4'-Hydroxypropiophenone

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  • Identifiers

    CAS number
    70-70-2

    Molecular formula
    C9H10O2

    SMILES
    CCC(=O)C1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 63.86%
    Phenolic 54.46%
    Vanilla 48.83%
    Fruity 43.5%
    Hay 40.7%
    Balsamic 37.8%
    Floral 37.03%
    Hawthorn 36.54%
    Nutty 35.77%
    Woody 35.31%

     

    Flavor
    Sweet 46.4%
    Phenolic 40.0%
    Balsam 34.22%
    Hawthorn 33.55%
    Bitter 30.6%
    Vanilla 27.01%
    Powdery 26.44%
    Nutty 25.98%
    Spicy 25.43%
    Almond 24.98%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    9.32 (weak base)

    Molecular weight
    150.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    299°C

    Flash point

    • 125.67 ˚C est.

  • Synonyms

    • 4'-Hydroxypropiophenone
    • 70-70-2
    • Paroxypropione
    • 1-(4-hydroxyphenyl)propan-1-one
    • 4-Hydroxypropiophenone
    • p-Hydroxypropiophenone
    • Mepal
    • Frenantol
    • Frenohypon
    • Proxiphenon
    • 1-Propanone, 1-(4-hydroxyphenyl)-
    • Paroxipropiona
    • H-365
    • Parossipropione
    • Paroxypropionum
    • B-360
    • H 365
    • NSC-2834
    • para-Hydroxypropiophenone
    • DTXSID8023426
    • X9952001TG
    • DTXCID103426
    • NSC2834
    • RefChem:170112
    • 200-743-2
    • Paroxypropion
    • Profenone
    • Paroxon
    • Hypostat
    • Possipione
    • p-Propiophenol
    • p-Propionylphenol
    • Hypophenon
    • Sterofenon
    • Frenormon
    • Ibiopopp
    • Frenon
    • Bio-fren
    • 1-(4-Hydroxyphenyl)-1-propanone
    • 4-Propionylphenol
    • p-Oxypropiophenone
    • Usaf ek-3302
    • Ethyl p-hydroxyphenyl ketone
    • Paraoxypropiophenone
    • p-Hydroxyphenyl-1-propanone
    • MFCD00002361
    • 1-(p-Hydroxyphenyl)-1-propanone
    • Propiophenone, 4'-hydroxy-
    • 1-(4-Hydroxy-phenyl)-propan-1-one
    • B 360
    • MLS000069406
    • CHEMBL312311
    • Paroxypropione (INN)
    • NCGC00018097-04
    • NCGC00018097-06
    • SMR000059092
    • WLN: QR DV2
    • PAROXYPROPIONE [INN]
    • p-Hydroxypropiophenone (JAN)
    • Possipion
    • Parossipropione [DCIT]
    • P-HYDROXYPROPIOPHENONE [JAN]
    • 4-Propanoylphenol
    • Paroxypropione [INN:DCF]
    • CAS-70-70-2
    • Paroxypropionum [INN-Latin]
    • Paroxipropiona [INN-Spanish]
    • NSC 2834
    • EINECS 200-743-2
    • BRN 0907511
    • AI3-03719
    • P.O.P.
    • UNII-X9952001TG
    • p-Hydroxypropiophenon
    • 4-Hydroxypropiophenon
    • 4-hydroxy propiophenone
    • 4`-Hydroxypropiophenone
    • Metaraminol Impurity 73
    • 4'-hydroxy-propiophenone
    • 4''-Hydroxypropiophenone
    • Opera_ID_1001
    • PAROXYPROPIONE [MI]
    • Ethyl 4-Hydroxyphenyl Ketone
    • 4-08-00-00441 (Beilstein Handbook Reference)
    • SCHEMBL440470
    • 4?-HYDROXYPROPIOPHENONE
    • PAROXYPROPIONE [MART.]
    • 4'-Hydroxypropiophenone, 98%
    • F1995-0235
    • orb1944913
    • SCHEMBL2644065
    • SCHEMBL7429718
    • PAROXYPROPIONE [WHO-DD]
    • CHEBI:32352
    • HMS2235G15
    • HMS3264A14
    • HMS3372E08
    • Pharmakon1600-01506169
    • 1-(4-hydroxyphenyl)-propan-1-one
    • BB_SC-06905
    • HY-B1353
    • NSC33949
    • Tox21_110822
    • AC7855
    • BBL011845
    • BDBM50177402
    • EBC-14444
    • NSC-33949
    • NSC760386
    • s5396
    • SBB040250
    • STK397478
    • AKOS000120374
    • Tox21_110822_1
    • CCG-214030
    • CS-7973
    • FH71324
    • NSC-760386
    • NCGC00018097-01
    • NCGC00018097-02
    • NCGC00018097-03
    • NCGC00018097-05
    • NCGC00022475-03
    • NCGC00022475-04
    • AC-10985
    • AS-12055
    • DA-59760
    • 70-70-2

  • Applications

    4'-Hydroxypropiophenone is primarily used as an intermediate in fragrance and flavor chemistry, where it serves as a starting point for para-hydroxyphenylpropanone–based aroma and flavor compounds. In cosmetics and personal care, it is employed as a fragrance precursor and can be used to prepare other aroma-related ingredients within formulation limits. The compound also finds use in polymer and coating applications as a building block for functionalized phenylpropanoid derivatives and in dye and ink chemistry as a precursor to specialty pigments and colorants. In pharmaceutical and agrochemical research, it may be evaluated as an intermediate for the synthesis of more complex molecules. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 710.01
    methanol 880.84
    isopropanol 537.53
    water 3.74
    ethyl acetate 671.0
    n-propanol 491.78
    acetone 1935.73
    n-butanol 358.2
    acetonitrile 1061.25
    DMF 2938.95
    toluene 147.05
    isobutanol 303.26
    1,4-dioxane 972.69
    methyl acetate 829.93
    THF 1583.26
    2-butanone 1074.95
    n-pentanol 294.53
    sec-butanol 395.13
    n-hexane 21.51
    ethylene glycol 212.14
    NMP 1961.93
    cyclohexane 13.26
    DMSO 4649.87
    n-butyl acetate 457.75
    n-octanol 114.98
    chloroform 628.21
    n-propyl acetate 487.07
    acetic acid 754.1
    dichloromethane 944.28
    cyclohexanone 945.96
    propylene glycol 199.13
    isopropyl acetate 324.59
    DMAc 1431.31
    2-ethoxyethanol 655.94
    isopentanol 314.73
    n-heptane 8.94
    ethyl formate 430.74
    1,2-dichloroethane 895.51
    n-hexanol 218.67
    2-methoxyethanol 936.79
    isobutyl acetate 212.01
    tetrachloromethane 101.21
    n-pentyl acetate 242.22
    transcutol 3100.46
    n-heptanol 100.17
    ethylbenzene 108.24
    MIBK 323.71
    2-propoxyethanol 484.66
    tert-butanol 650.79
    MTBE 560.9
    2-butoxyethanol 265.19
    propionic acid 555.74
    o-xylene 121.88
    formic acid 443.28
    diethyl ether 533.64
    m-xylene 117.0
    p-xylene 132.85
    chlorobenzene 315.79
    dimethyl carbonate 354.25
    n-octane 3.76
    formamide 1333.87
    cyclopentanone 1706.44
    2-pentanone 752.32
    anisole 433.33
    cyclopentyl methyl ether 537.73
    gamma-butyrolactone 2017.23
    1-methoxy-2-propanol 644.95
    pyridine 710.87
    3-pentanone 517.69
    furfural 1206.73
    n-dodecane 3.7
    diethylene glycol 436.97
    diisopropyl ether 119.66
    tert-amyl alcohol 498.83
    acetylacetone 822.55
    n-hexadecane 4.53
    acetophenone 417.39
    methyl propionate 616.13
    isopentyl acetate 340.46
    trichloroethylene 1484.88
    n-nonanol 96.55
    cyclohexanol 253.65
    benzyl alcohol 297.37
    2-ethylhexanol 125.31
    isooctanol 82.73
    dipropyl ether 161.3
    1,2-dichlorobenzene 310.58
    ethyl lactate 186.51
    propylene carbonate 694.2
    n-methylformamide 1450.61
    2-pentanol 258.35
    n-pentane 14.8
    1-propoxy-2-propanol 321.06
    1-methoxy-2-propyl acetate 424.51
    2-(2-methoxypropoxy) propanol 357.36
    mesitylene 73.34
    ε-caprolactone 779.19
    p-cymene 61.75
    epichlorohydrin 1766.18
    1,1,1-trichloroethane 513.39
    2-aminoethanol 351.96
    morpholine-4-carbaldehyde 1348.63
    sulfolane 2267.6
    2,2,4-trimethylpentane 15.33
    2-methyltetrahydrofuran 1043.42
    n-hexyl acetate 360.37
    isooctane 11.66
    2-(2-butoxyethoxy)ethanol 545.46
    sec-butyl acetate 256.68
    tert-butyl acetate 398.21
    decalin 18.5
    glycerin 289.46
    diglyme 1107.43
    acrylic acid 563.36
    isopropyl myristate 110.66
    n-butyric acid 464.41
    acetyl acetate 359.07
    di(2-ethylhexyl) phthalate 110.73
    ethyl propionate 350.6
    nitromethane 2623.33
    1,2-diethoxyethane 575.11
    benzonitrile 411.27
    trioctyl phosphate 77.85
    1-bromopropane 278.34
    gamma-valerolactone 1483.18
    n-decanol 68.59
    triethyl phosphate 124.36
    4-methyl-2-pentanol 132.49
    propionitrile 507.7
    vinylene carbonate 570.97
    1,1,2-trichlorotrifluoroethane 736.4
    DMS 412.19
    cumene 76.46
    2-octanol 75.68
    2-hexanone 508.68
    octyl acetate 147.89
    limonene 85.4
    1,2-dimethoxyethane 923.78
    ethyl orthosilicate 113.24
    tributyl phosphate 121.57
    diacetone alcohol 478.84
    N,N-dimethylaniline 243.31
    acrylonitrile 812.88
    aniline 331.17
    1,3-propanediol 447.71
    bromobenzene 270.86
    dibromomethane 503.35
    1,1,2,2-tetrachloroethane 900.93
    2-methyl-cyclohexyl acetate 194.54
    tetrabutyl urea 157.91
    diisobutyl methanol 76.92
    2-phenylethanol 226.66
    styrene 164.0
    dioctyl adipate 184.67
    dimethyl sulfate 712.54
    ethyl butyrate 265.05
    methyl lactate 267.63
    butyl lactate 210.63
    diethyl carbonate 189.75
    propanediol butyl ether 351.09
    triethyl orthoformate 162.26
    p-tert-butyltoluene 59.99
    methyl 4-tert-butylbenzoate 254.9
    morpholine 1194.78
    tert-butylamine 314.46
    n-dodecanol 48.62
    dimethoxymethane 983.58
    ethylene carbonate 449.38
    cyrene 321.89
    2-ethoxyethyl acetate 468.85
    2-ethylhexyl acetate 254.28
    1,2,4-trichlorobenzene 399.12
    4-methylpyridine 760.23
    dibutyl ether 164.39
    2,6-dimethyl-4-heptanol 76.92
    DEF 820.34
    dimethyl isosorbide 556.13
    tetrachloroethylene 553.97
    eugenol 278.78
    triacetin 399.86
    span 80 237.87
    1,4-butanediol 192.41
    1,1-dichloroethane 673.76
    2-methyl-1-pentanol 255.23
    methyl formate 974.1
    2-methyl-1-butanol 294.51
    n-decane 6.76
    butyronitrile 394.96
    3,7-dimethyl-1-octanol 128.45
    1-chlorooctane 60.94
    1-chlorotetradecane 19.58
    n-nonane 6.15
    undecane 4.89
    tert-butylcyclohexane 19.09
    cyclooctane 5.51
    cyclopentanol 396.97
    tetrahydropyran 723.02
    tert-amyl methyl ether 339.05
    2,5,8-trioxanonane 602.22
    1-hexene 120.77
    2-isopropoxyethanol 411.73
    2,2,2-trifluoroethanol 326.97
    methyl butyrate 502.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction