4-Cumylphenol

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  • Identifiers

    CAS number
    599-64-4

    Molecular formula
    C15H16O

    SMILES
    CC(C)(C1=CC=CC=C1)C2=CC=C(C=C2)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 56.85%
    Spicy 48.19%
    Leathery 45.1%
    Animal 38.31%
    Medicinal 34.69%
    Woody 34.0%
    Herbal 30.03%
    Smoky 29.35%
    Dry 26.34%
    Burnt 24.31%

     

    Flavor
    Woody 37.33%
    Medicinal 33.98%
    Phenolic 33.28%
    Camphor 29.75%
    Spice 28.84%
    Herbal 23.73%
    Creosote 22.11%
    Guaiacol 22.07%
    Herb 20.88%
    Leather 20.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.7

    pKa est.
    9.4 (weak base)

    Molecular weight
    212.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 74.5 °C

    Boiling point

    • 335 °C

    Flash point

    • 158.05 ˚C est.

  • Synonyms

    • 4-Cumylphenol
    • 599-64-4
    • p-Cumylphenol
    • Phenol, 4-(1-methyl-1-phenylethyl)-
    • 4-(Dimethylphenylmethyl)phenol
    • 4-Hydroxydiphenyldimethylmethane
    • 2-Phenyl-2-(4-hydroxyphenyl)propane
    • p-(alpha,alpha-Dimethylbenzyl)phenol
    • Phenol, 4-(1-methyl-1-phenethyl)-
    • 2RLA3OL3QT
    • 4-(1-methyl-1-phenyl-ethyl)phenol
    • DTXSID3022536
    • NSC-6237
    • Phenol, p-(alpha,alpha-dimethylbenzyl)-
    • DTXCID502536
    • p-[alpha,alpha-dimethylbenzyl)phenol
    • RefChem:858043
    • 209-968-0
    • 4-(2-phenylpropan-2-yl)phenol
    • 4-alpha-Cumylphenol
    • 4-(1-Methyl-1-phenylethyl)phenol
    • p-Cumyl phenol
    • 4-(2-PHENYLISOPROPYL)PHENOL
    • 2-Phenyl-2-(p-hydroxyphenyl)propane
    • 4-(alpha,alpha-Dimethylbenzyl)phenol
    • MFCD00002365
    • paracumylphenol
    • p-(.alpha.-Cumyl)phenol
    • NSC 6237
    • Phenol, p-(.alpha.,.alpha.-dimethylbenzyl)-
    • p-(.alpha.,.alpha.-Dimethylbenzyl)phenol
    • 4-(.alpha.,.alpha.-Dimethylbenzyl)phenol
    • 4-(1-Methyl-1-phenylethyl)-phenol
    • 2-(4'-Hydroxyphenyl)-2-phenylpropane
    • p-(alpha-Cumenyl)phenol
    • CAS-599-64-4
    • 4-(1-Methyl-1-phenethyl)phenol
    • EINECS 209-968-0
    • UNII-2RLA3OL3QT
    • BRN 1870517
    • p-Hydroxy-2,2-diphenylpropane
    • para-cumylphenol
    • AI3-08269
    • CCRIS 8908
    • p--cumylphenol
    • HSDB 8089
    • 2zas
    • 4-|A-Cumylphenol
    • 4-Cumylphenol, 99%
    • 2-(4-HYDROXYPHENYL)-2-PHENYLPROPANE
    • EC 209-968-0
    • Cambridge id 5142949
    • p-(.alpha.-Cumenyl)phenol
    • TimTec1_002380
    • p-(2-Phenylisopropyl)phenol
    • SCHEMBL51117
    • BIDD:ER0173
    • SCHEMBL269424
    • 4-(2-Phenylisopropyl) phenol
    • 4-.ALPHA.-CUMYLPHENOL
    • [1, ar'-(1-methylethyl)-
    • CHEMBL194805
    • orb1301639
    • SCHEMBL2192097
    • SCHEMBL4388664
    • SCHEMBL8150717
    • BDBM29609
    • CHEBI:35092
    • Phenol,.alpha.-dimethylbenzyl)-
    • NSC6237
    • HMS1540M04
    • HMS3604L17
    • KUC105982N
    • AAA59964
    • 4-(1-methyl-1-phenylethyl) phenol
    • Tox21_201297
    • Tox21_300056
    • EBC-03631
    • SBB043700
    • STK831902
    • 4-(1-Methyl-1-phenyl-ethyl)-phenol
    • AKOS000120751
    • MSK9315-1000M
    • CS-W014998
    • DB06902
    • HY-W014282
    • KSC-19-030
    • PHENYLISOPROPYL)PHENOL, 4-(2-
    • NCGC00090941-01
    • NCGC00090941-02
    • NCGC00090941-03
    • NCGC00090941-04
    • NCGC00090941-05
    • NCGC00253961-01
    • NCGC00258849-01
    • AS-57116
    • ST029283
    • SY049300
    • DB-072734
    • NS00009362
    • EN300-17891
    • E83013
    • 4-Cumylphenol Solution in Methanol, 1000ug/mL
    • F094614
    • BRD-K94049994-001-01-5
    • Q27095806
    • Z57068819
    • F0020-1559
    • 2-(4'-Hydroxyphenyl)-2-phenylpropane; 4-alpha-Cumylphenol
    • 1OH
    • 599-64-4

  • Applications

    4-Cumylphenol (CAS 599-64-4) is a bulky aryl phenol used primarily as an intermediate and building block in the manufacture of polymer stabilizers and antioxidants (including hindered phenolics) and UV stabilizers for plastics. It is also employed in fragrance chemistry as a specialty starting material and may serve as a processing aid or reactive intermediate in coatings, inks, and adhesive formulations. Depending on local regulations and formulation limits, it may be used as a precursor for other specialty chemicals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3447.39
    methanol 3068.55
    isopropanol 1227.54
    water 0.43
    ethyl acetate 3959.3
    n-propanol 3112.7
    acetone 3758.71
    n-butanol 1531.17
    acetonitrile 3548.73
    DMF 3306.98
    toluene 554.23
    isobutanol 922.35
    1,4-dioxane 3190.83
    methyl acetate 2953.39
    THF 4835.53
    2-butanone 3572.84
    n-pentanol 489.45
    sec-butanol 784.34
    n-hexane 26.3
    ethylene glycol 167.03
    NMP 761.55
    cyclohexane 35.55
    DMSO 1541.55
    n-butyl acetate 904.47
    n-octanol 120.02
    chloroform 1385.85
    n-propyl acetate 896.69
    acetic acid 452.48
    dichloromethane 1791.61
    cyclohexanone 1615.99
    propylene glycol 291.0
    isopropyl acetate 1289.41
    DMAc 1380.94
    2-ethoxyethanol 1098.51
    isopentanol 594.72
    n-heptane 27.09
    ethyl formate 1068.31
    1,2-dichloroethane 2033.46
    n-hexanol 546.39
    2-methoxyethanol 2560.14
    isobutyl acetate 403.76
    tetrachloromethane 121.75
    n-pentyl acetate 282.71
    transcutol 2593.53
    n-heptanol 154.97
    ethylbenzene 186.53
    MIBK 744.24
    2-propoxyethanol 1362.24
    tert-butanol 917.38
    MTBE 1671.08
    2-butoxyethanol 405.05
    propionic acid 893.55
    o-xylene 178.97
    formic acid 188.44
    diethyl ether 4557.89
    m-xylene 254.47
    p-xylene 175.85
    chlorobenzene 486.86
    dimethyl carbonate 795.56
    n-octane 10.84
    formamide 1216.58
    cyclopentanone 2819.78
    2-pentanone 2836.87
    anisole 721.55
    cyclopentyl methyl ether 1395.87
    gamma-butyrolactone 2590.56
    1-methoxy-2-propanol 1601.98
    pyridine 2019.28
    3-pentanone 1935.93
    furfural 1008.89
    n-dodecane 7.94
    diethylene glycol 565.26
    diisopropyl ether 422.71
    tert-amyl alcohol 614.71
    acetylacetone 1537.25
    n-hexadecane 9.6
    acetophenone 393.7
    methyl propionate 2981.39
    isopentyl acetate 586.37
    trichloroethylene 2372.76
    n-nonanol 110.43
    cyclohexanol 366.38
    benzyl alcohol 323.41
    2-ethylhexanol 208.03
    isooctanol 122.29
    dipropyl ether 760.24
    1,2-dichlorobenzene 289.62
    ethyl lactate 202.64
    propylene carbonate 728.48
    n-methylformamide 3209.42
    2-pentanol 614.81
    n-pentane 27.75
    1-propoxy-2-propanol 699.51
    1-methoxy-2-propyl acetate 859.0
    2-(2-methoxypropoxy) propanol 296.27
    mesitylene 119.67
    ε-caprolactone 1194.16
    p-cymene 81.37
    epichlorohydrin 3918.45
    1,1,1-trichloroethane 896.02
    2-aminoethanol 774.44
    morpholine-4-carbaldehyde 1198.9
    sulfolane 1440.48
    2,2,4-trimethylpentane 18.72
    2-methyltetrahydrofuran 2466.0
    n-hexyl acetate 382.56
    isooctane 18.67
    2-(2-butoxyethoxy)ethanol 514.56
    sec-butyl acetate 481.74
    tert-butyl acetate 922.93
    decalin 24.14
    glycerin 262.28
    diglyme 1175.45
    acrylic acid 457.79
    isopropyl myristate 123.5
    n-butyric acid 1166.56
    acetyl acetate 750.18
    di(2-ethylhexyl) phthalate 89.98
    ethyl propionate 953.28
    nitromethane 2462.94
    1,2-diethoxyethane 1266.84
    benzonitrile 408.44
    trioctyl phosphate 69.59
    1-bromopropane 938.07
    gamma-valerolactone 2365.02
    n-decanol 81.2
    triethyl phosphate 139.42
    4-methyl-2-pentanol 204.78
    propionitrile 2756.86
    vinylene carbonate 624.12
    1,1,2-trichlorotrifluoroethane 715.49
    DMS 411.17
    cumene 97.01
    2-octanol 86.32
    2-hexanone 768.28
    octyl acetate 153.31
    limonene 126.08
    1,2-dimethoxyethane 1799.11
    ethyl orthosilicate 138.86
    tributyl phosphate 100.29
    diacetone alcohol 714.5
    N,N-dimethylaniline 246.51
    acrylonitrile 2382.77
    aniline 686.17
    1,3-propanediol 911.28
    bromobenzene 462.56
    dibromomethane 946.74
    1,1,2,2-tetrachloroethane 1323.92
    2-methyl-cyclohexyl acetate 249.9
    tetrabutyl urea 112.85
    diisobutyl methanol 119.12
    2-phenylethanol 327.92
    styrene 257.33
    dioctyl adipate 167.32
    dimethyl sulfate 665.06
    ethyl butyrate 588.19
    methyl lactate 414.6
    butyl lactate 184.79
    diethyl carbonate 300.96
    propanediol butyl ether 238.21
    triethyl orthoformate 267.76
    p-tert-butyltoluene 88.51
    methyl 4-tert-butylbenzoate 233.03
    morpholine 4280.62
    tert-butylamine 501.41
    n-dodecanol 60.4
    dimethoxymethane 3744.56
    ethylene carbonate 612.66
    cyrene 245.23
    2-ethoxyethyl acetate 583.22
    2-ethylhexyl acetate 415.45
    1,2,4-trichlorobenzene 344.72
    4-methylpyridine 1360.95
    dibutyl ether 320.1
    2,6-dimethyl-4-heptanol 119.12
    DEF 1826.93
    dimethyl isosorbide 574.13
    tetrachloroethylene 698.51
    eugenol 223.26
    triacetin 299.08
    span 80 202.16
    1,4-butanediol 168.11
    1,1-dichloroethane 1457.65
    2-methyl-1-pentanol 280.33
    methyl formate 1489.0
    2-methyl-1-butanol 579.58
    n-decane 15.52
    butyronitrile 1878.0
    3,7-dimethyl-1-octanol 132.81
    1-chlorooctane 96.15
    1-chlorotetradecane 31.36
    n-nonane 14.44
    undecane 10.82
    tert-butylcyclohexane 27.62
    cyclooctane 14.46
    cyclopentanol 509.6
    tetrahydropyran 3401.09
    tert-amyl methyl ether 766.48
    2,5,8-trioxanonane 586.02
    1-hexene 241.45
    2-isopropoxyethanol 529.9
    2,2,2-trifluoroethanol 142.84
    methyl butyrate 959.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction