4-Ethoxy-2-butanone

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  • Identifiers

    CAS number
    60044-74-8

    Molecular formula
    C6H12O2

    SMILES
    CCOCCC(=O)C

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Fruity 78.22%
    Sweet 74.82%
    Ethereal 70.78%
    Fermented 45.95%
    Rummy 45.01%
    Solvent 43.63%
    Pungent 43.41%
    Alcoholic 42.46%
    Caramellic 41.93%
    Winey 39.93%

     

    Flavor
    Sweet 64.18%
    Fruity 59.55%
    Ethereal 56.7%
    Ether 51.22%
    Fruit 47.14%
    Banana 37.83%
    Pineapple 36.49%
    Solvent 36.08%
    Bitter 35.6%
    Alcohol 34.89%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    7.91 (neutral)

    Molecular weight
    116.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    156°C

    Flash point

    • 38.34 ˚C est.

  • Synonyms

    • 4-Ethoxy-2-butanone
    • 60044-74-8
    • DTXSID30336768
    • RefChem:522595
    • DTXCID20287856
    • 679-938-3
    • 4-ethoxybutan-2-one
    • MFCD00059372
    • SCHEMBL101044
    • AKOS009159206
    • E0298
    • D90475
    • Q63396160
    • InChI=1/C6H12O2/c1-3-8-5-4-6(2)7/h3-5H2,1-2H
    • 60044-74-8

  • Applications

    4-Ethoxy-2-butanone (CAS 60044-74-8) is primarily used as an intermediate in organic synthesis and may serve as a reactive solvent in industrial processes. In coatings and inks, as well as cleaning formulations, it functions as a solvent or processing aid; in fragrance and cosmetics, it is considered a fragrance intermediate or component; in polymers and plastics, it can act as a precursor for resin and plastic formulations. As an ether-ketone, it can be involved as a building block in other chemical syntheses. Overall, its main roles are as an intermediate and solvent across multiple sectors, subject to formulation and regulatory considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1582.59
    methanol 2302.32
    isopropanol 1126.98
    water 90.15
    ethyl acetate 353.57
    n-propanol 869.51
    acetone 666.08
    n-butanol 712.58
    acetonitrile 810.13
    DMF 1036.04
    toluene 148.91
    isobutanol 557.48
    1,4-dioxane 1035.2
    methyl acetate 479.58
    THF 903.97
    2-butanone 380.01
    n-pentanol 330.57
    sec-butanol 694.13
    n-hexane 80.22
    ethylene glycol 724.48
    NMP 855.0
    cyclohexane 185.26
    DMSO 805.19
    n-butyl acetate 138.2
    n-octanol 206.58
    chloroform 1474.01
    n-propyl acetate 131.52
    acetic acid 1497.96
    dichloromethane 1166.76
    cyclohexanone 584.13
    propylene glycol 840.81
    isopropyl acetate 152.34
    DMAc 870.13
    2-ethoxyethanol 529.15
    isopentanol 396.16
    n-heptane 67.89
    ethyl formate 320.69
    1,2-dichloroethane 428.45
    n-hexanol 346.32
    2-methoxyethanol 1284.52
    isobutyl acetate 83.96
    tetrachloromethane 289.19
    n-pentyl acetate 116.7
    transcutol 1077.7
    n-heptanol 139.11
    ethylbenzene 78.4
    MIBK 117.78
    2-propoxyethanol 501.94
    tert-butanol 965.61
    MTBE 314.33
    2-butoxyethanol 242.1
    propionic acid 791.03
    o-xylene 132.94
    formic acid 727.61
    diethyl ether 372.09
    m-xylene 100.62
    p-xylene 115.68
    chlorobenzene 218.13
    dimethyl carbonate 120.85
    n-octane 22.81
    formamide 641.32
    cyclopentanone 538.21
    2-pentanone 247.54
    anisole 201.72
    cyclopentyl methyl ether 350.9
    gamma-butyrolactone 632.58
    1-methoxy-2-propanol 750.37
    pyridine 578.47
    3-pentanone 217.69
    furfural 647.37
    n-dodecane 22.27
    diethylene glycol 575.08
    diisopropyl ether 74.14
    tert-amyl alcohol 621.03
    acetylacetone 263.58
    n-hexadecane 23.83
    acetophenone 173.64
    methyl propionate 296.68
    isopentyl acetate 107.96
    trichloroethylene 812.98
    n-nonanol 172.78
    cyclohexanol 692.12
    benzyl alcohol 235.8
    2-ethylhexanol 165.19
    isooctanol 99.63
    dipropyl ether 163.26
    1,2-dichlorobenzene 210.34
    ethyl lactate 149.57
    propylene carbonate 304.8
    n-methylformamide 638.95
    2-pentanol 379.11
    n-pentane 105.64
    1-propoxy-2-propanol 324.19
    1-methoxy-2-propyl acetate 156.48
    2-(2-methoxypropoxy) propanol 275.72
    mesitylene 62.0
    ε-caprolactone 482.55
    p-cymene 61.9
    epichlorohydrin 552.35
    1,1,1-trichloroethane 521.79
    2-aminoethanol 974.69
    morpholine-4-carbaldehyde 939.03
    sulfolane 589.27
    2,2,4-trimethylpentane 36.82
    2-methyltetrahydrofuran 604.95
    n-hexyl acetate 223.7
    isooctane 19.07
    2-(2-butoxyethoxy)ethanol 366.17
    sec-butyl acetate 87.04
    tert-butyl acetate 135.9
    decalin 48.45
    glycerin 883.41
    diglyme 571.31
    acrylic acid 721.11
    isopropyl myristate 86.91
    n-butyric acid 723.55
    acetyl acetate 223.86
    di(2-ethylhexyl) phthalate 104.7
    ethyl propionate 146.47
    nitromethane 1204.44
    1,2-diethoxyethane 226.73
    benzonitrile 282.54
    trioctyl phosphate 72.62
    1-bromopropane 287.63
    gamma-valerolactone 795.53
    n-decanol 122.95
    triethyl phosphate 82.35
    4-methyl-2-pentanol 145.72
    propionitrile 518.8
    vinylene carbonate 331.47
    1,1,2-trichlorotrifluoroethane 716.75
    DMS 166.23
    cumene 61.47
    2-octanol 103.71
    2-hexanone 141.48
    octyl acetate 122.16
    limonene 110.64
    1,2-dimethoxyethane 652.07
    ethyl orthosilicate 80.26
    tributyl phosphate 89.23
    diacetone alcohol 241.86
    N,N-dimethylaniline 155.77
    acrylonitrile 591.56
    aniline 330.75
    1,3-propanediol 928.99
    bromobenzene 195.19
    dibromomethane 693.62
    1,1,2,2-tetrachloroethane 728.92
    2-methyl-cyclohexyl acetate 118.58
    tetrabutyl urea 127.06
    diisobutyl methanol 77.68
    2-phenylethanol 185.81
    styrene 110.5
    dioctyl adipate 147.71
    dimethyl sulfate 187.91
    ethyl butyrate 124.3
    methyl lactate 266.72
    butyl lactate 135.31
    diethyl carbonate 98.31
    propanediol butyl ether 313.71
    triethyl orthoformate 107.11
    p-tert-butyltoluene 63.57
    methyl 4-tert-butylbenzoate 173.42
    morpholine 1267.88
    tert-butylamine 579.92
    n-dodecanol 94.69
    dimethoxymethane 417.61
    ethylene carbonate 276.06
    cyrene 238.28
    2-ethoxyethyl acetate 161.45
    2-ethylhexyl acetate 86.96
    1,2,4-trichlorobenzene 264.7
    4-methylpyridine 480.68
    dibutyl ether 162.81
    2,6-dimethyl-4-heptanol 77.68
    DEF 437.39
    dimethyl isosorbide 321.38
    tetrachloroethylene 537.03
    eugenol 182.91
    triacetin 256.11
    span 80 299.27
    1,4-butanediol 354.22
    1,1-dichloroethane 566.87
    2-methyl-1-pentanol 227.38
    methyl formate 388.59
    2-methyl-1-butanol 415.51
    n-decane 35.38
    butyronitrile 463.41
    3,7-dimethyl-1-octanol 162.87
    1-chlorooctane 97.0
    1-chlorotetradecane 44.52
    n-nonane 35.46
    undecane 26.52
    tert-butylcyclohexane 41.15
    cyclooctane 42.02
    cyclopentanol 702.96
    tetrahydropyran 792.15
    tert-amyl methyl ether 229.73
    2,5,8-trioxanonane 445.95
    1-hexene 172.7
    2-isopropoxyethanol 282.15
    2,2,2-trifluoroethanol 423.62
    methyl butyrate 201.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction