4-Hydroxybenzylamine

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  • Identifiers

    CAS number
    696-60-6

    Molecular formula
    C7H9NO

    SMILES
    C1=CC(=CC=C1CN)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 56.67%
    Fishy 42.48%
    Meaty 41.8%
    Smoky 40.43%
    Cheesy 40.01%
    Animal 38.3%
    Burnt 34.08%
    Ripe 33.38%
    Medicinal 32.7%
    Sweet 30.93%

     

    Flavor
    Phenolic 64.74%
    Meaty 49.36%
    Mild 43.47%
    Medicinal 39.2%
    Sulfurous 36.99%
    Phenol 29.35%
    Coffee 26.93%
    Fishy 26.1%
    Fruity 25.48%
    Onion 25.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.71 (neutral)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    276°C

    Melting point expt.

    • 114 - 115 °C

    Flash point

    • 134.66 ˚C est.

  • Synonyms

    • 4-Hydroxybenzylamine
    • 4-(aminomethyl)phenol
    • 696-60-6
    • para-Hydroxybenzylamine
    • Phenol, 4-(aminomethyl)-
    • NSC-125720
    • 7J7F85B7BI
    • DTXSID00219872
    • RefChem:99287
    • DTXCID50142363
    • 671-027-9
    • 4-Aminomethyl-phenol
    • MFCD00870499
    • 4-hydroxybenzyl amine
    • 4-(Aminomethyl)-Phenol
    • 4-HOBA
    • 4-aminomethylphenol
    • p-hydroxybenzylamine
    • CHEMBL202519
    • (4-HYDROXYPHENYL)METHANAMINIUM BROMIDE
    • UNII-7J7F85B7BI
    • a-Amino-p-cresol
    • F2158-0362
    • 4-hyroxybenzylamine
    • 4-hydroxylbenzylamine
    • 4-hydroxy benzylamine
    • NSC 125720
    • p-(aminomethyl)phenol
    • 4-(amino methyl)phenol
    • phenol, 4-aminomethyl-
    • (4-hydroxyphenyl)methanamine
    • P-(AMINOMETHYL)PHENO
    • SCHEMBL63122
    • SCHEMBL63123
    • 4-(Aminomethyl)phenol, 9CI
    • orb1306458
    • SCHEMBL1304221
    • SCHEMBL2642808
    • SCHEMBL5000696
    • SCHEMBL15666314
    • SCHEMBL27630948
    • P-HYDROXYBENZENEMETHANAMINE
    • 4-HYDROXYBENZENEMETHANAMINE
    • CHEBI:173335
    • P-CRESOL, .ALPHA.-AMINO-
    • SMSSF-0613750
    • ALBB-004114
    • BDBM50177412
    • CK2396
    • EBC-48164
    • NSC125720
    • SBB046561
    • STK502926
    • AKOS000131573
    • ((4-HYDROXYPHENYL)METHYL)AMINE
    • CS-W004078
    • FH09583
    • HY-W004078
    • PS-5924
    • SB38361
    • AC-16618
    • BP-21023
    • PD096512
    • SY002006
    • 4-Hydroxybenzylamine, min. 98% by HPLC
    • DB-055316
    • A2305
    • EN300-44825
    • 96H606
    • F023452
    • 4-(Aminomethyl)phenol(Discontinued,See C4X-193831)
    • Q27268396
    • 696-60-6

  • Applications

    4-Hydroxybenzylamine (CAS 696-60-6) is primarily used as an organic synthesis intermediate across several industries. It serves as a building block for pharmaceutical and agrochemical compounds by enabling introduction of the para-hydroxybenzylamine moiety into target molecules. In fragrance and cosmetics, it functions as a precursor for aroma-related derivatives and as a functional handle for conjugation. In polymer and coating formulations, it can be employed as a reactive intermediate to introduce phenolic and amino functionalities into polymers, resins, or UV-curable systems, potentially aiding crosslinking after appropriate modification. It is also encountered as a starting point in the synthesis of dyes and pigments, and may be explored as a ligand precursor in catalytic research. Use is typically governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 63.08
    methanol 56.18
    isopropanol 35.17
    water 7.15
    ethyl acetate 31.62
    n-propanol 43.89
    acetone 71.72
    n-butanol 31.61
    acetonitrile 40.95
    DMF 181.23
    toluene 2.46
    isobutanol 23.95
    1,4-dioxane 150.5
    methyl acetate 31.09
    THF 166.77
    2-butanone 30.26
    n-pentanol 16.42
    sec-butanol 17.86
    n-hexane 0.33
    ethylene glycol 38.02
    NMP 130.89
    cyclohexane 0.7
    DMSO 243.31
    n-butyl acetate 17.01
    n-octanol 13.64
    chloroform 8.58
    n-propyl acetate 14.29
    acetic acid 156.22
    dichloromethane 15.58
    cyclohexanone 49.55
    propylene glycol 36.33
    isopropyl acetate 16.78
    DMAc 111.65
    2-ethoxyethanol 60.5
    isopentanol 23.14
    n-heptane 1.79
    ethyl formate 40.95
    1,2-dichloroethane 10.72
    n-hexanol 27.24
    2-methoxyethanol 147.51
    isobutyl acetate 9.08
    tetrachloromethane 3.0
    n-pentyl acetate 11.94
    transcutol 126.48
    n-heptanol 20.09
    ethylbenzene 1.62
    MIBK 16.06
    2-propoxyethanol 74.8
    tert-butanol 41.86
    MTBE 13.92
    2-butoxyethanol 44.07
    propionic acid 58.62
    o-xylene 3.52
    formic acid 106.74
    diethyl ether 13.26
    m-xylene 3.48
    p-xylene 2.71
    chlorobenzene 6.31
    dimethyl carbonate 23.05
    n-octane 0.75
    formamide 146.14
    cyclopentanone 115.71
    2-pentanone 26.11
    anisole 11.29
    cyclopentyl methyl ether 29.07
    gamma-butyrolactone 167.03
    1-methoxy-2-propanol 84.61
    pyridine 32.61
    3-pentanone 14.32
    furfural 96.18
    n-dodecane 0.75
    diethylene glycol 81.59
    diisopropyl ether 4.18
    tert-amyl alcohol 20.95
    acetylacetone 47.25
    n-hexadecane 0.81
    acetophenone 14.51
    methyl propionate 30.71
    isopentyl acetate 14.88
    trichloroethylene 22.13
    n-nonanol 13.37
    cyclohexanol 17.32
    benzyl alcohol 14.34
    2-ethylhexanol 13.14
    isooctanol 14.68
    dipropyl ether 15.55
    1,2-dichlorobenzene 7.35
    ethyl lactate 15.45
    propylene carbonate 61.48
    n-methylformamide 115.34
    2-pentanol 12.59
    n-pentane 0.41
    1-propoxy-2-propanol 43.35
    1-methoxy-2-propyl acetate 31.55
    2-(2-methoxypropoxy) propanol 35.59
    mesitylene 3.15
    ε-caprolactone 46.82
    p-cymene 4.78
    epichlorohydrin 101.57
    1,1,1-trichloroethane 8.28
    2-aminoethanol 62.64
    morpholine-4-carbaldehyde 133.32
    sulfolane 163.55
    2,2,4-trimethylpentane 0.55
    2-methyltetrahydrofuran 58.1
    n-hexyl acetate 16.72
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 55.1
    sec-butyl acetate 8.21
    tert-butyl acetate 20.86
    decalin 0.64
    glycerin 81.8
    diglyme 101.62
    acrylic acid 61.11
    isopropyl myristate 8.24
    n-butyric acid 73.54
    acetyl acetate 28.84
    di(2-ethylhexyl) phthalate 12.8
    ethyl propionate 12.84
    nitromethane 224.15
    1,2-diethoxyethane 26.27
    benzonitrile 13.47
    trioctyl phosphate 10.72
    1-bromopropane 3.08
    gamma-valerolactone 144.93
    n-decanol 10.48
    triethyl phosphate 10.54
    4-methyl-2-pentanol 9.37
    propionitrile 20.77
    vinylene carbonate 47.34
    1,1,2-trichlorotrifluoroethane 74.31
    DMS 16.46
    cumene 2.36
    2-octanol 8.84
    2-hexanone 13.22
    octyl acetate 12.03
    limonene 6.71
    1,2-dimethoxyethane 79.0
    ethyl orthosilicate 10.19
    tributyl phosphate 9.77
    diacetone alcohol 40.05
    N,N-dimethylaniline 9.57
    acrylonitrile 34.56
    aniline 12.21
    1,3-propanediol 88.48
    bromobenzene 3.99
    dibromomethane 5.86
    1,1,2,2-tetrachloroethane 15.41
    2-methyl-cyclohexyl acetate 15.07
    tetrabutyl urea 15.11
    diisobutyl methanol 8.81
    2-phenylethanol 18.4
    styrene 1.78
    dioctyl adipate 15.19
    dimethyl sulfate 45.89
    ethyl butyrate 15.96
    methyl lactate 34.06
    butyl lactate 15.92
    diethyl carbonate 11.35
    propanediol butyl ether 34.97
    triethyl orthoformate 13.59
    p-tert-butyltoluene 4.82
    methyl 4-tert-butylbenzoate 26.31
    morpholine 137.52
    tert-butylamine 13.32
    n-dodecanol 8.14
    dimethoxymethane 76.77
    ethylene carbonate 40.25
    cyrene 40.79
    2-ethoxyethyl acetate 21.89
    2-ethylhexyl acetate 9.91
    1,2,4-trichlorobenzene 10.82
    4-methylpyridine 18.83
    dibutyl ether 8.53
    2,6-dimethyl-4-heptanol 8.81
    DEF 43.43
    dimethyl isosorbide 56.44
    tetrachloroethylene 11.39
    eugenol 27.31
    triacetin 25.11
    span 80 32.92
    1,4-butanediol 26.03
    1,1-dichloroethane 6.9
    2-methyl-1-pentanol 12.82
    methyl formate 81.67
    2-methyl-1-butanol 18.33
    n-decane 1.03
    butyronitrile 20.14
    3,7-dimethyl-1-octanol 10.8
    1-chlorooctane 3.7
    1-chlorotetradecane 2.09
    n-nonane 0.88
    undecane 0.87
    tert-butylcyclohexane 0.69
    cyclooctane 0.48
    cyclopentanol 38.65
    tetrahydropyran 45.48
    tert-amyl methyl ether 9.87
    2,5,8-trioxanonane 72.4
    1-hexene 1.26
    2-isopropoxyethanol 30.6
    2,2,2-trifluoroethanol 54.47
    methyl butyrate 18.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction