4-Hydroxy-3-methoxy-alpha-methylbenzyl Alcohol

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  • Identifiers

    CAS number
    2480-86-6

    Molecular formula
    C9H12O3

    SMILES
    CC(C1=CC(=C(C=C1)O)OC)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Vanilla 87.31%
    Sweet 82.63%
    Creamy 63.17%
    Phenolic 58.04%
    Balsamic 57.41%
    Powdery 52.71%
    Spicy 43.82%
    Smoky 42.78%
    Floral 38.31%
    Milky 37.65%

     

    Flavor
    Sweet 80.55%
    Vanilla 51.72%
    Woody 44.25%
    Powdery 43.49%
    Phenolic 42.83%
    Creamy 40.16%
    Smoky 39.6%
    Spicy 38.84%
    Bitter 37.25%
    Clove 33.66%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    9.47 (weak base)

    Molecular weight
    168.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    288°C

    Flash point

    • 137.0 ˚C est.

  • Synonyms

    • 4-Hydroxy-3-methoxy-alpha-methylbenzyl alcohol
    • RefChem:523812
    • 626-302-8
    • 4-(1-hydroxyethyl)-2-methoxyphenol
    • 2480-86-6
    • Apocynol
    • MFCD00238638
    • 1-(4-hydroxy-3-methoxyphenyl)ethanol
    • Benzenemethanol, 4-hydroxy-3-methoxy-alpha-methyl-
    • 4-Hydroxy-3-methoxy-a-methylbenzyl alcohol
    • NSC47035
    • bmse010002
    • 4-hydroxy-3-methoxyphenylethanol
    • 4-Hydroxy-3-methoxy-|A-methylbenzyl alcohol
    • NSC 47035
    • SCHEMBL1301569
    • SCHEMBL11383561
    • SCHEMBL29466173
    • CHEBI:86590
    • Ethyl 3-(Furan-2-Yl)Propionate
    • NSC-47035
    • 2-Hydroxy-5-(1-hydroxyethyl)anisole
    • 4-(1-hydroxyethyl)-2-methoxy-phenol
    • AKOS000125912
    • AKOS016843629
    • FH55324
    • 3-Methoxy-4-hydroxyphenylmethyl carbinol
    • SY052702
    • CS-0204321
    • H1386
    • 4-hydroxy-3-methoxy-alpha-methyl benzylalcohol
    • F17123
    • Benzenemethanol, 4-hydroxy-3-methoxy-?-methyl-
    • Benzenemethanol, 4-hydroxy-3-methoxy-|A-methyl-
    • EN300-7409172
    • 4-Hydroxy-3-methoxy- alpha -methylbenzyl alcohol
    • Benzenemethanol, 4-hydroxy-3-methoxy-|_-methyl-
    • 4-Hydroxy-3-methoxy-alpha-methylbenzyl alcohol, 97%
    • Q27159272
    • 2480-86-6

  • Applications

    4-Hydroxy-3-methoxy-alpha-methylbenzyl Alcohol (CAS 2480-86-6) is principally used as an intermediate in the synthesis of fragrance and aroma chemicals, where its 4-hydroxy-3-methoxy phenyl core and the chiral alpha-methylbenzyl alcohol moiety enable access to aldehyde- and ester-based fragrance materials. In perfumery and cosmetics, it serves as a building block for aroma compounds and as a precursor to derivatives that contribute specific floral or herbal notes. In pharmaceutical and agrochemical development, the compound is valued as a chiral building block or auxiliary for asymmetric synthesis, facilitating the preparation of enantiomerically enriched intermediates. In broader organic synthesis, it is employed as a starting material or scaffold for further functionalization to yield intermediates used in coatings, inks, and specialty polymers. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 240.98
    methanol 396.73
    isopropanol 126.17
    water 5.58
    ethyl acetate 57.13
    n-propanol 134.63
    acetone 165.04
    n-butanol 84.31
    acetonitrile 108.07
    DMF 378.95
    toluene 10.15
    isobutanol 69.22
    1,4-dioxane 345.81
    methyl acetate 108.97
    THF 373.64
    2-butanone 82.4
    n-pentanol 58.69
    sec-butanol 71.09
    n-hexane 0.95
    ethylene glycol 206.69
    NMP 168.31
    cyclohexane 4.12
    DMSO 741.68
    n-butyl acetate 34.64
    n-octanol 40.61
    chloroform 54.35
    n-propyl acetate 43.69
    acetic acid 226.07
    dichloromethane 122.27
    cyclohexanone 102.76
    propylene glycol 147.65
    isopropyl acetate 26.86
    DMAc 221.3
    2-ethoxyethanol 204.75
    isopentanol 58.46
    n-heptane 3.82
    ethyl formate 95.25
    1,2-dichloroethane 71.7
    n-hexanol 54.66
    2-methoxyethanol 427.31
    isobutyl acetate 24.61
    tetrachloromethane 8.89
    n-pentyl acetate 26.74
    transcutol 227.16
    n-heptanol 39.33
    ethylbenzene 10.9
    MIBK 31.95
    2-propoxyethanol 125.38
    tert-butanol 199.9
    MTBE 57.57
    2-butoxyethanol 81.67
    propionic acid 100.5
    o-xylene 14.69
    formic acid 217.4
    diethyl ether 40.29
    m-xylene 12.81
    p-xylene 15.95
    chlorobenzene 22.49
    dimethyl carbonate 40.58
    n-octane 2.34
    formamide 428.85
    cyclopentanone 163.51
    2-pentanone 44.53
    anisole 51.43
    cyclopentyl methyl ether 60.06
    gamma-butyrolactone 215.69
    1-methoxy-2-propanol 182.97
    pyridine 84.91
    3-pentanone 30.69
    furfural 177.39
    n-dodecane 2.84
    diethylene glycol 184.06
    diisopropyl ether 10.29
    tert-amyl alcohol 102.15
    acetylacetone 78.28
    n-hexadecane 3.11
    acetophenone 50.82
    methyl propionate 59.26
    isopentyl acetate 31.57
    trichloroethylene 104.5
    n-nonanol 36.89
    cyclohexanol 57.28
    benzyl alcohol 59.22
    2-ethylhexanol 31.54
    isooctanol 30.57
    dipropyl ether 28.66
    1,2-dichlorobenzene 27.1
    ethyl lactate 42.43
    propylene carbonate 90.92
    n-methylformamide 248.84
    2-pentanol 37.03
    n-pentane 1.22
    1-propoxy-2-propanol 75.77
    1-methoxy-2-propyl acetate 51.62
    2-(2-methoxypropoxy) propanol 79.56
    mesitylene 10.4
    ε-caprolactone 90.65
    p-cymene 13.79
    epichlorohydrin 238.95
    1,1,1-trichloroethane 32.25
    2-aminoethanol 235.45
    morpholine-4-carbaldehyde 248.59
    sulfolane 251.48
    2,2,4-trimethylpentane 2.01
    2-methyltetrahydrofuran 129.88
    n-hexyl acetate 42.6
    isooctane 1.69
    2-(2-butoxyethoxy)ethanol 110.97
    sec-butyl acetate 22.47
    tert-butyl acetate 39.5
    decalin 3.11
    glycerin 234.87
    diglyme 206.73
    acrylic acid 103.23
    isopropyl myristate 21.2
    n-butyric acid 88.78
    acetyl acetate 44.94
    di(2-ethylhexyl) phthalate 29.25
    ethyl propionate 31.26
    nitromethane 387.11
    1,2-diethoxyethane 59.34
    benzonitrile 46.05
    trioctyl phosphate 23.4
    1-bromopropane 19.49
    gamma-valerolactone 225.65
    n-decanol 29.36
    triethyl phosphate 27.16
    4-methyl-2-pentanol 23.41
    propionitrile 59.23
    vinylene carbonate 87.8
    1,1,2-trichlorotrifluoroethane 156.77
    DMS 38.76
    cumene 11.18
    2-octanol 23.17
    2-hexanone 40.41
    octyl acetate 29.41
    limonene 19.78
    1,2-dimethoxyethane 259.5
    ethyl orthosilicate 25.23
    tributyl phosphate 22.58
    diacetone alcohol 81.51
    N,N-dimethylaniline 38.89
    acrylonitrile 91.8
    aniline 36.79
    1,3-propanediol 230.73
    bromobenzene 17.41
    dibromomethane 46.4
    1,1,2,2-tetrachloroethane 69.19
    2-methyl-cyclohexyl acetate 37.07
    tetrabutyl urea 34.29
    diisobutyl methanol 21.36
    2-phenylethanol 49.59
    styrene 12.3
    dioctyl adipate 38.19
    dimethyl sulfate 76.94
    ethyl butyrate 34.12
    methyl lactate 62.13
    butyl lactate 32.01
    diethyl carbonate 29.56
    propanediol butyl ether 75.28
    triethyl orthoformate 30.16
    p-tert-butyltoluene 14.01
    methyl 4-tert-butylbenzoate 56.56
    morpholine 330.34
    tert-butylamine 68.85
    n-dodecanol 23.82
    dimethoxymethane 188.98
    ethylene carbonate 72.03
    cyrene 92.37
    2-ethoxyethyl acetate 48.62
    2-ethylhexyl acetate 22.59
    1,2,4-trichlorobenzene 36.42
    4-methylpyridine 56.53
    dibutyl ether 26.48
    2,6-dimethyl-4-heptanol 21.36
    DEF 76.67
    dimethyl isosorbide 118.91
    tetrachloroethylene 44.64
    eugenol 61.57
    triacetin 55.94
    span 80 65.02
    1,4-butanediol 92.16
    1,1-dichloroethane 36.3
    2-methyl-1-pentanol 45.45
    methyl formate 225.82
    2-methyl-1-butanol 51.76
    n-decane 3.97
    butyronitrile 52.48
    3,7-dimethyl-1-octanol 32.29
    1-chlorooctane 16.0
    1-chlorotetradecane 7.98
    n-nonane 3.43
    undecane 3.35
    tert-butylcyclohexane 2.81
    cyclooctane 1.88
    cyclopentanol 89.75
    tetrahydropyran 122.41
    tert-amyl methyl ether 38.09
    2,5,8-trioxanonane 160.43
    1-hexene 5.02
    2-isopropoxyethanol 103.63
    2,2,2-trifluoroethanol 85.07
    methyl butyrate 50.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction