4-(Methoxymethyl)phenol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    5355-17-9

    Molecular formula
    C8H10O2

    SMILES
    COCC1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Sweet 82.12%
    Phenolic 70.55%
    Green 55.7%
    Floral 51.09%
    Anisic 47.94%
    Medicinal 45.57%
    Vanilla 45.06%
    Earthy 43.29%
    Aromatic 42.36%
    Hawthorn 38.38%

    Scent© AI

  • Properties

    XLogP3-AA
    0.8

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    242°C

    Flash point est.
    107.5 ˚C

  • Synonyms

    • 4-(Methoxymethyl)phenol
    • 5355-17-9
    • alpha-Methoxy-p-cresol
    • Phenol, 4-(methoxymethyl)-
    • 4-Methoxymethylphenol
    • p-(methoxymethyl)phenol
    • 4-Hydroxybenzyl methyl ether
    • p-hydroxybenzyl methyl ether
    • 17CJ5983VN
    • EINECS 226-334-9
    • MFCD00020186
    • DTXSID2074746
    • CHEBI:133885
    • P-CRESOL, .ALPHA.-METHOXY
    • 4-Methoxymethyl-phenol
    • UNII-17CJ5983VN
    • 4-(methoxymethyl)-phenol
    • SCHEMBL63724
    • P-CRESOL, ALPHA-METHOXY
    • CHEMBL3929528
    • DTXCID7041463
    • .ALPHA.-METHOXY-P-CRESOL
    • AKOS006273184
    • DS-14089
    • SY026430
    • DB-071699
    • NS00022322
    • EN300-1851052
    • Q27251899
    • ETHER,(4-HYDROXYBENZYL),METHYL (TOLUENE,4-HYDROXY,ALPHA-METHOXY)
    • ETHER,(4-HYDROXYBENZYL),METHYL (TOLUENE,4-HYDROXY,ALPHA-METHOXY)

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1069.37
    methanol 1181.75
    isopropanol 793.64
    water 19.45
    ethyl acetate 398.18
    n-propanol 747.71
    acetone 1002.61
    n-butanol 549.38
    acetonitrile 486.36
    DMF 1143.61
    toluene 73.66
    isobutanol 445.79
    1,4-dioxane 586.16
    methyl acetate 563.38
    THF 922.0
    2-butanone 608.22
    n-pentanol 340.12
    sec-butanol 550.74
    n-hexane 22.95
    ethylene glycol 472.47
    NMP 715.38
    cyclohexane 21.78
    DMSO 1733.62
    n-butyl acetate 213.22
    n-octanol 108.07
    chloroform 392.69
    n-propyl acetate 254.35
    acetic acid 990.52
    dichloromethane 368.9
    cyclohexanone 433.27
    propylene glycol 538.34
    isopropyl acetate 196.99
    DMAc 695.57
    2-ethoxyethanol 730.96
    isopentanol 391.98
    n-heptane 16.96
    ethyl formate 266.18
    1,2-dichloroethane 355.04
    n-hexanol 253.61
    2-methoxyethanol 1066.61
    isobutyl acetate 134.66
    tetrachloromethane 110.51
    n-pentyl acetate 102.3
    transcutol 1515.88
    n-heptanol 104.47
    ethylbenzene 47.7
    MIBK 233.29
    2-propoxyethanol 456.81
    tert-butanol 912.53
    MTBE 470.12
    2-butoxyethanol 227.31
    propionic acid 606.42
    o-xylene 65.61
    formic acid 697.81
    diethyl ether 419.3
    m-xylene 64.37
    p-xylene 55.35
    chlorobenzene 128.93
    dimethyl carbonate 205.35
    n-octane 5.28
    formamide 1027.21
    cyclopentanone 684.28
    2-pentanone 434.05
    anisole 210.55
    cyclopentyl methyl ether 372.15
    gamma-butyrolactone 712.86
    1-methoxy-2-propanol 726.66
    pyridine 352.43
    3-pentanone 287.89
    furfural 552.67
    n-dodecane 4.22
    diethylene glycol 496.96
    diisopropyl ether 100.22
    tert-amyl alcohol 607.49
    acetylacetone 409.75
    n-hexadecane 4.76
    acetophenone 186.33
    methyl propionate 386.75
    isopentyl acetate 177.58
    trichloroethylene 657.96
    n-nonanol 85.74
    cyclohexanol 287.76
    benzyl alcohol 196.27
    2-ethylhexanol 128.31
    isooctanol 83.95
    dipropyl ether 137.88
    1,2-dichlorobenzene 122.91
    ethyl lactate 160.97
    propylene carbonate 324.38
    n-methylformamide 819.61
    2-pentanol 353.03
    n-pentane 25.38
    1-propoxy-2-propanol 294.84
    1-methoxy-2-propyl acetate 239.94
    2-(2-methoxypropoxy) propanol 247.81
    mesitylene 45.23
    ε-caprolactone 353.21
    p-cymene 41.28
    epichlorohydrin 791.19
    1,1,1-trichloroethane 298.55
    2-aminoethanol 670.18
    morpholine-4-carbaldehyde 629.17
    sulfolane 886.52
    2,2,4-trimethylpentane 22.14
    2-methyltetrahydrofuran 622.78
    n-hexyl acetate 167.51
    isooctane 16.09
    2-(2-butoxyethoxy)ethanol 348.4
    sec-butyl acetate 148.07
    tert-butyl acetate 268.84
    decalin 15.48
    glycerin 631.32
    diglyme 599.15
    acrylic acid 570.6
    isopropyl myristate 56.21
    n-butyric acid 490.4
    acetyl acetate 209.25
    di(2-ethylhexyl) phthalate 64.95
    ethyl propionate 200.67
    nitromethane 1331.47
    1,2-diethoxyethane 258.59
    benzonitrile 162.14
    trioctyl phosphate 49.64
    1-bromopropane 171.14
    gamma-valerolactone 680.64
    n-decanol 60.89
    triethyl phosphate 83.06
    4-methyl-2-pentanol 165.18
    propionitrile 319.64
    vinylene carbonate 277.04
    1,1,2-trichlorotrifluoroethane 680.23
    DMS 170.45
    cumene 41.8
    2-octanol 63.6
    2-hexanone 271.55
    octyl acetate 75.96
    limonene 64.84
    1,2-dimethoxyethane 658.34
    ethyl orthosilicate 80.82
    tributyl phosphate 64.71
    diacetone alcohol 416.35
    N,N-dimethylaniline 135.7
    acrylonitrile 380.32
    aniline 231.2
    1,3-propanediol 700.26
    bromobenzene 98.97
    dibromomethane 230.66
    1,1,2,2-tetrachloroethane 475.05
    2-methyl-cyclohexyl acetate 124.67
    tetrabutyl urea 80.72
    diisobutyl methanol 72.46
    2-phenylethanol 162.4
    styrene 62.17
    dioctyl adipate 96.39
    dimethyl sulfate 351.96
    ethyl butyrate 146.73
    methyl lactate 249.92
    butyl lactate 121.96
    diethyl carbonate 106.21
    propanediol butyl ether 290.85
    triethyl orthoformate 109.93
    p-tert-butyltoluene 43.28
    methyl 4-tert-butylbenzoate 152.76
    morpholine 808.69
    tert-butylamine 463.53
    n-dodecanol 43.07
    dimethoxymethane 530.97
    ethylene carbonate 222.77
    cyrene 236.36
    2-ethoxyethyl acetate 192.64
    2-ethylhexyl acetate 132.6
    1,2,4-trichlorobenzene 173.7
    4-methylpyridine 293.03
    dibutyl ether 95.51
    2,6-dimethyl-4-heptanol 72.46
    DEF 412.5
    dimethyl isosorbide 313.95
    tetrachloroethylene 334.36
    eugenol 157.76
    triacetin 203.53
    span 80 181.15
    1,4-butanediol 310.98
    1,1-dichloroethane 315.58
    2-methyl-1-pentanol 257.9
    methyl formate 532.52
    2-methyl-1-butanol 379.82
    n-decane 7.81
    butyronitrile 271.67
    3,7-dimethyl-1-octanol 114.66
    1-chlorooctane 43.44
    1-chlorotetradecane 14.91
    n-nonane 7.61
    undecane 5.43
    tert-butylcyclohexane 18.83
    cyclooctane 9.05
    cyclopentanol 393.41
    tetrahydropyran 528.35
    tert-amyl methyl ether 301.96
    2,5,8-trioxanonane 385.73
    1-hexene 85.17
    2-isopropoxyethanol 411.66
    2,2,2-trifluoroethanol 388.43
    methyl butyrate 268.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Vanilla 1 8024-06-4 Vanilla fragrans Ames (V. planifolia Andrews), fam. Orchidaceae 1.0%