4-Amino-m-cresol

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  • Identifiers

    CAS number
    2835-99-6

    Molecular formula
    C7H9NO

    SMILES
    CC1=C(C=CC(=C1)O)N

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 66.63%
    Smoky 41.65%
    Sweet 41.1%
    Burnt 38.99%
    Medicinal 36.78%
    Animal 33.89%
    Meaty 32.9%
    Woody 30.37%
    Musty 29.88%
    Leathery 28.51%

     

    Flavor
    Phenolic 60.64%
    Medicinal 40.72%
    Mild 36.16%
    Meaty 32.33%
    Bitter 31.06%
    Phenol 27.86%
    Smoke 27.58%
    Musty 27.14%
    Medical 26.78%
    Nutty 25.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    7.15 (neutral)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    291°C

    Flash point

    • 136.76 ˚C est.

  • Synonyms

    • 4-Amino-3-methylphenol
    • 4-Amino-m-cresol
    • 2835-99-6
    • Phenol, 4-amino-3-methyl-
    • 4-amino-3-cresol
    • 4-hydroxy-6-methylaniline
    • 3-methyl-p-aminophenol
    • 4-OH-6'-methylalanine
    • 4-Amino-3-methyl phenol
    • 4-hydroxy-6'-methylalanine
    • EINECS 220-621-2
    • NSC 72170
    • UNII-12R07I1K8C
    • BRN 2078803
    • CCRIS 8320
    • DTXSID2049262
    • AI3-16313
    • 12R07I1K8C
    • COLOREX 4AMC
    • JAROCOL 4A3MP
    • ORISTAR AMPH43
    • NSC-72170
    • 4A3MP
    • M-METHYL-P-AMINOPHENOL
    • DTXCID7029118
    • CHEBI:55546
    • 4-13-00-01698 (Beilstein Handbook Reference)
    • RefChem:97812
    • 4-AMINO-M-CRESOL [INCI]
    • 220-621-2
    • InChI=1/C7H9NO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,8H2,1H
    • QGNGOGOOPUYKMC-UHFFFAOYSA-N
    • 4-Hydroxy-2-methylaniline
    • 3-Methyl-4-aminophenol
    • p-Amino-m-cresol
    • p-Hydroxy-o-toluidine
    • 2-Methyl-4-hydroxyaniline
    • 2-Amino-5-hydroxytoluene
    • m-CRESOL, 4-AMINO-
    • 4-Amino-3-methyl-phenol
    • 4-Hydroxy-o-toluidine
    • 4-Amino-Meta-Cresol
    • MFCD00007871
    • 4amino-m-cresol
    • NSC72170
    • WLN: ZR DQ B1
    • NCIOpen2_000353
    • SCHEMBL34069
    • 4-hydroxy-2-methylphenylamine
    • BIDD:GT0474
    • orb1987237
    • SCHEMBL5919306
    • SCHEMBL9479496
    • 4-Amino-3-methylphenol, 97%
    • CHEMBL3092390
    • SCHEMBL29357630
    • Tox21_202910
    • MSK000395
    • SBB058775
    • STL194284
    • AKOS000345094
    • AC-1820
    • CS-W013540
    • EBC-152034
    • FA33380
    • NCGC00260456-01
    • AS-12563
    • CAS-2835-99-6
    • DB-011281
    • A0288
    • NS00013353
    • ST51037953
    • EN300-79071
    • A23134
    • F11227
    • F078902
    • 4-Amino-3-methylphenol 100 microg/mL in Acetonitrile
    • Q27124363
    • F0001-0896
    • Z419012258
    • 4-Hydroxy-2-methylaniline;4 -Amino-3-cresol;2-Amino-5-hydroxytoluene
    • 2835-99-6

  • Applications

    4-Amino-m-cresol (CAS 2835-99-6) is primarily used as a chemical intermediate in the colorant sector, notably as an oxidative hair dye precursor in cosmetic formulations. It is also used as a building block for azo dyes and related pigments for textiles and other industrial color applications. As a colorant intermediate, it is employed in the production of colorants for plastics and polymer materials, and in coatings and inks.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 95.91
    methanol 129.8
    isopropanol 56.79
    water 19.67
    ethyl acetate 61.57
    n-propanol 59.98
    acetone 79.74
    n-butanol 47.89
    acetonitrile 57.56
    DMF 94.56
    toluene 4.87
    isobutanol 32.58
    1,4-dioxane 143.45
    methyl acetate 62.65
    THF 357.33
    2-butanone 70.65
    n-pentanol 36.4
    sec-butanol 37.22
    n-hexane 1.16
    ethylene glycol 34.56
    NMP 66.07
    cyclohexane 0.55
    DMSO 148.61
    n-butyl acetate 41.46
    n-octanol 26.31
    chloroform 33.87
    n-propyl acetate 25.17
    acetic acid 105.03
    dichloromethane 20.41
    cyclohexanone 56.22
    propylene glycol 26.56
    isopropyl acetate 31.92
    DMAc 122.38
    2-ethoxyethanol 92.6
    isopentanol 41.38
    n-heptane 2.97
    ethyl formate 56.73
    1,2-dichloroethane 16.48
    n-hexanol 76.29
    2-methoxyethanol 152.45
    isobutyl acetate 15.55
    tetrachloromethane 17.5
    n-pentyl acetate 25.5
    transcutol 81.98
    n-heptanol 44.82
    ethylbenzene 4.53
    MIBK 37.78
    2-propoxyethanol 150.72
    tert-butanol 93.67
    MTBE 47.83
    2-butoxyethanol 82.45
    propionic acid 63.01
    o-xylene 6.66
    formic acid 146.25
    diethyl ether 30.19
    m-xylene 8.56
    p-xylene 6.3
    chlorobenzene 11.4
    dimethyl carbonate 35.47
    n-octane 1.52
    formamide 163.27
    cyclopentanone 130.43
    2-pentanone 53.64
    anisole 26.88
    cyclopentyl methyl ether 59.7
    gamma-butyrolactone 158.22
    1-methoxy-2-propanol 98.54
    pyridine 33.68
    3-pentanone 29.87
    furfural 104.53
    n-dodecane 1.28
    diethylene glycol 120.43
    diisopropyl ether 9.58
    tert-amyl alcohol 63.52
    acetylacetone 63.32
    n-hexadecane 1.37
    acetophenone 24.29
    methyl propionate 49.51
    isopentyl acetate 34.8
    trichloroethylene 41.18
    n-nonanol 23.8
    cyclohexanol 20.86
    benzyl alcohol 23.15
    2-ethylhexanol 35.66
    isooctanol 33.45
    dipropyl ether 26.94
    1,2-dichlorobenzene 14.69
    ethyl lactate 21.24
    propylene carbonate 62.24
    n-methylformamide 99.15
    2-pentanol 27.48
    n-pentane 0.87
    1-propoxy-2-propanol 75.28
    1-methoxy-2-propyl acetate 51.01
    2-(2-methoxypropoxy) propanol 47.15
    mesitylene 6.54
    ε-caprolactone 50.01
    p-cymene 8.55
    epichlorohydrin 132.09
    1,1,1-trichloroethane 31.82
    2-aminoethanol 63.15
    morpholine-4-carbaldehyde 101.8
    sulfolane 119.71
    2,2,4-trimethylpentane 1.5
    2-methyltetrahydrofuran 109.74
    n-hexyl acetate 31.03
    isooctane 1.61
    2-(2-butoxyethoxy)ethanol 64.16
    sec-butyl acetate 15.6
    tert-butyl acetate 48.47
    decalin 1.19
    glycerin 73.77
    diglyme 110.3
    acrylic acid 50.47
    isopropyl myristate 12.88
    n-butyric acid 83.78
    acetyl acetate 35.15
    di(2-ethylhexyl) phthalate 16.04
    ethyl propionate 22.96
    nitromethane 189.75
    1,2-diethoxyethane 32.6
    benzonitrile 20.61
    trioctyl phosphate 15.19
    1-bromopropane 7.28
    gamma-valerolactone 153.5
    n-decanol 17.42
    triethyl phosphate 17.56
    4-methyl-2-pentanol 22.87
    propionitrile 35.77
    vinylene carbonate 50.65
    1,1,2-trichlorotrifluoroethane 87.31
    DMS 19.25
    cumene 6.15
    2-octanol 22.73
    2-hexanone 35.03
    octyl acetate 19.48
    limonene 11.66
    1,2-dimethoxyethane 120.04
    ethyl orthosilicate 18.22
    tributyl phosphate 13.8
    diacetone alcohol 78.17
    N,N-dimethylaniline 20.86
    acrylonitrile 48.02
    aniline 18.6
    1,3-propanediol 92.95
    bromobenzene 8.14
    dibromomethane 12.06
    1,1,2,2-tetrachloroethane 35.92
    2-methyl-cyclohexyl acetate 24.57
    tetrabutyl urea 19.62
    diisobutyl methanol 20.0
    2-phenylethanol 45.26
    styrene 4.22
    dioctyl adipate 15.58
    dimethyl sulfate 60.56
    ethyl butyrate 28.57
    methyl lactate 37.65
    butyl lactate 23.03
    diethyl carbonate 18.15
    propanediol butyl ether 37.37
    triethyl orthoformate 21.42
    p-tert-butyltoluene 9.48
    methyl 4-tert-butylbenzoate 39.68
    morpholine 123.52
    tert-butylamine 35.01
    n-dodecanol 12.97
    dimethoxymethane 92.49
    ethylene carbonate 42.42
    cyrene 47.81
    2-ethoxyethyl acetate 35.71
    2-ethylhexyl acetate 24.46
    1,2,4-trichlorobenzene 16.82
    4-methylpyridine 32.07
    dibutyl ether 15.37
    2,6-dimethyl-4-heptanol 20.0
    DEF 42.7
    dimethyl isosorbide 80.96
    tetrachloroethylene 34.51
    eugenol 42.64
    triacetin 23.28
    span 80 37.01
    1,4-butanediol 31.35
    1,1-dichloroethane 20.47
    2-methyl-1-pentanol 31.54
    methyl formate 80.85
    2-methyl-1-butanol 33.97
    n-decane 2.14
    butyronitrile 37.86
    3,7-dimethyl-1-octanol 22.47
    1-chlorooctane 10.16
    1-chlorotetradecane 3.86
    n-nonane 1.85
    undecane 1.61
    tert-butylcyclohexane 2.04
    cyclooctane 0.5
    cyclopentanol 39.24
    tetrahydropyran 57.04
    tert-amyl methyl ether 32.51
    2,5,8-trioxanonane 81.33
    1-hexene 4.8
    2-isopropoxyethanol 57.68
    2,2,2-trifluoroethanol 73.2
    methyl butyrate 31.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction