4-Ethoxy-3-methoxybenzaldehyde

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  • Identifiers

    CAS number
    120-25-2

    Molecular formula
    C10H12O3

    SMILES
    CCOC1=C(C=C(C=C1)C=O)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 87.93%
    Vanilla 82.87%
    Floral 72.29%
    Powdery 57.59%
    Spicy 57.1%
    Creamy 53.69%
    Woody 51.18%
    Anisic 48.37%
    Balsamic 47.31%
    Aromatic 39.74%

     

    Flavor
    Sweet 81.35%
    Vanilla 66.88%
    Woody 58.75%
    Creamy 51.7%
    Floral 49.96%
    Powdery 47.5%
    Spicy 43.09%
    Bitter 41.95%
    Balsam 39.93%
    Spice 39.48%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    6.45 (neutral)

    Molecular weight
    180.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 64 - 65 °C

    Boiling point

    • 288.00 to 289.00 °C. @ 760.00 mm Hg

    Flash point

    • 112.85 ˚C est.

    Solubility expt.

    • 1.16 mg/mL at 25 °C

  • Synonyms

    • 4-Ethoxy-3-methoxybenzaldehyde
    • 120-25-2
    • 4-Ethoxy-m-anisaldehyde
    • Benzaldehyde, 4-ethoxy-3-methoxy-
    • 4-Ethoxy-3-anisaldehyde
    • vanillin ethyl ether
    • MFCD00016614
    • EM2BBS3H88
    • 3-methoxy-4-ethoxybenzaldehyde
    • EINECS 204-382-1
    • NSC 16945
    • NSC-16945
    • AI3-21263
    • DTXSID3059509
    • Ethylvanillin?
    • 4-ethoxy-3-methoxy-benzaldehyde
    • NSC16945
    • bmse010097
    • UNII-EM2BBS3H88
    • SCHEMBL356800
    • 3-methoxy-4-ethoxy-benzaldehyde
    • DTXCID1033533
    • CHEBI:173856
    • ALBB-007462
    • NSC62097
    • BBL023007
    • NSC-62097
    • STK036493
    • 4-Ethoxy-3-methoxybenzaldehyde, 98%
    • AKOS000119708
    • FE46006
    • AS-61246
    • SY048300
    • DB-041546
    • CS-0075664
    • E0406
    • NS00021562
    • EN300-16103
    • N11911
    • AG-205/01773011
    • Z53833578
    • F1791-0527

  • Applications

    4-Ethoxy-3-methoxybenzaldehyde (CAS 120-25-2) is primarily used as an odorant and fragrance ingredient in perfumery, and as a synthetic building block for other aroma compounds; it may also serve as a fragrance component in cosmetics and personal care products, and as an odorant in household and cleaning formulations. In industrial manufacturing it is used as an intermediate in organic synthesis for specialty aroma chemicals, and may be employed as a fragrance additive in coatings and inks. The material may be considered for flavor applications as a synthetic flavor intermediate, subject to regulatory and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 165.54
    methanol 295.41
    isopropanol 94.11
    water 1.41
    ethyl acetate 616.18
    n-propanol 106.11
    acetone 866.29
    n-butanol 90.42
    acetonitrile 965.47
    DMF 665.41
    toluene 124.54
    isobutanol 76.2
    1,4-dioxane 690.93
    methyl acetate 686.35
    THF 647.03
    2-butanone 428.82
    n-pentanol 90.45
    sec-butanol 81.57
    n-hexane 13.78
    ethylene glycol 129.13
    NMP 489.58
    cyclohexane 48.62
    DMSO 1153.05
    n-butyl acetate 379.46
    n-octanol 68.36
    chloroform 1322.67
    n-propyl acetate 413.11
    acetic acid 615.73
    dichloromethane 2150.03
    cyclohexanone 566.99
    propylene glycol 60.93
    isopropyl acetate 235.73
    DMAc 454.53
    2-ethoxyethanol 324.45
    isopentanol 91.45
    n-heptane 18.33
    ethyl formate 537.15
    1,2-dichloroethane 1347.78
    n-hexanol 101.07
    2-methoxyethanol 455.72
    isobutyl acetate 184.76
    tetrachloromethane 202.59
    n-pentyl acetate 151.49
    transcutol 568.33
    n-heptanol 55.9
    ethylbenzene 103.17
    MIBK 148.29
    2-propoxyethanol 247.83
    tert-butanol 182.08
    MTBE 167.71
    2-butoxyethanol 133.47
    propionic acid 285.59
    o-xylene 109.74
    formic acid 251.66
    diethyl ether 253.14
    m-xylene 98.45
    p-xylene 154.12
    chlorobenzene 338.0
    dimethyl carbonate 263.42
    n-octane 11.08
    formamide 508.25
    cyclopentanone 660.83
    2-pentanone 296.86
    anisole 270.79
    cyclopentyl methyl ether 224.76
    gamma-butyrolactone 986.12
    1-methoxy-2-propanol 212.25
    pyridine 560.4
    3-pentanone 261.68
    furfural 944.94
    n-dodecane 11.5
    diethylene glycol 262.65
    diisopropyl ether 63.23
    tert-amyl alcohol 130.09
    acetylacetone 480.09
    n-hexadecane 13.37
    acetophenone 277.52
    methyl propionate 399.17
    isopentyl acetate 245.09
    trichloroethylene 1981.23
    n-nonanol 61.04
    cyclohexanol 126.67
    benzyl alcohol 192.34
    2-ethylhexanol 84.92
    isooctanol 51.52
    dipropyl ether 132.83
    1,2-dichlorobenzene 347.76
    ethyl lactate 163.09
    propylene carbonate 560.99
    n-methylformamide 480.7
    2-pentanol 59.19
    n-pentane 12.14
    1-propoxy-2-propanol 159.36
    1-methoxy-2-propyl acetate 245.56
    2-(2-methoxypropoxy) propanol 149.95
    mesitylene 75.64
    ε-caprolactone 485.76
    p-cymene 76.58
    epichlorohydrin 1103.72
    1,1,1-trichloroethane 840.11
    2-aminoethanol 122.04
    morpholine-4-carbaldehyde 572.97
    sulfolane 975.65
    2,2,4-trimethylpentane 12.11
    2-methyltetrahydrofuran 381.21
    n-hexyl acetate 197.56
    isooctane 8.87
    2-(2-butoxyethoxy)ethanol 187.41
    sec-butyl acetate 191.19
    tert-butyl acetate 207.35
    decalin 30.87
    glycerin 135.37
    diglyme 488.07
    acrylic acid 333.95
    isopropyl myristate 83.5
    n-butyric acid 319.41
    acetyl acetate 433.92
    di(2-ethylhexyl) phthalate 78.21
    ethyl propionate 320.75
    nitromethane 1597.83
    1,2-diethoxyethane 260.27
    benzonitrile 356.78
    trioctyl phosphate 59.64
    1-bromopropane 330.25
    gamma-valerolactone 719.11
    n-decanol 49.68
    triethyl phosphate 133.36
    4-methyl-2-pentanol 44.49
    propionitrile 430.22
    vinylene carbonate 598.06
    1,1,2-trichlorotrifluoroethane 619.72
    DMS 278.95
    cumene 74.7
    2-octanol 45.35
    2-hexanone 261.85
    octyl acetate 104.71
    limonene 102.84
    1,2-dimethoxyethane 643.4
    ethyl orthosilicate 110.48
    tributyl phosphate 84.21
    diacetone alcohol 193.62
    N,N-dimethylaniline 158.13
    acrylonitrile 697.07
    aniline 180.42
    1,3-propanediol 166.6
    bromobenzene 387.53
    dibromomethane 1110.65
    1,1,2,2-tetrachloroethane 1163.32
    2-methyl-cyclohexyl acetate 164.91
    tetrabutyl urea 107.05
    diisobutyl methanol 54.82
    2-phenylethanol 162.88
    styrene 145.71
    dioctyl adipate 132.17
    dimethyl sulfate 386.52
    ethyl butyrate 278.65
    methyl lactate 166.04
    butyl lactate 111.06
    diethyl carbonate 236.28
    propanediol butyl ether 112.05
    triethyl orthoformate 161.58
    p-tert-butyltoluene 68.87
    methyl 4-tert-butylbenzoate 170.54
    morpholine 560.3
    tert-butylamine 94.71
    n-dodecanol 42.43
    dimethoxymethane 441.69
    ethylene carbonate 496.57
    cyrene 200.89
    2-ethoxyethyl acetate 227.6
    2-ethylhexyl acetate 197.04
    1,2,4-trichlorobenzene 390.71
    4-methylpyridine 410.71
    dibutyl ether 117.95
    2,6-dimethyl-4-heptanol 54.82
    DEF 359.98
    dimethyl isosorbide 285.82
    tetrachloroethylene 831.81
    eugenol 165.86
    triacetin 233.53
    span 80 109.15
    1,4-butanediol 89.57
    1,1-dichloroethane 833.03
    2-methyl-1-pentanol 92.46
    methyl formate 641.78
    2-methyl-1-butanol 81.39
    n-decane 16.8
    butyronitrile 341.83
    3,7-dimethyl-1-octanol 71.27
    1-chlorooctane 72.54
    1-chlorotetradecane 34.63
    n-nonane 15.88
    undecane 13.54
    tert-butylcyclohexane 23.52
    cyclooctane 16.56
    cyclopentanol 149.35
    tetrahydropyran 384.44
    tert-amyl methyl ether 121.15
    2,5,8-trioxanonane 289.31
    1-hexene 58.4
    2-isopropoxyethanol 198.4
    2,2,2-trifluoroethanol 281.86
    methyl butyrate 455.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction