4-Menthane-1,7,8-triol

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  • Identifiers

    CAS number
    145385-69-9

    Molecular formula
    C10H20O3

    SMILES
    CC(C)(C1CCC(CC1)(CO)O)O

    Safety labels

  • Odor profile

    Fragrance
    Mint 45.43%
    Sweet 40.79%
    Camphoreous 39.74%
    Odorless 37.52%
    Woody 36.84%
    Cooling 34.12%
    Balsamic 30.52%
    Pine 25.21%
    Herbal 23.95%
    Clean 23.84%

     

    Flavor
    Sweet 44.46%
    Herbal 41.84%
    Minty 39.53%
    Odorless 28.69%
    Mild 25.21%
    Herb 24.68%
    Fruity 23.39%
    Fruit 22.61%
    Terpenic 22.32%
    Eucalyptus 21.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    9.23 (weak base)

    Molecular weight
    188.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    325°C

    Melting point expt.

    • 137 - 139 °C

    Flash point

    • 164.95 ˚C est.

  • Synonyms

    • 4-Menthane-1,7,8-triol
    • 145385-69-9
    • DTXSID20163000
    • RefChem:912628
    • DTXCID1085491
    • 1-(hydroxymethyl)-4-(2-hydroxypropan-2-yl)cyclohexan-1-ol
    • cis-p-menthane-1,7,8-triol
    • SCHEMBL562197
    • CHEBI:171756
    • DTXSID501210982
    • (1s,4s)-1-(hydroxymethyl)-4-(2-hydroxypropan-2-yl)cyclohexan-1-ol
    • 1,4-Cyclohexanedimethanol, 1-hydroxy-alpha4,alpha4-dimethyl-
    • cis-1-Hydroxy-I+/-4,I+/-4-dimethyl-1,4-cyclohexanedimethanol
    • 154843-72-8
    • 145385-69-9

  • Applications

    4-Menthane-1,7,8-triol (CAS 145385-69-9) is a menthane-based polyol with real-world applications primarily in fragrance and cosmetic-related sectors, as well as in industrial formulations; it can serve as a fragrance ingredient or precursor to aroma compounds and may act as a fixative in fragrance systems; in cosmetics and personal care, it can function as a polyol to adjust texture and skin feel; in the polymers/plastics arena, it may be used as a polyol for polyurethane, coatings, and adhesive formulations; in cleaning and household products, it can be used as a fragrance additive or solvent component in formulations; and in industrial manufacturing, it can serve as an intermediate for the synthesis of specialty chemicals, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 370.89
    methanol 799.6
    isopropanol 190.01
    water 48.12
    ethyl acetate 80.23
    n-propanol 228.66
    acetone 113.44
    n-butanol 183.77
    acetonitrile 67.15
    DMF 315.8
    toluene 15.6
    isobutanol 114.53
    1,4-dioxane 270.04
    methyl acetate 68.13
    THF 516.96
    2-butanone 66.17
    n-pentanol 73.54
    sec-butanol 108.78
    n-hexane 4.36
    ethylene glycol 187.06
    NMP 281.63
    cyclohexane 10.46
    DMSO 413.47
    n-butyl acetate 54.24
    n-octanol 52.75
    chloroform 62.25
    n-propyl acetate 48.33
    acetic acid 403.08
    dichloromethane 53.85
    cyclohexanone 140.85
    propylene glycol 201.66
    isopropyl acetate 59.78
    DMAc 196.3
    2-ethoxyethanol 217.93
    isopentanol 120.76
    n-heptane 6.52
    ethyl formate 90.66
    1,2-dichloroethane 35.65
    n-hexanol 99.17
    2-methoxyethanol 504.52
    isobutyl acetate 31.92
    tetrachloromethane 21.3
    n-pentyl acetate 41.68
    transcutol 573.91
    n-heptanol 61.79
    ethylbenzene 10.23
    MIBK 58.32
    2-propoxyethanol 233.41
    tert-butanol 193.93
    MTBE 65.32
    2-butoxyethanol 139.94
    propionic acid 191.13
    o-xylene 18.73
    formic acid 490.37
    diethyl ether 72.31
    m-xylene 21.0
    p-xylene 14.3
    chlorobenzene 23.64
    dimethyl carbonate 46.84
    n-octane 2.83
    formamide 538.78
    cyclopentanone 221.44
    2-pentanone 71.38
    anisole 40.53
    cyclopentyl methyl ether 127.81
    gamma-butyrolactone 310.28
    1-methoxy-2-propanol 311.62
    pyridine 78.85
    3-pentanone 44.28
    furfural 235.92
    n-dodecane 1.91
    diethylene glycol 253.55
    diisopropyl ether 23.7
    tert-amyl alcohol 116.39
    acetylacetone 108.58
    n-hexadecane 2.08
    acetophenone 49.59
    methyl propionate 73.34
    isopentyl acetate 54.64
    trichloroethylene 74.09
    n-nonanol 44.81
    cyclohexanol 103.34
    benzyl alcohol 54.67
    2-ethylhexanol 43.8
    isooctanol 44.6
    dipropyl ether 44.25
    1,2-dichlorobenzene 25.97
    ethyl lactate 58.42
    propylene carbonate 156.66
    n-methylformamide 310.09
    2-pentanol 83.02
    n-pentane 6.33
    1-propoxy-2-propanol 146.89
    1-methoxy-2-propyl acetate 102.5
    2-(2-methoxypropoxy) propanol 120.15
    mesitylene 17.29
    ε-caprolactone 143.39
    p-cymene 14.05
    epichlorohydrin 188.33
    1,1,1-trichloroethane 29.5
    2-aminoethanol 328.13
    morpholine-4-carbaldehyde 324.0
    sulfolane 343.38
    2,2,4-trimethylpentane 4.4
    2-methyltetrahydrofuran 179.61
    n-hexyl acetate 62.42
    isooctane 3.88
    2-(2-butoxyethoxy)ethanol 177.13
    sec-butyl acetate 31.4
    tert-butyl acetate 79.89
    decalin 4.43
    glycerin 333.83
    diglyme 296.82
    acrylic acid 186.07
    isopropyl myristate 22.81
    n-butyric acid 216.04
    acetyl acetate 66.62
    di(2-ethylhexyl) phthalate 34.85
    ethyl propionate 42.54
    nitromethane 353.99
    1,2-diethoxyethane 81.49
    benzonitrile 42.9
    trioctyl phosphate 27.5
    1-bromopropane 17.26
    gamma-valerolactone 328.77
    n-decanol 30.11
    triethyl phosphate 32.99
    4-methyl-2-pentanol 52.85
    propionitrile 58.13
    vinylene carbonate 128.21
    1,1,2-trichlorotrifluoroethane 221.33
    DMS 48.45
    cumene 11.16
    2-octanol 30.79
    2-hexanone 40.93
    octyl acetate 32.02
    limonene 21.15
    1,2-dimethoxyethane 223.21
    ethyl orthosilicate 34.09
    tributyl phosphate 30.24
    diacetone alcohol 141.9
    N,N-dimethylaniline 34.25
    acrylonitrile 76.31
    aniline 61.85
    1,3-propanediol 371.21
    bromobenzene 16.64
    dibromomethane 31.81
    1,1,2,2-tetrachloroethane 66.86
    2-methyl-cyclohexyl acetate 50.67
    tetrabutyl urea 37.2
    diisobutyl methanol 29.05
    2-phenylethanol 61.45
    styrene 10.59
    dioctyl adipate 40.0
    dimethyl sulfate 96.01
    ethyl butyrate 46.14
    methyl lactate 100.83
    butyl lactate 62.57
    diethyl carbonate 32.74
    propanediol butyl ether 149.28
    triethyl orthoformate 45.71
    p-tert-butyltoluene 15.35
    methyl 4-tert-butylbenzoate 75.61
    morpholine 352.35
    tert-butylamine 93.68
    n-dodecanol 20.2
    dimethoxymethane 194.64
    ethylene carbonate 116.65
    cyrene 120.79
    2-ethoxyethyl acetate 68.53
    2-ethylhexyl acetate 40.6
    1,2,4-trichlorobenzene 39.08
    4-methylpyridine 62.11
    dibutyl ether 28.64
    2,6-dimethyl-4-heptanol 29.05
    DEF 98.28
    dimethyl isosorbide 178.22
    tetrachloroethylene 63.95
    eugenol 72.75
    triacetin 80.49
    span 80 106.59
    1,4-butanediol 107.06
    1,1-dichloroethane 24.92
    2-methyl-1-pentanol 51.87
    methyl formate 204.73
    2-methyl-1-butanol 98.92
    n-decane 3.79
    butyronitrile 64.89
    3,7-dimethyl-1-octanol 43.69
    1-chlorooctane 13.28
    1-chlorotetradecane 4.71
    n-nonane 3.51
    undecane 2.53
    tert-butylcyclohexane 4.52
    cyclooctane 4.72
    cyclopentanol 139.29
    tetrahydropyran 158.39
    tert-amyl methyl ether 52.32
    2,5,8-trioxanonane 207.08
    1-hexene 10.81
    2-isopropoxyethanol 115.89
    2,2,2-trifluoroethanol 172.22
    methyl butyrate 56.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction