4-Hydroxy-2-Methoxybenzaldehyde

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  • Identifiers

    CAS number
    18278-34-7

    Molecular formula
    C8H8O3

    SMILES
    COC1=C(C=CC(=C1)O)C=O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 81.75%
    Phenolic 62.25%
    Vanilla 61.67%
    Spicy 51.0%
    Almond 42.67%
    Medicinal 39.91%
    Aromatic 39.27%
    Bitter 38.74%
    Smoky 36.17%
    Woody 34.45%

     

    Flavor
    Bitter 41.0%
    Sweet 39.01%
    Vanilla 34.72%
    Woody 34.28%
    Phenolic 31.79%
    Spicy 29.87%
    Almond 26.86%
    Powdery 26.37%
    Spice 26.36%
    Creamy 25.46%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    8.29 (weak base)

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    308°C

    Flash point

    • 122.67 ˚C est.

  • Synonyms

    • 4-Hydroxy-2-methoxybenzaldehyde
    • 18278-34-7
    • DTXSID70334061
    • RefChem:523744
    • DTXCID80285151
    • 628-847-7
    • 4-Hydroxy-o-anisaldehyde
    • Benzaldehyde, 4-hydroxy-2-methoxy-
    • MFCD00051964
    • 4-hydroxy-2-methoxy-benzaldehyde
    • 4-Formyl-3-methoxyphenol
    • 4-Hydroxy-2-methoxybenaldehyde
    • Entacapone Impurity 66
    • SCHEMBL37462
    • MLS000760729
    • p-hydroxy-o-methoxybenzaldehyde
    • SCHEMBL1157155
    • SCHEMBL7607683
    • 2-methoxy-4-hydroxybenzaldehyde
    • CHEMBL1309669
    • 2-methoxy-4-hydroxy-benzaldehyde
    • HMS2764H22
    • 4-Hydroxy-2-methoxybenzaldehyde #
    • ALBB-006227
    • SBB008607
    • STK503774
    • AKOS001284090
    • CS-W016303
    • EBC-618225
    • FH24199
    • PS-3220
    • AC-19108
    • BP-13155
    • SMR000370826
    • SY041931
    • DB-012201
    • H1191
    • ST50824318
    • EN300-24459
    • F10509
    • H13500
    • AB00651417-06
    • 278H347
    • F092410
    • 4-Hydroxy-2-methoxybenzaldehyde, >=98.0% (HPLC)
    • ArgoGel(TM)-MB-CHO, 120-230 mum particle size
    • Z197510770
    • 18278-34-7

  • Applications

    4-Hydroxy-2-Methoxybenzaldehyde, CAS 18278-34-7, is an aromatic aldehyde bearing a hydroxyl and a methoxy group. It is primarily used as a fragrance ingredient in perfumery and as a precursor for other aroma compounds; it can serve as a building block for fragrance formulations and, where permitted, as a flavor/aroma intermediate in food and beverage applications. In cosmetics and personal care, it commonly functions as a fragrance ingredient; in household and cleaning products, it helps establish odor profiles and lasting scent. In industrial manufacturing, it is utilized as a chemical intermediate for the synthesis of additional aromatic compounds and related organic intermediates. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 172.57
    methanol 224.51
    isopropanol 106.32
    water 2.77
    ethyl acetate 168.68
    n-propanol 115.89
    acetone 363.97
    n-butanol 83.13
    acetonitrile 199.35
    DMF 547.35
    toluene 19.64
    isobutanol 67.05
    1,4-dioxane 294.33
    methyl acetate 216.13
    THF 730.2
    2-butanone 190.21
    n-pentanol 59.14
    sec-butanol 70.4
    n-hexane 2.84
    ethylene glycol 149.86
    NMP 302.92
    cyclohexane 2.0
    DMSO 1093.74
    n-butyl acetate 55.69
    n-octanol 35.23
    chloroform 101.32
    n-propyl acetate 79.17
    acetic acid 138.79
    dichloromethane 147.73
    cyclohexanone 144.95
    propylene glycol 102.04
    isopropyl acetate 78.58
    DMAc 343.99
    2-ethoxyethanol 193.92
    isopentanol 65.6
    n-heptane 3.99
    ethyl formate 126.51
    1,2-dichloroethane 132.49
    n-hexanol 60.35
    2-methoxyethanol 376.93
    isobutyl acetate 48.46
    tetrachloromethane 20.01
    n-pentyl acetate 35.02
    transcutol 189.21
    n-heptanol 31.93
    ethylbenzene 16.99
    MIBK 89.18
    2-propoxyethanol 154.91
    tert-butanol 150.31
    MTBE 82.57
    2-butoxyethanol 75.53
    propionic acid 120.54
    o-xylene 20.21
    formic acid 115.5
    diethyl ether 94.03
    m-xylene 24.41
    p-xylene 22.18
    chlorobenzene 37.11
    dimethyl carbonate 111.33
    n-octane 2.21
    formamide 214.83
    cyclopentanone 363.48
    2-pentanone 146.83
    anisole 77.29
    cyclopentyl methyl ether 141.07
    gamma-butyrolactone 434.43
    1-methoxy-2-propanol 223.29
    pyridine 92.53
    3-pentanone 94.43
    furfural 226.17
    n-dodecane 2.91
    diethylene glycol 210.66
    diisopropyl ether 24.64
    tert-amyl alcohol 87.07
    acetylacetone 205.17
    n-hexadecane 3.32
    acetophenone 68.82
    methyl propionate 164.47
    isopentyl acetate 49.94
    trichloroethylene 182.76
    n-nonanol 31.35
    cyclohexanol 56.28
    benzyl alcohol 58.1
    2-ethylhexanol 34.25
    isooctanol 26.3
    dipropyl ether 42.63
    1,2-dichlorobenzene 41.73
    ethyl lactate 62.34
    propylene carbonate 146.17
    n-methylformamide 310.15
    2-pentanol 49.97
    n-pentane 2.23
    1-propoxy-2-propanol 93.08
    1-methoxy-2-propyl acetate 86.34
    2-(2-methoxypropoxy) propanol 76.99
    mesitylene 18.33
    ε-caprolactone 119.93
    p-cymene 16.78
    epichlorohydrin 418.75
    1,1,1-trichloroethane 99.77
    2-aminoethanol 142.79
    morpholine-4-carbaldehyde 270.76
    sulfolane 488.4
    2,2,4-trimethylpentane 3.17
    2-methyltetrahydrofuran 233.78
    n-hexyl acetate 52.03
    isooctane 3.35
    2-(2-butoxyethoxy)ethanol 95.14
    sec-butyl acetate 48.59
    tert-butyl acetate 91.48
    decalin 4.18
    glycerin 165.7
    diglyme 178.9
    acrylic acid 118.19
    isopropyl myristate 26.98
    n-butyric acid 107.09
    acetyl acetate 89.23
    di(2-ethylhexyl) phthalate 27.71
    ethyl propionate 77.8
    nitromethane 442.07
    1,2-diethoxyethane 57.07
    benzonitrile 60.23
    trioctyl phosphate 25.33
    1-bromopropane 48.73
    gamma-valerolactone 313.66
    n-decanol 25.03
    triethyl phosphate 37.69
    4-methyl-2-pentanol 36.57
    propionitrile 115.15
    vinylene carbonate 121.08
    1,1,2-trichlorotrifluoroethane 204.96
    DMS 67.33
    cumene 15.94
    2-octanol 23.01
    2-hexanone 82.14
    octyl acetate 34.03
    limonene 23.4
    1,2-dimethoxyethane 249.99
    ethyl orthosilicate 32.85
    tributyl phosphate 27.79
    diacetone alcohol 134.08
    N,N-dimethylaniline 53.71
    acrylonitrile 161.54
    aniline 49.38
    1,3-propanediol 177.98
    bromobenzene 31.41
    dibromomethane 76.46
    1,1,2,2-tetrachloroethane 131.05
    2-methyl-cyclohexyl acetate 43.72
    tetrabutyl urea 39.16
    diisobutyl methanol 25.03
    2-phenylethanol 55.48
    styrene 19.61
    dioctyl adipate 41.06
    dimethyl sulfate 213.92
    ethyl butyrate 52.47
    methyl lactate 109.04
    butyl lactate 36.9
    diethyl carbonate 42.0
    propanediol butyl ether 69.13
    triethyl orthoformate 39.08
    p-tert-butyltoluene 17.74
    methyl 4-tert-butylbenzoate 64.75
    morpholine 286.3
    tert-butylamine 55.73
    n-dodecanol 20.07
    dimethoxymethane 313.08
    ethylene carbonate 100.56
    cyrene 97.65
    2-ethoxyethyl acetate 55.65
    2-ethylhexyl acetate 36.82
    1,2,4-trichlorobenzene 51.06
    4-methylpyridine 86.33
    dibutyl ether 29.34
    2,6-dimethyl-4-heptanol 25.03
    DEF 139.9
    dimethyl isosorbide 126.72
    tetrachloroethylene 77.72
    eugenol 64.74
    triacetin 60.99
    span 80 53.15
    1,4-butanediol 74.71
    1,1-dichloroethane 105.87
    2-methyl-1-pentanol 47.7
    methyl formate 270.6
    2-methyl-1-butanol 57.1
    n-decane 4.15
    butyronitrile 98.68
    3,7-dimethyl-1-octanol 33.71
    1-chlorooctane 19.79
    1-chlorotetradecane 9.36
    n-nonane 3.8
    undecane 3.45
    tert-butylcyclohexane 5.33
    cyclooctane 1.46
    cyclopentanol 105.84
    tetrahydropyran 151.37
    tert-amyl methyl ether 60.04
    2,5,8-trioxanonane 132.1
    1-hexene 14.85
    2-isopropoxyethanol 108.5
    2,2,2-trifluoroethanol 89.0
    methyl butyrate 99.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction