4'-Methoxyacrylophenone

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  • Identifiers

    CAS number
    7448-86-4

    Molecular formula
    C10H10O2

    SMILES
    COC1=CC=C(C=C1)C(=O)C=C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Sweet 68.71%
    Spicy 52.4%
    Vanilla 52.08%
    Balsamic 42.19%
    Nutty 40.2%
    Cherry 39.72%
    Almond 39.69%
    Powdery 39.49%
    Phenolic 39.42%
    Floral 38.57%

     

    Flavor
    Sweet 38.07%
    Balsam 36.34%
    Bitter 31.02%
    Powdery 28.33%
    Nutty 27.11%
    Cinnamon 27.03%
    Honey 26.95%
    Almond 26.19%
    Cherry 26.15%
    Faint 25.58%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    6.79 (neutral)

    Molecular weight
    162.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    277°C

    Flash point

    • 105.02 ˚C est.

  • Synonyms

    • 4'-Methoxyacrylophenone
    • 7448-86-4
    • 1'-Oxoestragole
    • p-Methoxyacrylophenone
    • p-Methoxyphenyl vinyl ketone
    • 1-(4-Methoxyphenyl)-2-propen-1-one
    • 2-Propen-1-one, 1-(4-methoxyphenyl)-
    • ACRYLOPHENONE, 4'-METHOXY-
    • BRN 2041093
    • UNII-A8M9Z5074S
    • A8M9Z5074S
    • DTXSID90225482
    • 4-08-00-00887 (Beilstein Handbook Reference)
    • 1-(P-METHOXYPHENYL)-2-PROPEN-1-ONE
    • RefChem:96029
    • DTXCID90147973
    • 2-Propen-1-one, 1-(4-methoxyphenyl)-(9CI)
    • YMESWDPSFKMFND-UHFFFAOYSA-N
    • 1-(4-methoxyphenyl)prop-2-en-1-one
    • MFCD01673932
    • 1-methoxy-4-acryloylbenzene
    • SCHEMBL546672
    • SCHEMBL7828631
    • AKOS014316244
    • SY503381
    • CS-0238731
    • EN300-200200
    • G65304
    • Q27273775
    • 7448-86-4

  • Applications

    4'-Methoxyacrylophenone (CAS 7448-86-4) is used as an odorant and fragrance intermediate in perfumery, and may be incorporated into cosmetic and household product formulations as a fragrance component; owing to its acrylate moiety, it can serve as a reactive monomer or intermediate in UV-curable coatings, inks, and adhesives, and it also functions as a building block for the synthesis of aroma-related compounds and specialty polymers. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 55.68
    methanol 56.81
    isopropanol 42.31
    water 0.37
    ethyl acetate 217.56
    n-propanol 54.32
    acetone 340.4
    n-butanol 50.05
    acetonitrile 227.06
    DMF 536.03
    toluene 108.11
    isobutanol 38.21
    1,4-dioxane 379.26
    methyl acetate 252.75
    THF 518.9
    2-butanone 289.43
    n-pentanol 50.82
    sec-butanol 51.92
    n-hexane 17.55
    ethylene glycol 28.29
    NMP 673.25
    cyclohexane 21.42
    DMSO 864.77
    n-butyl acetate 179.05
    n-octanol 19.52
    chloroform 619.75
    n-propyl acetate 168.41
    acetic acid 165.33
    dichloromethane 778.0
    cyclohexanone 329.94
    propylene glycol 28.95
    isopropyl acetate 132.86
    DMAc 553.89
    2-ethoxyethanol 192.4
    isopentanol 54.88
    n-heptane 6.57
    ethyl formate 127.18
    1,2-dichloroethane 620.1
    n-hexanol 46.45
    2-methoxyethanol 213.17
    isobutyl acetate 84.27
    tetrachloromethane 92.11
    n-pentyl acetate 71.36
    transcutol 1284.55
    n-heptanol 19.22
    ethylbenzene 94.25
    MIBK 115.83
    2-propoxyethanol 156.16
    tert-butanol 96.92
    MTBE 178.89
    2-butoxyethanol 78.86
    propionic acid 103.97
    o-xylene 96.22
    formic acid 92.4
    diethyl ether 197.15
    m-xylene 72.22
    p-xylene 93.68
    chlorobenzene 246.0
    dimethyl carbonate 153.55
    n-octane 1.96
    formamide 268.51
    cyclopentanone 493.17
    2-pentanone 201.05
    anisole 319.58
    cyclopentyl methyl ether 213.49
    gamma-butyrolactone 585.5
    1-methoxy-2-propanol 155.5
    pyridine 355.92
    3-pentanone 214.04
    furfural 598.03
    n-dodecane 1.64
    diethylene glycol 143.19
    diisopropyl ether 61.06
    tert-amyl alcohol 104.03
    acetylacetone 320.21
    n-hexadecane 2.06
    acetophenone 266.75
    methyl propionate 203.98
    isopentyl acetate 158.76
    trichloroethylene 1161.3
    n-nonanol 19.81
    cyclohexanol 61.98
    benzyl alcohol 140.64
    2-ethylhexanol 41.07
    isooctanol 19.02
    dipropyl ether 81.29
    1,2-dichlorobenzene 294.84
    ethyl lactate 81.99
    propylene carbonate 253.3
    n-methylformamide 228.09
    2-pentanol 44.61
    n-pentane 9.84
    1-propoxy-2-propanol 113.64
    1-methoxy-2-propyl acetate 235.87
    2-(2-methoxypropoxy) propanol 187.68
    mesitylene 52.21
    ε-caprolactone 275.23
    p-cymene 45.31
    epichlorohydrin 855.6
    1,1,1-trichloroethane 452.21
    2-aminoethanol 48.45
    morpholine-4-carbaldehyde 577.26
    sulfolane 812.59
    2,2,4-trimethylpentane 11.4
    2-methyltetrahydrofuran 336.04
    n-hexyl acetate 102.11
    isooctane 7.07
    2-(2-butoxyethoxy)ethanol 206.41
    sec-butyl acetate 117.84
    tert-butyl acetate 202.08
    decalin 20.67
    glycerin 68.34
    diglyme 519.73
    acrylic acid 137.95
    isopropyl myristate 46.3
    n-butyric acid 106.1
    acetyl acetate 180.66
    di(2-ethylhexyl) phthalate 52.74
    ethyl propionate 169.3
    nitromethane 659.52
    1,2-diethoxyethane 302.77
    benzonitrile 188.93
    trioctyl phosphate 29.15
    1-bromopropane 198.34
    gamma-valerolactone 537.61
    n-decanol 14.79
    triethyl phosphate 97.95
    4-methyl-2-pentanol 32.17
    propionitrile 141.87
    vinylene carbonate 232.29
    1,1,2-trichlorotrifluoroethane 471.19
    DMS 236.64
    cumene 58.58
    2-octanol 13.43
    2-hexanone 178.33
    octyl acetate 52.44
    limonene 62.68
    1,2-dimethoxyethane 397.36
    ethyl orthosilicate 86.48
    tributyl phosphate 54.76
    diacetone alcohol 181.7
    N,N-dimethylaniline 183.63
    acrylonitrile 238.02
    aniline 152.17
    1,3-propanediol 67.19
    bromobenzene 273.22
    dibromomethane 445.28
    1,1,2,2-tetrachloroethane 809.07
    2-methyl-cyclohexyl acetate 126.67
    tetrabutyl urea 70.79
    diisobutyl methanol 30.65
    2-phenylethanol 116.8
    styrene 142.43
    dioctyl adipate 99.67
    dimethyl sulfate 351.66
    ethyl butyrate 145.11
    methyl lactate 109.96
    butyl lactate 67.47
    diethyl carbonate 121.89
    propanediol butyl ether 79.05
    triethyl orthoformate 116.23
    p-tert-butyltoluene 44.36
    methyl 4-tert-butylbenzoate 142.53
    morpholine 374.21
    tert-butylamine 62.64
    n-dodecanol 11.75
    dimethoxymethane 309.03
    ethylene carbonate 171.37
    cyrene 184.23
    2-ethoxyethyl acetate 177.18
    2-ethylhexyl acetate 135.14
    1,2,4-trichlorobenzene 358.2
    4-methylpyridine 298.64
    dibutyl ether 60.01
    2,6-dimethyl-4-heptanol 30.65
    DEF 288.24
    dimethyl isosorbide 372.29
    tetrachloroethylene 485.95
    eugenol 141.35
    triacetin 196.04
    span 80 99.74
    1,4-butanediol 35.9
    1,1-dichloroethane 380.12
    2-methyl-1-pentanol 64.23
    methyl formate 197.35
    2-methyl-1-butanol 55.7
    n-decane 2.89
    butyronitrile 104.9
    3,7-dimethyl-1-octanol 34.47
    1-chlorooctane 20.86
    1-chlorotetradecane 8.68
    n-nonane 2.54
    undecane 2.09
    tert-butylcyclohexane 16.74
    cyclooctane 8.47
    cyclopentanol 70.43
    tetrahydropyran 248.99
    tert-amyl methyl ether 155.88
    2,5,8-trioxanonane 365.8
    1-hexene 58.06
    2-isopropoxyethanol 129.72
    2,2,2-trifluoroethanol 109.38
    methyl butyrate 196.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction