(4-Hydroxyphenoxy)acetic acid

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  • Identifiers

    CAS number
    1878-84-8

    Molecular formula
    C8H8O4

    SMILES
    C1=CC(=CC=C1O)OCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 48.11%
    Odorless 41.87%
    Sweet 39.6%
    Vanilla 39.19%
    Balsamic 31.87%
    Creamy 31.08%
    Nutty 28.41%
    Burnt 27.74%
    Milky 26.7%
    Caramellic 25.15%

     

    Flavor
    Sweet 51.04%
    Odorless 42.42%
    Mild 36.37%
    Phenolic 34.55%
    Sour 33.52%
    Creamy 32.94%
    Faint 29.22%
    Balsamic 27.13%
    Powdery 25.14%
    Nutty 22.65%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    8.35 (weak base)

    Molecular weight
    168.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    353°C

    Flash point

    • 175.69 ˚C est.

  • Synonyms

    • 4-Hydroxyphenoxyacetic acid
    • 1878-84-8
    • 2-(4-Hydroxyphenoxy)acetic acid
    • (4-Hydroxyphenoxy)acetic acid
    • 6E65R48EBN
    • RefChem:524056
    • 217-525-8
    • 4-Hydroxypheoxyacetate
    • Acetic acid, (4-hydroxyphenoxy)-
    • Acetic acid, 2-(4-hydroxyphenoxy)-
    • MFCD00014362
    • (4-Hydroxy-phenoxy)-acetic acid
    • P-HYDROXYPHENOXYACETIC ACID
    • CHEMBL297343
    • Acetic acid, (p-hydroxyphenoxy)-
    • 2-(4-Hydroxyphenoxy)acetic Acid; (4-Hydroxyphenoxy)acetic Acid; O-(4-Hydroxyphenyl)glycolic Acid; p-Hydroxyphenoxyacetic Acid
    • EINECS 217-525-8
    • SCHEMBL274850
    • (4-hydroxyphenoxy) acetic acid
    • CHEBI:1881
    • SCHEMBL4002619
    • 2-(4-Hydroxyphenoxy)aceticacid
    • DTXSID7062033
    • BDBM50114882
    • EBC-03280
    • (4-Hydroxyphenoxy)acetic acid, 98%
    • AKOS002685377
    • AT23403
    • FH67443
    • AS-61791
    • SY048454
    • DB-044656
    • CS-0127993
    • H0992
    • NS00026144
    • ST50405540
    • EN300-77149
    • C03235
    • F607841
    • Q27105517
    • Z1192367471
    • InChI=1/C8H8O4/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4,9H,5H2,(H,10,11
    • 1878-84-8

  • Applications

    For (4-Hydroxyphenoxy)acetic acid, CAS 1878-84-8, common applications include serving as an agrochemical intermediate for the synthesis of phenoxyacetic acid herbicides, a building block in fragrance and cosmetic chemistry for aromatic ester formation, a functionalized monomer or intermediate in polymer and coating formulations (including polyesters, polyurethanes, and UV-curable systems), and a pharmaceutical intermediate evaluated for small-molecule drug synthesis. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 344.46
    methanol 610.89
    isopropanol 180.76
    water 22.41
    ethyl acetate 63.02
    n-propanol 195.21
    acetone 301.4
    n-butanol 135.01
    acetonitrile 65.38
    DMF 451.79
    toluene 3.66
    isobutanol 97.37
    1,4-dioxane 153.27
    methyl acetate 104.29
    THF 319.71
    2-butanone 114.51
    n-pentanol 81.15
    sec-butanol 100.7
    n-hexane 0.54
    ethylene glycol 223.03
    NMP 143.66
    cyclohexane 0.83
    DMSO 344.69
    n-butyl acetate 26.34
    n-octanol 25.72
    chloroform 1.6
    n-propyl acetate 38.98
    acetic acid 125.83
    dichloromethane 4.2
    cyclohexanone 56.21
    propylene glycol 179.57
    isopropyl acetate 36.0
    DMAc 403.39
    2-ethoxyethanol 384.77
    isopentanol 89.54
    n-heptane 2.33
    ethyl formate 72.2
    1,2-dichloroethane 7.61
    n-hexanol 39.55
    2-methoxyethanol 661.78
    isobutyl acetate 18.02
    tetrachloromethane 0.36
    n-pentyl acetate 18.3
    transcutol 245.62
    n-heptanol 25.48
    ethylbenzene 4.14
    MIBK 41.74
    2-propoxyethanol 165.52
    tert-butanol 261.74
    MTBE 66.81
    2-butoxyethanol 81.4
    propionic acid 71.51
    o-xylene 6.09
    formic acid 243.55
    diethyl ether 45.23
    m-xylene 5.02
    p-xylene 5.28
    chlorobenzene 2.42
    dimethyl carbonate 46.66
    n-octane 1.34
    formamide 447.74
    cyclopentanone 110.18
    2-pentanone 78.18
    anisole 33.16
    cyclopentyl methyl ether 46.08
    gamma-butyrolactone 152.18
    1-methoxy-2-propanol 293.73
    pyridine 29.53
    3-pentanone 36.87
    furfural 84.21
    n-dodecane 1.65
    diethylene glycol 224.67
    diisopropyl ether 11.0
    tert-amyl alcohol 135.64
    acetylacetone 82.93
    n-hexadecane 1.72
    acetophenone 29.55
    methyl propionate 66.74
    isopentyl acetate 24.44
    trichloroethylene 6.96
    n-nonanol 25.6
    cyclohexanol 39.23
    benzyl alcohol 39.41
    2-ethylhexanol 19.63
    isooctanol 20.34
    dipropyl ether 28.84
    1,2-dichlorobenzene 2.97
    ethyl lactate 41.57
    propylene carbonate 46.09
    n-methylformamide 314.09
    2-pentanol 54.77
    n-pentane 0.71
    1-propoxy-2-propanol 88.66
    1-methoxy-2-propyl acetate 54.03
    2-(2-methoxypropoxy) propanol 90.85
    mesitylene 4.77
    ε-caprolactone 59.65
    p-cymene 6.45
    epichlorohydrin 121.36
    1,1,1-trichloroethane 2.9
    2-aminoethanol 302.37
    morpholine-4-carbaldehyde 221.93
    sulfolane 112.6
    2,2,4-trimethylpentane 1.01
    2-methyltetrahydrofuran 108.45
    n-hexyl acetate 25.51
    isooctane 0.85
    2-(2-butoxyethoxy)ethanol 121.92
    sec-butyl acetate 22.06
    tert-butyl acetate 46.32
    decalin 1.06
    glycerin 242.08
    diglyme 187.5
    acrylic acid 58.91
    isopropyl myristate 15.66
    n-butyric acid 69.22
    acetyl acetate 28.67
    di(2-ethylhexyl) phthalate 18.01
    ethyl propionate 34.52
    nitromethane 271.93
    1,2-diethoxyethane 61.09
    benzonitrile 16.36
    trioctyl phosphate 14.62
    1-bromopropane 4.03
    gamma-valerolactone 170.19
    n-decanol 21.76
    triethyl phosphate 18.6
    4-methyl-2-pentanol 28.18
    propionitrile 41.88
    vinylene carbonate 34.44
    1,1,2-trichlorotrifluoroethane 67.48
    DMS 25.33
    cumene 4.78
    2-octanol 15.37
    2-hexanone 41.68
    octyl acetate 21.87
    limonene 8.34
    1,2-dimethoxyethane 331.39
    ethyl orthosilicate 18.0
    tributyl phosphate 15.77
    diacetone alcohol 116.61
    N,N-dimethylaniline 26.53
    acrylonitrile 52.94
    aniline 16.19
    1,3-propanediol 327.24
    bromobenzene 1.56
    dibromomethane 1.77
    1,1,2,2-tetrachloroethane 6.96
    2-methyl-cyclohexyl acetate 22.86
    tetrabutyl urea 33.49
    diisobutyl methanol 15.26
    2-phenylethanol 29.0
    styrene 4.22
    dioctyl adipate 26.68
    dimethyl sulfate 60.8
    ethyl butyrate 28.61
    methyl lactate 74.56
    butyl lactate 24.77
    diethyl carbonate 20.28
    propanediol butyl ether 66.46
    triethyl orthoformate 25.33
    p-tert-butyltoluene 6.8
    methyl 4-tert-butylbenzoate 40.41
    morpholine 234.1
    tert-butylamine 69.49
    n-dodecanol 17.71
    dimethoxymethane 290.64
    ethylene carbonate 31.65
    cyrene 82.24
    2-ethoxyethyl acetate 34.56
    2-ethylhexyl acetate 15.51
    1,2,4-trichlorobenzene 4.31
    4-methylpyridine 27.64
    dibutyl ether 21.22
    2,6-dimethyl-4-heptanol 15.26
    DEF 102.29
    dimethyl isosorbide 115.41
    tetrachloroethylene 3.56
    eugenol 45.65
    triacetin 34.61
    span 80 49.28
    1,4-butanediol 156.31
    1,1-dichloroethane 4.69
    2-methyl-1-pentanol 53.65
    methyl formate 216.48
    2-methyl-1-butanol 76.67
    n-decane 2.21
    butyronitrile 43.83
    3,7-dimethyl-1-octanol 22.21
    1-chlorooctane 5.68
    1-chlorotetradecane 3.81
    n-nonane 1.92
    undecane 1.87
    tert-butylcyclohexane 1.07
    cyclooctane 0.65
    cyclopentanol 70.1
    tetrahydropyran 60.99
    tert-amyl methyl ether 49.84
    2,5,8-trioxanonane 171.85
    1-hexene 3.24
    2-isopropoxyethanol 162.96
    2,2,2-trifluoroethanol 56.08
    methyl butyrate 49.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction