 3.56
    di(2-ethylhexyl) phthalate 4.23
    ethyl propionate 2.39
    nitromethane 24.75
    1,2-diethoxyethane 3.39
    benzonitrile 7.37
    trioctyl phosphate 2.51
    1-bromopropane 1.44
    gamma-valerolactone 29.88
    n-decanol 1.76
    triethyl phosphate 4.84
    4-methyl-2-pentanol 1.16
    propionitrile 4.99
    vinylene carbonate 15.16
    1,1,2-trichlorotrifluoroethane 24.54
    DMS 4.44
    cumene 1.31
    2-octanol 1.3
    2-hexanone 2.34
    octyl acetate 2.33
    limonene 2.45
    1,2-dimethoxyethane 17.98
    ethyl orthosilicate 4.25
    tributyl phosphate 2.66
    diacetone alcohol 6.16
    N,N-dimethylaniline 5.48
    acrylonitrile 9.8
    aniline 6.29
    1,3-propanediol 12.15
    bromobenzene 2.59
    dibromomethane 3.0
    1,1,2,2-tetrachloroethane 6.0
    2-methyl-cyclohexyl acetate 5.02
    tetrabutyl urea 5.07
    diisobutyl methanol 1.61
    2-phenylethanol 6.74
    styrene 1.32
    dioctyl adipate 3.61
    dimethyl sulfate 17.37
    ethyl butyrate 3.39
    methyl lactate 8.67
    butyl lactate 3.55
    diethyl carbonate 3.72
    propanediol butyl ether 5.92
    triethyl orthoformate 4.01
    p-tert-butyltoluene 1.67
    methyl 4-tert-butylbenzoate 8.06
    morpholine 17.87
    tert-butylamine 2.25
    n-dodecanol 1.42
    dimethoxymethane 13.36
    ethylene carbonate 10.86
    cyrene 18.73
    2-ethoxyethyl acetate 3.9
    2-ethylhexyl acetate 2.47
    1,2,4-trichlorobenzene 6.51
    4-methylpyridine 12.32
    dibutyl ether 1.45
    2,6-dimethyl-4-heptanol 1.61
    DEF 12.16
    dimethyl isosorbide 19.54
    tetrachloroethylene 4.2
    eugenol 9.74
    triacetin 5.45
    span 80 7.05
    1,4-butanediol 5.78
    1,1-dichloroethane 1.87
    2-methyl-1-pentanol 2.93
    methyl formate 19.52
    2-methyl-1-butanol 3.09
    n-decane 0.23
    butyronitrile 4.5
    3,7-dimethyl-1-octanol 2.06
    1-chlorooctane 0.8
    1-chlorotetradecane 0.49
    n-nonane 0.18
    undecane 0.2
    tert-butylcyclohexane 0.22
    cyclooctane 0.17
    cyclopentanol 7.63
    tetrahydropyran 5.66
    tert-amyl methyl ether 1.96
    2,5,8-trioxanonane 19.28
    1-hexene 0.32
    2-isopropoxyethanol 6.17
    2,2,2-trifluoroethanol 11.49
    methyl butyrate 4.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction