4-Aminobenzoic Acid

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  • Identifiers

    CAS number
    150-13-0

    Molecular formula
    C7H7NO2

    SMILES
    C1=CC(=CC=C1C(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 42.1%
    Grape 38.84%
    Odorless 38.62%
    Floral 37.09%
    Sweet 34.25%
    Animal 34.09%
    Honey 30.49%
    Bitter 30.33%
    Powdery 27.76%
    Burnt 26.74%

     

    Flavor
    Phenolic 48.24%
    Mild 46.07%
    Odorless 42.84%
    Nutty 37.79%
    Faint 37.67%
    Sour 36.98%
    Balsam 33.88%
    Honey 32.38%
    Sweet 31.61%
    Balsamic 28.76%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    5.67 (weak acid)

    Molecular weight
    137.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    354°C

    Melting point expt.

    • 370 to 372 °F (NTP, 1992)
    • 188.5 °C

    Flash point

    • 183.17 ˚C est.

    Solubility expt.

    • >20.6 [ug/mL] (The mean of the results at pH 7.4)
    • 6110 mg/L (at 30 °C)
    • In water, 5,390 mg/L at 25 °C; 6,110 mg/L at 30 °C
    • One gram dissolves in 90 mL boiling water; in 8 ml alcohol, in 60 mL ether. Soluble in ethyl acetate, glacial acetic acid; slightly soluble in benzene; practically insoluble in petroleum ether.
    • Freely soluble in alcohol
    • Soluble in alkalis and ethane (C2H6)
    • For more Solubility (Complete) data for 4-AMINOBENZOIC ACID (8 total), please visit the HSDB record page.
    • 6.11 mg/mL

  • Synonyms

    • 4-aminobenzoic acid
    • 150-13-0
    • p-aminobenzoic acid
    • PABA
    • para-aminobenzoic acid
    • AMINOBENZOIC ACID
    • Vitamin BX
    • p-Carboxyaniline
    • Benzoic acid, 4-amino-
    • 4-Carboxyaniline
    • Hachemina
    • Paraminol
    • Sunbrella
    • p-Carboxyphenylamine
    • 1-Amino-4-carboxybenzene
    • Pabacyd
    • Pabafilm
    • Pabamine
    • Paranate
    • Amben
    • Potaba
    • Romavit
    • Bacterial vitamin H1
    • Vitamin H'
    • Anticanitic vitamin
    • Chromotrichia factor
    • RVPaba Lipstick
    • Papacidum
    • Rvpaba
    • Trichochromogenic factor
    • Anti-chromotrichia factor
    • Super Shade by Coppertone
    • Benzoic acid, p-amino-
    • Acidum paraminobenzoicum
    • benzoic acid, 4-amino
    • Caswell No. 033B
    • 4-azaniumylbenzoate
    • MFCD00007894
    • ABEE
    • Pabagel
    • Pabanol
    • 4-AMINO-BENZOIC ACID
    • Kyselina p-aminobenzoova
    • Vitamin H1
    • p-Aminobenzoesaeure
    • 4-Aminobenzoesaeure
    • 4-Carboxyphenylamine
    • p-amino-Benzoic acid
    • Acido p-aminobenzoico
    • PAB
    • gamma-Aminobenzoic acid
    • Aminobenzoate
    • Actipol
    • CCRIS 6209
    • EPA Pesticide Chemical Code 233300
    • Acido p-aminobenzoico [Italian]
    • UNII-TL2TJE8QTX
    • BRN 0471605
    • HSDB 6840
    • Kyselina p-aminobenzoova [Czech]
    • Aminobenzoic acid (USP)
    • Aminobenzoic acid [USP]
    • AI3-02436
    • para-aminobenzoate
    • Anticantic vitamin
    • NSC 7627
    • NSC-7627
    • EINECS 205-753-0
    • gamma-Aminobenzoate
    • Trochromogenic factor
    • AMINOBENZOIC ACID, PARA
    • Aniline-4-carboxylate
    • DTXSID6024466
    • CHEBI:30753
    • P-AMINO-BENZOATE
    • TL2TJE8QTX
    • .gamma.-Aminobenzoic acid
    • Aniline-4-carboxylic acid
    • CHEMBL542
    • DTXCID404466
    • component of Presun (Salt/Mix)
    • P-AMINOBENZOIC ACID [MI]
    • 4-Aminobenzoate, Potassium
    • AMINOBENZOIC ACID [MART.]
    • EC 205-753-0
    • AMINOBENZOIC ACID [USP-RS]
    • AMINOBENZOIC ACID [WHO-DD]
    • 4-AMINOBENZOIC ACID [HSDB]
    • PARA-AMINOBENZOIC ACID [IARC]
    • PARA-AMINOBENZOIC ACID [VANDF]
    • NCGC00091051-01
    • AMINOBENZOIC ACID [USP MONOGRAPH]
    • 4-AMINOBENZOIC ACID [EP IMPURITY]
    • 4-AMINOBENZOIC ACID [EP MONOGRAPH]
    • 4-aminobenzoic acid, potassium salt
    • trichromogenic factor
    • 4 Aminobenzoic Acid, Potassium Salt
    • TETRACAINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
    • PROCAINE BENZYLPENICILLIN IMPURITY A [EP IMPURITY]
    • AMINOBENZOIC ACID (MART.)
    • Paraminan
    • AMINOBENZOIC ACID (USP-RS)
    • PARA-AMINOBENZOIC ACID (IARC)
    • AMINOBENZOIC ACID (USP MONOGRAPH)
    • CAS-150-13-0
    • SMR000471833
    • 4-AMINOBENZOIC ACID (EP IMPURITY)
    • 4-aminobenzoic-acid
    • 4-AMINOBENZOIC ACID (EP MONOGRAPH)
    • p-amino benzoic acid
    • TETRACAINE HYDROCHLORIDE IMPURITY A (EP IMPURITY)
    • PROCAINE BENZYLPENICILLIN IMPURITY A (EP IMPURITY)
    • pCarboxyaniline
    • 4Carboxyaniline
    • g-Aminobenzoate
    • Aminobenzoesaeure
    • 4-amino-benzoate
    • 4-ammoniobenzoate
    • Jumer Brand of Aminobenzoic Acid
    • Medea Brand of Aminobenzoic Acid
    • p-carboxy aniline
    • pCarboxyphenylamine
    • 4aminobenzoic acid
    • amino benzoic acid
    • p-aminobezoic acid
    • Llorens Brand of Aminobenzoic Acid
    • 4-aminobezoic acid
    • Acido paminobenzoico

  • Applications

    4-Aminobenzoic Acid, CAS 150-13-0, is used as a chemical building block in the synthesis of dyes and pigments for coatings, inks, textiles, and plastics. It also serves as a precursor for UV-absorbing agents used in cosmetic and personal care formulations. In the pharmaceutical arena, it functions as an intermediate for the preparation of active pharmaceutical ingredients and related drug-like compounds, particularly in folate pathway chemistry. Additionally, it is employed in the synthesis of specialty intermediates for agrochemical and other fine-chemical products, where its para-substituted benzoic acid framework provides a versatile starting point. These applications reflect its role as an aromatic building block and functionalized intermediate, with use governed by regulatory and formulation considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.5
    methanol 12.02
    isopropanol 4.28
    water 0.98
    ethyl acetate 1.59
    n-propanol 4.08
    acetone 8.0
    n-butanol 3.22
    acetonitrile 2.32
    DMF 44.83
    toluene 0.07
    isobutanol 2.13
    1,4-dioxane 103.51
    methyl acetate 2.29
    THF 42.29
    2-butanone 3.44
    n-pentanol 2.76
    sec-butanol 2.15
    n-hexane 0.05
    ethylene glycol 7.95
    NMP 74.85
    cyclohexane 0.05
    DMSO 47.44
    n-butyl acetate 2.29
    n-octanol 6.54
    chloroform 0.04
    n-propyl acetate 1.56
    acetic acid 21.88
    dichloromethane 0.16
    cyclohexanone 6.69
    propylene glycol 7.96
    isopropyl acetate 1.63
    DMAc 40.13
    2-ethoxyethanol 18.76
    isopentanol 2.97
    n-heptane 0.21
    ethyl formate 3.21
    1,2-dichloroethane 0.32
    n-hexanol 3.22
    2-methoxyethanol 40.95
    isobutyl acetate 0.83
    tetrachloromethane 0.03
    n-pentyl acetate 3.85
    transcutol 67.2
    n-heptanol 6.06
    ethylbenzene 0.12
    MIBK 2.16
    2-propoxyethanol 19.91
    tert-butanol 5.46
    MTBE 1.8
    2-butoxyethanol 19.79
    propionic acid 5.59
    o-xylene 0.19
    formic acid 24.46
    diethyl ether 1.74
    m-xylene 0.14
    p-xylene 0.22
    chlorobenzene 0.15
    dimethyl carbonate 2.6
    n-octane 0.12
    formamide 32.96
    cyclopentanone 17.14
    2-pentanone 2.57
    anisole 1.41
    cyclopentyl methyl ether 4.1
    gamma-butyrolactone 27.53
    1-methoxy-2-propanol 22.8
    pyridine 2.8
    3-pentanone 1.35
    furfural 19.89
    n-dodecane 0.16
    diethylene glycol 24.16
    diisopropyl ether 0.57
    tert-amyl alcohol 3.19
    acetylacetone 6.71
    n-hexadecane 0.18
    acetophenone 2.24
    methyl propionate 2.16
    isopentyl acetate 2.56
    trichloroethylene 0.31
    n-nonanol 6.4
    cyclohexanol 1.87
    benzyl alcohol 2.01
    2-ethylhexanol 2.14
    isooctanol 4.41
    dipropyl ether 2.43
    1,2-dichlorobenzene 0.27
    ethyl lactate 3.26
    propylene carbonate 9.08
    n-methylformamide 16.52
    2-pentanol 1.49
    n-pentane 0.04
    1-propoxy-2-propanol 11.49
    1-methoxy-2-propyl acetate 6.68
    2-(2-methoxypropoxy) propanol 20.08
    mesitylene 0.22
    ε-caprolactone 9.85
    p-cymene 0.57
    epichlorohydrin 13.67
    1,1,1-trichloroethane 0.1
    2-aminoethanol 11.45
    morpholine-4-carbaldehyde 65.0
    sulfolane 41.04
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 11.15
    n-hexyl acetate 7.58
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 33.88
    sec-butyl acetate 1.05
    tert-butyl acetate 3.19
    decalin 0.07
    glycerin 22.82
    diglyme 49.39
    acrylic acid 7.72
    isopropyl myristate 2.92
    n-butyric acid 5.74
    acetyl acetate 1.9
    di(2-ethylhexyl) phthalate 5.37
    ethyl propionate 1.38
    nitromethane 29.23
    1,2-diethoxyethane 8.33
    benzonitrile 1.17
    trioctyl phosphate 4.29
    1-bromopropane 0.1
    gamma-valerolactone 43.35
    n-decanol 4.63
    triethyl phosphate 2.34
    4-methyl-2-pentanol 1.39
    propionitrile 1.03
    vinylene carbonate 5.46
    1,1,2-trichlorotrifluoroethane 11.79
    DMS 4.01
    cumene 0.22
    2-octanol 3.19
    2-hexanone 2.16
    octyl acetate 5.06
    limonene 0.88
    1,2-dimethoxyethane 24.1
    ethyl orthosilicate 2.24
    tributyl phosphate 3.22
    diacetone alcohol 9.82
    N,N-dimethylaniline 1.62
    acrylonitrile 1.95
    aniline 0.7
    1,3-propanediol 16.45
    bromobenzene 0.08
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 0.32
    2-methyl-cyclohexyl acetate 3.35
    tetrabutyl urea 6.89
    diisobutyl methanol 1.73
    2-phenylethanol 3.15
    styrene 0.12
    dioctyl adipate 5.88
    dimethyl sulfate 8.13
    ethyl butyrate 2.31
    methyl lactate 6.5
    butyl lactate 6.51
    diethyl carbonate 1.67
    propanediol butyl ether 22.59
    triethyl orthoformate 2.77
    p-tert-butyltoluene 0.62
    methyl 4-tert-butylbenzoate 11.13
    morpholine 59.71
    tert-butylamine 1.59
    n-dodecanol 3.12
    dimethoxymethane 18.38
    ethylene carbonate 4.34
    cyrene 22.25
    2-ethoxyethyl acetate 8.4
    2-ethylhexyl acetate 1.77
    1,2,4-trichlorobenzene 0.52
    4-methylpyridine 1.49
    dibutyl ether 2.79
    2,6-dimethyl-4-heptanol 1.73
    DEF 8.14
    dimethyl isosorbide 28.5
    tetrachloroethylene 0.25
    eugenol 11.48
    triacetin 9.92
    span 80 18.39
    1,4-butanediol 5.88
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 2.32
    methyl formate 10.96
    2-methyl-1-butanol 2.17
    n-decane 0.23
    butyronitrile 1.31
    3,7-dimethyl-1-octanol 3.5
    1-chlorooctane 0.83
    1-chlorotetradecane 0.48
    n-nonane 0.18
    undecane 0.19
    tert-butylcyclohexane 0.08
    cyclooctane 0.04
    cyclopentanol 5.07
    tetrahydropyran 6.92
    tert-amyl methyl ether 1.56
    2,5,8-trioxanonane 40.09
    1-hexene 0.17
    2-isopropoxyethanol 9.48
    2,2,2-trifluoroethanol 8.26
    methyl butyrate 2.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction