4-Ethyl-2-methylphenol

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  • Identifiers

    CAS number
    2219-73-0

    Molecular formula
    C9H12O

    SMILES
    CCC1=CC(=C(C=C1)O)C

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 87.73%
    Smoky 71.46%
    Spicy 68.83%
    Medicinal 65.29%
    Leathery 55.08%
    Woody 47.09%
    Burnt 46.58%
    Herbal 38.13%
    Musty 37.86%
    Animal 36.77%

     

    Flavor
    Phenolic 78.29%
    Medicinal 65.46%
    Spicy 50.51%
    Smoky 47.63%
    Phenol 44.85%
    Smoke 42.55%
    Spice 42.08%
    Clove 39.88%
    Sweet 39.87%
    Bacon 37.36%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    10.34 (weak base)

    Molecular weight
    136.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    227°C

    Flash point

    • 101.52 ˚C est.

  • Synonyms

    • 4-Ethyl-2-methylphenol
    • 4-Ethyl-o-cresol
    • 2-Methyl-4-ethylphenol
    • o-Cresol, 4-ethyl-
    • UNII-Z98H442K3U
    • Z98H442K3U
    • EINECS 218-733-1
    • 4-Ethyl-O-cresol, 8CI
    • DTXSID10176725
    • RefChem:98864
    • DTXCID7099216
    • 218-733-1
    • QDQMEHXIUFCIGR-UHFFFAOYSA-N
    • 2219-73-0
    • Phenol, 4-ethyl-2-methyl-
    • 4-Ethyl-2-methyl-Phenol
    • Phenol, 4-ethylmethyl-
    • starbld0032259
    • SCHEMBL1416648
    • SCHEMBL3169916
    • SCHEMBL27777637
    • SCHEMBL27829497
    • SCHEMBL30676220
    • CHEBI:196445
    • CAA21973
    • MB23862
    • NS00027100
    • G46914
    • EN300-3187598
    • Q27295176
    • Z1255463943
    • 2219-73-0

  • Applications

    4-Ethyl-2-methylphenol (CAS 2219-73-0) is primarily used as an intermediate and building block in the synthesis of specialty organic chemicals. In perfumery and fragrance applications it can act as an odorant component and may serve as a fixative for phenolic notes. In industrial manufacturing it is a precursor for dyes, pigments and phenolic resins used in coatings, adhesives and laminates. It can also function as a solvent or processing aid in chemical synthesis. As a flexible building block, it is often evaluated in research and development as a starting point for the preparation of substituted phenols and related intermediates for further chemical manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3001.66
    methanol 1149.69
    isopropanol 2314.78
    water 0.96
    ethyl acetate 2578.21
    n-propanol 2568.5
    acetone 2849.49
    n-butanol 1840.15
    acetonitrile 3884.76
    DMF 2218.2
    toluene 597.29
    isobutanol 1581.83
    1,4-dioxane 3601.94
    methyl acetate 2540.02
    THF 4032.69
    2-butanone 2768.3
    n-pentanol 916.14
    sec-butanol 1672.92
    n-hexane 152.61
    ethylene glycol 202.59
    NMP 897.26
    cyclohexane 164.71
    DMSO 1853.34
    n-butyl acetate 2132.14
    n-octanol 499.14
    chloroform 3438.11
    n-propyl acetate 1069.74
    acetic acid 829.47
    dichloromethane 5002.39
    cyclohexanone 1859.43
    propylene glycol 322.3
    isopropyl acetate 946.65
    DMAc 998.52
    2-ethoxyethanol 972.18
    isopentanol 1094.08
    n-heptane 190.6
    ethyl formate 1944.61
    1,2-dichloroethane 2916.49
    n-hexanol 1620.87
    2-methoxyethanol 1741.31
    isobutyl acetate 521.99
    tetrachloromethane 573.89
    n-pentyl acetate 673.9
    transcutol 1877.63
    n-heptanol 541.59
    ethylbenzene 298.28
    MIBK 703.55
    2-propoxyethanol 1754.74
    tert-butanol 1972.33
    MTBE 2110.26
    2-butoxyethanol 736.86
    propionic acid 1111.6
    o-xylene 300.19
    formic acid 185.68
    diethyl ether 2500.37
    m-xylene 359.61
    p-xylene 347.43
    chlorobenzene 774.93
    dimethyl carbonate 420.64
    n-octane 80.68
    formamide 574.66
    cyclopentanone 2412.18
    2-pentanone 1879.46
    anisole 675.39
    cyclopentyl methyl ether 1267.83
    gamma-butyrolactone 2673.66
    1-methoxy-2-propanol 1305.52
    pyridine 1835.51
    3-pentanone 1166.5
    furfural 1252.92
    n-dodecane 61.3
    diethylene glycol 710.82
    diisopropyl ether 431.16
    tert-amyl alcohol 1303.93
    acetylacetone 1177.52
    n-hexadecane 69.15
    acetophenone 461.26
    methyl propionate 1513.72
    isopentyl acetate 1229.28
    trichloroethylene 3771.73
    n-nonanol 384.99
    cyclohexanol 765.93
    benzyl alcohol 405.03
    2-ethylhexanol 712.49
    isooctanol 383.3
    dipropyl ether 1188.3
    1,2-dichlorobenzene 549.75
    ethyl lactate 263.14
    propylene carbonate 1066.22
    n-methylformamide 1663.38
    2-pentanol 1014.79
    n-pentane 159.12
    1-propoxy-2-propanol 1212.12
    1-methoxy-2-propyl acetate 959.74
    2-(2-methoxypropoxy) propanol 456.1
    mesitylene 208.92
    ε-caprolactone 1414.86
    p-cymene 233.71
    epichlorohydrin 3651.15
    1,1,1-trichloroethane 2063.26
    2-aminoethanol 606.08
    morpholine-4-carbaldehyde 1324.73
    sulfolane 1545.03
    2,2,4-trimethylpentane 78.6
    2-methyltetrahydrofuran 2862.82
    n-hexyl acetate 824.25
    isooctane 81.02
    2-(2-butoxyethoxy)ethanol 706.18
    sec-butyl acetate 524.82
    tert-butyl acetate 774.83
    decalin 84.26
    glycerin 286.87
    diglyme 1323.87
    acrylic acid 593.1
    isopropyl myristate 271.54
    n-butyric acid 1588.26
    acetyl acetate 704.48
    di(2-ethylhexyl) phthalate 198.69
    ethyl propionate 789.33
    nitromethane 2222.69
    1,2-diethoxyethane 1447.52
    benzonitrile 743.55
    trioctyl phosphate 182.14
    1-bromopropane 2037.6
    gamma-valerolactone 2314.13
    n-decanol 290.87
    triethyl phosphate 226.57
    4-methyl-2-pentanol 406.76
    propionitrile 2719.06
    vinylene carbonate 957.83
    1,1,2-trichlorotrifluoroethane 765.26
    DMS 465.54
    cumene 205.76
    2-octanol 377.38
    2-hexanone 1045.25
    octyl acetate 361.76
    limonene 361.22
    1,2-dimethoxyethane 1834.95
    ethyl orthosilicate 230.91
    tributyl phosphate 218.95
    diacetone alcohol 704.92
    N,N-dimethylaniline 328.57
    acrylonitrile 2398.98
    aniline 639.65
    1,3-propanediol 997.13
    bromobenzene 840.17
    dibromomethane 3053.34
    1,1,2,2-tetrachloroethane 1956.17
    2-methyl-cyclohexyl acetate 423.69
    tetrabutyl urea 259.72
    diisobutyl methanol 330.59
    2-phenylethanol 579.96
    styrene 371.5
    dioctyl adipate 305.29
    dimethyl sulfate 443.61
    ethyl butyrate 995.68
    methyl lactate 315.42
    butyl lactate 344.0
    diethyl carbonate 483.41
    propanediol butyl ether 506.31
    triethyl orthoformate 441.77
    p-tert-butyltoluene 232.28
    methyl 4-tert-butylbenzoate 379.59
    morpholine 3798.23
    tert-butylamine 1276.12
    n-dodecanol 224.5
    dimethoxymethane 1758.81
    ethylene carbonate 909.55
    cyrene 338.45
    2-ethoxyethyl acetate 817.03
    2-ethylhexyl acetate 878.35
    1,2,4-trichlorobenzene 559.61
    4-methylpyridine 1598.01
    dibutyl ether 673.91
    2,6-dimethyl-4-heptanol 330.59
    DEF 1418.32
    dimethyl isosorbide 699.05
    tetrachloroethylene 1149.38
    eugenol 360.46
    triacetin 427.09
    span 80 397.6
    1,4-butanediol 302.67
    1,1-dichloroethane 3446.91
    2-methyl-1-pentanol 634.47
    methyl formate 1167.36
    2-methyl-1-butanol 1098.47
    n-decane 105.45
    butyronitrile 2536.93
    3,7-dimethyl-1-octanol 389.95
    1-chlorooctane 369.39
    1-chlorotetradecane 138.44
    n-nonane 109.04
    undecane 78.76
    tert-butylcyclohexane 98.31
    cyclooctane 63.78
    cyclopentanol 1026.6
    tetrahydropyran 3117.43
    tert-amyl methyl ether 921.19
    2,5,8-trioxanonane 741.55
    1-hexene 646.88
    2-isopropoxyethanol 655.37
    2,2,2-trifluoroethanol 240.32
    methyl butyrate 1086.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction