4-Ethyl-2,5-dimethylthiazole

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  • Identifiers

    CAS number
    32272-57-4

    Molecular formula
    C7H11NS

    SMILES
    CCC1=C(SC(=N1)C)C

  • Odor profile

    Fragrance
    Nutty 80.15%
    Roasted 74.95%
    Meaty 62.48%
    Earthy 59.75%
    Green 58.3%
    Cocoa 54.45%
    Vegetable 51.95%
    Burnt 51.34%
    Coffee 50.65%
    Hazelnut 49.54%

     

    Flavor
    Nutty 69.79%
    Roasted 65.49%
    Earthy 50.67%
    Vegetable 46.97%
    Meaty 46.02%
    Burnt 45.17%
    Coffee 44.51%
    Roast 44.26%
    Hazelnut 43.83%
    Potato 43.56%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    6.73 (neutral)

    Molecular weight
    141.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    178°C

    Melting point expt.

    • 115 - 116 °C

    Flash point

    • 50.42 ˚C est.

  • Synonyms

    • 2,5-DIMETHYL-4-ETHYLTHIAZOLE
    • 4-Ethyl-2,5-dimethylthiazole
    • 4-Ethyl-2,5-dimethyl-1,3-thiazole
    • 32272-57-4
    • Thiazole, 4-ethyl-2,5-dimethyl-
    • UNII-N9ZS090JBQ
    • N9ZS090JBQ
    • 4-Ethyl-2,5-dimethyl-Thiazole
    • DTXSID10186021
    • SCHEMBL6760698
    • 2,5-dimethyl-4-ethyl thiazole
    • DTXCID20108512
    • AKOS006239019
    • 4-Ethyl-2,5-dimethyl-1,3-thiazole #
    • NS00127219
    • Q27284751

  • Applications

    4-Ethyl-2,5-dimethylthiazole (CAS 32272-57-4) is primarily employed as an organic synthesis intermediate for the construction of more complex heterocyclic compounds used in pharmaceutical and agrochemical research. It is also evaluated as an odorant/fragrance component in perfumery and may be explored as a fragrance ingredient in cosmetics and personal care formulations. In industrial manufacturing, it can serve as a building block for specialty polymers and coatings with thiazole motifs, and as a potential precursor in catalyst or ligand chemistry for organic synthesis. Additionally, it may be used as a preparatory chemical in electronics or materials research where heteroaromatic building blocks are desired.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 816.86
    methanol 1199.66
    isopropanol 570.78
    water 13.89
    ethyl acetate 733.67
    n-propanol 707.28
    acetone 861.14
    n-butanol 753.49
    acetonitrile 652.95
    DMF 1173.41
    toluene 800.03
    isobutanol 594.58
    1,4-dioxane 1436.11
    methyl acetate 689.24
    THF 1765.91
    2-butanone 855.36
    n-pentanol 589.14
    sec-butanol 631.39
    n-hexane 294.17
    ethylene glycol 264.48
    NMP 1350.27
    cyclohexane 354.67
    DMSO 934.23
    n-butyl acetate 691.83
    n-octanol 463.95
    chloroform 2598.4
    n-propyl acetate 508.72
    acetic acid 532.35
    dichloromethane 2269.07
    cyclohexanone 1392.92
    propylene glycol 279.39
    isopropyl acetate 552.38
    DMAc 999.05
    2-ethoxyethanol 867.49
    isopentanol 647.33
    n-heptane 235.5
    ethyl formate 531.37
    1,2-dichloroethane 1234.73
    n-hexanol 796.05
    2-methoxyethanol 1217.44
    isobutyl acetate 417.62
    tetrachloromethane 862.22
    n-pentyl acetate 586.6
    transcutol 1305.97
    n-heptanol 458.67
    ethylbenzene 439.12
    MIBK 587.97
    2-propoxyethanol 1206.56
    tert-butanol 668.55
    MTBE 856.69
    2-butoxyethanol 715.16
    propionic acid 463.84
    o-xylene 524.61
    formic acid 263.76
    diethyl ether 1005.48
    m-xylene 607.05
    p-xylene 554.15
    chlorobenzene 1012.57
    dimethyl carbonate 384.2
    n-octane 124.08
    formamide 307.25
    cyclopentanone 1414.76
    2-pentanone 808.61
    anisole 807.16
    cyclopentyl methyl ether 1190.87
    gamma-butyrolactone 1298.72
    1-methoxy-2-propanol 868.3
    pyridine 1053.55
    3-pentanone 722.99
    furfural 1289.88
    n-dodecane 92.15
    diethylene glycol 791.44
    diisopropyl ether 426.94
    tert-amyl alcohol 657.31
    acetylacetone 806.07
    n-hexadecane 104.43
    acetophenone 642.3
    methyl propionate 640.03
    isopentyl acetate 661.48
    trichloroethylene 2058.45
    n-nonanol 396.31
    cyclohexanol 757.9
    benzyl alcohol 576.31
    2-ethylhexanol 543.86
    isooctanol 379.0
    dipropyl ether 654.96
    1,2-dichlorobenzene 943.15
    ethyl lactate 276.42
    propylene carbonate 713.04
    n-methylformamide 590.21
    2-pentanol 552.86
    n-pentane 262.8
    1-propoxy-2-propanol 768.21
    1-methoxy-2-propyl acetate 652.13
    2-(2-methoxypropoxy) propanol 485.68
    mesitylene 441.71
    ε-caprolactone 1113.7
    p-cymene 337.38
    epichlorohydrin 1524.6
    1,1,1-trichloroethane 1367.18
    2-aminoethanol 412.72
    morpholine-4-carbaldehyde 1401.15
    sulfolane 1408.1
    2,2,4-trimethylpentane 163.08
    2-methyltetrahydrofuran 1430.73
    n-hexyl acetate 764.88
    isooctane 136.61
    2-(2-butoxyethoxy)ethanol 642.27
    sec-butyl acetate 406.29
    tert-butyl acetate 622.66
    decalin 218.54
    glycerin 420.78
    diglyme 1140.82
    acrylic acid 416.29
    isopropyl myristate 327.5
    n-butyric acid 699.97
    acetyl acetate 481.79
    di(2-ethylhexyl) phthalate 304.42
    ethyl propionate 477.21
    nitromethane 801.66
    1,2-diethoxyethane 729.6
    benzonitrile 771.41
    trioctyl phosphate 237.67
    1-bromopropane 959.53
    gamma-valerolactone 1597.26
    n-decanol 287.61
    triethyl phosphate 282.62
    4-methyl-2-pentanol 370.62
    propionitrile 694.67
    vinylene carbonate 731.77
    1,1,2-trichlorotrifluoroethane 933.53
    DMS 513.57
    cumene 349.83
    2-octanol 362.19
    2-hexanone 606.63
    octyl acetate 399.63
    limonene 499.84
    1,2-dimethoxyethane 1237.93
    ethyl orthosilicate 297.25
    tributyl phosphate 274.84
    diacetone alcohol 567.32
    N,N-dimethylaniline 597.44
    acrylonitrile 691.92
    aniline 716.26
    1,3-propanediol 606.59
    bromobenzene 1093.16
    dibromomethane 1656.46
    1,1,2,2-tetrachloroethane 1716.55
    2-methyl-cyclohexyl acetate 484.09
    tetrabutyl urea 333.74
    diisobutyl methanol 304.57
    2-phenylethanol 661.24
    styrene 525.98
    dioctyl adipate 379.26
    dimethyl sulfate 564.34
    ethyl butyrate 491.82
    methyl lactate 362.99
    butyl lactate 380.31
    diethyl carbonate 333.02
    propanediol butyl ether 493.63
    triethyl orthoformate 385.23
    p-tert-butyltoluene 351.39
    methyl 4-tert-butylbenzoate 595.71
    morpholine 1373.38
    tert-butylamine 540.44
    n-dodecanol 226.54
    dimethoxymethane 1061.54
    ethylene carbonate 627.57
    cyrene 554.08
    2-ethoxyethyl acetate 659.22
    2-ethylhexyl acetate 597.07
    1,2,4-trichlorobenzene 1019.28
    4-methylpyridine 1236.48
    dibutyl ether 541.69
    2,6-dimethyl-4-heptanol 304.57
    DEF 904.6
    dimethyl isosorbide 847.86
    tetrachloroethylene 1248.3
    eugenol 579.64
    triacetin 505.55
    span 80 468.65
    1,4-butanediol 327.26
    1,1-dichloroethane 1287.14
    2-methyl-1-pentanol 581.29
    methyl formate 522.26
    2-methyl-1-butanol 683.1
    n-decane 146.79
    butyronitrile 773.22
    3,7-dimethyl-1-octanol 428.27
    1-chlorooctane 439.29
    1-chlorotetradecane 183.58
    n-nonane 159.1
    undecane 111.69
    tert-butylcyclohexane 219.78
    cyclooctane 199.38
    cyclopentanol 734.59
    tetrahydropyran 1324.06
    tert-amyl methyl ether 776.06
    2,5,8-trioxanonane 745.46
    1-hexene 542.76
    2-isopropoxyethanol 614.82
    2,2,2-trifluoroethanol 281.73
    methyl butyrate 587.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction