4-Ethyl-1,3-thiazole

Overview IFRA Request a quote

  • Identifiers

    CAS number
    17626-72-1

    Molecular formula
    C5H7NS

    SMILES
    CCC1=CSC=N1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 90.4%
    Vegetable 71.23%
    Nutty 66.14%
    Meaty 50.94%
    Roasted 46.53%
    Tomato 42.28%
    Earthy 39.45%
    Cocoa 38.62%
    Musty 37.8%
    Sulfurous 36.55%

     

    Flavor
    Green 85.07%
    Nutty 78.66%
    Vegetable 50.01%
    Roasted 41.04%
    Earthy 38.9%
    Raw 36.25%
    Tomato 32.86%
    Musty 31.74%
    Peanut 30.54%
    Hazelnut 29.85%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    5.03 (weak acid)

    Molecular weight
    113.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    159°C

    Flash point

    • 44.59 ˚C est.

  • Synonyms

    • 4-Ethyl-1,3-thiazole
    • RefChem:522716
    • 804-794-7
    • 4-Ethylthiazole
    • 17626-72-1
    • Thiazole, 4-ethyl-
    • MFCD14706926
    • 4-Athylthiazol
    • SCHEMBL91156
    • SCHEMBL128232
    • SCHEMBL358062
    • SCHEMBL468073
    • SCHEMBL5004288
    • DTXSID80276847
    • CGOVTZGCKPMLMN-UHFFFAOYSA-N
    • AKOS015944288
    • GH-0707
    • DA-39415
    • CS-0448330
    • EN300-134857
    • 17626-72-1

  • Applications

    4-Ethyl-1,3-thiazole (CAS 17626-72-1) is typically used as a building block and/or intermediate in the synthesis of heterocyclic compounds for pharmaceutical and agrochemical applications; it is also considered an odorant/fragrance component in perfumery and cosmetics, and may serve as a precursor for industrial applications such as coatings, inks, and cleaning formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 188.43
    methanol 285.43
    isopropanol 94.92
    water 1.4
    ethyl acetate 165.93
    n-propanol 133.76
    acetone 292.51
    n-butanol 145.55
    acetonitrile 165.52
    DMF 297.25
    toluene 154.35
    isobutanol 95.07
    1,4-dioxane 346.82
    methyl acetate 169.6
    THF 484.97
    2-butanone 218.82
    n-pentanol 132.99
    sec-butanol 86.93
    n-hexane 34.23
    ethylene glycol 47.73
    NMP 421.49
    cyclohexane 52.14
    DMSO 418.96
    n-butyl acetate 233.33
    n-octanol 73.43
    chloroform 627.25
    n-propyl acetate 145.52
    acetic acid 198.36
    dichloromethane 639.61
    cyclohexanone 357.64
    propylene glycol 37.77
    isopropyl acetate 105.85
    DMAc 228.98
    2-ethoxyethanol 176.46
    isopentanol 125.9
    n-heptane 41.09
    ethyl formate 144.24
    1,2-dichloroethane 335.16
    n-hexanol 152.27
    2-methoxyethanol 245.95
    isobutyl acetate 106.81
    tetrachloromethane 140.57
    n-pentyl acetate 134.71
    transcutol 647.59
    n-heptanol 74.87
    ethylbenzene 63.92
    MIBK 117.35
    2-propoxyethanol 249.26
    tert-butanol 107.12
    MTBE 122.72
    2-butoxyethanol 145.01
    propionic acid 115.69
    o-xylene 86.18
    formic acid 90.8
    diethyl ether 192.2
    m-xylene 97.01
    p-xylene 88.58
    chlorobenzene 259.98
    dimethyl carbonate 70.45
    n-octane 16.58
    formamide 110.92
    cyclopentanone 390.01
    2-pentanone 190.92
    anisole 153.41
    cyclopentyl methyl ether 214.77
    gamma-butyrolactone 369.3
    1-methoxy-2-propanol 149.79
    pyridine 347.78
    3-pentanone 150.67
    furfural 425.02
    n-dodecane 13.82
    diethylene glycol 177.04
    diisopropyl ether 62.37
    tert-amyl alcohol 94.27
    acetylacetone 214.86
    n-hexadecane 15.76
    acetophenone 149.99
    methyl propionate 131.64
    isopentyl acetate 185.22
    trichloroethylene 606.86
    n-nonanol 67.67
    cyclohexanol 128.34
    benzyl alcohol 125.65
    2-ethylhexanol 105.65
    isooctanol 63.14
    dipropyl ether 152.9
    1,2-dichlorobenzene 215.05
    ethyl lactate 63.69
    propylene carbonate 192.23
    n-methylformamide 153.97
    2-pentanol 87.17
    n-pentane 36.24
    1-propoxy-2-propanol 170.82
    1-methoxy-2-propyl acetate 175.95
    2-(2-methoxypropoxy) propanol 156.35
    mesitylene 68.85
    ε-caprolactone 260.03
    p-cymene 68.85
    epichlorohydrin 385.49
    1,1,1-trichloroethane 297.92
    2-aminoethanol 75.66
    morpholine-4-carbaldehyde 396.47
    sulfolane 416.27
    2,2,4-trimethylpentane 20.05
    2-methyltetrahydrofuran 318.29
    n-hexyl acetate 149.49
    isooctane 17.16
    2-(2-butoxyethoxy)ethanol 210.83
    sec-butyl acetate 92.91
    tert-butyl acetate 124.68
    decalin 30.67
    glycerin 70.21
    diglyme 358.21
    acrylic acid 118.42
    isopropyl myristate 75.18
    n-butyric acid 165.07
    acetyl acetate 120.21
    di(2-ethylhexyl) phthalate 85.83
    ethyl propionate 102.74
    nitromethane 287.82
    1,2-diethoxyethane 285.09
    benzonitrile 212.42
    trioctyl phosphate 58.95
    1-bromopropane 205.71
    gamma-valerolactone 452.75
    n-decanol 54.81
    triethyl phosphate 74.51
    4-methyl-2-pentanol 60.52
    propionitrile 138.78
    vinylene carbonate 204.54
    1,1,2-trichlorotrifluoroethane 247.64
    DMS 124.53
    cumene 53.08
    2-octanol 53.37
    2-hexanone 169.85
    octyl acetate 88.71
    limonene 102.17
    1,2-dimethoxyethane 293.1
    ethyl orthosilicate 75.61
    tributyl phosphate 76.7
    diacetone alcohol 124.76
    N,N-dimethylaniline 114.07
    acrylonitrile 157.87
    aniline 157.93
    1,3-propanediol 113.48
    bromobenzene 285.29
    dibromomethane 428.86
    1,1,2,2-tetrachloroethane 390.46
    2-methyl-cyclohexyl acetate 126.87
    tetrabutyl urea 98.02
    diisobutyl methanol 65.61
    2-phenylethanol 145.85
    styrene 96.22
    dioctyl adipate 101.97
    dimethyl sulfate 117.76
    ethyl butyrate 144.46
    methyl lactate 66.6
    butyl lactate 91.48
    diethyl carbonate 92.77
    propanediol butyl ether 110.49
    triethyl orthoformate 106.71
    p-tert-butyltoluene 64.85
    methyl 4-tert-butylbenzoate 124.21
    morpholine 319.76
    tert-butylamine 80.64
    n-dodecanol 46.29
    dimethoxymethane 210.91
    ethylene carbonate 158.51
    cyrene 157.13
    2-ethoxyethyl acetate 200.39
    2-ethylhexyl acetate 160.07
    1,2,4-trichlorobenzene 246.55
    4-methylpyridine 325.56
    dibutyl ether 121.44
    2,6-dimethyl-4-heptanol 65.61
    DEF 201.16
    dimethyl isosorbide 272.47
    tetrachloroethylene 306.41
    eugenol 145.73
    triacetin 144.59
    span 80 142.16
    1,4-butanediol 64.4
    1,1-dichloroethane 284.6
    2-methyl-1-pentanol 116.06
    methyl formate 133.66
    2-methyl-1-butanol 109.24
    n-decane 20.27
    butyronitrile 173.29
    3,7-dimethyl-1-octanol 81.11
    1-chlorooctane 68.84
    1-chlorotetradecane 36.18
    n-nonane 20.35
    undecane 16.06
    tert-butylcyclohexane 28.8
    cyclooctane 23.02
    cyclopentanol 130.52
    tetrahydropyran 302.83
    tert-amyl methyl ether 103.07
    2,5,8-trioxanonane 279.59
    1-hexene 93.36
    2-isopropoxyethanol 129.18
    2,2,2-trifluoroethanol 78.18
    methyl butyrate 138.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction