4-Chloro-3,5-dimethoxybenzyl alcohol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    152570-76-8

    Molecular formula
    C9H11ClO3

    SMILES
    COC1=CC(=CC(=C1Cl)OC)CO

    Safety labels

  • Odor profile

    Fragrance
    Vanilla 67.93%
    Sweet 59.12%
    Floral 54.45%
    Balsamic 47.13%
    Powdery 43.06%
    Phenolic 42.91%
    Fruity 42.84%
    Spicy 41.19%
    Creamy 35.48%
    Smoky 32.16%

     

    Flavor
    Bitter 45.31%
    Sweet 38.86%
    Vanilla 32.17%
    Smoky 30.54%
    Powdery 28.8%
    Phenolic 28.45%
    Woody 28.06%
    Mild 27.22%
    Spicy 25.18%
    Spice 24.86%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    7.73 (neutral)

    Molecular weight
    202.63 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    315°C

    Melting point expt.

    • 83 - 85 °C

    Flash point

    • 129.42 ˚C est.

  • Synonyms

    • 4-Chloro-3,5-dimethoxybenzyl alcohol
    • (4-chloro-3,5-dimethoxyphenyl)methanol
    • RefChem:1070484
    • 4-Chloro-3,5-dimethoxybenzenemethanol
    • 152570-76-8
    • CHEBI:180451
    • DTXSID701286090
    • 3,5-dimethoxy-4-chloro-benzyl alcohol
    • Benzenemethanol, 4-chloro-3,5-dimethoxy-
    • 152570-76-8

  • Applications

    4-Chloro-3,5-dimethoxybenzyl alcohol is typically used as an intermediate for the synthesis of fragrance ingredients and other specialty chemicals. In practice, it serves as a building block for fragrance components and pharmaceutical intermediates, and can be converted into benzyl derivatives to support specialty chemical applications in cosmetics, coatings and inks, or other industrial sectors. Its use may be subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 142.99
    methanol 155.47
    isopropanol 92.67
    water 1.71
    ethyl acetate 119.79
    n-propanol 101.06
    acetone 306.69
    n-butanol 80.32
    acetonitrile 179.94
    DMF 593.52
    toluene 50.05
    isobutanol 72.85
    1,4-dioxane 316.35
    methyl acetate 195.87
    THF 428.01
    2-butanone 183.75
    n-pentanol 72.0
    sec-butanol 73.02
    n-hexane 2.82
    ethylene glycol 195.32
    NMP 330.57
    cyclohexane 12.48
    DMSO 761.72
    n-butyl acetate 76.3
    n-octanol 52.78
    chloroform 388.55
    n-propyl acetate 95.74
    acetic acid 211.81
    dichloromethane 546.15
    cyclohexanone 226.87
    propylene glycol 103.6
    isopropyl acetate 59.54
    DMAc 350.22
    2-ethoxyethanol 227.33
    isopentanol 64.03
    n-heptane 9.17
    ethyl formate 221.0
    1,2-dichloroethane 303.21
    n-hexanol 73.38
    2-methoxyethanol 410.01
    isobutyl acetate 57.17
    tetrachloromethane 67.34
    n-pentyl acetate 62.64
    transcutol 164.25
    n-heptanol 52.77
    ethylbenzene 37.96
    MIBK 61.74
    2-propoxyethanol 180.6
    tert-butanol 129.24
    MTBE 69.56
    2-butoxyethanol 114.66
    propionic acid 117.27
    o-xylene 46.15
    formic acid 120.69
    diethyl ether 59.94
    m-xylene 40.51
    p-xylene 55.74
    chlorobenzene 104.81
    dimethyl carbonate 107.04
    n-octane 5.74
    formamide 241.97
    cyclopentanone 335.05
    2-pentanone 106.16
    anisole 118.46
    cyclopentyl methyl ether 114.54
    gamma-butyrolactone 407.98
    1-methoxy-2-propanol 204.41
    pyridine 230.06
    3-pentanone 81.7
    furfural 432.69
    n-dodecane 6.08
    diethylene glycol 233.73
    diisopropyl ether 17.97
    tert-amyl alcohol 87.34
    acetylacetone 163.3
    n-hexadecane 6.97
    acetophenone 130.72
    methyl propionate 129.04
    isopentyl acetate 66.53
    trichloroethylene 545.12
    n-nonanol 48.67
    cyclohexanol 93.49
    benzyl alcohol 130.78
    2-ethylhexanol 52.64
    isooctanol 44.67
    dipropyl ether 49.49
    1,2-dichlorobenzene 114.29
    ethyl lactate 80.93
    propylene carbonate 210.94
    n-methylformamide 304.63
    2-pentanol 42.85
    n-pentane 3.63
    1-propoxy-2-propanol 102.41
    1-methoxy-2-propyl acetate 97.83
    2-(2-methoxypropoxy) propanol 86.44
    mesitylene 25.84
    ε-caprolactone 187.72
    p-cymene 37.04
    epichlorohydrin 477.07
    1,1,1-trichloroethane 208.12
    2-aminoethanol 151.73
    morpholine-4-carbaldehyde 359.76
    sulfolane 470.09
    2,2,4-trimethylpentane 4.39
    2-methyltetrahydrofuran 201.49
    n-hexyl acetate 76.58
    isooctane 3.47
    2-(2-butoxyethoxy)ethanol 110.36
    sec-butyl acetate 48.15
    tert-butyl acetate 68.17
    decalin 8.92
    glycerin 183.79
    diglyme 243.4
    acrylic acid 140.3
    isopropyl myristate 36.64
    n-butyric acid 123.78
    acetyl acetate 96.3
    di(2-ethylhexyl) phthalate 48.49
    ethyl propionate 70.82
    nitromethane 466.35
    1,2-diethoxyethane 75.08
    benzonitrile 149.87
    trioctyl phosphate 41.15
    1-bromopropane 85.75
    gamma-valerolactone 392.29
    n-decanol 38.83
    triethyl phosphate 54.21
    4-methyl-2-pentanol 28.0
    propionitrile 112.04
    vinylene carbonate 228.22
    1,1,2-trichlorotrifluoroethane 391.15
    DMS 77.67
    cumene 31.08
    2-octanol 36.74
    2-hexanone 88.33
    octyl acetate 51.85
    limonene 49.47
    1,2-dimethoxyethane 333.45
    ethyl orthosilicate 45.88
    tributyl phosphate 39.16
    diacetone alcohol 111.91
    N,N-dimethylaniline 85.21
    acrylonitrile 189.98
    aniline 103.61
    1,3-propanediol 185.07
    bromobenzene 104.02
    dibromomethane 278.69
    1,1,2,2-tetrachloroethane 375.61
    2-methyl-cyclohexyl acetate 69.99
    tetrabutyl urea 58.84
    diisobutyl methanol 32.6
    2-phenylethanol 110.04
    styrene 48.35
    dioctyl adipate 63.52
    dimethyl sulfate 181.19
    ethyl butyrate 77.34
    methyl lactate 108.85
    butyl lactate 62.81
    diethyl carbonate 66.66
    propanediol butyl ether 92.69
    triethyl orthoformate 56.58
    p-tert-butyltoluene 34.66
    methyl 4-tert-butylbenzoate 105.85
    morpholine 304.9
    tert-butylamine 61.31
    n-dodecanol 31.73
    dimethoxymethane 293.62
    ethylene carbonate 171.25
    cyrene 142.91
    2-ethoxyethyl acetate 85.67
    2-ethylhexyl acetate 51.02
    1,2,4-trichlorobenzene 139.46
    4-methylpyridine 192.96
    dibutyl ether 38.05
    2,6-dimethyl-4-heptanol 32.6
    DEF 164.2
    dimethyl isosorbide 160.81
    tetrachloroethylene 257.6
    eugenol 110.61
    triacetin 87.22
    span 80 79.69
    1,4-butanediol 106.13
    1,1-dichloroethane 198.67
    2-methyl-1-pentanol 60.05
    methyl formate 346.49
    2-methyl-1-butanol 60.85
    n-decane 8.77
    butyronitrile 106.62
    3,7-dimethyl-1-octanol 44.64
    1-chlorooctane 35.51
    1-chlorotetradecane 17.87
    n-nonane 7.82
    undecane 7.17
    tert-butylcyclohexane 7.65
    cyclooctane 4.8
    cyclopentanol 139.31
    tetrahydropyran 166.19
    tert-amyl methyl ether 51.64
    2,5,8-trioxanonane 166.41
    1-hexene 15.34
    2-isopropoxyethanol 123.91
    2,2,2-trifluoroethanol 125.33
    methyl butyrate 119.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction