4-Ethyl-5-methyl-2-propylthiazole

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  • Identifiers

    CAS number
    86290-19-9

    Molecular formula
    C9H15NS

    SMILES
    CCCC1=NC(=C(S1)C)CC

    Safety labels

  • Odor profile

    Fragrance
    Green 82.12%
    Nutty 60.21%
    Fruity 59.66%
    Roasted 56.37%
    Vegetable 54.59%
    Earthy 48.69%
    Meaty 44.03%
    Tropical 37.11%
    Burnt 36.14%
    Sulfurous 34.63%

     

    Flavor
    Green 71.09%
    Earthy 53.02%
    Nutty 52.01%
    Roasted 49.36%
    Vegetable 46.2%
    Meaty 37.97%
    Pepper 35.16%
    Burnt 34.74%
    Raw 33.42%
    Potato 31.74%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    7.36 (neutral)

    Molecular weight
    169.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    216°C

    Melting point expt.

    • 78 - 79 °C

    Flash point

    • 68.94 ˚C est.

  • Synonyms

    • 4-Ethyl-5-methyl-2-propylthiazole
    • 86290-19-9
    • RefChem:292611
    • SCHEMBL13533946
    • DTXSID201299826
    • 4-Ethyl-5-methyl-2-propyl-1,3-thiazole
    • 86290-19-9

  • Applications

    4-Ethyl-5-methyl-2-propylthiazole is typically used as an odorant in perfumery and cosmetics/personal care, providing thiazole-type aroma notes. It is also evaluated for use in household products such as cleaners and air fresheners to impart a distinctive scent. As a potential intermediate in organic synthesis, it can serve as a building block for other heterocyclic aroma compounds in industrial manufacturing. In food processing, it may be explored as a flavor/aroma note at limited levels, subject to regulatory constraints. It may also be considered for use as an odorant in coatings/inks and adhesives, depending on formulation and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 780.33
    methanol 805.19
    isopropanol 659.66
    water 0.7
    ethyl acetate 976.39
    n-propanol 758.93
    acetone 1494.48
    n-butanol 882.93
    acetonitrile 827.83
    DMF 1767.25
    toluene 1286.57
    isobutanol 717.19
    1,4-dioxane 1835.51
    methyl acetate 933.66
    THF 2922.18
    2-butanone 1316.35
    n-pentanol 792.07
    sec-butanol 759.05
    n-hexane 403.26
    ethylene glycol 114.04
    NMP 1953.67
    cyclohexane 651.86
    DMSO 1226.71
    n-butyl acetate 1731.18
    n-octanol 701.28
    chloroform 4151.72
    n-propyl acetate 946.6
    acetic acid 640.3
    dichloromethane 3522.46
    cyclohexanone 2498.93
    propylene glycol 189.51
    isopropyl acetate 736.72
    DMAc 1234.89
    2-ethoxyethanol 701.67
    isopentanol 891.66
    n-heptane 400.23
    ethyl formate 750.73
    1,2-dichloroethane 1951.28
    n-hexanol 1238.3
    2-methoxyethanol 900.67
    isobutyl acetate 779.74
    tetrachloromethane 1003.58
    n-pentyl acetate 1037.42
    transcutol 1607.11
    n-heptanol 621.89
    ethylbenzene 725.42
    MIBK 793.31
    2-propoxyethanol 1208.73
    tert-butanol 796.67
    MTBE 1112.84
    2-butoxyethanol 744.76
    propionic acid 531.58
    o-xylene 704.94
    formic acid 125.39
    diethyl ether 1214.96
    m-xylene 805.16
    p-xylene 1015.11
    chlorobenzene 1721.37
    dimethyl carbonate 431.37
    n-octane 195.49
    formamide 191.88
    cyclopentanone 2319.71
    2-pentanone 1194.03
    anisole 998.99
    cyclopentyl methyl ether 1433.44
    gamma-butyrolactone 2127.66
    1-methoxy-2-propanol 724.81
    pyridine 1956.64
    3-pentanone 962.3
    furfural 1721.23
    n-dodecane 142.58
    diethylene glycol 560.23
    diisopropyl ether 497.81
    tert-amyl alcohol 820.59
    acetylacetone 1141.5
    n-hexadecane 165.75
    acetophenone 943.62
    methyl propionate 751.61
    isopentyl acetate 1397.0
    trichloroethylene 3513.11
    n-nonanol 582.52
    cyclohexanol 1108.52
    benzyl alcohol 782.48
    2-ethylhexanol 871.94
    isooctanol 525.51
    dipropyl ether 977.2
    1,2-dichlorobenzene 1414.8
    ethyl lactate 336.02
    propylene carbonate 1357.1
    n-methylformamide 599.0
    2-pentanol 661.82
    n-pentane 319.26
    1-propoxy-2-propanol 936.07
    1-methoxy-2-propyl acetate 1007.59
    2-(2-methoxypropoxy) propanol 663.75
    mesitylene 565.41
    ε-caprolactone 1692.41
    p-cymene 568.36
    epichlorohydrin 2157.79
    1,1,1-trichloroethane 2179.49
    2-aminoethanol 256.1
    morpholine-4-carbaldehyde 1646.28
    sulfolane 2081.83
    2,2,4-trimethylpentane 198.06
    2-methyltetrahydrofuran 2150.31
    n-hexyl acetate 1352.09
    isooctane 161.07
    2-(2-butoxyethoxy)ethanol 816.1
    sec-butyl acetate 670.34
    tert-butyl acetate 835.37
    decalin 322.92
    glycerin 249.2
    diglyme 1458.18
    acrylic acid 442.51
    isopropyl myristate 568.02
    n-butyric acid 947.24
    acetyl acetate 678.48
    di(2-ethylhexyl) phthalate 499.78
    ethyl propionate 703.41
    nitromethane 920.83
    1,2-diethoxyethane 1157.75
    benzonitrile 1402.67
    trioctyl phosphate 386.34
    1-bromopropane 1531.73
    gamma-valerolactone 2332.47
    n-decanol 419.08
    triethyl phosphate 432.76
    4-methyl-2-pentanol 447.0
    propionitrile 926.49
    vinylene carbonate 1244.36
    1,1,2-trichlorotrifluoroethane 1040.09
    DMS 836.79
    cumene 497.12
    2-octanol 553.77
    2-hexanone 1116.72
    octyl acetate 671.77
    limonene 856.04
    1,2-dimethoxyethane 1548.99
    ethyl orthosilicate 446.87
    tributyl phosphate 488.1
    diacetone alcohol 674.91
    N,N-dimethylaniline 750.71
    acrylonitrile 963.96
    aniline 940.28
    1,3-propanediol 463.91
    bromobenzene 2068.96
    dibromomethane 2543.52
    1,1,2,2-tetrachloroethane 2660.18
    2-methyl-cyclohexyl acetate 897.63
    tetrabutyl urea 628.02
    diisobutyl methanol 455.59
    2-phenylethanol 942.22
    styrene 947.26
    dioctyl adipate 671.82
    dimethyl sulfate 596.3
    ethyl butyrate 977.25
    methyl lactate 321.45
    butyl lactate 618.49
    diethyl carbonate 631.01
    propanediol butyl ether 603.45
    triethyl orthoformate 688.21
    p-tert-butyltoluene 539.96
    methyl 4-tert-butylbenzoate 779.33
    morpholine 1759.89
    tert-butylamine 640.41
    n-dodecanol 334.18
    dimethoxymethane 1098.55
    ethylene carbonate 1099.54
    cyrene 716.97
    2-ethoxyethyl acetate 1022.52
    2-ethylhexyl acetate 1234.53
    1,2,4-trichlorobenzene 1489.89
    4-methylpyridine 2238.32
    dibutyl ether 997.94
    2,6-dimethyl-4-heptanol 455.59
    DEF 1201.07
    dimethyl isosorbide 1258.2
    tetrachloroethylene 1844.67
    eugenol 782.26
    triacetin 848.91
    span 80 712.72
    1,4-butanediol 267.69
    1,1-dichloroethane 2041.69
    2-methyl-1-pentanol 820.77
    methyl formate 563.57
    2-methyl-1-butanol 838.28
    n-decane 236.77
    butyronitrile 1313.76
    3,7-dimethyl-1-octanol 618.4
    1-chlorooctane 701.28
    1-chlorotetradecane 289.31
    n-nonane 259.67
    undecane 173.85
    tert-butylcyclohexane 293.83
    cyclooctane 271.15
    cyclopentanol 1013.75
    tetrahydropyran 2136.81
    tert-amyl methyl ether 870.68
    2,5,8-trioxanonane 1005.43
    1-hexene 944.87
    2-isopropoxyethanol 567.53
    2,2,2-trifluoroethanol 223.25
    methyl butyrate 1036.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction