4-Ethylpyridine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    536-75-4

    Molecular formula
    C7H9N

    SMILES
    CCC1=CC=NC=C1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Green 85.86%
    Sweet 68.48%
    Earthy 59.08%
    Herbal 57.18%
    Nutty 45.11%
    Tobacco 44.82%
    Fishy 43.69%
    Animal 38.74%
    Musty 38.67%
    Vegetable 34.21%

     

    Flavor
    Green 77.56%
    Nutty 62.53%
    Fatty 46.48%
    Woody 42.17%
    Earthy 40.57%
    Spicy 38.2%
    Vegetable 37.96%
    Herbal 36.26%
    Musty 33.02%
    Roasted 32.34%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    5.78 (weak acid)

    Molecular weight
    107.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    165°C

    Flash point

    • 52.52 ˚C est.

  • Synonyms

    • 4-ETHYLPYRIDINE
    • 536-75-4
    • Pyridine, 4-ethyl-
    • .gamma.-Ethylpyridine
    • gamma-Ethylpyridine
    • UNII-3KW0SE2TL5
    • 4-Ethyl-pyridine
    • 3KW0SE2TL5
    • NSC 822
    • NSC-822
    • 4-(C2H5)-pyridine
    • EINECS 208-646-7
    • EINECS 275-172-5
    • 4-ETHYLPYRIDINE [MI]
    • DTXSID60873555
    • 151103-55-8
    • Pyridine, 4-ethyl-, radical ion(1+) (9CI)
    • 4-Ethylpyridine; NSC 822; NSC 965; gamma-Ethylpyridine
    • gammaEthylpyridine
    • 4-ethyl pyridine
    • Pyridine, 4ethyl
    • MFCD00006450
    • 4-Ethylpyridine, 98%
    • SCHEMBL14208
    • CHEMBL22977
    • DTXCID509009
    • NSC822
    • NSC965
    • NSC-965
    • AKOS005146195
    • FS-4257
    • DB-052377
    • A7810
    • E0170
    • NS00043061
    • EN300-18200
    • D90449
    • Q27257452
    • Z1251171246
    • 208-646-7

  • Applications

    4-Ethylpyridine (CAS 536-75-4) is primarily used as an intermediate in the synthesis of pyridine-based compounds, with common applications in the production of agrochemicals and pharmaceutical intermediates; it also serves as a precursor for pyridine-derived ligands used in metal-catalyzed processes in industrial manufacturing. In addition, it is employed as a solvent or reagent in organic synthesis and as a building block for functionalized pyridines used in coatings and inks, as well as in polymer chemistry where pyridine derivatives are relevant.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 533.72
    methanol 522.62
    isopropanol 240.92
    water 1.0
    ethyl acetate 772.75
    n-propanol 457.6
    acetone 455.99
    n-butanol 383.19
    acetonitrile 516.05
    DMF 865.13
    toluene 476.23
    isobutanol 226.25
    1,4-dioxane 1188.88
    methyl acetate 559.96
    THF 589.13
    2-butanone 457.99
    n-pentanol 216.23
    sec-butanol 209.91
    n-hexane 29.46
    ethylene glycol 113.4
    NMP 542.21
    cyclohexane 76.13
    DMSO 858.93
    n-butyl acetate 594.15
    n-octanol 66.67
    chloroform 1883.85
    n-propyl acetate 258.94
    acetic acid 466.98
    dichloromethane 1766.13
    cyclohexanone 715.8
    propylene glycol 102.51
    isopropyl acetate 221.1
    DMAc 473.91
    2-ethoxyethanol 278.95
    isopentanol 214.08
    n-heptane 46.63
    ethyl formate 419.96
    1,2-dichloroethane 1113.59
    n-hexanol 402.6
    2-methoxyethanol 619.5
    isobutyl acetate 127.96
    tetrachloromethane 325.62
    n-pentyl acetate 170.87
    transcutol 1049.63
    n-heptanol 96.39
    ethylbenzene 100.96
    MIBK 136.58
    2-propoxyethanol 525.0
    tert-butanol 227.21
    MTBE 251.4
    2-butoxyethanol 183.52
    propionic acid 462.22
    o-xylene 192.69
    formic acid 192.63
    diethyl ether 574.4
    m-xylene 204.66
    p-xylene 128.37
    chlorobenzene 675.15
    dimethyl carbonate 166.99
    n-octane 11.97
    formamide 270.52
    cyclopentanone 581.24
    2-pentanone 331.84
    anisole 217.93
    cyclopentyl methyl ether 388.94
    gamma-butyrolactone 788.53
    1-methoxy-2-propanol 320.13
    pyridine 1204.5
    3-pentanone 343.58
    furfural 790.81
    n-dodecane 8.81
    diethylene glycol 328.97
    diisopropyl ether 81.06
    tert-amyl alcohol 171.97
    acetylacetone 327.27
    n-hexadecane 10.44
    acetophenone 182.74
    methyl propionate 528.49
    isopentyl acetate 327.28
    trichloroethylene 1838.4
    n-nonanol 61.48
    cyclohexanol 272.23
    benzyl alcohol 178.2
    2-ethylhexanol 184.11
    isooctanol 67.06
    dipropyl ether 289.3
    1,2-dichlorobenzene 425.67
    ethyl lactate 78.76
    propylene carbonate 406.51
    n-methylformamide 547.62
    2-pentanol 170.24
    n-pentane 40.05
    1-propoxy-2-propanol 321.04
    1-methoxy-2-propyl acetate 350.08
    2-(2-methoxypropoxy) propanol 146.37
    mesitylene 95.42
    ε-caprolactone 605.58
    p-cymene 78.07
    epichlorohydrin 897.32
    1,1,1-trichloroethane 897.57
    2-aminoethanol 212.83
    morpholine-4-carbaldehyde 704.77
    sulfolane 688.56
    2,2,4-trimethylpentane 16.78
    2-methyltetrahydrofuran 554.15
    n-hexyl acetate 176.61
    isooctane 13.52
    2-(2-butoxyethoxy)ethanol 227.81
    sec-butyl acetate 124.53
    tert-butyl acetate 183.55
    decalin 27.32
    glycerin 153.49
    diglyme 472.97
    acrylic acid 373.86
    isopropyl myristate 58.88
    n-butyric acid 617.96
    acetyl acetate 317.48
    di(2-ethylhexyl) phthalate 65.64
    ethyl propionate 223.83
    nitromethane 892.9
    1,2-diethoxyethane 544.64
    benzonitrile 356.63
    trioctyl phosphate 43.95
    1-bromopropane 588.16
    gamma-valerolactone 941.17
    n-decanol 47.61
    triethyl phosphate 83.74
    4-methyl-2-pentanol 72.3
    propionitrile 486.92
    vinylene carbonate 479.22
    1,1,2-trichlorotrifluoroethane 525.95
    DMS 192.53
    cumene 53.79
    2-octanol 51.87
    2-hexanone 207.36
    octyl acetate 81.85
    limonene 128.26
    1,2-dimethoxyethane 469.08
    ethyl orthosilicate 88.34
    tributyl phosphate 65.17
    diacetone alcohol 172.55
    N,N-dimethylaniline 108.59
    acrylonitrile 607.93
    aniline 499.31
    1,3-propanediol 301.19
    bromobenzene 725.25
    dibromomethane 1099.32
    1,1,2,2-tetrachloroethane 1209.75
    2-methyl-cyclohexyl acetate 132.25
    tetrabutyl urea 82.19
    diisobutyl methanol 80.17
    2-phenylethanol 259.25
    styrene 183.29
    dioctyl adipate 86.25
    dimethyl sulfate 233.51
    ethyl butyrate 289.1
    methyl lactate 138.68
    butyl lactate 101.89
    diethyl carbonate 168.85
    propanediol butyl ether 104.91
    triethyl orthoformate 165.21
    p-tert-butyltoluene 70.87
    methyl 4-tert-butylbenzoate 113.39
    morpholine 1116.2
    tert-butylamine 150.51
    n-dodecanol 38.53
    dimethoxymethane 462.03
    ethylene carbonate 424.17
    cyrene 116.71
    2-ethoxyethyl acetate 288.15
    2-ethylhexyl acetate 278.93
    1,2,4-trichlorobenzene 513.52
    4-methylpyridine 936.01
    dibutyl ether 134.67
    2,6-dimethyl-4-heptanol 80.17
    DEF 564.65
    dimethyl isosorbide 275.05
    tetrachloroethylene 941.34
    eugenol 126.93
    triacetin 145.9
    span 80 128.93
    1,4-butanediol 96.54
    1,1-dichloroethane 1001.27
    2-methyl-1-pentanol 145.2
    methyl formate 344.6
    2-methyl-1-butanol 207.5
    n-decane 14.27
    butyronitrile 447.45
    3,7-dimethyl-1-octanol 79.55
    1-chlorooctane 67.44
    1-chlorotetradecane 26.9
    n-nonane 14.17
    undecane 10.91
    tert-butylcyclohexane 23.55
    cyclooctane 23.91
    cyclopentanol 239.13
    tetrahydropyran 866.79
    tert-amyl methyl ether 169.45
    2,5,8-trioxanonane 293.39
    1-hexene 133.13
    2-isopropoxyethanol 158.51
    2,2,2-trifluoroethanol 145.81
    methyl butyrate 290.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction