4-Hexadecanol

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  • Identifiers

    CAS number
    19781-43-2

    Molecular formula
    C16H34O

    SMILES
    CCCCCCCCCCCCC(CCC)O

  • Odor profile

    Fragrance
    Oily 66.96%
    Fruity 66.3%
    Fatty 65.55%
    Waxy 62.05%
    Floral 56.11%
    Citrus 45.24%
    Fresh 38.83%
    Orange 38.42%
    Rose 35.84%
    Clean 32.44%

     

    Flavor
    Waxy 58.06%
    Fatty 44.47%
    Floral 41.16%
    Fresh 40.6%
    Fat 38.31%
    Citrus 33.7%
    Mild 33.65%
    Soapy 32.86%
    Oily 32.75%
    Flower 32.5%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    7.0

    pKa est.
    7.45 (neutral)

    Molecular weight
    242.44 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    304°C

    Flash point

    • 138.81 ˚C est.

  • Synonyms

    • 4-Hexadecanol
    • hexadecan-4-ol
    • 19781-43-2
    • 29354-98-1
    • DTXSID50275100
    • 4-hydroxyhexadecane
    • SCHEMBL378816
    • DTXCID20226548
    • DTXSID70865486
    • CHEBI:197394
    • EINECS 249-583-5
    • AKOS012718077
    • NS00122530
    • G69827

  • Applications

    4-Hexadecanol (CAS 19781-43-2) is a long-chain fatty alcohol used in cosmetics and personal care as an emollient and thickener for creams, lotions, and shampoos; it also serves as a processing aid and texture modifier in polymer and coating formulations to influence rheology and surface feel; it functions as a precursor for fragrance-related esters and other plasticizer intermediates in fragrance and plastics chemistry; and it can be regarded as a building block for fragrance ingredients and for coating/ink systems to improve surface properties and formulation stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1714.62
    methanol 752.39
    isopropanol 2901.98
    water 0.01
    ethyl acetate 3741.27
    n-propanol 2211.8
    acetone 3684.62
    n-butanol 2796.66
    acetonitrile 901.19
    DMF 1941.44
    toluene 1173.05
    isobutanol 2234.82
    1,4-dioxane 3509.7
    methyl acetate 1779.53
    THF 8849.92
    2-butanone 3628.44
    n-pentanol 1779.29
    sec-butanol 2766.23
    n-hexane 2977.2
    ethylene glycol 32.77
    NMP 2185.28
    cyclohexane 5125.91
    DMSO 2507.82
    n-butyl acetate 5997.14
    n-octanol 1244.5
    chloroform 4268.86
    n-propyl acetate 3981.67
    acetic acid 594.91
    dichloromethane 4113.78
    cyclohexanone 6531.56
    propylene glycol 157.72
    isopropyl acetate 3427.75
    DMAc 1710.63
    2-ethoxyethanol 1483.52
    isopentanol 3069.76
    n-heptane 3067.07
    ethyl formate 1222.86
    1,2-dichloroethane 3637.78
    n-hexanol 2516.15
    2-methoxyethanol 1821.65
    isobutyl acetate 2563.68
    tetrachloromethane 1370.83
    n-pentyl acetate 3575.53
    transcutol 5786.28
    n-heptanol 1369.6
    ethylbenzene 889.68
    MIBK 2995.98
    2-propoxyethanol 2392.17
    tert-butanol 4109.58
    MTBE 5993.41
    2-butoxyethanol 1932.8
    propionic acid 913.64
    o-xylene 848.59
    formic acid 42.86
    diethyl ether 6223.89
    m-xylene 874.7
    p-xylene 1222.79
    chlorobenzene 1449.76
    dimethyl carbonate 329.2
    n-octane 750.79
    formamide 98.17
    cyclopentanone 5095.05
    2-pentanone 4578.87
    anisole 1285.75
    cyclopentyl methyl ether 5421.85
    gamma-butyrolactone 3488.86
    1-methoxy-2-propanol 2207.79
    pyridine 2711.08
    3-pentanone 2724.15
    furfural 1790.09
    n-dodecane 241.82
    diethylene glycol 553.87
    diisopropyl ether 2578.41
    tert-amyl alcohol 3335.35
    acetylacetone 2589.1
    n-hexadecane 303.9
    acetophenone 1247.78
    methyl propionate 1850.43
    isopentyl acetate 5176.55
    trichloroethylene 4077.27
    n-nonanol 1194.33
    cyclohexanol 3595.37
    benzyl alcohol 743.26
    2-ethylhexanol 2647.38
    isooctanol 1519.93
    dipropyl ether 7996.25
    1,2-dichlorobenzene 1412.38
    ethyl lactate 761.97
    propylene carbonate 2098.4
    n-methylformamide 605.41
    2-pentanol 2726.02
    n-pentane 1745.55
    1-propoxy-2-propanol 3313.4
    1-methoxy-2-propyl acetate 2804.57
    2-(2-methoxypropoxy) propanol 1128.73
    mesitylene 754.19
    ε-caprolactone 4515.16
    p-cymene 982.83
    epichlorohydrin 3875.5
    1,1,1-trichloroethane 4051.41
    2-aminoethanol 209.54
    morpholine-4-carbaldehyde 2111.66
    sulfolane 3901.54
    2,2,4-trimethylpentane 602.76
    2-methyltetrahydrofuran 7279.75
    n-hexyl acetate 3263.62
    isooctane 568.4
    2-(2-butoxyethoxy)ethanol 1843.22
    sec-butyl acetate 3100.73
    tert-butyl acetate 3912.41
    decalin 1014.66
    glycerin 173.33
    diglyme 3894.6
    acrylic acid 364.34
    isopropyl myristate 1284.61
    n-butyric acid 3089.16
    acetyl acetate 1396.92
    di(2-ethylhexyl) phthalate 572.1
    ethyl propionate 3000.8
    nitromethane 1201.21
    1,2-diethoxyethane 5184.37
    benzonitrile 1199.63
    trioctyl phosphate 601.17
    1-bromopropane 4433.21
    gamma-valerolactone 4660.86
    n-decanol 807.22
    triethyl phosphate 1211.42
    4-methyl-2-pentanol 1712.06
    propionitrile 1664.76
    vinylene carbonate 1218.51
    1,1,2-trichlorotrifluoroethane 1848.53
    DMS 1009.88
    cumene 687.38
    2-octanol 1278.33
    2-hexanone 3784.3
    octyl acetate 1333.88
    limonene 2269.93
    1,2-dimethoxyethane 4612.35
    ethyl orthosilicate 1389.05
    tributyl phosphate 829.42
    diacetone alcohol 2505.14
    N,N-dimethylaniline 943.81
    acrylonitrile 1000.43
    aniline 1094.9
    1,3-propanediol 711.86
    bromobenzene 1769.03
    dibromomethane 3643.22
    1,1,2,2-tetrachloroethane 4435.1
    2-methyl-cyclohexyl acetate 2275.34
    tetrabutyl urea 1119.61
    diisobutyl methanol 1892.09
    2-phenylethanol 985.87
    styrene 1031.19
    dioctyl adipate 1383.42
    dimethyl sulfate 557.16
    ethyl butyrate 4768.81
    methyl lactate 476.87
    butyl lactate 1681.3
    diethyl carbonate 1986.87
    propanediol butyl ether 1061.84
    triethyl orthoformate 3072.54
    p-tert-butyltoluene 953.03
    methyl 4-tert-butylbenzoate 1262.63
    morpholine 5231.8
    tert-butylamine 3562.53
    n-dodecanol 598.57
    dimethoxymethane 1888.08
    ethylene carbonate 1554.23
    cyrene 754.15
    2-ethoxyethyl acetate 2473.18
    2-ethylhexyl acetate 4204.15
    1,2,4-trichlorobenzene 1459.29
    4-methylpyridine 2727.02
    dibutyl ether 5179.19
    2,6-dimethyl-4-heptanol 1892.09
    DEF 3581.0
    dimethyl isosorbide 1995.77
    tetrachloroethylene 2795.34
    eugenol 853.34
    triacetin 1715.43
    span 80 1267.95
    1,4-butanediol 233.61
    1,1-dichloroethane 3965.7
    2-methyl-1-pentanol 1792.51
    methyl formate 372.22
    2-methyl-1-butanol 2439.58
    n-decane 651.25
    butyronitrile 2824.28
    3,7-dimethyl-1-octanol 1687.42
    1-chlorooctane 1744.75
    1-chlorotetradecane 528.39
    n-nonane 779.43
    undecane 367.03
    tert-butylcyclohexane 896.1
    cyclooctane 1248.88
    cyclopentanol 2929.01
    tetrahydropyran 9583.07
    tert-amyl methyl ether 3604.04
    2,5,8-trioxanonane 1890.29
    1-hexene 4551.08
    2-isopropoxyethanol 1522.33
    2,2,2-trifluoroethanol 152.62
    methyl butyrate 4102.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction