4-Ethyl-2-methylthiazole

Overview IFRA Request a quote

  • Identifiers

    CAS number
    32272-48-3

    Molecular formula
    C6H9NS

    SMILES
    CCC1=CSC(=N1)C

  • Odor profile

    Fragrance
    Green 87.9%
    Nutty 69.97%
    Vegetable 67.24%
    Meaty 65.53%
    Roasted 61.07%
    Sulfurous 56.4%
    Cocoa 47.18%
    Earthy 44.16%
    Burnt 39.34%
    Coffee 38.99%

     

    Flavor
    Nutty 62.74%
    Roasted 54.25%
    Green 53.1%
    Vegetable 41.7%
    Coffee 35.25%
    Earthy 33.38%
    Potato 30.54%
    Roast 30.13%
    Meaty 29.97%
    Cocoa 29.17%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.75 (weak acid)

    Molecular weight
    127.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Melting point expt.

    • 80.00 °C. @ 760.00 mm Hg

    Boiling point

    • 171.00 to 173.00 °C. @ 760.00 mm Hg

    Flash point

    • 42.91 ˚C est.

  • Synonyms

    • 4-Ethyl-2-methylthiazole
    • 2-Methyl-4-ethylthiazole
    • 32272-48-3
    • 4-Ethyl-2-methyl-1,3-thiazole
    • Thiazole, 4-ethyl-2-methyl-
    • UNII-88L38Q5K6X
    • 88L38Q5K6X
    • 4-Ethyl-2-methyIthiazole
    • DTXSID40334396
    • 2-Methyl-4-ethylthiazol
    • 4-ethyl-2-methyl thiazole
    • SCHEMBL91500
    • DTXCID50285486
    • CHEBI:178616
    • AKOS006370481
    • DB-218900
    • NS00122477
    • Q27269934

  • Applications

    4-Ethyl-2-methylthiazole (CAS 32272-48-3) is a heterocyclic aroma compound primarily used as a fragrance and flavor ingredient in industrial applications; it typically acts as an odorant and aroma contributor in perfumery and flavor formulations. In cosmetics and personal care, it may appear as an aroma note within formulations. In consumer products and industrial chemical systems, it can be employed as an aroma additive or as a synthetic intermediate to influence aroma profiles in coatings, inks, or cleaning formulations, subject to local regulations and formulation limits. These applications reflect the role of 4-Ethyl-2-methylthiazole in the fragrance and flavor sectors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 227.18
    methanol 337.04
    isopropanol 168.83
    water 3.36
    ethyl acetate 232.8
    n-propanol 201.32
    acetone 343.56
    n-butanol 213.49
    acetonitrile 209.41
    DMF 515.81
    toluene 245.04
    isobutanol 167.46
    1,4-dioxane 476.28
    methyl acetate 239.66
    THF 601.72
    2-butanone 311.56
    n-pentanol 176.37
    sec-butanol 175.99
    n-hexane 66.6
    ethylene glycol 97.45
    NMP 615.65
    cyclohexane 75.38
    DMSO 489.91
    n-butyl acetate 217.98
    n-octanol 160.7
    chloroform 830.41
    n-propyl acetate 166.23
    acetic acid 177.91
    dichloromethane 749.06
    cyclohexanone 491.41
    propylene glycol 106.28
    isopropyl acetate 177.29
    DMAc 493.23
    2-ethoxyethanol 284.78
    isopentanol 186.31
    n-heptane 60.29
    ethyl formate 170.53
    1,2-dichloroethane 424.78
    n-hexanol 237.36
    2-methoxyethanol 416.81
    isobutyl acetate 145.48
    tetrachloromethane 232.81
    n-pentyl acetate 194.29
    transcutol 593.6
    n-heptanol 148.18
    ethylbenzene 136.55
    MIBK 208.41
    2-propoxyethanol 398.89
    tert-butanol 192.97
    MTBE 245.46
    2-butoxyethanol 249.07
    propionic acid 165.49
    o-xylene 177.14
    formic acid 72.21
    diethyl ether 257.65
    m-xylene 196.75
    p-xylene 175.32
    chlorobenzene 344.52
    dimethyl carbonate 139.59
    n-octane 34.78
    formamide 88.2
    cyclopentanone 547.29
    2-pentanone 283.58
    anisole 274.82
    cyclopentyl methyl ether 353.15
    gamma-butyrolactone 513.34
    1-methoxy-2-propanol 335.99
    pyridine 380.15
    3-pentanone 244.17
    furfural 549.22
    n-dodecane 33.09
    diethylene glycol 304.98
    diisopropyl ether 112.9
    tert-amyl alcohol 193.06
    acetylacetone 353.77
    n-hexadecane 37.2
    acetophenone 258.94
    methyl propionate 219.91
    isopentyl acetate 207.55
    trichloroethylene 726.18
    n-nonanol 140.13
    cyclohexanol 209.74
    benzyl alcohol 209.34
    2-ethylhexanol 165.92
    isooctanol 124.13
    dipropyl ether 185.63
    1,2-dichlorobenzene 340.91
    ethyl lactate 116.47
    propylene carbonate 265.51
    n-methylformamide 208.51
    2-pentanol 149.63
    n-pentane 59.52
    1-propoxy-2-propanol 272.46
    1-methoxy-2-propyl acetate 252.92
    2-(2-methoxypropoxy) propanol 223.68
    mesitylene 143.3
    ε-caprolactone 373.4
    p-cymene 120.24
    epichlorohydrin 551.98
    1,1,1-trichloroethane 459.67
    2-aminoethanol 143.34
    morpholine-4-carbaldehyde 596.29
    sulfolane 660.34
    2,2,4-trimethylpentane 45.66
    2-methyltetrahydrofuran 447.1
    n-hexyl acetate 269.98
    isooctane 37.6
    2-(2-butoxyethoxy)ethanol 283.01
    sec-butyl acetate 135.41
    tert-butyl acetate 209.84
    decalin 66.53
    glycerin 178.86
    diglyme 464.35
    acrylic acid 159.38
    isopropyl myristate 134.68
    n-butyric acid 215.85
    acetyl acetate 185.45
    di(2-ethylhexyl) phthalate 139.32
    ethyl propionate 160.07
    nitromethane 306.95
    1,2-diethoxyethane 264.94
    benzonitrile 311.34
    trioctyl phosphate 99.32
    1-bromopropane 293.99
    gamma-valerolactone 593.54
    n-decanol 110.65
    triethyl phosphate 111.51
    4-methyl-2-pentanol 113.48
    propionitrile 212.59
    vinylene carbonate 282.37
    1,1,2-trichlorotrifluoroethane 377.86
    DMS 221.97
    cumene 117.23
    2-octanol 117.8
    2-hexanone 213.44
    octyl acetate 160.88
    limonene 166.87
    1,2-dimethoxyethane 443.34
    ethyl orthosilicate 110.57
    tributyl phosphate 115.5
    diacetone alcohol 231.13
    N,N-dimethylaniline 218.85
    acrylonitrile 240.55
    aniline 244.41
    1,3-propanediol 195.85
    bromobenzene 384.83
    dibromomethane 513.5
    1,1,2,2-tetrachloroethane 601.65
    2-methyl-cyclohexyl acetate 178.46
    tetrabutyl urea 153.78
    diisobutyl methanol 103.51
    2-phenylethanol 237.66
    styrene 175.65
    dioctyl adipate 162.57
    dimethyl sulfate 258.39
    ethyl butyrate 162.28
    methyl lactate 154.16
    butyl lactate 151.38
    diethyl carbonate 120.98
    propanediol butyl ether 215.56
    triethyl orthoformate 132.19
    p-tert-butyltoluene 122.51
    methyl 4-tert-butylbenzoate 236.23
    morpholine 443.97
    tert-butylamine 144.05
    n-dodecanol 90.91
    dimethoxymethane 388.24
    ethylene carbonate 216.48
    cyrene 250.03
    2-ethoxyethyl acetate 246.4
    2-ethylhexyl acetate 185.29
    1,2,4-trichlorobenzene 401.92
    4-methylpyridine 428.75
    dibutyl ether 185.66
    2,6-dimethyl-4-heptanol 103.51
    DEF 325.08
    dimethyl isosorbide 378.98
    tetrachloroethylene 423.8
    eugenol 241.73
    triacetin 237.15
    span 80 219.19
    1,4-butanediol 109.35
    1,1-dichloroethane 429.16
    2-methyl-1-pentanol 180.53
    methyl formate 184.84
    2-methyl-1-butanol 189.11
    n-decane 47.16
    butyronitrile 226.78
    3,7-dimethyl-1-octanol 152.7
    1-chlorooctane 146.97
    1-chlorotetradecane 75.44
    n-nonane 48.62
    undecane 38.17
    tert-butylcyclohexane 68.72
    cyclooctane 41.84
    cyclopentanol 229.21
    tetrahydropyran 368.17
    tert-amyl methyl ether 221.78
    2,5,8-trioxanonane 353.78
    1-hexene 148.11
    2-isopropoxyethanol 216.07
    2,2,2-trifluoroethanol 95.54
    methyl butyrate 201.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction