4-Hydroxybenzyl Alcohol

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  • Identifiers

    CAS number
    623-05-2

    Molecular formula
    C7H8O2

    SMILES
    C1=CC(=CC=C1CO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 88.34%
    Phenolic 73.59%
    Fruity 69.57%
    Almond 56.5%
    Vanilla 54.63%
    Medicinal 51.79%
    Nutty 45.68%
    Bitter 45.37%
    Cherry 44.88%
    Balsamic 44.37%

     

    Flavor
    Sweet 85.62%
    Fruity 68.57%
    Bitter 55.01%
    Phenolic 47.1%
    Almond 46.51%
    Floral 43.0%
    Powdery 42.77%
    Hawthorn 42.43%
    Mild 38.28%
    Vanilla 36.5%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.2

    pKa est.
    9.6 (weak base)

    Molecular weight
    124.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 124.5 °C

    Boiling point

    • 252.00 °C. @ 760.00 mm Hg

    Flash point

    • 145.71 ˚C est.

    Solubility expt.

    • 6700 mg/L @ 20 °C (exp)
    • slightly soluble in water; soluble in organic solvents
    • soluble (in ethanol)

  • Synonyms

    • 4-hydroxybenzyl alcohol
    • 623-05-2
    • 4-(Hydroxymethyl)phenol
    • p-Hydroxybenzyl alcohol
    • p-Methylolphenol
    • 4-Methylolphenol
    • 4-Hydroxybenzenemethanol
    • Benzenemethanol, 4-hydroxy-
    • p-(Hydroxymethyl)phenol
    • 4-Hydroxybenzylalcohol
    • Gastrodigenin
    • Benzyl alcohol, p-hydroxy-
    • alpha-Hydroxy-p-cresol
    • Parahydroxybenzyl Alcohol
    • MFCD00004658
    • .alpha.-Hydroxy-p-cresol
    • CCRIS 5114
    • (4-Hydroxyphenyl)methanol
    • EINECS 210-768-0
    • 1A3AH1FP1B
    • hydroxybenzyl alcohol
    • NSC 227926
    • CHEBI:67410
    • NSC-227926
    • CHEMBL202132
    • DTXSID8073920
    • FEMA NO. 3987
    • EC 210-768-0
    • 4-HYDROXYBENZYL ALCOHOL [FHFI]
    • 4-Hydroxymethyl-phenol
    • 4-methylol phenol
    • p-hydroxy benzyl alcohol
    • UNII-1A3AH1FP1B
    • pMethylolphenol
    • 4Methylolphenol
    • alphaHydroxypcresol
    • a-hydroxy-p-cresol
    • 4-hydroxymethylphenol
    • hydroxybenzyl alcohols
    • pHydroxybenzyl alcohol
    • 4Hydroxybenzenemethanol
    • p(Hydroxymethyl)phenol
    • p-Hydroxybenzyl alcoho
    • 4-hydroxymethyl phenol
    • 4(Hydroxymethyl)phenol
    • 4-hydroxybenzyl-alcohol
    • 4-Hydroxy-benzylalcohol
    • (4Hydroxyphenyl)methanol
    • 4-Hydroxyphenyl methanol
    • Benzyl alcohol, phydroxy
    • p-hydroxy-Benzyl alcohol
    • 4-Hydroxyphenyl Carbinol
    • 4-hydroxy benzyl alcohol
    • 4-hydroxy-benzyl alcohol
    • 4HBA
    • B4-hydroxy-enzenemethanol
    • Benzenemethanol, 4hydroxy
    • para-hydroxybenzyl alcohol
    • 4-hydroxyl-benzyl alcohol
    • phenol, 4-hydroxymethyl-
    • bmse000623
    • bmse010028
    • SCHEMBL62690
    • 4-Hydroxybenzyl alcohol, 99%
    • DTXCID7043293
    • Benzyl alcohol, phydroxy (8CI)
    • CHEBI:24679
    • Benzyl alcohol, p-hydroxy-(8CI)
    • HMS3885O08
    • Benzenemethanol, 4-hydroxy-(9CI)
    • BCP27109
    • Benzyl alcohol, p-hydroxy- (8CI)
    • HY-Y0892
    • STR00674
    • HYDROXYBENZYL ALCOHOL [INCI]
    • BDBM50177408
    • Benzenemethanol, 4-hydroxy- (9CI)
    • NSC227926
    • s3857
    • STL284640
    • AKOS000121529
    • 4-Hydroxybenzyl alcohol, >=98%, FG
    • CCG-266090
    • CS-W019891
    • FH30015
    • PS-3494
    • AC-24727
    • SY003753
    • 4-(hydroxymethyl)phenol (ACD/Name 4.0)
    • DB-003490
    • 4-Hydroxybenzyl alcohol, analytical standard
    • H0224
    • NS00005609
    • EN300-21091
    • C17467
    • C93495
    • Q5526828
    • F0001-1668
    • Z104490108
    • 4-(Hydroxymethyl)phenol;p-Hydroxybenzyl alcohol;p-Methylolphenol
    • 210-768-0

  • Applications

    4-Hydroxybenzyl Alcohol (CAS 623-05-2) is widely used as a fragrance intermediate and odorant in perfumery, serving as a building block for aroma chemicals and vanillin-related derivatives in flavor and fragrance applications; it also finds use in cosmetics and personal care as a fragrance ingredient; as a synthetic intermediate it is employed in pharmaceutical and agrochemical manufacturing; in polymers and coatings it can act as a precursor for functional monomers and resin systems used in specialty plastics, coatings, adhesives, and inks; and in industrial and household formulations it is used for derivatization to tailor scent profiles and processing properties.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 178.64
    methanol 114.11
    isopropanol 130.64
    water 7.24
    ethyl acetate 68.49
    n-propanol 124.22
    acetone 136.52
    n-butanol 95.84
    acetonitrile 83.06
    DMF 254.25
    toluene 3.36
    isobutanol 72.97
    1,4-dioxane 229.14
    methyl acetate 79.72
    THF 253.91
    2-butanone 75.42
    n-pentanol 51.97
    sec-butanol 67.63
    n-hexane 0.91
    ethylene glycol 96.0
    NMP 152.0
    cyclohexane 1.59
    DMSO 333.09
    n-butyl acetate 30.53
    n-octanol 44.52
    chloroform 13.59
    n-propyl acetate 33.22
    acetic acid 192.37
    dichloromethane 23.72
    cyclohexanone 67.07
    propylene glycol 95.3
    isopropyl acetate 39.1
    DMAc 179.95
    2-ethoxyethanol 135.12
    isopentanol 64.62
    n-heptane 4.61
    ethyl formate 59.67
    1,2-dichloroethane 21.38
    n-hexanol 57.02
    2-methoxyethanol 264.69
    isobutyl acetate 19.52
    tetrachloromethane 4.0
    n-pentyl acetate 28.68
    transcutol 275.33
    n-heptanol 47.05
    ethylbenzene 3.67
    MIBK 41.92
    2-propoxyethanol 129.78
    tert-butanol 140.85
    MTBE 47.4
    2-butoxyethanol 87.63
    propionic acid 102.93
    o-xylene 6.39
    formic acid 111.61
    diethyl ether 44.81
    m-xylene 6.46
    p-xylene 5.32
    chlorobenzene 7.67
    dimethyl carbonate 42.66
    n-octane 2.16
    formamide 192.21
    cyclopentanone 140.1
    2-pentanone 58.55
    anisole 25.54
    cyclopentyl methyl ether 53.79
    gamma-butyrolactone 195.77
    1-methoxy-2-propanol 174.55
    pyridine 42.37
    3-pentanone 32.81
    furfural 101.19
    n-dodecane 2.5
    diethylene glycol 134.11
    diisopropyl ether 13.95
    tert-amyl alcohol 71.94
    acetylacetone 82.74
    n-hexadecane 2.69
    acetophenone 28.04
    methyl propionate 65.68
    isopentyl acetate 28.61
    trichloroethylene 32.61
    n-nonanol 40.25
    cyclohexanol 38.54
    benzyl alcohol 28.76
    2-ethylhexanol 30.32
    isooctanol 36.47
    dipropyl ether 35.4
    1,2-dichlorobenzene 10.41
    ethyl lactate 31.84
    propylene carbonate 76.5
    n-methylformamide 165.66
    2-pentanol 47.18
    n-pentane 1.36
    1-propoxy-2-propanol 87.62
    1-methoxy-2-propyl acetate 53.67
    2-(2-methoxypropoxy) propanol 76.69
    mesitylene 6.44
    ε-caprolactone 72.12
    p-cymene 9.52
    epichlorohydrin 161.39
    1,1,1-trichloroethane 14.76
    2-aminoethanol 140.39
    morpholine-4-carbaldehyde 186.72
    sulfolane 191.1
    2,2,4-trimethylpentane 1.76
    2-methyltetrahydrofuran 108.26
    n-hexyl acetate 43.35
    isooctane 1.97
    2-(2-butoxyethoxy)ethanol 110.27
    sec-butyl acetate 20.67
    tert-butyl acetate 46.73
    decalin 1.55
    glycerin 150.28
    diglyme 194.55
    acrylic acid 95.32
    isopropyl myristate 22.23
    n-butyric acid 114.04
    acetyl acetate 44.25
    di(2-ethylhexyl) phthalate 23.98
    ethyl propionate 31.03
    nitromethane 274.49
    1,2-diethoxyethane 57.65
    benzonitrile 22.37
    trioctyl phosphate 22.27
    1-bromopropane 7.57
    gamma-valerolactone 176.66
    n-decanol 31.22
    triethyl phosphate 18.03
    4-methyl-2-pentanol 30.15
    propionitrile 49.95
    vinylene carbonate 57.46
    1,1,2-trichlorotrifluoroethane 105.12
    DMS 30.37
    cumene 5.44
    2-octanol 26.27
    2-hexanone 33.83
    octyl acetate 30.83
    limonene 13.87
    1,2-dimethoxyethane 154.26
    ethyl orthosilicate 17.59
    tributyl phosphate 19.89
    diacetone alcohol 88.93
    N,N-dimethylaniline 21.45
    acrylonitrile 68.09
    aniline 17.18
    1,3-propanediol 185.44
    bromobenzene 4.78
    dibromomethane 8.89
    1,1,2,2-tetrachloroethane 25.22
    2-methyl-cyclohexyl acetate 26.94
    tetrabutyl urea 30.86
    diisobutyl methanol 22.48
    2-phenylethanol 31.54
    styrene 3.83
    dioctyl adipate 34.53
    dimethyl sulfate 69.48
    ethyl butyrate 29.78
    methyl lactate 62.68
    butyl lactate 32.67
    diethyl carbonate 20.35
    propanediol butyl ether 77.51
    triethyl orthoformate 23.78
    p-tert-butyltoluene 9.92
    methyl 4-tert-butylbenzoate 50.78
    morpholine 229.17
    tert-butylamine 49.18
    n-dodecanol 23.86
    dimethoxymethane 144.95
    ethylene carbonate 49.78
    cyrene 69.45
    2-ethoxyethyl acetate 45.62
    2-ethylhexyl acetate 18.58
    1,2,4-trichlorobenzene 15.05
    4-methylpyridine 27.41
    dibutyl ether 26.13
    2,6-dimethyl-4-heptanol 22.48
    DEF 82.14
    dimethyl isosorbide 102.35
    tetrachloroethylene 15.88
    eugenol 51.51
    triacetin 51.33
    span 80 68.05
    1,4-butanediol 61.58
    1,1-dichloroethane 15.41
    2-methyl-1-pentanol 36.47
    methyl formate 107.47
    2-methyl-1-butanol 54.94
    n-decane 3.63
    butyronitrile 47.12
    3,7-dimethyl-1-octanol 32.79
    1-chlorooctane 12.94
    1-chlorotetradecane 6.66
    n-nonane 3.2
    undecane 2.95
    tert-butylcyclohexane 1.87
    cyclooctane 1.11
    cyclopentanol 75.28
    tetrahydropyran 90.09
    tert-amyl methyl ether 31.31
    2,5,8-trioxanonane 141.85
    1-hexene 3.84
    2-isopropoxyethanol 78.08
    2,2,2-trifluoroethanol 71.31
    methyl butyrate 40.49

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction