4-Ethoxybenzyl alcohol

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  • Identifiers

    CAS number
    6214-44-4

    Molecular formula
    C9H12O2

    SMILES
    CCOC1=CC=C(C=C1)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 89.47%
    Vanilla 70.64%
    Anisic 65.79%
    Floral 61.18%
    Aromatic 52.3%
    Powdery 45.93%
    Phenolic 44.52%
    Balsamic 43.71%
    Hawthorn 40.84%
    Cherry 40.53%

     

    Flavor
    Sweet 89.03%
    Floral 71.74%
    Vanilla 59.57%
    Powdery 56.14%
    Rose 52.95%
    Fruity 51.81%
    Balsam 49.75%
    Flower 48.01%
    Chocolate 45.45%
    Cherry 44.04%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    7.59 (neutral)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    257°C

    Flash point

    • 113.62 ˚C est.

  • Synonyms

    • 4-Ethoxybenzyl alcohol
    • (4-Ethoxyphenyl)methanol
    • 6214-44-4
    • p-Ethoxybenzyl alcohol
    • 4-Ethoxybenzylalcohol
    • Benzenemethanol, 4-ethoxy-
    • 4-Ethoxybenzenemethanol
    • EINECS 228-283-8
    • MFCD00004655
    • AI3-05517
    • DTXSID80211197
    • NSC 406713
    • NSC-406713
    • Benzyl alcohol, p-ethoxy-
    • (4-Ethoxyphenyl)methanol #
    • [4-(ethyloxy)phenyl]methanol
    • SCHEMBL131727
    • CHEMBL1650240
    • DTXCID80133688
    • 4633ZFA6U4
    • NSC406713
    • STL254143
    • AKOS000249230
    • FE70748
    • PS-5198
    • SY048263
    • DS-018552
    • CS-0151465
    • E0492
    • NS00034937
    • EN300-49131
    • 228-283-8

  • Applications

    4-Ethoxybenzyl alcohol (CAS 6214-44-4) is principally used as an intermediate in the synthesis of p-ethoxybenzaldehyde and related aromatic derivatives that underpin fragrance and flavor chemistry, and it also serves as a building block for benzyl ether derivatives employed in polymers, coatings, and inks. It is commonly used as a synthetic intermediate in pharmaceutical synthesis to access substituted benzyl compounds. In cosmetics and personal care, it may function as a fragrance-related intermediate, and in industrial manufacturing it provides a versatile precursor for functionalized benzyl compounds used in resin and coating applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1073.82
    methanol 1392.92
    isopropanol 627.6
    water 4.03
    ethyl acetate 737.32
    n-propanol 760.49
    acetone 943.14
    n-butanol 662.37
    acetonitrile 877.72
    DMF 835.89
    toluene 137.9
    isobutanol 409.05
    1,4-dioxane 1443.98
    methyl acetate 649.21
    THF 1134.39
    2-butanone 544.75
    n-pentanol 414.85
    sec-butanol 435.8
    n-hexane 48.21
    ethylene glycol 365.89
    NMP 523.94
    cyclohexane 65.08
    DMSO 1894.97
    n-butyl acetate 425.66
    n-octanol 123.02
    chloroform 1134.68
    n-propyl acetate 387.15
    acetic acid 1133.15
    dichloromethane 1233.45
    cyclohexanone 577.05
    propylene glycol 354.64
    isopropyl acetate 287.32
    DMAc 562.18
    2-ethoxyethanol 755.51
    isopentanol 425.89
    n-heptane 31.36
    ethyl formate 392.77
    1,2-dichloroethane 912.52
    n-hexanol 328.43
    2-methoxyethanol 1103.58
    isobutyl acetate 210.34
    tetrachloromethane 167.52
    n-pentyl acetate 155.95
    transcutol 1877.03
    n-heptanol 112.98
    ethylbenzene 70.87
    MIBK 223.36
    2-propoxyethanol 572.92
    tert-butanol 900.92
    MTBE 613.46
    2-butoxyethanol 238.72
    propionic acid 626.63
    o-xylene 89.01
    formic acid 519.98
    diethyl ether 850.12
    m-xylene 87.63
    p-xylene 90.16
    chlorobenzene 289.89
    dimethyl carbonate 207.9
    n-octane 11.63
    formamide 731.21
    cyclopentanone 645.95
    2-pentanone 427.85
    anisole 267.8
    cyclopentyl methyl ether 399.39
    gamma-butyrolactone 826.03
    1-methoxy-2-propanol 565.07
    pyridine 648.74
    3-pentanone 299.31
    furfural 671.5
    n-dodecane 11.02
    diethylene glycol 562.65
    diisopropyl ether 139.16
    tert-amyl alcohol 536.48
    acetylacetone 469.54
    n-hexadecane 12.59
    acetophenone 202.32
    methyl propionate 422.46
    isopentyl acetate 309.7
    trichloroethylene 1301.29
    n-nonanol 108.14
    cyclohexanol 366.25
    benzyl alcohol 217.57
    2-ethylhexanol 173.56
    isooctanol 94.14
    dipropyl ether 251.81
    1,2-dichlorobenzene 229.65
    ethyl lactate 165.61
    propylene carbonate 393.42
    n-methylformamide 572.77
    2-pentanol 331.19
    n-pentane 47.73
    1-propoxy-2-propanol 359.15
    1-methoxy-2-propyl acetate 331.47
    2-(2-methoxypropoxy) propanol 278.93
    mesitylene 66.71
    ε-caprolactone 492.83
    p-cymene 61.88
    epichlorohydrin 995.6
    1,1,1-trichloroethane 596.3
    2-aminoethanol 546.17
    morpholine-4-carbaldehyde 719.6
    sulfolane 888.47
    2,2,4-trimethylpentane 30.0
    2-methyltetrahydrofuran 719.53
    n-hexyl acetate 218.29
    isooctane 23.52
    2-(2-butoxyethoxy)ethanol 390.9
    sec-butyl acetate 206.29
    tert-butyl acetate 308.0
    decalin 33.47
    glycerin 464.1
    diglyme 753.94
    acrylic acid 535.54
    isopropyl myristate 92.59
    n-butyric acid 707.41
    acetyl acetate 361.99
    di(2-ethylhexyl) phthalate 89.19
    ethyl propionate 270.11
    nitromethane 1545.96
    1,2-diethoxyethane 563.99
    benzonitrile 275.76
    trioctyl phosphate 67.91
    1-bromopropane 450.33
    gamma-valerolactone 753.19
    n-decanol 81.36
    triethyl phosphate 123.67
    4-methyl-2-pentanol 154.66
    propionitrile 548.61
    vinylene carbonate 386.11
    1,1,2-trichlorotrifluoroethane 704.93
    DMS 223.67
    cumene 58.44
    2-octanol 75.73
    2-hexanone 322.7
    octyl acetate 110.97
    limonene 99.28
    1,2-dimethoxyethane 968.12
    ethyl orthosilicate 123.16
    tributyl phosphate 99.55
    diacetone alcohol 330.95
    N,N-dimethylaniline 151.49
    acrylonitrile 605.89
    aniline 293.44
    1,3-propanediol 654.22
    bromobenzene 277.7
    dibromomethane 767.19
    1,1,2,2-tetrachloroethane 990.45
    2-methyl-cyclohexyl acetate 170.01
    tetrabutyl urea 118.99
    diisobutyl methanol 101.12
    2-phenylethanol 188.23
    styrene 110.9
    dioctyl adipate 144.97
    dimethyl sulfate 306.82
    ethyl butyrate 255.52
    methyl lactate 217.62
    butyl lactate 139.45
    diethyl carbonate 188.07
    propanediol butyl ether 244.23
    triethyl orthoformate 184.39
    p-tert-butyltoluene 61.49
    methyl 4-tert-butylbenzoate 171.02
    morpholine 1407.66
    tert-butylamine 502.14
    n-dodecanol 63.45
    dimethoxymethane 643.13
    ethylene carbonate 346.44
    cyrene 232.54
    2-ethoxyethyl acetate 269.54
    2-ethylhexyl acetate 226.65
    1,2,4-trichlorobenzene 272.57
    4-methylpyridine 429.11
    dibutyl ether 191.57
    2,6-dimethyl-4-heptanol 101.12
    DEF 460.24
    dimethyl isosorbide 373.29
    tetrachloroethylene 679.18
    eugenol 190.93
    triacetin 242.72
    span 80 212.94
    1,4-butanediol 279.92
    1,1-dichloroethane 731.53
    2-methyl-1-pentanol 305.65
    methyl formate 442.74
    2-methyl-1-butanol 386.57
    n-decane 18.25
    butyronitrile 485.95
    3,7-dimethyl-1-octanol 134.22
    1-chlorooctane 82.45
    1-chlorotetradecane 34.08
    n-nonane 17.64
    undecane 13.76
    tert-butylcyclohexane 33.24
    cyclooctane 20.87
    cyclopentanol 337.67
    tetrahydropyran 1009.07
    tert-amyl methyl ether 325.56
    2,5,8-trioxanonane 503.8
    1-hexene 179.4
    2-isopropoxyethanol 417.16
    2,2,2-trifluoroethanol 314.16
    methyl butyrate 383.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction