4-(Ethoxymethyl)phenol

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  • Identifiers

    CAS number
    57726-26-8

    Molecular formula
    C9H12O2

    SMILES
    CCOCC1=CC=C(C=C1)O

  • Odor profile

    Fragrance
    Sweet 89.34%
    Phenolic 62.49%
    Floral 62.0%
    Vanilla 59.73%
    Anisic 54.89%
    Aromatic 48.19%
    Hawthorn 42.79%
    Powdery 40.59%
    Almond 39.06%
    Fruity 38.87%

     

    Flavor
    Sweet 77.63%
    Fruity 59.02%
    Floral 55.69%
    Spicy 49.62%
    Powdery 41.78%
    Vanilla 40.26%
    Chocolate 38.06%
    Phenolic 37.12%
    Almond 33.27%
    Flower 32.38%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    8.52 (weak base)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 52.00 to 53.00 °C. @ 760.00 mm Hg

    Boiling point

    • 240.00 to 242.00 °C. @ 760.00 mm Hg

    Flash point

    • 111.38 ˚C est.

  • Synonyms

    • 4-(ethoxymethyl)phenol
    • 57726-26-8
    • alpha-Ethoxy-p-cresol
    • 4-Ethoxymethylphenol
    • 4-Hydroxybenzyl ethyl ether
    • p-Hydroxybenzyl ethyl ether
    • 4-(Ethoxymethyl)-Phenol
    • EINECS 260-918-4
    • DTXSID20206426
    • Phenol, 4-(ethoxymethyl)-
    • MFCD00464284
    • 4Em CPD
    • SCHEMBL62426
    • CHEMBL3911844
    • DTXCID20128917
    • CHEBI:179248
    • AKOS016006285
    • DS-2520
    • DB-339856
    • NS00022410
    • 260-918-4

  • Applications

    4-(Ethoxymethyl)phenol (CAS 57726-26-8) is primarily used as an intermediate and building block for fragrance compounds and specialty chemicals in the chemical, cosmetics, and personal care industries; it also serves as a precursor in polymer and plastics formulations and in coatings and adhesives, where it can act as a reactive linker or modifier of resin properties; in coatings and inks, it may be incorporated into resin systems through reactive incorporation; in cleaning and household formulations, it can appear as a precursor or fragrance-related component. Overall, its role is as an intermediate and formulation modifier for chemical synthesis and material development, with exact use governed by formulation needs and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1602.59
    methanol 1251.61
    isopropanol 1198.64
    water 2.1
    ethyl acetate 789.58
    n-propanol 1095.58
    acetone 864.84
    n-butanol 830.48
    acetonitrile 915.37
    DMF 523.12
    toluene 102.68
    isobutanol 608.59
    1,4-dioxane 1164.62
    methyl acetate 837.77
    THF 938.71
    2-butanone 645.71
    n-pentanol 507.11
    sec-butanol 770.26
    n-hexane 27.28
    ethylene glycol 404.09
    NMP 241.92
    cyclohexane 31.19
    DMSO 1435.13
    n-butyl acetate 336.96
    n-octanol 145.32
    chloroform 811.83
    n-propyl acetate 357.66
    acetic acid 911.25
    dichloromethane 755.18
    cyclohexanone 420.9
    propylene glycol 729.59
    isopropyl acetate 271.54
    DMAc 449.25
    2-ethoxyethanol 774.84
    isopentanol 517.57
    n-heptane 22.93
    ethyl formate 346.7
    1,2-dichloroethane 533.91
    n-hexanol 400.53
    2-methoxyethanol 1186.51
    isobutyl acetate 201.53
    tetrachloromethane 93.64
    n-pentyl acetate 135.42
    transcutol 1767.08
    n-heptanol 139.56
    ethylbenzene 63.04
    MIBK 227.15
    2-propoxyethanol 591.06
    tert-butanol 1236.64
    MTBE 616.05
    2-butoxyethanol 259.02
    propionic acid 749.64
    o-xylene 75.21
    formic acid 300.27
    diethyl ether 678.68
    m-xylene 81.7
    p-xylene 80.1
    chlorobenzene 162.16
    dimethyl carbonate 149.37
    n-octane 10.5
    formamide 467.19
    cyclopentanone 491.55
    2-pentanone 442.92
    anisole 232.07
    cyclopentyl methyl ether 335.3
    gamma-butyrolactone 594.43
    1-methoxy-2-propanol 748.34
    pyridine 459.89
    3-pentanone 282.05
    furfural 461.93
    n-dodecane 10.59
    diethylene glycol 541.71
    diisopropyl ether 109.45
    tert-amyl alcohol 749.12
    acetylacetone 415.23
    n-hexadecane 11.51
    acetophenone 180.94
    methyl propionate 435.05
    isopentyl acetate 266.11
    trichloroethylene 859.23
    n-nonanol 119.14
    cyclohexanol 344.03
    benzyl alcohol 208.9
    2-ethylhexanol 184.25
    isooctanol 112.62
    dipropyl ether 217.86
    1,2-dichlorobenzene 137.96
    ethyl lactate 163.83
    propylene carbonate 300.61
    n-methylformamide 446.18
    2-pentanol 496.23
    n-pentane 25.31
    1-propoxy-2-propanol 387.61
    1-methoxy-2-propyl acetate 287.08
    2-(2-methoxypropoxy) propanol 272.67
    mesitylene 55.23
    ε-caprolactone 384.51
    p-cymene 50.5
    epichlorohydrin 757.82
    1,1,1-trichloroethane 407.13
    2-aminoethanol 745.84
    morpholine-4-carbaldehyde 479.85
    sulfolane 576.28
    2,2,4-trimethylpentane 22.57
    2-methyltetrahydrofuran 623.62
    n-hexyl acetate 207.03
    isooctane 19.78
    2-(2-butoxyethoxy)ethanol 391.58
    sec-butyl acetate 194.02
    tert-butyl acetate 279.93
    decalin 21.92
    glycerin 642.63
    diglyme 681.33
    acrylic acid 497.53
    isopropyl myristate 82.38
    n-butyric acid 725.31
    acetyl acetate 290.04
    di(2-ethylhexyl) phthalate 79.65
    ethyl propionate 241.57
    nitromethane 1125.68
    1,2-diethoxyethane 414.54
    benzonitrile 208.83
    trioctyl phosphate 62.08
    1-bromopropane 286.75
    gamma-valerolactone 565.75
    n-decanol 91.53
    triethyl phosphate 94.79
    4-methyl-2-pentanol 190.42
    propionitrile 566.99
    vinylene carbonate 272.04
    1,1,2-trichlorotrifluoroethane 562.15
    DMS 182.81
    cumene 53.02
    2-octanol 87.88
    2-hexanone 309.03
    octyl acetate 102.6
    limonene 77.31
    1,2-dimethoxyethane 820.91
    ethyl orthosilicate 95.18
    tributyl phosphate 84.14
    diacetone alcohol 372.44
    N,N-dimethylaniline 132.57
    acrylonitrile 555.49
    aniline 244.78
    1,3-propanediol 799.01
    bromobenzene 146.53
    dibromomethane 463.42
    1,1,2,2-tetrachloroethane 684.38
    2-methyl-cyclohexyl acetate 147.32
    tetrabutyl urea 100.46
    diisobutyl methanol 106.63
    2-phenylethanol 186.71
    styrene 82.78
    dioctyl adipate 125.4
    dimethyl sulfate 216.95
    ethyl butyrate 213.25
    methyl lactate 216.6
    butyl lactate 135.94
    diethyl carbonate 148.94
    propanediol butyl ether 298.8
    triethyl orthoformate 142.1
    p-tert-butyltoluene 51.11
    methyl 4-tert-butylbenzoate 157.14
    morpholine 1316.54
    tert-butylamine 649.02
    n-dodecanol 71.56
    dimethoxymethane 459.0
    ethylene carbonate 239.48
    cyrene 200.12
    2-ethoxyethyl acetate 223.72
    2-ethylhexyl acetate 185.3
    1,2,4-trichlorobenzene 177.92
    4-methylpyridine 342.99
    dibutyl ether 168.82
    2,6-dimethyl-4-heptanol 106.63
    DEF 379.56
    dimethyl isosorbide 308.37
    tetrachloroethylene 409.53
    eugenol 172.9
    triacetin 222.66
    span 80 214.73
    1,4-butanediol 328.03
    1,1-dichloroethane 582.08
    2-methyl-1-pentanol 321.64
    methyl formate 320.72
    2-methyl-1-butanol 456.82
    n-decane 16.58
    butyronitrile 503.87
    3,7-dimethyl-1-octanol 142.98
    1-chlorooctane 73.79
    1-chlorotetradecane 30.45
    n-nonane 16.24
    undecane 12.92
    tert-butylcyclohexane 26.67
    cyclooctane 11.8
    cyclopentanol 354.74
    tetrahydropyran 815.32
    tert-amyl methyl ether 312.81
    2,5,8-trioxanonane 450.12
    1-hexene 147.45
    2-isopropoxyethanol 456.38
    2,2,2-trifluoroethanol 215.11
    methyl butyrate 337.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction