4-(Dimethylamino)cinnamaldehyde

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6203-18-5

    Molecular formula
    C11H13NO

    SMILES
    CN(C)C1=CC=C(C=C1)/C=C/C=O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 60.22%
    Spicy 46.93%
    Floral 46.6%
    Fruity 38.78%
    Green 34.0%
    Cherry 31.46%
    Cinnamon 30.79%
    Powdery 30.34%
    Almond 29.27%
    Vanilla 28.76%

     

    Flavor
    Sweet 58.37%
    Spicy 42.13%
    Cinnamon 40.3%
    Green 37.45%
    Floral 37.36%
    Spice 33.19%
    Oily 32.74%
    Fruity 29.51%
    Cherry 29.34%
    Cocoa 28.51%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    5.36 (weak acid)

    Molecular weight
    175.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    354°C

    Flash point

    • 148.74 ˚C est.

  • Synonyms

    • 4-(Dimethylamino)cinnamaldehyde
    • 6203-18-5
    • 4-Dimethylaminocinnamaldehyde
    • 20432-35-3
    • p-Dimethylaminocinnamaldehyde
    • 2-Propenal, 3-[4-(dimethylamino)phenyl]-, (2E)-
    • 3-(4-(Dimethylamino)phenyl)-2-propenal
    • trans-4-(N,N-dimethylamino)cinnamaldehyde
    • 2-Propenal, 3-(4-(dimethylamino)phenyl)-
    • 9RSI7WZ9F0
    • trans-p-(Dimethylamino)cinnamaldehyde
    • NSC-62138
    • DTXSID9022237
    • Cinnamaldehyde, p-(dimethylamino)-, (E)-
    • 2-Propenal, 3-[4-(dimethylamino)phenyl]-
    • 2-Propenal, 3-(4-(dimethylamino)phenyl)-, (E)-
    • 2-Propenal, 3-(4-(dimethylamino)phenyl)-, (2E)-
    • 3-[4-(Dimethylamino)phenyl]-2-propenal
    • 4-DACA
    • RefChem:515980
    • DTXCID302237
    • 228-267-0
    • 3-(4-(Dimethylamino)phenyl)acrylaldehyde
    • 4-Dimethylcinnamaldehyde
    • p-Dimethylaminocinnamic aldehyde
    • (E)-3-(4-(dimethylamino)phenyl)acrylaldehyde
    • p-(Dimethylamino)cinnamaldehyde
    • (E)-3-[4-(dimethylamino)phenyl]prop-2-enal
    • Cinnamaldehyde, p-(dimethylamino)-
    • MFCD00007002
    • (2E)-3-[4-(dimethylamino)phenyl]prop-2-enal
    • EINECS 228-267-0
    • NSC 62138
    • 3-[4-(dimethylamino)phenyl]acrylaldehyde
    • E-4-(Dimethylamino)cinnamaldehyde
    • 4-(N,N-Dimethylamino)cinnamaldehyde
    • (E)-3-(4-dimethylaminophenyl)prop-2-enal
    • CCRIS 3773
    • (E)-3-[4-(Dimethylamino)phenyl]acrylaldehyde
    • UNII-9RSI7WZ9F0
    • p-N,N-Dimethylaminocinnamaldehyde
    • 4-(Dimethylamino)-trans-cinnamaldehyde; (E)-3-[4-(Dimethylamino)phenyl]-2-propenal; (E)-3-(4-Dimethylaminophenyl)-prop-2-enal; trans-p-(Dimethylamino)cinnamaldehyde;
    • (E)-4-(dimethylamino)cinnamaldehyde
    • SCHEMBL374619
    • 4-Dimethylaminocinnamic aldehyde
    • CHEMBL2299418
    • SCHEMBL28156362
    • DMACA Reagent, for microbiology
    • (N,N-dimethylamino)cinnamaldehyde
    • CHEBI:167815
    • NSC62138
    • SBB067624
    • STL284482
    • trans-4-(Dimethylamino)cinnamaldehyde
    • AKOS003220800
    • CS-W017445
    • FD10898
    • HY-W016729
    • (PARA-DIMETHYLAMINO)CINNAMALDEHYDE
    • AS-14579
    • SY020108
    • SY272356
    • D0648
    • NS00015088
    • ST50827331
    • (E)-3-[4-(dimethylamino)phenyl]-2-propenal
    • D77810
    • EN300-250434
    • EN300-6494221
    • F242631
    • F862145
    • 4-(Dimethylamino)cinnamaldehyde, >=98.0% (HPLC)
    • Q5205585
    • F1967-0937
    • Z3064090061
    • 4-(Dimethylamino)cinnamaldehyde, chromogenic reagent for indoles and flavanols
    • InChI=1/C11H13NO/c1-12(2)11-7-5-10(6-8-11)4-3-9-13/h3-9H,1-2H3/b4-3
    • 6203-18-5

  • Applications

    4-(Dimethylamino)cinnamaldehyde (CAS 6203-18-5) is primarily used as a colorimetric reagent in analytical chemistry, notably in the DMACA assay for polyphenols such as catechins and proanthocyanidins, enabling quantification in foods and plant extracts (e.g., tea, cocoa, wine, fruit extracts) and in quality-control workflows. It is also employed as a chemical intermediate in the synthesis of dyes and pigments, where its conjugated cinnamaldehyde framework provides a versatile building block for colorants and related materials. Additionally, it serves as a functional aldehyde building block in organic synthesis to introduce a para-dimethylamino-styryl motif into target compounds, supporting the development of specialty polymers, sensors, or other functional materials. In practice, use and handling are subject to local regulations and formulation-specific requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 140.25
    methanol 158.24
    isopropanol 57.29
    water 2.71
    ethyl acetate 144.71
    n-propanol 92.05
    acetone 74.09
    n-butanol 67.67
    acetonitrile 100.26
    DMF 219.44
    toluene 41.61
    isobutanol 48.35
    1,4-dioxane 215.76
    methyl acetate 138.81
    THF 146.29
    2-butanone 82.68
    n-pentanol 42.58
    sec-butanol 40.51
    n-hexane 1.83
    ethylene glycol 79.12
    NMP 125.8
    cyclohexane 3.65
    DMSO 187.59
    n-butyl acetate 53.47
    n-octanol 10.31
    chloroform 331.68
    n-propyl acetate 51.83
    acetic acid 165.75
    dichloromethane 345.6
    cyclohexanone 97.2
    propylene glycol 77.44
    isopropyl acetate 45.53
    DMAc 206.52
    2-ethoxyethanol 139.06
    isopentanol 43.73
    n-heptane 2.65
    ethyl formate 90.73
    1,2-dichloroethane 195.65
    n-hexanol 44.41
    2-methoxyethanol 236.46
    isobutyl acetate 31.64
    tetrachloromethane 30.03
    n-pentyl acetate 18.44
    transcutol 302.69
    n-heptanol 15.53
    ethylbenzene 17.91
    MIBK 30.16
    2-propoxyethanol 115.27
    tert-butanol 72.34
    MTBE 42.62
    2-butoxyethanol 45.42
    propionic acid 114.63
    o-xylene 27.97
    formic acid 137.1
    diethyl ether 67.78
    m-xylene 27.71
    p-xylene 21.62
    chlorobenzene 66.93
    dimethyl carbonate 47.93
    n-octane 1.13
    formamide 197.45
    cyclopentanone 111.93
    2-pentanone 51.55
    anisole 60.44
    cyclopentyl methyl ether 60.49
    gamma-butyrolactone 178.96
    1-methoxy-2-propanol 118.15
    pyridine 153.07
    3-pentanone 55.41
    furfural 185.4
    n-dodecane 1.07
    diethylene glycol 137.39
    diisopropyl ether 12.06
    tert-amyl alcohol 47.25
    acetylacetone 70.69
    n-hexadecane 1.19
    acetophenone 55.5
    methyl propionate 113.32
    isopentyl acetate 45.24
    trichloroethylene 382.8
    n-nonanol 10.94
    cyclohexanol 44.65
    benzyl alcohol 60.06
    2-ethylhexanol 24.1
    isooctanol 13.02
    dipropyl ether 30.71
    1,2-dichlorobenzene 66.68
    ethyl lactate 39.63
    propylene carbonate 94.88
    n-methylformamide 143.24
    2-pentanol 29.35
    n-pentane 1.96
    1-propoxy-2-propanol 63.41
    1-methoxy-2-propyl acetate 76.37
    2-(2-methoxypropoxy) propanol 57.07
    mesitylene 15.71
    ε-caprolactone 99.37
    p-cymene 14.8
    epichlorohydrin 237.21
    1,1,1-trichloroethane 128.58
    2-aminoethanol 125.26
    morpholine-4-carbaldehyde 181.65
    sulfolane 164.9
    2,2,4-trimethylpentane 2.43
    2-methyltetrahydrofuran 94.06
    n-hexyl acetate 24.05
    isooctane 1.69
    2-(2-butoxyethoxy)ethanol 72.09
    sec-butyl acetate 34.08
    tert-butyl acetate 46.52
    decalin 3.29
    glycerin 117.44
    diglyme 149.02
    acrylic acid 113.11
    isopropyl myristate 12.25
    n-butyric acid 116.46
    acetyl acetate 66.82
    di(2-ethylhexyl) phthalate 19.0
    ethyl propionate 54.29
    nitromethane 250.96
    1,2-diethoxyethane 77.56
    benzonitrile 53.1
    trioctyl phosphate 11.19
    1-bromopropane 66.52
    gamma-valerolactone 183.66
    n-decanol 9.04
    triethyl phosphate 33.51
    4-methyl-2-pentanol 17.94
    propionitrile 75.54
    vinylene carbonate 106.26
    1,1,2-trichlorotrifluoroethane 205.64
    DMS 49.94
    cumene 14.59
    2-octanol 7.49
    2-hexanone 36.85
    octyl acetate 14.99
    limonene 19.6
    1,2-dimethoxyethane 145.85
    ethyl orthosilicate 32.68
    tributyl phosphate 16.9
    diacetone alcohol 60.57
    N,N-dimethylaniline 38.93
    acrylonitrile 103.85
    aniline 80.74
    1,3-propanediol 120.65
    bromobenzene 60.78
    dibromomethane 171.83
    1,1,2,2-tetrachloroethane 269.6
    2-methyl-cyclohexyl acetate 42.64
    tetrabutyl urea 21.45
    diisobutyl methanol 15.23
    2-phenylethanol 51.78
    styrene 24.47
    dioctyl adipate 25.12
    dimethyl sulfate 76.99
    ethyl butyrate 50.26
    methyl lactate 58.36
    butyl lactate 23.62
    diethyl carbonate 44.45
    propanediol butyl ether 34.85
    triethyl orthoformate 40.4
    p-tert-butyltoluene 13.92
    methyl 4-tert-butylbenzoate 40.7
    morpholine 241.63
    tert-butylamine 37.63
    n-dodecanol 7.53
    dimethoxymethane 118.99
    ethylene carbonate 83.13
    cyrene 66.45
    2-ethoxyethyl acetate 48.46
    2-ethylhexyl acetate 36.28
    1,2,4-trichlorobenzene 83.94
    4-methylpyridine 108.58
    dibutyl ether 16.02
    2,6-dimethyl-4-heptanol 15.23
    DEF 93.36
    dimethyl isosorbide 102.79
    tetrachloroethylene 169.48
    eugenol 46.22
    triacetin 44.65
    span 80 36.12
    1,4-butanediol 46.45
    1,1-dichloroethane 151.88
    2-methyl-1-pentanol 36.09
    methyl formate 108.44
    2-methyl-1-butanol 41.83
    n-decane 1.54
    butyronitrile 61.89
    3,7-dimethyl-1-octanol 14.72
    1-chlorooctane 7.58
    1-chlorotetradecane 3.76
    n-nonane 1.35
    undecane 1.24
    tert-butylcyclohexane 3.39
    cyclooctane 1.48
    cyclopentanol 43.22
    tetrahydropyran 105.7
    tert-amyl methyl ether 34.45
    2,5,8-trioxanonane 109.16
    1-hexene 10.18
    2-isopropoxyethanol 75.43
    2,2,2-trifluoroethanol 82.75
    methyl butyrate 66.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction