4-(3-Hydroxypropyl)-2,6-Dimethoxyphenol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    20736-25-8

    Molecular formula
    C11H16O4

    SMILES
    COC1=CC(=CC(=C1O)OC)CCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Vanilla 68.37%
    Balsamic 52.08%
    Sweet 50.94%
    Spicy 47.81%
    Floral 47.78%
    Phenolic 40.76%
    Powdery 37.74%
    Creamy 34.61%
    Smoky 33.46%
    Fruity 32.36%

     

    Flavor
    Sweet 62.11%
    Vanilla 48.04%
    Woody 44.55%
    Smoky 44.25%
    Phenolic 42.88%
    Spicy 41.71%
    Spice 38.83%
    Powdery 34.91%
    Clove 34.2%
    Bacon 33.74%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    9.91 (weak base)

    Molecular weight
    212.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    413°C

    Flash point

    • 157.76 ˚C est.

  • Synonyms

    • 4-(3-hydroxypropyl)-2,6-dimethoxyphenol
    • 20736-25-8
    • DTXSID50336200
    • RefChem:513278
    • DTXCID10287289
    • 815-845-8
    • Dihydrosinapyl alcohol
    • DIHYDROSINAPYLALCOHOL
    • Benzenepropanol, 4-hydroxy-3,5-dimethoxy-
    • MFCD00016572
    • 1-Propanol, 3-(4-hydroxy-3,5-dimethoxyphenyl)
    • 3,5-Dimethoxy-4-hydroxyhydrocinnamyl alcohol
    • bmse000586
    • CHEMBL3793371
    • 2,6-dimethoxy-4-(3-oxidanylpropyl)phenol
    • 4-(3-hydroxypropyl)-2,6-dimethoxy-phenol
    • Dihydrosyringenin
    • AC1LB5S3
    • propanol syringol
    • 55B
    • QBF
    • orb1297106
    • SCHEMBL2914283
    • PHOPGVYKZWPIGA-UHFFFAOYSA-N
    • BDBM50162704
    • AKOS022186532
    • DS-8445
    • EBC-610685
    • FD67266
    • HY-W025371
    • SY121232
    • CS-0061898
    • EN300-264459
    • W17166
    • F450433
    • 20736-25-8

  • Applications

    4-(3-Hydroxypropyl)-2,6-Dimethoxyphenol (CAS 20736-25-8) is commonly used as an intermediate in fragrance and flavor chemistry, providing a phenolic scaffold for the synthesis of odor-active aroma chemicals and related derivatives. It can serve as a building block for cosmetic and personal-care fragrance ingredients and for odorant components in consumer products. In industrial manufacturing, it is evaluated as a precursor for aromatic ethers and other phenolic derivatives used in coatings and inks, and in polymer formulations as a functionalized aryl compound incorporated into certain resins. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 207.05
    methanol 360.73
    isopropanol 83.12
    water 2.02
    ethyl acetate 88.56
    n-propanol 108.33
    acetone 173.61
    n-butanol 71.31
    acetonitrile 83.08
    DMF 394.0
    toluene 9.77
    isobutanol 55.84
    1,4-dioxane 260.46
    methyl acetate 116.69
    THF 235.09
    2-butanone 79.28
    n-pentanol 58.2
    sec-butanol 55.45
    n-hexane 0.68
    ethylene glycol 273.79
    NMP 157.85
    cyclohexane 3.72
    DMSO 823.64
    n-butyl acetate 42.67
    n-octanol 31.0
    chloroform 138.3
    n-propyl acetate 55.09
    acetic acid 391.63
    dichloromethane 186.01
    cyclohexanone 127.97
    propylene glycol 153.33
    isopropyl acetate 34.54
    DMAc 195.49
    2-ethoxyethanol 270.84
    isopentanol 49.22
    n-heptane 1.59
    ethyl formate 156.47
    1,2-dichloroethane 145.35
    n-hexanol 51.25
    2-methoxyethanol 520.46
    isobutyl acetate 30.09
    tetrachloromethane 21.81
    n-pentyl acetate 30.15
    transcutol 216.97
    n-heptanol 36.29
    ethylbenzene 10.75
    MIBK 31.19
    2-propoxyethanol 148.23
    tert-butanol 139.94
    MTBE 38.91
    2-butoxyethanol 90.13
    propionic acid 131.49
    o-xylene 14.37
    formic acid 314.37
    diethyl ether 28.33
    m-xylene 11.33
    p-xylene 14.39
    chlorobenzene 36.62
    dimethyl carbonate 60.32
    n-octane 1.5
    formamide 432.73
    cyclopentanone 168.45
    2-pentanone 48.8
    anisole 46.72
    cyclopentyl methyl ether 46.94
    gamma-butyrolactone 267.53
    1-methoxy-2-propanol 210.0
    pyridine 102.56
    3-pentanone 32.46
    furfural 279.03
    n-dodecane 2.11
    diethylene glycol 264.48
    diisopropyl ether 7.16
    tert-amyl alcohol 80.53
    acetylacetone 108.79
    n-hexadecane 2.34
    acetophenone 60.4
    methyl propionate 79.82
    isopentyl acetate 37.31
    trichloroethylene 236.54
    n-nonanol 28.69
    cyclohexanol 61.76
    benzyl alcohol 75.92
    2-ethylhexanol 28.04
    isooctanol 29.54
    dipropyl ether 17.38
    1,2-dichlorobenzene 48.03
    ethyl lactate 63.3
    propylene carbonate 139.93
    n-methylformamide 292.27
    2-pentanol 27.64
    n-pentane 0.78
    1-propoxy-2-propanol 73.47
    1-methoxy-2-propyl acetate 57.88
    2-(2-methoxypropoxy) propanol 69.28
    mesitylene 9.05
    ε-caprolactone 125.21
    p-cymene 12.74
    epichlorohydrin 277.32
    1,1,1-trichloroethane 71.87
    2-aminoethanol 251.79
    morpholine-4-carbaldehyde 229.54
    sulfolane 337.9
    2,2,4-trimethylpentane 1.79
    2-methyltetrahydrofuran 90.85
    n-hexyl acetate 41.59
    isooctane 1.31
    2-(2-butoxyethoxy)ethanol 104.79
    sec-butyl acetate 25.61
    tert-butyl acetate 46.66
    decalin 3.16
    glycerin 303.04
    diglyme 204.64
    acrylic acid 159.18
    isopropyl myristate 17.38
    n-butyric acid 154.45
    acetyl acetate 70.85
    di(2-ethylhexyl) phthalate 31.09
    ethyl propionate 38.26
    nitromethane 508.28
    1,2-diethoxyethane 47.48
    benzonitrile 68.43
    trioctyl phosphate 24.31
    1-bromopropane 26.56
    gamma-valerolactone 270.64
    n-decanol 22.75
    triethyl phosphate 29.91
    4-methyl-2-pentanol 19.06
    propionitrile 54.9
    vinylene carbonate 150.93
    1,1,2-trichlorotrifluoroethane 328.68
    DMS 47.7
    cumene 11.11
    2-octanol 20.53
    2-hexanone 42.95
    octyl acetate 26.39
    limonene 18.24
    1,2-dimethoxyethane 244.73
    ethyl orthosilicate 26.64
    tributyl phosphate 25.09
    diacetone alcohol 94.18
    N,N-dimethylaniline 34.06
    acrylonitrile 110.19
    aniline 45.37
    1,3-propanediol 289.26
    bromobenzene 29.55
    dibromomethane 90.92
    1,1,2,2-tetrachloroethane 175.63
    2-methyl-cyclohexyl acetate 39.82
    tetrabutyl urea 33.61
    diisobutyl methanol 17.25
    2-phenylethanol 61.38
    styrene 13.64
    dioctyl adipate 35.87
    dimethyl sulfate 110.9
    ethyl butyrate 34.76
    methyl lactate 100.36
    butyl lactate 41.73
    diethyl carbonate 33.54
    propanediol butyl ether 89.49
    triethyl orthoformate 30.33
    p-tert-butyltoluene 12.74
    methyl 4-tert-butylbenzoate 58.88
    morpholine 259.15
    tert-butylamine 42.96
    n-dodecanol 18.04
    dimethoxymethane 182.86
    ethylene carbonate 119.94
    cyrene 99.0
    2-ethoxyethyl acetate 53.05
    2-ethylhexyl acetate 26.41
    1,2,4-trichlorobenzene 59.52
    4-methylpyridine 68.24
    dibutyl ether 17.82
    2,6-dimethyl-4-heptanol 17.25
    DEF 80.33
    dimethyl isosorbide 102.94
    tetrachloroethylene 136.32
    eugenol 70.86
    triacetin 56.49
    span 80 63.24
    1,4-butanediol 129.67
    1,1-dichloroethane 69.65
    2-methyl-1-pentanol 45.01
    methyl formate 280.57
    2-methyl-1-butanol 44.35
    n-decane 2.82
    butyronitrile 51.89
    3,7-dimethyl-1-octanol 25.49
    1-chlorooctane 14.0
    1-chlorotetradecane 6.86
    n-nonane 2.34
    undecane 2.38
    tert-butylcyclohexane 2.73
    cyclooctane 1.41
    cyclopentanol 76.31
    tetrahydropyran 92.07
    tert-amyl methyl ether 28.32
    2,5,8-trioxanonane 142.18
    1-hexene 4.14
    2-isopropoxyethanol 119.4
    2,2,2-trifluoroethanol 162.36
    methyl butyrate 66.76

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction