4'-Hydroxyflavanone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6515-37-3

    Molecular formula
    C15H12O3

    SMILES
    C1C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 72.07%
    Phenolic 61.67%
    Coumarinic 51.74%
    Spicy 47.23%
    Vanilla 42.5%
    Coconut 41.26%
    Hay 38.94%
    Herbal 38.72%
    Aromatic 35.45%
    Medicinal 34.98%

     

    Flavor
    Bitter 88.38%
    Tonka 30.58%
    Sweet 30.36%
    Herbal 27.25%
    Balsam 23.3%
    Coconut 23.22%
    Lovage 21.03%
    Naphthalic 20.26%
    Moth ball 19.5%
    Tarragon 19.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    9.67 (weak base)

    Molecular weight
    240.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    441°C

    Flash point

    • 198.86 ˚C est.

  • Synonyms

    • 4'-Hydroxyflavanone
    • 6515-37-3
    • 2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
    • 2,3-Dihydro-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    • 4'-Hydroxy-Flavanone
    • 5K6L8O868Y
    • 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-
    • DTXSID5022487
    • CHEBI:34361
    • RefChem:96014
    • GlyTouCan:G92110JN
    • DTXCID202487
    • G92110JN
    • 2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE
    • 2-(4-hydroxyphenyl)chroman-4-one
    • MFCD00017705
    • 4'-hydroxy flavanone
    • CHEMBL73933
    • 4-hydroxyflavanone
    • 2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
    • (+/-)-4'-HYDROXYFLAVANONE
    • 2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
    • ST080603
    • 4 inverted exclamation mark -Hydroxyflavanone
    • Flavanone, 4'-hydroxy-
    • UNII-5K6L8O868Y
    • 4'-hydroxyflavanones
    • 4''-Hydroxyflavanone
    • a 4'-hydroxyflavanone
    • Spectrum_001900
    • SpecPlus_000881
    • Spectrum5_001744
    • 4;-HYDROXYFLAVANONE
    • KBioSS_002430
    • MLS001359949
    • DivK1c_006977
    • SPECTRUM1500908
    • MEGxp0_001694
    • orb1299318
    • SCHEMBL2283823
    • ACon1_000184
    • KBio1_001921
    • KBio2_002424
    • KBio2_004992
    • KBio2_007560
    • 2-(4-Hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
    • STX 310
    • CHEBI:140331
    • HMS3058P18
    • HY-N8495
    • BDBM50051350
    • AKOS015856459
    • CCG-214552
    • EBC-615772
    • FH68044
    • NCGC00095897-01
    • NCGC00095897-02
    • NCGC00095897-04
    • AS-60971
    • PD118905
    • SMR001224351
    • SY116952
    • DB-054768
    • CS-0144901
    • H1026
    • C19896
    • D90993
    • F622117
    • SR-01000858826
    • SR-01000858826-2
    • BRD-A87125101-001-01-4
    • 2-(4-HYDROXYPHENYL)-2,3-DIHYDRO-4H-CHROMEN-4-ON
    • 6515-37-3

  • Applications

    4'-Hydroxyflavanone (CAS 6515-37-3) is typically used as an organic synthesis intermediate and building block for flavonoid-derived compounds in pharmaceutical and agrochemical research; it is commonly evaluated as a precursor to prepare flavanone libraries and functionalized derivatives. In industrial manufacturing, it can serve as a precursor to more complex aromatics used in specialty polymers and dye or pigment chemistry. In cosmetics and personal care, it may be encountered as a synthetic intermediate in fragrance and flavor compound development, or in formulation research. It is also employed in academic and industrial R&D as a reference material for method development in chromatographic and spectroscopic characterization. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.12
    methanol 29.46
    isopropanol 17.38
    water 0.18
    ethyl acetate 42.95
    n-propanol 12.9
    acetone 25.54
    n-butanol 13.61
    acetonitrile 65.45
    DMF 30.46
    toluene 10.8
    isobutanol 10.36
    1,4-dioxane 196.36
    methyl acetate 52.49
    THF 146.52
    2-butanone 34.79
    n-pentanol 17.26
    sec-butanol 11.44
    n-hexane 0.11
    ethylene glycol 16.36
    NMP 12.19
    cyclohexane 0.37
    DMSO 132.58
    n-butyl acetate 25.72
    n-octanol 11.3
    chloroform 35.51
    n-propyl acetate 32.62
    acetic acid 37.03
    dichloromethane 38.51
    cyclohexanone 37.19
    propylene glycol 18.72
    isopropyl acetate 33.06
    DMAc 76.84
    2-ethoxyethanol 81.51
    isopentanol 18.17
    n-heptane 0.85
    ethyl formate 25.45
    1,2-dichloroethane 34.91
    n-hexanol 13.36
    2-methoxyethanol 103.6
    isobutyl acetate 25.83
    tetrachloromethane 1.69
    n-pentyl acetate 17.89
    transcutol 554.81
    n-heptanol 10.11
    ethylbenzene 7.14
    MIBK 31.62
    2-propoxyethanol 72.04
    tert-butanol 34.88
    MTBE 20.7
    2-butoxyethanol 38.12
    propionic acid 22.87
    o-xylene 8.25
    formic acid 20.44
    diethyl ether 18.2
    m-xylene 8.64
    p-xylene 9.97
    chlorobenzene 15.08
    dimethyl carbonate 36.45
    n-octane 0.57
    formamide 59.76
    cyclopentanone 36.46
    2-pentanone 25.68
    anisole 40.72
    cyclopentyl methyl ether 25.7
    gamma-butyrolactone 54.16
    1-methoxy-2-propanol 82.22
    pyridine 55.33
    3-pentanone 25.28
    furfural 71.27
    n-dodecane 1.31
    diethylene glycol 87.51
    diisopropyl ether 8.13
    tert-amyl alcohol 18.22
    acetylacetone 71.26
    n-hexadecane 1.56
    acetophenone 37.84
    methyl propionate 32.67
    isopentyl acetate 29.37
    trichloroethylene 71.32
    n-nonanol 13.51
    cyclohexanol 15.71
    benzyl alcohol 33.55
    2-ethylhexanol 11.89
    isooctanol 10.74
    dipropyl ether 21.87
    1,2-dichlorobenzene 16.73
    ethyl lactate 28.64
    propylene carbonate 31.88
    n-methylformamide 26.36
    2-pentanol 12.02
    n-pentane 0.12
    1-propoxy-2-propanol 50.96
    1-methoxy-2-propyl acetate 57.63
    2-(2-methoxypropoxy) propanol 78.74
    mesitylene 6.68
    ε-caprolactone 34.52
    p-cymene 8.5
    epichlorohydrin 115.89
    1,1,1-trichloroethane 17.26
    2-aminoethanol 20.7
    morpholine-4-carbaldehyde 92.9
    sulfolane 53.12
    2,2,4-trimethylpentane 0.49
    2-methyltetrahydrofuran 32.3
    n-hexyl acetate 27.69
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 107.65
    sec-butyl acetate 25.55
    tert-butyl acetate 41.62
    decalin 0.95
    glycerin 44.25
    diglyme 229.49
    acrylic acid 26.72
    isopropyl myristate 19.2
    n-butyric acid 29.33
    acetyl acetate 43.61
    di(2-ethylhexyl) phthalate 19.22
    ethyl propionate 30.32
    nitromethane 107.69
    1,2-diethoxyethane 117.24
    benzonitrile 36.1
    trioctyl phosphate 12.12
    1-bromopropane 6.2
    gamma-valerolactone 80.12
    n-decanol 11.97
    triethyl phosphate 22.78
    4-methyl-2-pentanol 12.12
    propionitrile 41.36
    vinylene carbonate 38.62
    1,1,2-trichlorotrifluoroethane 65.61
    DMS 47.57
    cumene 6.21
    2-octanol 7.26
    2-hexanone 31.41
    octyl acetate 20.03
    limonene 9.42
    1,2-dimethoxyethane 159.5
    ethyl orthosilicate 21.63
    tributyl phosphate 17.6
    diacetone alcohol 58.66
    N,N-dimethylaniline 23.14
    acrylonitrile 58.47
    aniline 22.02
    1,3-propanediol 38.34
    bromobenzene 13.52
    dibromomethane 12.58
    1,1,2,2-tetrachloroethane 49.89
    2-methyl-cyclohexyl acetate 27.92
    tetrabutyl urea 25.41
    diisobutyl methanol 12.59
    2-phenylethanol 28.68
    styrene 9.33
    dioctyl adipate 32.02
    dimethyl sulfate 46.04
    ethyl butyrate 28.09
    methyl lactate 37.44
    butyl lactate 22.2
    diethyl carbonate 27.23
    propanediol butyl ether 41.83
    triethyl orthoformate 30.25
    p-tert-butyltoluene 8.13
    methyl 4-tert-butylbenzoate 37.57
    morpholine 118.29
    tert-butylamine 11.25
    n-dodecanol 10.65
    dimethoxymethane 101.26
    ethylene carbonate 33.8
    cyrene 49.17
    2-ethoxyethyl acetate 51.42
    2-ethylhexyl acetate 21.77
    1,2,4-trichlorobenzene 22.88
    4-methylpyridine 28.99
    dibutyl ether 26.49
    2,6-dimethyl-4-heptanol 12.59
    DEF 29.89
    dimethyl isosorbide 107.7
    tetrachloroethylene 23.69
    eugenol 42.4
    triacetin 62.32
    span 80 39.04
    1,4-butanediol 19.67
    1,1-dichloroethane 17.23
    2-methyl-1-pentanol 16.67
    methyl formate 30.21
    2-methyl-1-butanol 12.18
    n-decane 1.74
    butyronitrile 25.82
    3,7-dimethyl-1-octanol 16.43
    1-chlorooctane 7.23
    1-chlorotetradecane 4.72
    n-nonane 1.22
    undecane 1.51
    tert-butylcyclohexane 0.99
    cyclooctane 0.29
    cyclopentanol 13.16
    tetrahydropyran 47.22
    tert-amyl methyl ether 15.93
    2,5,8-trioxanonane 176.23
    1-hexene 1.05
    2-isopropoxyethanol 54.05
    2,2,2-trifluoroethanol 18.81
    methyl butyrate 32.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction