4-Methoxyphenyl acetate

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  • Identifiers

    CAS number
    1200-06-2

    Molecular formula
    C9H10O3

    SMILES
    CC(=O)OC1=CC=C(C=C1)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 70.22%
    Phenolic 67.18%
    Floral 57.54%
    Vanilla 54.92%
    Spicy 49.33%
    Woody 48.31%
    Powdery 46.24%
    Anisic 43.64%
    Balsamic 42.66%
    Aromatic 41.75%

     

    Flavor
    Sweet 91.29%
    Woody 55.11%
    Powdery 47.94%
    Vanilla 47.09%
    Floral 45.92%
    Balsam 40.19%
    Spice 38.4%
    Clove 35.13%
    Creamy 34.98%
    Hawthorn 34.24%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    7.74 (neutral)

    Molecular weight
    166.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    255°C

    Flash point

    • 103.91 ˚C est.

  • Synonyms

    • 4-Methoxyphenyl acetate
    • 1200-06-2
    • Phenol, p-methoxy-, acetate
    • 4-Methoxyphenol, acetate
    • NSC 43148
    • Phenol, p-methoxy-, acetate (8CI)
    • AI3-22704
    • DTXSID50152649
    • RefChem:99665
    • DTXCID6075140
    • 839-657-0
    • YAPCNXGBNRDBIW-UHFFFAOYSA-N
    • p-Acetoxyanisole
    • p-Methoxyphenyl acetate
    • (4-methoxyphenyl) acetate
    • Acetic acid p-methoxyphenyl ester
    • Phenol, 4-methoxy-, acetate
    • Acetic acid 4-methoxy-phenyl ester
    • MFCD00048211
    • NSC-43148
    • 4-methoxy phenyl acetic acid
    • 4-Acetoxyanisole
    • 5R7WLL62AN
    • CHEMBL40604
    • SCHEMBL155983
    • SCHEMBL2003787
    • Phenol, 4-methoxy-, 1-acetate
    • BAA20006
    • NSC43148
    • Benzenemethanol,ar-methoxy-,1-acetate
    • AKOS002953963
    • BS-14538
    • SY157936
    • CS-0155015
    • NS00045237
    • ST45022179
    • EN300-169864
    • F546764
    • Z30195429
    • 1200-06-2

  • Applications

    4-Methoxyphenyl acetate (CAS 1200-06-2) is mainly used as a fragrance ingredient in perfumery, providing almond/anise-like notes, and as a synthetic intermediate to prepare anisyl derivatives for further chemical synthesis in flavors, cosmetics, and polymers. In cosmetics and personal care, it appears as a fragrance component; in household and cleaning products, it contributes aroma. In industrial manufacturing, it may be used as a solvent or processing aid and as a precursor for anisyl compounds employed in coatings, inks, and plastics. It can also serve as a chemical intermediate for the synthesis of specialty aromatics, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 42.76
    methanol 49.6
    isopropanol 34.85
    water 1.22
    ethyl acetate 58.15
    n-propanol 30.27
    acetone 127.77
    n-butanol 31.37
    acetonitrile 84.1
    DMF 300.97
    toluene 16.35
    isobutanol 24.32
    1,4-dioxane 115.1
    methyl acetate 96.55
    THF 154.3
    2-butanone 90.95
    n-pentanol 25.79
    sec-butanol 31.49
    n-hexane 5.78
    ethylene glycol 30.81
    NMP 292.12
    cyclohexane 2.65
    DMSO 506.73
    n-butyl acetate 45.78
    n-octanol 16.29
    chloroform 147.5
    n-propyl acetate 36.73
    acetic acid 88.16
    dichloromethane 182.75
    cyclohexanone 81.31
    propylene glycol 28.25
    isopropyl acetate 42.14
    DMAc 480.5
    2-ethoxyethanol 93.36
    isopentanol 33.76
    n-heptane 2.94
    ethyl formate 39.94
    1,2-dichloroethane 110.24
    n-hexanol 22.29
    2-methoxyethanol 141.82
    isobutyl acetate 25.52
    tetrachloromethane 19.39
    n-pentyl acetate 22.68
    transcutol 341.12
    n-heptanol 11.29
    ethylbenzene 19.55
    MIBK 44.01
    2-propoxyethanol 74.91
    tert-butanol 73.78
    MTBE 76.58
    2-butoxyethanol 35.7
    propionic acid 51.62
    o-xylene 23.75
    formic acid 56.37
    diethyl ether 50.43
    m-xylene 17.68
    p-xylene 24.83
    chlorobenzene 42.87
    dimethyl carbonate 57.73
    n-octane 1.44
    formamide 107.39
    cyclopentanone 131.17
    2-pentanone 56.51
    anisole 84.06
    cyclopentyl methyl ether 60.61
    gamma-butyrolactone 164.66
    1-methoxy-2-propanol 103.18
    pyridine 66.54
    3-pentanone 58.95
    furfural 185.31
    n-dodecane 1.89
    diethylene glycol 89.37
    diisopropyl ether 18.94
    tert-amyl alcohol 64.9
    acetylacetone 113.69
    n-hexadecane 2.17
    acetophenone 76.42
    methyl propionate 65.96
    isopentyl acetate 49.81
    trichloroethylene 218.78
    n-nonanol 16.0
    cyclohexanol 25.47
    benzyl alcohol 43.4
    2-ethylhexanol 20.16
    isooctanol 11.11
    dipropyl ether 27.24
    1,2-dichlorobenzene 59.72
    ethyl lactate 35.81
    propylene carbonate 82.5
    n-methylformamide 89.33
    2-pentanol 22.74
    n-pentane 3.0
    1-propoxy-2-propanol 53.23
    1-methoxy-2-propyl acetate 76.49
    2-(2-methoxypropoxy) propanol 97.12
    mesitylene 14.08
    ε-caprolactone 79.42
    p-cymene 16.5
    epichlorohydrin 210.17
    1,1,1-trichloroethane 92.59
    2-aminoethanol 40.13
    morpholine-4-carbaldehyde 268.31
    sulfolane 284.33
    2,2,4-trimethylpentane 4.67
    2-methyltetrahydrofuran 99.1
    n-hexyl acetate 42.13
    isooctane 2.72
    2-(2-butoxyethoxy)ethanol 91.77
    sec-butyl acetate 31.61
    tert-butyl acetate 69.31
    decalin 6.36
    glycerin 70.95
    diglyme 183.71
    acrylic acid 60.07
    isopropyl myristate 22.5
    n-butyric acid 47.17
    acetyl acetate 60.04
    di(2-ethylhexyl) phthalate 29.14
    ethyl propionate 44.84
    nitromethane 259.29
    1,2-diethoxyethane 72.2
    benzonitrile 49.23
    trioctyl phosphate 16.35
    1-bromopropane 45.55
    gamma-valerolactone 193.28
    n-decanol 12.73
    triethyl phosphate 42.84
    4-methyl-2-pentanol 17.99
    propionitrile 42.36
    vinylene carbonate 78.32
    1,1,2-trichlorotrifluoroethane 175.46
    DMS 76.06
    cumene 17.89
    2-octanol 9.21
    2-hexanone 49.12
    octyl acetate 26.58
    limonene 21.58
    1,2-dimethoxyethane 178.84
    ethyl orthosilicate 37.68
    tributyl phosphate 28.03
    diacetone alcohol 88.48
    N,N-dimethylaniline 67.47
    acrylonitrile 63.64
    aniline 41.06
    1,3-propanediol 51.97
    bromobenzene 44.55
    dibromomethane 94.36
    1,1,2,2-tetrachloroethane 172.09
    2-methyl-cyclohexyl acetate 47.08
    tetrabutyl urea 38.92
    diisobutyl methanol 16.16
    2-phenylethanol 39.01
    styrene 24.1
    dioctyl adipate 41.78
    dimethyl sulfate 168.31
    ethyl butyrate 42.34
    methyl lactate 59.33
    butyl lactate 28.03
    diethyl carbonate 40.99
    propanediol butyl ether 44.01
    triethyl orthoformate 39.63
    p-tert-butyltoluene 17.35
    methyl 4-tert-butylbenzoate 66.03
    morpholine 126.2
    tert-butylamine 40.16
    n-dodecanol 10.54
    dimethoxymethane 127.2
    ethylene carbonate 55.5
    cyrene 92.93
    2-ethoxyethyl acetate 50.42
    2-ethylhexyl acetate 40.55
    1,2,4-trichlorobenzene 82.24
    4-methylpyridine 81.22
    dibutyl ether 27.27
    2,6-dimethyl-4-heptanol 16.16
    DEF 97.4
    dimethyl isosorbide 158.1
    tetrachloroethylene 87.0
    eugenol 62.62
    triacetin 76.26
    span 80 50.51
    1,4-butanediol 24.65
    1,1-dichloroethane 80.65
    2-methyl-1-pentanol 31.72
    methyl formate 74.12
    2-methyl-1-butanol 31.74
    n-decane 2.82
    butyronitrile 36.34
    3,7-dimethyl-1-octanol 23.4
    1-chlorooctane 13.03
    1-chlorotetradecane 7.13
    n-nonane 2.54
    undecane 2.25
    tert-butylcyclohexane 7.07
    cyclooctane 1.45
    cyclopentanol 31.21
    tetrahydropyran 54.43
    tert-amyl methyl ether 67.4
    2,5,8-trioxanonane 160.93
    1-hexene 16.38
    2-isopropoxyethanol 60.01
    2,2,2-trifluoroethanol 59.58
    methyl butyrate 53.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction