4-Biphenylamine

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  • Identifiers

    CAS number
    92-67-1

    Molecular formula
    C12H11N

    SMILES
    C1=CC=C(C=C1)C2=CC=C(C=C2)N

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Floral 78.31%
    Sweet 57.38%
    Animal 43.81%
    Rose 38.68%
    Grape 34.85%
    Orange 34.44%
    Honey 34.18%
    Phenolic 31.06%
    Neroli 30.78%
    Musty 27.97%

     

    Flavor
    Pungent 34.57%
    Geranium 34.54%
    Rose 33.39%
    Phenolic 32.28%
    Plastic 31.61%
    Floral 29.77%
    Tar 27.52%
    Sweet 27.13%
    Tarry 26.78%
    Medicinal 26.59%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    5.7 (weak acid)

    Molecular weight
    169.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 127 °F (NTP, 1992)
    • 51.0 °C
    • 53.5 °C
    • 53 °C
    • 127 °F

    Boiling point

    • 576 °F at 760 mmHg (NTP, 1992)
    • 302 °C
    • 576 °F

    Flash point

    • 171.2 ˚C est.
    • greater than 235 °F (NTP, 1992)
    • Flash point > 235 °F
    • 113 °C (235 °F) - closed cup
    • 153 °C (closed cup)
    • 113 °C c.c.
    • >235 °F

    Solubility expt.

    • less than 0.1 mg/mL at 66 °F (NTP, 1992)
    • Slightly soluble in cold water; readily soluble in hot water
    • Soluble in ethanol, ether, acetone, chloroform
    • Soluble in dichloromethane, DMSO, methanol
    • Soluble in lipids
    • Solubility in water, g/100ml at 25 °C: 0.2 (poor)
    • Slight

  • Synonyms

    • 4-Aminobiphenyl
    • 92-67-1
    • 4-Phenylaniline
    • 4-Aminodiphenyl
    • 4-BIPHENYLAMINE
    • [1,1'-Biphenyl]-4-amine
    • biphenyl-4-amine
    • Xenylamine
    • Biphenyl-4-ylamine
    • p-Biphenylamine
    • p-Phenylaniline
    • 4-Biphenylylamine
    • p-Aminobiphenyl
    • p-Aminodiphenyl
    • p-Xenylamine
    • Biphenylamine
    • Paraaminodiphenyl
    • Xenylamin
    • 4-Amino-1,1'-biphenyl
    • 4-Aminodifenil
    • Aniline, p-phenyl-
    • 4-Aminobifenyl
    • 4-Bifenylamin
    • Xenylamin [Czech]
    • 4-Bifenylamin [Czech]
    • 4-Aminobifenyl [Czech]
    • NSC 7660
    • 4-Aminodifenil [Spanish]
    • (1,1'-Biphenyl)-4-amine
    • CCRIS 26
    • HSDB 1325
    • (4-phenyl-phenyl)-amine
    • 1,1'-biphenyl-4-amine
    • EINECS 202-177-1
    • Xenylamin (czech)
    • MFCD00007879
    • BRN 0386533
    • CHEBI:1784
    • DTXSID5020071
    • AI3-00124
    • UNII-16054949HJ
    • NSC-7660
    • 4-Aminodifenil (spanish)
    • DTXCID9071
    • P-BIPHENYLAMINE [MI]
    • 4-AMINODIPHENYL-D9
    • 4-AMINOBIPHENYL [IARC]
    • 4-BIPHENYLAMINE [HSDB]
    • 16054949HJ
    • {[1,1'-Biphenyl]-4-amine}
    • NSC7660
    • 4-12-00-03241 (Beilstein Handbook Reference)
    • biphenyl, 4-amino-
    • 4-Bifenylamin (Czech)
    • 4-Aminobifenyl (Czech)
    • EN300-17141
    • (1,1'-biphenyl)-4-ylamine
    • [1,1'-biphenyl]-4-ylamine
    • 4-AMINOBIPHENYL (IARC)
    • ((1,1'-Biphenyl)-4-amine)
    • 116267-93-7
    • 4-biphenylnitrenium ion
    • 4-Aminobiphenyl min. 93%
    • pAminobiphenyl
    • pAminodiphenyl
    • pBiphenylamine
    • pPhenylaniline
    • pXenylamine
    • 4aminobiphenyl
    • 4biphenylamine
    • 4phenylaniline
    • p-Aminobifenilo
    • 4Aminobifenyl
    • 4Aminodifenil
    • 4Aminodiphenyl
    • 4Bifenylamin
    • (1,1'-Biphenyl-4-yl)amine
    • 4Biphenylylamine
    • 4-Aminobifenilo
    • p-biphenyl amine
    • Aniline, pphenyl
    • p-Amino diphenyl
    • p-Phenyl aniline
    • para-aminobiphenyl
    • 4-amino-biphenyl
    • 4-phenyl aniline
    • 4Amino1,1'biphenyl
    • P-DIPHENYLAMINE
    • 1,1'Biphenyl)4amine
    • p-Aminobifenilo (Spanish)
    • WLN: ZR DR
    • 4-Aminobifenilo (Spanish)
    • 4-PHENYLBENZENEAMINE
    • 4-ADP
    • SCHEMBL62469
    • MLS002303005
    • CHEMBL44201
    • 4-Aminodiphenyl (ACGIH:OSHA)
    • MSK1201
    • BDBM626040
    • HMS1722B15
    • HMS3091M12
    • AAA09267
    • ALBB-025794
    • BCP25781
    • CS-B0270
    • QIA52772
    • 4-Aminobiphenyl, analytical standard
    • Tox21_200376
    • STK315364
    • AKOS000114495
    • GS-3083
    • CAS-92-67-1
    • NCGC00091372-01
    • NCGC00091372-02
    • NCGC00091372-03
    • NCGC00257930-01
    • BP-11958
    • SMR000062444
    • DB-002657
    • 4-Aminobiphenyl 10 microg/mL in Cyclohexane
    • NS00015359
    • [1,1'-biphenyl]-4-amine (ACD/Name 4.0)
    • [1,1'-biphenyl]-4-ylamine (ACD/Name 4.0)
    • A844308
    • AC-907/25014308
    • Q229922
    • F0096-0021

  • Applications

    4-Biphenylamine (CAS 92-67-1) is primarily used as an aromatic amine intermediate in the synthesis of dyes and pigments, particularly for azo dyes and colorants based on biphenyl frameworks. It is also employed as a building block in the production of pharmaceutical and agrochemical intermediates. In materials science, it serves as a precursor for specialty polymers and for liquid-crystal or organic electronic materials, enabling various functionalities after functionalization of the amine group. Additionally, it may be used as a starting material in organic synthesis for research and development, and it finds applications in coatings and inks as a colorant precursor.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 557.95
    methanol 777.38
    isopropanol 226.31
    water 0.77
    ethyl acetate 1924.88
    n-propanol 491.08
    acetone 1951.24
    n-butanol 317.98
    acetonitrile 1776.82
    DMF 1743.58
    toluene 205.23
    isobutanol 171.4
    1,4-dioxane 1633.64
    methyl acetate 1199.18
    THF 1856.61
    2-butanone 1361.78
    n-pentanol 164.92
    sec-butanol 162.74
    n-hexane 4.61
    ethylene glycol 113.86
    NMP 627.33
    cyclohexane 7.24
    DMSO 2162.82
    n-butyl acetate 427.95
    n-octanol 35.2
    chloroform 454.56
    n-propyl acetate 454.2
    acetic acid 577.63
    dichloromethane 500.92
    cyclohexanone 774.47
    propylene glycol 160.9
    isopropyl acetate 545.96
    DMAc 1020.28
    2-ethoxyethanol 564.36
    isopentanol 172.03
    n-heptane 7.99
    ethyl formate 767.43
    1,2-dichloroethane 689.18
    n-hexanol 152.68
    2-methoxyethanol 1288.44
    isobutyl acetate 174.79
    tetrachloromethane 54.27
    n-pentyl acetate 123.5
    transcutol 1419.86
    n-heptanol 56.36
    ethylbenzene 57.7
    MIBK 300.84
    2-propoxyethanol 509.01
    tert-butanol 221.96
    MTBE 309.73
    2-butoxyethanol 177.94
    propionic acid 508.0
    o-xylene 65.96
    formic acid 218.07
    diethyl ether 855.99
    m-xylene 84.04
    p-xylene 57.1
    chlorobenzene 228.61
    dimethyl carbonate 675.93
    n-octane 2.42
    formamide 939.17
    cyclopentanone 1560.21
    2-pentanone 1092.82
    anisole 331.2
    cyclopentyl methyl ether 502.13
    gamma-butyrolactone 1916.79
    1-methoxy-2-propanol 682.78
    pyridine 1244.8
    3-pentanone 753.75
    furfural 946.76
    n-dodecane 2.13
    diethylene glycol 360.73
    diisopropyl ether 90.09
    tert-amyl alcohol 138.89
    acetylacetone 1180.21
    n-hexadecane 2.49
    acetophenone 209.84
    methyl propionate 1415.76
    isopentyl acetate 251.57
    trichloroethylene 1126.1
    n-nonanol 35.0
    cyclohexanol 108.03
    benzyl alcohol 158.32
    2-ethylhexanol 84.0
    isooctanol 42.41
    dipropyl ether 296.33
    1,2-dichlorobenzene 157.84
    ethyl lactate 128.6
    propylene carbonate 607.81
    n-methylformamide 1627.28
    2-pentanol 131.75
    n-pentane 4.54
    1-propoxy-2-propanol 309.26
    1-methoxy-2-propyl acetate 481.67
    2-(2-methoxypropoxy) propanol 141.48
    mesitylene 35.86
    ε-caprolactone 612.81
    p-cymene 31.79
    epichlorohydrin 1881.69
    1,1,1-trichloroethane 344.15
    2-aminoethanol 293.12
    morpholine-4-carbaldehyde 822.99
    sulfolane 1327.56
    2,2,4-trimethylpentane 4.56
    2-methyltetrahydrofuran 824.67
    n-hexyl acetate 140.21
    isooctane 3.82
    2-(2-butoxyethoxy)ethanol 275.36
    sec-butyl acetate 196.28
    tert-butyl acetate 353.02
    decalin 6.29
    glycerin 230.46
    diglyme 744.91
    acrylic acid 421.08
    isopropyl myristate 46.5
    n-butyric acid 749.62
    acetyl acetate 619.31
    di(2-ethylhexyl) phthalate 43.87
    ethyl propionate 475.46
    nitromethane 2908.82
    1,2-diethoxyethane 541.26
    benzonitrile 226.25
    trioctyl phosphate 31.56
    1-bromopropane 167.71
    gamma-valerolactone 1552.84
    n-decanol 26.51
    triethyl phosphate 86.84
    4-methyl-2-pentanol 61.39
    propionitrile 895.55
    vinylene carbonate 524.57
    1,1,2-trichlorotrifluoroethane 678.62
    DMS 208.29
    cumene 30.06
    2-octanol 24.87
    2-hexanone 365.6
    octyl acetate 64.78
    limonene 48.15
    1,2-dimethoxyethane 1023.42
    ethyl orthosilicate 84.96
    tributyl phosphate 47.93
    diacetone alcohol 325.33
    N,N-dimethylaniline 107.12
    acrylonitrile 1150.18
    aniline 345.96
    1,3-propanediol 409.76
    bromobenzene 194.6
    dibromomethane 229.97
    1,1,2,2-tetrachloroethane 697.4
    2-methyl-cyclohexyl acetate 112.87
    tetrabutyl urea 57.66
    diisobutyl methanol 46.65
    2-phenylethanol 137.87
    styrene 101.47
    dioctyl adipate 75.73
    dimethyl sulfate 625.69
    ethyl butyrate 315.55
    methyl lactate 307.91
    butyl lactate 92.49
    diethyl carbonate 185.49
    propanediol butyl ether 111.31
    triethyl orthoformate 166.55
    p-tert-butyltoluene 32.74
    methyl 4-tert-butylbenzoate 110.88
    morpholine 1676.43
    tert-butylamine 98.11
    n-dodecanol 20.69
    dimethoxymethane 1786.27
    ethylene carbonate 483.49
    cyrene 138.58
    2-ethoxyethyl acetate 285.01
    2-ethylhexyl acetate 173.06
    1,2,4-trichlorobenzene 200.47
    4-methylpyridine 717.67
    dibutyl ether 109.27
    2,6-dimethyl-4-heptanol 46.65
    DEF 951.02
    dimethyl isosorbide 287.02
    tetrachloroethylene 422.76
    eugenol 110.14
    triacetin 157.42
    span 80 101.44
    1,4-butanediol 93.02
    1,1-dichloroethane 380.17
    2-methyl-1-pentanol 106.29
    methyl formate 1110.05
    2-methyl-1-butanol 158.66
    n-decane 3.6
    butyronitrile 575.18
    3,7-dimethyl-1-octanol 42.73
    1-chlorooctane 25.47
    1-chlorotetradecane 9.5
    n-nonane 2.99
    undecane 2.66
    tert-butylcyclohexane 7.0
    cyclooctane 3.07
    cyclopentanol 183.92
    tetrahydropyran 907.91
    tert-amyl methyl ether 175.87
    2,5,8-trioxanonane 338.27
    1-hexene 41.99
    2-isopropoxyethanol 242.91
    2,2,2-trifluoroethanol 201.15
    methyl butyrate 548.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction