4-(Cyclohexyloxy)-4-oxobutanoic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    10018-78-7

    Molecular formula
    C10H16O4

    SMILES
    C1CCC(CC1)OC(=O)CCC(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Fruity 64.55%
    Caramellic 40.41%
    Winey 39.2%
    Fatty 37.55%
    Sweet 36.87%
    Sour 36.68%
    Buttery 36.29%
    Cheesy 30.31%
    Oily 27.95%
    Creamy 27.61%

     

    Flavor
    Odorless 42.6%
    Fruity 37.84%
    Sour 33.2%
    Cheese 27.32%
    Sweet 26.85%
    Fatty 26.7%
    Mild 25.81%
    Very mild 24.52%
    Yeast 23.52%
    Buttery 23.36%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    6.41 (neutral)

    Molecular weight
    200.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    305°C

    Flash point

    • 169.04 ˚C est.

  • Synonyms

    • 4-(cyclohexyloxy)-4-oxobutanoic acid
    • 10018-78-7
    • DTXSID40905242
    • RefChem:1070071
    • DTXCID30201326
    • MFCD00785959
    • 4-cyclohexyloxy-4-oxobutanoic acid
    • Butanedioic acid,1-cyclohexyl ester
    • Cyclohexanol succinate
    • 4-(cyclohexyloxy)-4-oxobutanoate
    • Succinic acid, monocyclohexyl ester
    • BRN 2558695
    • cyclo-hexyl hydrogen succinate
    • SCHEMBL3472508
    • 4-(cyclohexyloxy)-4-oxobutanoicacid
    • STL064937
    • 4-(cyclohexoxy)-4-oxo-butanoic acid
    • AKOS000498440
    • 3-(cyclohexyloxycarbonyl)propanoic acid
    • AS-62514
    • DB-194701
    • CS-0155320
    • ST45045696
    • Butanedioic acid pound not 1-cyclohexyl ester
    • A10964
    • 10018-78-7

  • Applications

    The chemical 4-(Cyclohexyloxy)-4-oxobutanoic acid, CAS 10018-78-7, is primarily an organic synthesis intermediate and building block for gamma-ketoester chemistry, enabling access to more complex cyclohexyl-containing derivatives via esterification and acylation. It is commonly used as a precursor in polymer science as a functionalized monomer or chain extender for polyester and polyurethane formulations used in coatings, adhesives, and related materials. It is also employed as a starting point in pharmaceutical and agrochemical intermediate synthesis to access downstream bioactive scaffolds. Additionally, its dual carboxyl and ketone functionality allows it to participate in specialized synthetic routes, such as masked gamma-ketoester chemistry or Michael-type transformations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 290.82
    methanol 447.48
    isopropanol 188.92
    water 1.4
    ethyl acetate 95.03
    n-propanol 144.52
    acetone 240.71
    n-butanol 109.5
    acetonitrile 127.19
    DMF 790.8
    toluene 15.2
    isobutanol 94.06
    1,4-dioxane 154.15
    methyl acetate 120.83
    THF 286.6
    2-butanone 135.61
    n-pentanol 98.57
    sec-butanol 123.93
    n-hexane 2.33
    ethylene glycol 70.17
    NMP 325.9
    cyclohexane 1.41
    DMSO 1165.35
    n-butyl acetate 91.17
    n-octanol 28.31
    chloroform 100.63
    n-propyl acetate 84.54
    acetic acid 262.48
    dichloromethane 108.23
    cyclohexanone 138.32
    propylene glycol 89.89
    isopropyl acetate 74.05
    DMAc 670.33
    2-ethoxyethanol 259.14
    isopentanol 109.86
    n-heptane 0.93
    ethyl formate 97.26
    1,2-dichloroethane 92.61
    n-hexanol 55.67
    2-methoxyethanol 393.97
    isobutyl acetate 56.57
    tetrachloromethane 10.21
    n-pentyl acetate 44.63
    transcutol 587.28
    n-heptanol 25.38
    ethylbenzene 21.02
    MIBK 74.89
    2-propoxyethanol 154.68
    tert-butanol 237.95
    MTBE 100.25
    2-butoxyethanol 85.53
    propionic acid 127.42
    o-xylene 22.17
    formic acid 182.75
    diethyl ether 53.85
    m-xylene 18.4
    p-xylene 29.9
    chlorobenzene 32.11
    dimethyl carbonate 52.01
    n-octane 0.82
    formamide 325.51
    cyclopentanone 227.36
    2-pentanone 97.41
    anisole 79.74
    cyclopentyl methyl ether 69.74
    gamma-butyrolactone 294.54
    1-methoxy-2-propanol 257.79
    pyridine 100.99
    3-pentanone 55.96
    furfural 286.65
    n-dodecane 1.1
    diethylene glycol 171.24
    diisopropyl ether 15.66
    tert-amyl alcohol 162.92
    acetylacetone 157.89
    n-hexadecane 1.26
    acetophenone 93.55
    methyl propionate 82.13
    isopentyl acetate 93.69
    trichloroethylene 172.58
    n-nonanol 26.64
    cyclohexanol 55.12
    benzyl alcohol 90.66
    2-ethylhexanol 32.23
    isooctanol 24.14
    dipropyl ether 21.39
    1,2-dichlorobenzene 42.34
    ethyl lactate 58.96
    propylene carbonate 153.67
    n-methylformamide 289.63
    2-pentanol 65.28
    n-pentane 1.17
    1-propoxy-2-propanol 100.01
    1-methoxy-2-propyl acetate 105.7
    2-(2-methoxypropoxy) propanol 122.32
    mesitylene 13.52
    ε-caprolactone 143.57
    p-cymene 13.37
    epichlorohydrin 251.04
    1,1,1-trichloroethane 50.35
    2-aminoethanol 154.02
    morpholine-4-carbaldehyde 328.73
    sulfolane 408.22
    2,2,4-trimethylpentane 2.27
    2-methyltetrahydrofuran 140.87
    n-hexyl acetate 65.02
    isooctane 1.5
    2-(2-butoxyethoxy)ethanol 164.33
    sec-butyl acetate 60.25
    tert-butyl acetate 92.31
    decalin 3.46
    glycerin 144.18
    diglyme 285.51
    acrylic acid 120.14
    isopropyl myristate 26.59
    n-butyric acid 146.82
    acetyl acetate 73.26
    di(2-ethylhexyl) phthalate 39.18
    ethyl propionate 63.18
    nitromethane 415.87
    1,2-diethoxyethane 96.83
    benzonitrile 77.31
    trioctyl phosphate 24.45
    1-bromopropane 32.52
    gamma-valerolactone 320.06
    n-decanol 19.82
    triethyl phosphate 39.35
    4-methyl-2-pentanol 43.13
    propionitrile 71.11
    vinylene carbonate 129.08
    1,1,2-trichlorotrifluoroethane 230.17
    DMS 72.58
    cumene 18.48
    2-octanol 18.81
    2-hexanone 82.77
    octyl acetate 33.7
    limonene 16.5
    1,2-dimethoxyethane 334.05
    ethyl orthosilicate 35.08
    tributyl phosphate 36.72
    diacetone alcohol 150.21
    N,N-dimethylaniline 64.46
    acrylonitrile 108.63
    aniline 51.03
    1,3-propanediol 199.99
    bromobenzene 28.37
    dibromomethane 59.64
    1,1,2,2-tetrachloroethane 151.31
    2-methyl-cyclohexyl acetate 55.12
    tetrabutyl urea 49.0
    diisobutyl methanol 21.44
    2-phenylethanol 60.09
    styrene 25.76
    dioctyl adipate 52.41
    dimethyl sulfate 139.26
    ethyl butyrate 58.78
    methyl lactate 84.46
    butyl lactate 59.37
    diethyl carbonate 47.82
    propanediol butyl ether 113.52
    triethyl orthoformate 44.0
    p-tert-butyltoluene 12.96
    methyl 4-tert-butylbenzoate 77.46
    morpholine 216.55
    tert-butylamine 89.55
    n-dodecanol 14.59
    dimethoxymethane 191.42
    ethylene carbonate 102.16
    cyrene 116.33
    2-ethoxyethyl acetate 81.37
    2-ethylhexyl acetate 63.43
    1,2,4-trichlorobenzene 56.65
    4-methylpyridine 115.03
    dibutyl ether 30.04
    2,6-dimethyl-4-heptanol 21.44
    DEF 143.69
    dimethyl isosorbide 179.64
    tetrachloroethylene 83.19
    eugenol 82.62
    triacetin 92.08
    span 80 86.5
    1,4-butanediol 92.45
    1,1-dichloroethane 64.06
    2-methyl-1-pentanol 95.25
    methyl formate 168.5
    2-methyl-1-butanol 93.45
    n-decane 1.67
    butyronitrile 82.43
    3,7-dimethyl-1-octanol 37.41
    1-chlorooctane 10.55
    1-chlorotetradecane 4.83
    n-nonane 1.34
    undecane 1.32
    tert-butylcyclohexane 3.58
    cyclooctane 0.72
    cyclopentanol 85.45
    tetrahydropyran 79.61
    tert-amyl methyl ether 74.2
    2,5,8-trioxanonane 212.77
    1-hexene 16.52
    2-isopropoxyethanol 156.89
    2,2,2-trifluoroethanol 92.62
    methyl butyrate 102.83

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction