4-[(2-Hydroxyethyl)amino]-3-nitrophenol

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  • Identifiers

    CAS number
    65235-31-6

    Molecular formula
    C8H10N2O4

    SMILES
    C1=CC(=C(C=C1O)[N+](=O)[O-])NCCO

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 65.85%
    Sweet 37.52%
    Savory 26.24%
    Milky 23.03%
    Bitter 23.01%
    Vanilla 21.46%
    Grape 18.6%
    Meaty 17.39%
    Animal 17.0%
    Creamy 16.55%

     

    Flavor
    Odorless 60.97%
    Bitter 60.52%
    Mild 38.25%
    Bland 28.29%
    Very mild 24.65%
    Sweet-like 24.07%
    Yeast 20.78%
    Nitrile 20.29%
    Orange flower 20.18%
    Bread crust 19.77%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    9.12 (weak base)

    Molecular weight
    198.18 g/mol

    Flash point

    • 213.91 ˚C est.

  • Synonyms

    • 4-((2-Hydroxyethyl)amino)-3-nitrophenol
    • 4-[(2-HYDROXYETHYL)AMINO]-3-NITROPHENOL
    • 3-Nitro-p-hydroxyethylaminophenol
    • UNII-AIP2J155AN
    • EINECS 265-648-0
    • AIP2J155AN
    • JAROCOL NHEAP
    • IMEXINE FH
    • RODOL HENP
    • COLOREX RED 54
    • DTXSID00215536
    • 3-NITRO-4-.BETA.-HYDROXYETHYLAMINOPHENOL
    • HYDROXYETHYL-AMINO-3-NITROPHENOL, 4-N-BETA-
    • 3-NITRO-4-N-(.BETA.-HYDROXYETHYL)AMINOPHENOL
    • RefChem:96846
    • DTXCID30138027
    • 3-NITRO-4-BETA-HYDROXYETHYLAMINOPHENOL
    • 3-NITRO-P-HYDROXYETHYLAMINOPHENOL [INCI]
    • 3-NITRO-4-N-(BETA-HYDROXYETHYL)AMINOPHENOL
    • 65235-31-6
    • 4-(2-hydroxyethylamino)-3-nitrophenol
    • N-(2-Hydroxyethyl) 4-hydroxy-2-nitroaniline
    • MFCD02684022
    • 3-Nitro-4-hydroxyethylaminophenol
    • Phenol, 4-[(2-hydroxyethyl)amino]-3-nitro-
    • Phenol, 4-((2-hydroxyethyl)amino)-3-nitro-
    • HC RED B54
    • 4-(2-hydroxyethylamino)-3-nitro-phenol
    • 4-Amino-N-(2-hydroxyethyl)-3-nitrophenol
    • SCHEMBL24055
    • SCHEMBL29410422
    • STR08779
    • SBB064145
    • AKOS006343531
    • AC-8182
    • FH37090
    • SY024573
    • DB-054783
    • CS-0208721
    • NS00013893
    • H11856
    • 3-nitro-4-[N-(beta-hydroxyethyl)-amino]-phenol
    • 235N316
    • Q27273942
    • 4-((2-Hydroxyethyl)amino)-3-nitrophenol ;3-Nitro-p-hydroxyethylaminophenol
    • 65235-31-6

  • Applications

    4-[(2-Hydroxyethyl)amino]-3-nitrophenol is commonly used as an intermediate in the synthesis of nitroaromatic colorants, with applications in textiles and printing inks; it also serves as a building block for colorant systems in industrial coatings and polymer formulations; it may be employed as a starting material in the development of specialty chemicals and color additives for polymer formulations; and it can function as a dye intermediate for cosmetics and personal care products, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 25.43
    methanol 50.76
    isopropanol 12.99
    water 2.77
    ethyl acetate 19.93
    n-propanol 14.45
    acetone 85.1
    n-butanol 12.55
    acetonitrile 17.34
    DMF 271.05
    toluene 2.23
    isobutanol 9.09
    1,4-dioxane 20.0
    methyl acetate 29.74
    THF 105.03
    2-butanone 40.49
    n-pentanol 10.49
    sec-butanol 10.49
    n-hexane 0.08
    ethylene glycol 36.23
    NMP 213.61
    cyclohexane 0.13
    DMSO 536.55
    n-butyl acetate 12.3
    n-octanol 4.84
    chloroform 0.8
    n-propyl acetate 12.19
    acetic acid 28.49
    dichloromethane 2.38
    cyclohexanone 39.16
    propylene glycol 21.11
    isopropyl acetate 9.9
    DMAc 320.44
    2-ethoxyethanol 51.61
    isopentanol 15.43
    n-heptane 0.25
    ethyl formate 19.5
    1,2-dichloroethane 5.52
    n-hexanol 11.43
    2-methoxyethanol 104.51
    isobutyl acetate 4.82
    tetrachloromethane 0.6
    n-pentyl acetate 5.95
    transcutol 57.16
    n-heptanol 6.26
    ethylbenzene 2.16
    MIBK 15.22
    2-propoxyethanol 37.41
    tert-butanol 32.27
    MTBE 8.77
    2-butoxyethanol 19.32
    propionic acid 18.1
    o-xylene 3.74
    formic acid 65.0
    diethyl ether 4.01
    m-xylene 3.22
    p-xylene 2.86
    chlorobenzene 1.85
    dimethyl carbonate 18.41
    n-octane 0.14
    formamide 113.8
    cyclopentanone 83.44
    2-pentanone 29.14
    anisole 10.71
    cyclopentyl methyl ether 14.18
    gamma-butyrolactone 88.75
    1-methoxy-2-propanol 54.46
    pyridine 14.2
    3-pentanone 15.74
    furfural 58.86
    n-dodecane 0.19
    diethylene glycol 57.3
    diisopropyl ether 1.57
    tert-amyl alcohol 21.82
    acetylacetone 44.49
    n-hexadecane 0.22
    acetophenone 19.25
    methyl propionate 26.74
    isopentyl acetate 11.49
    trichloroethylene 7.38
    n-nonanol 4.8
    cyclohexanol 8.9
    benzyl alcohol 15.99
    2-ethylhexanol 6.84
    isooctanol 5.01
    dipropyl ether 4.55
    1,2-dichlorobenzene 2.9
    ethyl lactate 18.02
    propylene carbonate 29.38
    n-methylformamide 98.59
    2-pentanol 6.54
    n-pentane 0.07
    1-propoxy-2-propanol 23.11
    1-methoxy-2-propyl acetate 22.05
    2-(2-methoxypropoxy) propanol 26.9
    mesitylene 2.23
    ε-caprolactone 32.9
    p-cymene 3.24
    epichlorohydrin 58.68
    1,1,1-trichloroethane 2.59
    2-aminoethanol 32.94
    morpholine-4-carbaldehyde 96.62
    sulfolane 155.27
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 31.44
    n-hexyl acetate 8.34
    isooctane 0.15
    2-(2-butoxyethoxy)ethanol 28.77
    sec-butyl acetate 7.17
    tert-butyl acetate 15.33
    decalin 0.27
    glycerin 55.67
    diglyme 52.49
    acrylic acid 21.11
    isopropyl myristate 4.03
    n-butyric acid 17.55
    acetyl acetate 11.12
    di(2-ethylhexyl) phthalate 7.85
    ethyl propionate 12.9
    nitromethane 94.25
    1,2-diethoxyethane 10.18
    benzonitrile 9.86
    trioctyl phosphate 5.96
    1-bromopropane 1.42
    gamma-valerolactone 78.88
    n-decanol 3.98
    triethyl phosphate 10.07
    4-methyl-2-pentanol 5.41
    propionitrile 10.32
    vinylene carbonate 20.27
    1,1,2-trichlorotrifluoroethane 49.79
    DMS 13.85
    cumene 2.14
    2-octanol 3.19
    2-hexanone 15.17
    octyl acetate 6.03
    limonene 4.12
    1,2-dimethoxyethane 59.75
    ethyl orthosilicate 8.0
    tributyl phosphate 6.58
    diacetone alcohol 42.56
    N,N-dimethylaniline 10.45
    acrylonitrile 20.42
    aniline 7.71
    1,3-propanediol 43.28
    bromobenzene 1.26
    dibromomethane 1.2
    1,1,2,2-tetrachloroethane 6.3
    2-methyl-cyclohexyl acetate 11.27
    tetrabutyl urea 12.47
    diisobutyl methanol 4.41
    2-phenylethanol 14.88
    styrene 2.04
    dioctyl adipate 9.0
    dimethyl sulfate 61.41
    ethyl butyrate 11.4
    methyl lactate 33.49
    butyl lactate 10.79
    diethyl carbonate 9.51
    propanediol butyl ether 19.18
    triethyl orthoformate 8.95
    p-tert-butyltoluene 2.85
    methyl 4-tert-butylbenzoate 18.36
    morpholine 34.88
    tert-butylamine 6.82
    n-dodecanol 3.06
    dimethoxymethane 62.39
    ethylene carbonate 16.5
    cyrene 42.07
    2-ethoxyethyl acetate 11.53
    2-ethylhexyl acetate 7.78
    1,2,4-trichlorobenzene 4.64
    4-methylpyridine 16.83
    dibutyl ether 3.08
    2,6-dimethyl-4-heptanol 4.41
    DEF 48.93
    dimethyl isosorbide 44.29
    tetrachloroethylene 4.26
    eugenol 19.61
    triacetin 13.73
    span 80 16.14
    1,4-butanediol 20.19
    1,1-dichloroethane 1.82
    2-methyl-1-pentanol 11.87
    methyl formate 68.45
    2-methyl-1-butanol 12.65
    n-decane 0.25
    butyronitrile 9.73
    3,7-dimethyl-1-octanol 5.28
    1-chlorooctane 1.24
    1-chlorotetradecane 0.71
    n-nonane 0.19
    undecane 0.22
    tert-butylcyclohexane 0.27
    cyclooctane 0.09
    cyclopentanol 14.85
    tetrahydropyran 8.61
    tert-amyl methyl ether 9.17
    2,5,8-trioxanonane 44.71
    1-hexene 0.58
    2-isopropoxyethanol 26.45
    2,2,2-trifluoroethanol 22.82
    methyl butyrate 20.25

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction