4-Chloro-3,5-dimethylphenol

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  • Identifiers

    CAS number
    88-04-0

    Molecular formula
    C8H9ClO

    SMILES
    CC1=CC(=CC(=C1Cl)C)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 65.61%
    Woody 56.53%
    Spicy 43.08%
    Dry 39.36%
    Smoky 39.13%
    Medicinal 38.03%
    Leathery 37.5%
    Burnt 34.16%
    Sweet 33.91%
    Animal 31.64%

     

    Flavor
    Bitter 43.78%
    Phenolic 41.46%
    Medicinal 28.64%
    Mild 28.07%
    Musty 26.22%
    Flat 25.07%
    Smoke 24.26%
    Soybean 22.83%
    Thymol 22.59%
    Very strong 22.54%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    8.69 (weak base)

    Molecular weight
    156.61 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 112-116 degrees Celsius
    • 115.5 °C

    Boiling point

    • 246 degrees Celsius
    • 246 °C

    Flash point

    • 111.97 ˚C est.

    Solubility expt.

    • 0.03 g/100ml at 15 degrees Celsius, 0.5 g/100ml at 100 degrees Celsius
    • At 15 °C in petroleum ether, benzene, acetone, toluene, chloroform, isopropanol solubility of 0.5, 6.0, 58.0, 7.0, 6.2, 38.0 g/100mL, respectively. At 25 °C in isopropanol, 1 M NaOH and glycerine solubility of 50.0, 8.8 and 1.5, respectively.
    • Soluble in ethanol, ether. Slightly soluble in benzene and pet ether.
    • Soluble 1 part of 95% alcohol, ether, benzene, terpenes fixed oils, solutions of alkali and hydroxides
    • In water, 2.5X10+2 mg/L at 20 °C

  • Synonyms

    • 4-Chloro-3,5-dimethylphenol
    • chloroxylenol
    • 88-04-0
    • PCMX
    • 4-Chloro-3,5-xylenol
    • Benzytol
    • p-Chloro-m-xylenol
    • Ottasept
    • parachlorometaxylenol
    • 2-Chloro-m-xylenol
    • 4-Chloro-m-xylenol
    • Desson
    • Espadol
    • Chloro-xylenol
    • Ottasept Extra
    • Phenol, 4-chloro-3,5-dimethyl-
    • Husept Extra
    • Willenol V
    • 3,5-Dimethyl-4-chlorophenol
    • p-Chloro-3,5-xylenol
    • Cloroxilenol
    • Septiderm-Hydrochloride
    • Chloroxylenolum
    • Chlorxylenolum
    • Dettol, liquid antiseptic
    • 2-Chloro-5-hydroxy-m-xylene
    • Nipacide MX
    • Clorossilenolo
    • RBA 777
    • 2-Chloro-5-hydroxy-1,3-dimethylbenzene
    • 4-Chloro-1-hydroxy-3,5-dimethylbenzene
    • Parachlorometoxylenol
    • DTXSID0032316
    • NSC-4971
    • 0F32U78V2Q
    • DTXCID8012316
    • CHEBI:34393
    • chlorxylenol
    • choroxylenol
    • dishwashing
    • Chemseptic
    • Chloroxyenol
    • Pearlescent
    • Lagarde
    • Prevent
    • Vitavie
    • Secure
    • AloeGuard
    • DishWorks
    • PowerHouse
    • Sysco
    • Ultra
    • hobby wash
    • PurKlenz
    • Antiseptic Hand
    • Ecolab Keystone
    • PurSan
    • VioNex
    • Maxim Assure
    • Micro-Aseptic
    • Skin Cleanser
    • Acute-Kare
    • Fresh Start
    • Golden Medicated
    • Klean-Hands
    • Medi-Hands
    • Tattoo Goo
    • TenderLaven Hand
    • VioNex Towelette
    • CarrollCLEAN
    • Chemstation E2
    • DigiClean E
    • Gold and Sudsy
    • Absorbine Hooflex
    • Antibacterial Bar
    • Clorox Oxi Dish
    • Well and Good
    • Ecolab Inc.
    • Rushing FAHS
    • Absorbine Fungasol
    • Antibacterial Foam
    • Antibacterial Hand
    • Antibacterial Soap
    • Ban-Aid
    • Hand Antibacterial
    • Hi-Tech
    • Lynx Antibacterial
    • Purgo Ultra PC
    • Servo-Stat P
    • Surgent Antiseptic
    • Zep Applaud AB
    • Clorox Lemon Dish
    • Germ A Stat
    • Kindest Kare Hand
    • Maxim FDF
    • Mosaic Lemon Hand
    • Antibacterial Green
    • PureBac Foam Wash
    • Ecolab Clean Force
    • Kay McD
    • Anti-bacterial Hand
    • SoftCIDE-ES
    • Antifungal Medicated
    • Antimicrobial 652
    • Clorox Antibacterial
    • Clorox Antimicrobial
    • Footbath Concentrate
    • Orange Chloroxylenol
    • PCMX, Hand Soap
    • CaseysDishwashingSoap
    • WhiskCare 362
    • WhiskCare 365
    • WhiskCare 367
    • Bd E-Z Scrub
    • NorthWoods PowerPlay
    • AMERIWASH
    • Champion Ultra Clean
    • CHEMSTAR
    • DERMAKLEEN
    • KLEENFOAM
    • Maxim Anti-Bacterial
    • Mosaic Lavender Hand
    • PALM
    • PCMX with Emollient
    • PERIGIENE
    • PMCX
    • SEPTISURGE
    • 88-04-0

  • Applications

    4-Chloro-3,5-dimethylphenol (CAS 88-04-0), commonly known as para-chloro-meta-xylenol (PCMX), is used primarily as an antimicrobial preservative and antiseptic in cosmetics and personal care products such as soaps, hand washes, and wipes. It also serves as a disinfectant additive in household and industrial cleaning formulations. In chemical manufacturing, it functions as a building block or intermediate for the synthesis of other specialty phenolic compounds, dyes, and polymer-related additives. Its use is governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1306.0
    methanol 1378.5
    isopropanol 905.37
    water 2.41
    ethyl acetate 914.59
    n-propanol 961.38
    acetone 1322.89
    n-butanol 821.6
    acetonitrile 940.9
    DMF 1252.8
    toluene 360.02
    isobutanol 584.77
    1,4-dioxane 2606.12
    methyl acetate 728.0
    THF 4024.86
    2-butanone 861.59
    n-pentanol 607.82
    sec-butanol 633.38
    n-hexane 162.87
    ethylene glycol 164.6
    NMP 851.46
    cyclohexane 139.91
    DMSO 1184.01
    n-butyl acetate 526.25
    n-octanol 228.82
    chloroform 942.51
    n-propyl acetate 476.76
    acetic acid 503.14
    dichloromethane 990.51
    cyclohexanone 1051.75
    propylene glycol 174.22
    isopropyl acetate 466.61
    DMAc 456.17
    2-ethoxyethanol 853.7
    isopentanol 569.32
    n-heptane 113.6
    ethyl formate 548.2
    1,2-dichloroethane 781.28
    n-hexanol 691.66
    2-methoxyethanol 1302.31
    isobutyl acetate 271.87
    tetrachloromethane 243.89
    n-pentyl acetate 314.84
    transcutol 1256.38
    n-heptanol 264.84
    ethylbenzene 160.36
    MIBK 492.2
    2-propoxyethanol 1140.74
    tert-butanol 950.79
    MTBE 895.39
    2-butoxyethanol 458.86
    propionic acid 407.99
    o-xylene 153.55
    formic acid 239.74
    diethyl ether 1692.55
    m-xylene 244.13
    p-xylene 168.52
    chlorobenzene 350.08
    dimethyl carbonate 299.2
    n-octane 40.0
    formamide 487.95
    cyclopentanone 1427.49
    2-pentanone 927.15
    anisole 433.61
    cyclopentyl methyl ether 1397.28
    gamma-butyrolactone 1505.5
    1-methoxy-2-propanol 953.28
    pyridine 748.97
    3-pentanone 507.51
    furfural 791.13
    n-dodecane 25.6
    diethylene glycol 663.77
    diisopropyl ether 353.64
    tert-amyl alcohol 577.41
    acetylacetone 699.03
    n-hexadecane 29.17
    acetophenone 264.25
    methyl propionate 630.81
    isopentyl acetate 415.16
    trichloroethylene 993.81
    n-nonanol 202.2
    cyclohexanol 671.1
    benzyl alcohol 301.5
    2-ethylhexanol 298.48
    isooctanol 203.16
    dipropyl ether 508.76
    1,2-dichlorobenzene 251.19
    ethyl lactate 180.62
    propylene carbonate 544.69
    n-methylformamide 777.37
    2-pentanol 588.64
    n-pentane 155.72
    1-propoxy-2-propanol 626.9
    1-methoxy-2-propyl acetate 506.22
    2-(2-methoxypropoxy) propanol 310.4
    mesitylene 151.1
    ε-caprolactone 808.85
    p-cymene 111.51
    epichlorohydrin 1704.79
    1,1,1-trichloroethane 656.71
    2-aminoethanol 347.44
    morpholine-4-carbaldehyde 1089.35
    sulfolane 1125.57
    2,2,4-trimethylpentane 54.17
    2-methyltetrahydrofuran 2104.02
    n-hexyl acetate 394.5
    isooctane 65.13
    2-(2-butoxyethoxy)ethanol 501.3
    sec-butyl acetate 290.22
    tert-butyl acetate 557.34
    decalin 65.41
    glycerin 235.64
    diglyme 878.86
    acrylic acid 302.5
    isopropyl myristate 169.7
    n-butyric acid 621.57
    acetyl acetate 373.01
    di(2-ethylhexyl) phthalate 123.06
    ethyl propionate 414.57
    nitromethane 1017.97
    1,2-diethoxyethane 693.26
    benzonitrile 322.12
    trioctyl phosphate 116.58
    1-bromopropane 600.53
    gamma-valerolactone 1525.21
    n-decanol 153.8
    triethyl phosphate 159.54
    4-methyl-2-pentanol 292.81
    propionitrile 607.65
    vinylene carbonate 478.8
    1,1,2-trichlorotrifluoroethane 503.13
    DMS 274.27
    cumene 106.77
    2-octanol 184.25
    2-hexanone 512.2
    octyl acetate 208.85
    limonene 175.49
    1,2-dimethoxyethane 1189.23
    ethyl orthosilicate 171.15
    tributyl phosphate 142.8
    diacetone alcohol 566.09
    N,N-dimethylaniline 226.32
    acrylonitrile 553.5
    aniline 407.9
    1,3-propanediol 616.4
    bromobenzene 324.03
    dibromomethane 729.33
    1,1,2,2-tetrachloroethane 639.9
    2-methyl-cyclohexyl acetate 248.51
    tetrabutyl urea 168.02
    diisobutyl methanol 185.92
    2-phenylethanol 359.69
    styrene 202.46
    dioctyl adipate 195.38
    dimethyl sulfate 349.64
    ethyl butyrate 339.46
    methyl lactate 240.33
    butyl lactate 204.59
    diethyl carbonate 205.85
    propanediol butyl ether 304.28
    triethyl orthoformate 229.56
    p-tert-butyltoluene 122.76
    methyl 4-tert-butylbenzoate 275.52
    morpholine 2416.15
    tert-butylamine 584.15
    n-dodecanol 119.08
    dimethoxymethane 1390.46
    ethylene carbonate 467.66
    cyrene 308.1
    2-ethoxyethyl acetate 427.06
    2-ethylhexyl acetate 321.81
    1,2,4-trichlorobenzene 277.89
    4-methylpyridine 721.42
    dibutyl ether 301.67
    2,6-dimethyl-4-heptanol 185.92
    DEF 680.23
    dimethyl isosorbide 585.77
    tetrachloroethylene 448.86
    eugenol 278.96
    triacetin 252.18
    span 80 282.26
    1,4-butanediol 248.15
    1,1-dichloroethane 793.03
    2-methyl-1-pentanol 402.08
    methyl formate 638.44
    2-methyl-1-butanol 519.91
    n-decane 45.25
    butyronitrile 690.94
    3,7-dimethyl-1-octanol 216.08
    1-chlorooctane 160.18
    1-chlorotetradecane 66.11
    n-nonane 46.89
    undecane 33.01
    tert-butylcyclohexane 69.42
    cyclooctane 56.89
    cyclopentanol 742.64
    tetrahydropyran 2297.36
    tert-amyl methyl ether 547.83
    2,5,8-trioxanonane 557.07
    1-hexene 422.11
    2-isopropoxyethanol 514.84
    2,2,2-trifluoroethanol 196.95
    methyl butyrate 475.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction