[4]-Gingerdiol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    53254-75-4

    Molecular formula
    C15H24O4

    SMILES
    CCC[C@@H](C[C@@H](CCC1=CC(=C(C=C1)O)OC)O)O

  • Odor profile

    Sweet 55.44%
    Vanilla 49.68%
    Creamy 36.56%
    Fruity 33.72%
    Spicy 31.23%
    Odorless 31.2%
    Balsamic 29.75%
    Milky 29.28%
    Dairy 23.45%
    Floral 21.96%

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  • Properties

    XLogP3-AA
    1.9

    Molecular weight
    268.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    437°C

    Flash point est.
    176.88 ˚C

  • Synonyms

    • [4]-Gingerdiol
    • (4)-Gingerdiol
    • 53254-75-4
    • AKOS040762932
    • 1-(4-hydroxy-3-methoxyphenyl)octane-3,5-diol

  • Applications

    [4]-Gingerdiol (CAS 53254-75-4) is used primarily as a reference standard in phytochemical analysis (HPLC/LC–MS, GC–MS after derivatization) to identify and quantify ginger constituents, build fingerprints, and support quality control of herbal and food products; as a metabolic marker of gingerol–shogaol transformation in studies of absorption, distribution, metabolism, and excretion (ADME) and in metabolomics; as a scaffold for structure–activity relationship studies and the synthesis of new derivatives; it is evaluated for bioactivities (antioxidant, anti-inflammatory, cytoprotective) in preclinical in vitro/in vivo models for lead discovery; it also serves in formulation research (solubility enhancement, nano/nanoemulsion) and in food-processing stability studies; additionally, it is explored as a potential natural ingredient in cosmetics and nutraceutical research as an antioxidant or mild preservative aid, noting that direct therapeutic applications have not been clinically established.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1622.4
    methanol 3479.78
    isopropanol 638.25
    water 0.75
    ethyl acetate 296.87
    n-propanol 663.33
    acetone 788.49
    n-butanol 365.15
    acetonitrile 229.36
    DMF 496.1
    toluene 16.07
    isobutanol 246.91
    1,4-dioxane 682.04
    methyl acetate 215.21
    THF 1166.51
    2-butanone 215.3
    n-pentanol 173.72
    sec-butanol 213.46
    n-hexane 0.9
    ethylene glycol 314.17
    NMP 154.75
    cyclohexane 3.59
    DMSO 2842.55
    n-butyl acetate 81.9
    n-octanol 51.73
    chloroform 94.08
    n-propyl acetate 104.34
    acetic acid 749.51
    dichloromethane 105.65
    cyclohexanone 259.22
    propylene glycol 495.16
    isopropyl acetate 136.32
    DMAc 296.28
    2-ethoxyethanol 606.83
    isopentanol 209.35
    n-heptane 1.39
    ethyl formate 170.92
    1,2-dichloroethane 121.14
    n-hexanol 131.76
    2-methoxyethanol 1562.73
    isobutyl acetate 67.26
    tetrachloromethane 11.62
    n-pentyl acetate 49.32
    transcutol 815.31
    n-heptanol 59.04
    ethylbenzene 11.36
    MIBK 123.17
    2-propoxyethanol 365.31
    tert-butanol 703.0
    MTBE 165.17
    2-butoxyethanol 157.04
    propionic acid 272.23
    o-xylene 15.23
    formic acid 390.44
    diethyl ether 111.14
    m-xylene 19.4
    p-xylene 14.25
    chlorobenzene 30.03
    dimethyl carbonate 69.64
    n-octane 1.36
    formamide 590.83
    cyclopentanone 392.04
    2-pentanone 213.1
    anisole 57.33
    cyclopentyl methyl ether 149.66
    gamma-butyrolactone 430.77
    1-methoxy-2-propanol 728.65
    pyridine 111.21
    3-pentanone 73.33
    furfural 233.3
    n-dodecane 1.93
    diethylene glycol 463.14
    diisopropyl ether 22.13
    tert-amyl alcohol 263.53
    acetylacetone 334.89
    n-hexadecane 2.11
    acetophenone 65.62
    methyl propionate 156.02
    isopentyl acetate 79.34
    trichloroethylene 172.78
    n-nonanol 45.88
    cyclohexanol 166.85
    benzyl alcohol 85.72
    2-ethylhexanol 44.19
    isooctanol 47.71
    dipropyl ether 35.11
    1,2-dichlorobenzene 32.35
    ethyl lactate 82.25
    propylene carbonate 164.08
    n-methylformamide 419.25
    2-pentanol 121.44
    n-pentane 0.84
    1-propoxy-2-propanol 188.89
    1-methoxy-2-propyl acetate 133.92
    2-(2-methoxypropoxy) propanol 134.39
    mesitylene 13.12
    ε-caprolactone 203.29
    p-cymene 12.1
    epichlorohydrin 484.17
    1,1,1-trichloroethane 57.51
    2-aminoethanol 685.02
    morpholine-4-carbaldehyde 310.48
    sulfolane 491.69
    2,2,4-trimethylpentane 2.24
    2-methyltetrahydrofuran 294.36
    n-hexyl acetate 72.99
    isooctane 2.24
    2-(2-butoxyethoxy)ethanol 220.56
    sec-butyl acetate 57.79
    tert-butyl acetate 157.28
    decalin 2.9
    glycerin 554.18
    diglyme 404.48
    acrylic acid 186.68
    isopropyl myristate 30.58
    n-butyric acid 377.35
    acetyl acetate 132.08
    di(2-ethylhexyl) phthalate 39.3
    ethyl propionate 70.82
    nitromethane 962.39
    1,2-diethoxyethane 132.02
    benzonitrile 60.5
    trioctyl phosphate 31.85
    1-bromopropane 28.83
    gamma-valerolactone 512.53
    n-decanol 34.79
    triethyl phosphate 34.88
    4-methyl-2-pentanol 66.09
    propionitrile 106.25
    vinylene carbonate 120.71
    1,1,2-trichlorotrifluoroethane 299.71
    DMS 65.16
    cumene 10.89
    2-octanol 32.89
    2-hexanone 93.05
    octyl acetate 40.3
    limonene 17.8
    1,2-dimethoxyethane 551.28
    ethyl orthosilicate 33.43
    tributyl phosphate 34.79
    diacetone alcohol 265.04
    N,N-dimethylaniline 35.98
    acrylonitrile 137.34
    aniline 59.49
    1,3-propanediol 944.76
    bromobenzene 22.76
    dibromomethane 52.77
    1,1,2,2-tetrachloroethane 152.27
    2-methyl-cyclohexyl acetate 57.06
    tetrabutyl urea 45.29
    diisobutyl methanol 29.52
    2-phenylethanol 76.41
    styrene 12.97
    dioctyl adipate 55.62
    dimethyl sulfate 123.12
    ethyl butyrate 54.48
    methyl lactate 143.56
    butyl lactate 66.07
    diethyl carbonate 40.92
    propanediol butyl ether 170.37
    triethyl orthoformate 44.8
    p-tert-butyltoluene 12.94
    methyl 4-tert-butylbenzoate 78.53
    morpholine 847.25
    tert-butylamine 156.07
    n-dodecanol 26.32
    dimethoxymethane 474.47
    ethylene carbonate 120.08
    cyrene 125.77
    2-ethoxyethyl acetate 102.25
    2-ethylhexyl acetate 49.25
    1,2,4-trichlorobenzene 40.9
    4-methylpyridine 79.94
    dibutyl ether 35.91
    2,6-dimethyl-4-heptanol 29.52
    DEF 132.79
    dimethyl isosorbide 189.69
    tetrachloroethylene 93.6
    eugenol 89.23
    triacetin 96.44
    span 80 117.42
    1,4-butanediol 255.81
    1,1-dichloroethane 73.74
    2-methyl-1-pentanol 104.11
    methyl formate 283.78
    2-methyl-1-butanol 142.98
    n-decane 2.94
    butyronitrile 117.18
    3,7-dimethyl-1-octanol 48.08
    1-chlorooctane 16.02
    1-chlorotetradecane 7.04
    n-nonane 2.37
    undecane 2.28
    tert-butylcyclohexane 2.82
    cyclooctane 1.43
    cyclopentanol 217.33
    tetrahydropyran 341.2
    tert-amyl methyl ether 80.01
    2,5,8-trioxanonane 277.34
    1-hexene 6.63
    2-isopropoxyethanol 273.92
    2,2,2-trifluoroethanol 149.66
    methyl butyrate 112.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Myrtle leaf (Turkey) 1 8008-46-6 Myrtus communis L., fam. Myrtaceae 0.7%