4-Chlorotoluene

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  • Identifiers

    CAS number
    106-43-4

    Molecular formula
    C7H7Cl

    SMILES
    CC1=CC=C(C=C1)Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 65.72%
    Sweet 46.59%
    Woody 45.68%
    Phenolic 41.47%
    Green 40.6%
    Animal 35.25%
    Rose 32.7%
    Earthy 30.95%
    Leathery 29.53%
    Oily 29.12%

     

    Flavor
    Phenolic 51.4%
    Medicinal 42.16%
    Plastic 30.92%
    Phenol 29.95%
    Meaty 29.3%
    Sulfurous 26.83%
    Naphthyl 24.87%
    Guaiacol 24.27%
    Smoke 23.63%
    Penetrating 23.07%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.05 [mmHg]. [ICSC] Odor threshold from CHEMINFO

  • Properties

    XLogP3-AA
    3.3

    pKa est.
    6.9 (neutral)

    Molecular weight
    126.58 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • 45.5 °F (NTP, 1992)
    • 7.5 °C

    Boiling point

    • 323.4 °F at 760 mmHg (NTP, 1992)
    • 162.4 °C
    • 162 °C

    Flash point

    • 66.84 ˚C est.
    • 121 °F (NTP, 1992)
    • 49 °C
    • 140 °F, open cup

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • SOL IN ALCOHOL, BENZENE
    • SOL IN ACETIC ACID
    • >10% in ethyl ether
    • >10% in ethanol
    • For more Solubility (Complete) data for 4-CHLOROTOLUENE (9 total), please visit the HSDB record page.
    • Solubility in water, g/100ml at 20 °C: 0.01

  • Synonyms

    • 4-Chlorotoluene
    • 106-43-4
    • 1-Chloro-4-methylbenzene
    • P-CHLOROTOLUENE
    • Benzene, 1-chloro-4-methyl-
    • p-Tolyl chloride
    • Toluene, p-chloro-
    • 1-Methyl-4-chlorobenzene
    • 4-Chloro-1-methylbenzene
    • 4-methylchlorobenzene
    • para-Chlorotoluene
    • CCRIS 6000
    • NSC 404114
    • HSDB 1343
    • 4-tolyl chloride
    • EINECS 203-397-0
    • UNII-Q8R236H42N
    • DTXSID8024814
    • AI3-16045
    • TOLUENE,4-CHLORO
    • CHLOROTOLUENE, P-
    • NSC-404114
    • P-CHLOROTOLUENE [MI]
    • 1-chloranyl-4-methyl-benzene
    • DTXCID904814
    • 4-CHLOROTOLUENE [HSDB]
    • CHEBI:34401
    • EC 203-397-0
    • Q8R236H42N
    • Monochlorotoluene
    • CAS-106-43-4
    • 4-methyl-chlorobenzene
    • Benzene,1-chloro-4-methyl
    • Chlorotoluenes
    • pChlorotoluene
    • p-chlortoluene
    • pTolyl chloride
    • ar-Chlorotoluene
    • Toluene, pchloro
    • parachloro toluene
    • 1Chloro4methylbenzene
    • 1Methyl4chlorobenzene
    • 4Chloro1methylbenzene
    • Oxsol 10
    • p-methyphenyl chloride
    • p-methylphenyl chloride
    • 4-methylphenyl chloride
    • TOLUENE,P-CHLORO
    • Benzene, 1chloro4methyl
    • 4-Chlorotoluene, 98%
    • TOLUENE, P-CHLORO
    • PARA-TOLYL CHLORIDE
    • 1-chloro-4-methyl-benzene
    • P-CHLOROMETHYLBENZENE
    • P-METHYLCHLOROBENZENE
    • WLN: GR D1
    • SCHEMBL12679
    • BIDD:ER0277
    • CHEMBL1797268
    • 4-Chlorotoluene, analytical standard
    • Tox21_201408
    • Tox21_300346
    • MFCD00000631
    • NSC404114
    • STL280325
    • AKOS000120044
    • FC63430
    • NCGC00090812-01
    • NCGC00090812-02
    • NCGC00090812-03
    • NCGC00254345-01
    • NCGC00258959-01
    • AC-14711
    • BS-23242
    • 4-Chlorotoluene 100 microg/mL in Methanol
    • 4-Chlorotoluene, purum, >=99.0% (GC)
    • NS00003921
    • S0660
    • EN300-17395
    • p-Chlorotoluene [UN2238] [Flammable liquid]
    • 4-Chlorotoluene, PESTANAL(R), analytical standard
    • Q22328364
    • Z56924546
    • F0001-0121
    • C4O

  • Applications

    4-Chlorotoluene is primarily used as an industrial chemical intermediate and feedstock. It serves as a precursor to aryl amines such as p-chloroaniline, supporting the production of dyes and pigments. It can be oxidized to 4-chlorobenzoic acid and subsequently transformed into intermediates for agrochemicals and pharmaceutical synthesis. In multi-step syntheses, it provides building blocks for aromatic compounds used in coatings, inks, and specialty polymers. The material is typically handled as a reactive intermediate within regulated manufacturing processes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 68.02
    methanol 39.48
    isopropanol 54.13
    water 0.19
    ethyl acetate 175.82
    n-propanol 69.01
    acetone 159.47
    n-butanol 59.52
    acetonitrile 124.02
    DMF 163.93
    toluene 131.23
    isobutanol 46.56
    1,4-dioxane 254.67
    methyl acetate 209.44
    THF 253.85
    2-butanone 256.31
    n-pentanol 56.54
    sec-butanol 71.74
    n-hexane 12.41
    ethylene glycol 12.92
    NMP 98.84
    cyclohexane 9.91
    DMSO 84.27
    n-butyl acetate 156.22
    n-octanol 60.87
    chloroform 293.86
    n-propyl acetate 116.75
    acetic acid 48.49
    dichloromethane 247.76
    cyclohexanone 140.35
    propylene glycol 27.22
    isopropyl acetate 99.31
    DMAc 220.83
    2-ethoxyethanol 106.34
    isopentanol 57.71
    n-heptane 19.79
    ethyl formate 70.92
    1,2-dichloroethane 160.24
    n-hexanol 91.17
    2-methoxyethanol 114.62
    isobutyl acetate 85.51
    tetrachloromethane 42.06
    n-pentyl acetate 89.33
    transcutol 440.66
    n-heptanol 55.78
    ethylbenzene 96.28
    MIBK 89.87
    2-propoxyethanol 153.69
    tert-butanol 74.23
    MTBE 131.18
    2-butoxyethanol 107.22
    propionic acid 63.87
    o-xylene 79.53
    formic acid 12.12
    diethyl ether 132.25
    m-xylene 80.2
    p-xylene 106.84
    chlorobenzene 116.36
    dimethyl carbonate 63.54
    n-octane 11.25
    formamide 29.51
    cyclopentanone 171.01
    2-pentanone 126.37
    anisole 214.32
    cyclopentyl methyl ether 95.2
    gamma-butyrolactone 151.42
    1-methoxy-2-propanol 103.18
    pyridine 272.68
    3-pentanone 127.52
    furfural 172.96
    n-dodecane 9.32
    diethylene glycol 80.99
    diisopropyl ether 40.84
    tert-amyl alcohol 85.15
    acetylacetone 156.92
    n-hexadecane 10.6
    acetophenone 156.59
    methyl propionate 131.98
    isopentyl acetate 141.77
    trichloroethylene 379.74
    n-nonanol 55.29
    cyclohexanol 43.77
    benzyl alcohol 92.38
    2-ethylhexanol 74.76
    isooctanol 50.48
    dipropyl ether 104.07
    1,2-dichlorobenzene 101.64
    ethyl lactate 46.97
    propylene carbonate 94.25
    n-methylformamide 66.79
    2-pentanol 49.27
    n-pentane 8.57
    1-propoxy-2-propanol 128.55
    1-methoxy-2-propyl acetate 159.18
    2-(2-methoxypropoxy) propanol 130.03
    mesitylene 47.27
    ε-caprolactone 127.36
    p-cymene 60.96
    epichlorohydrin 262.54
    1,1,1-trichloroethane 192.27
    2-aminoethanol 31.96
    morpholine-4-carbaldehyde 178.76
    sulfolane 112.55
    2,2,4-trimethylpentane 9.77
    2-methyltetrahydrofuran 178.62
    n-hexyl acetate 129.63
    isooctane 8.27
    2-(2-butoxyethoxy)ethanol 159.1
    sec-butyl acetate 91.25
    tert-butyl acetate 119.2
    decalin 15.9
    glycerin 32.61
    diglyme 308.59
    acrylic acid 51.92
    isopropyl myristate 61.52
    n-butyric acid 70.94
    acetyl acetate 101.89
    di(2-ethylhexyl) phthalate 52.95
    ethyl propionate 101.93
    nitromethane 124.69
    1,2-diethoxyethane 217.12
    benzonitrile 109.1
    trioctyl phosphate 33.0
    1-bromopropane 105.26
    gamma-valerolactone 214.3
    n-decanol 43.06
    triethyl phosphate 54.56
    4-methyl-2-pentanol 40.19
    propionitrile 112.67
    vinylene carbonate 98.89
    1,1,2-trichlorotrifluoroethane 140.19
    DMS 116.64
    cumene 62.58
    2-octanol 46.01
    2-hexanone 137.22
    octyl acetate 74.41
    limonene 70.61
    1,2-dimethoxyethane 213.08
    ethyl orthosilicate 57.07
    tributyl phosphate 43.37
    diacetone alcohol 121.19
    N,N-dimethylaniline 133.4
    acrylonitrile 129.07
    aniline 99.01
    1,3-propanediol 46.32
    bromobenzene 135.84
    dibromomethane 160.6
    1,1,2,2-tetrachloroethane 253.03
    2-methyl-cyclohexyl acetate 96.15
    tetrabutyl urea 58.62
    diisobutyl methanol 51.76
    2-phenylethanol 120.58
    styrene 114.04
    dioctyl adipate 80.48
    dimethyl sulfate 80.67
    ethyl butyrate 113.51
    methyl lactate 52.3
    butyl lactate 64.34
    diethyl carbonate 77.83
    propanediol butyl ether 84.65
    triethyl orthoformate 84.25
    p-tert-butyltoluene 61.24
    methyl 4-tert-butylbenzoate 118.67
    morpholine 227.64
    tert-butylamine 45.41
    n-dodecanol 35.11
    dimethoxymethane 128.75
    ethylene carbonate 72.34
    cyrene 93.5
    2-ethoxyethyl acetate 160.05
    2-ethylhexyl acetate 126.36
    1,2,4-trichlorobenzene 137.17
    4-methylpyridine 228.36
    dibutyl ether 100.72
    2,6-dimethyl-4-heptanol 51.76
    DEF 111.34
    dimethyl isosorbide 224.47
    tetrachloroethylene 141.21
    eugenol 123.33
    triacetin 125.37
    span 80 97.92
    1,4-butanediol 23.6
    1,1-dichloroethane 175.42
    2-methyl-1-pentanol 61.74
    methyl formate 54.3
    2-methyl-1-butanol 57.9
    n-decane 15.08
    butyronitrile 86.43
    3,7-dimethyl-1-octanol 70.95
    1-chlorooctane 59.17
    1-chlorotetradecane 26.12
    n-nonane 15.13
    undecane 11.34
    tert-butylcyclohexane 19.16
    cyclooctane 6.43
    cyclopentanol 45.59
    tetrahydropyran 169.8
    tert-amyl methyl ether 109.78
    2,5,8-trioxanonane 221.22
    1-hexene 56.18
    2-isopropoxyethanol 95.39
    2,2,2-trifluoroethanol 22.83
    methyl butyrate 119.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction