3,6,9,12-Tetraoxatetracosan-1-ol

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  • Identifiers

    CAS number
    5274-68-0

    Molecular formula
    C20H42O5

    SMILES
    CCCCCCCCCCCCOCCOCCOCCOCCO

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Waxy 36.76%
    Oily 33.87%
    Fresh 32.62%
    Alcoholic 31.67%
    Odorless 30.4%
    Fruity 28.41%
    Sweet 26.98%
    Clean 24.55%
    Fatty 23.75%
    Floral 22.01%

     

    Flavor
    Waxy 50.07%
    Green 40.16%
    Fatty 39.07%
    Mushroom 37.57%
    Sweet 37.0%
    Oily 35.25%
    Floral 34.45%
    Fruity 33.18%
    Earthy 32.83%
    Rose 29.28%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.7

    pKa est.
    4.95 (weak acid)

    Molecular weight
    362.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    472°C

    Flash point

    • 188.21 ˚C est.

  • Synonyms

    • 5274-68-0
    • Tetraethylene glycol monododecyl ether
    • 3,6,9,12-Tetraoxatetracosan-1-ol
    • Tetra(oxydiethanol) monodecyl ether
    • Tetraethylene glycol monolauryl ether
    • Lauryl alcohol tri(oxyethylene) ethanol
    • Tetraoxyethylene glycol monododecyl ether
    • DTXSID3063752
    • Dodecyl tetraethylene glycol ether
    • RefChem:1066059
    • DTXCID9041283
    • 2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethanol
    • PEG 4 lauryl ether
    • LA 4
    • Mulsifan CPA
    • n-Dodecyl tetraethylene glycol ether
    • MFCD00043063
    • NSC 190605
    • NSC-190605
    • Ethanol, 2-(2-(2-(2-(dodecyloxy)ethoxy)ethoxy)ethoxy)-
    • Tetraethylene glycol mono-n-dodecyl ether
    • Dodecyltetraglycol
    • Brij-30
    • C12E4
    • tetraethyleneglycol monododecyl ether
    • 2-{2-[2-(2-dodecyloxyethoxy)ethoxy]ethoxy}ethan-1-ol
    • Ethanol, 2-[2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethoxy]-
    • Marlowet bl
    • Empilan kbe4
    • Ethosperse la-4
    • Brijl4-lq
    • Rhodasurf l-4
    • Unihydol ls-4
    • Hetoxol la-4
    • Jeecol la-4
    • Lipocol l-4
    • Lumulse l-4
    • Procol la-4
    • Unicol la-4
    • Brij l4
    • Ethal la-4
    • Lanycol-30
    • Pegnol l-4
    • Dodecyltetraethylene glycol monoether
    • EINECS 226-097-1
    • Lauromacrogol 200
    • 3,6,9,12-Tetraoxa-1-tetracosanol
    • Akypo rox rlm 40
    • Genapol la 040
    • Nikkol bl-4.2
    • Safol 23e4 ethoxylate
    • Brij(R) 30 detergent
    • Macrogol 2 lauryl ether
    • C12-Alcohol-4-ethoxylate
    • SCHEMBL43045
    • Polyoxyethylene(4)lauryl ether
    • C12EO4
    • CHEMBL500128
    • Dodecyl-tetraethyleneoxide ether
    • Dodecyl tetra(oxyethylene) ether
    • C12-AEO-4
    • CHEBI:181087
    • 3,9,12-Tetraoxatetracosan-1-ol
    • Brij(R) L4, average Mn ~362
    • NSC190605
    • SBB061291
    • AKOS015902798
    • HY-W099536
    • NCGC00159385-02
    • NCGC00159385-03
    • AS-75638
    • C-12-E-4
    • DA-49515
    • Polidocanol Impurity 3 (Polidocanol E4)
    • SY076049
    • CS-0152178
    • NS00013816
    • ST51047321
    • T0769
    • T72570
    • A870917
    • F692150
    • Q63395633
    • Tetraethylene glycol monododecyl ether, BioXtra, >=98.0% (GC)
    • 5274-68-0

  • Applications

    3,6,9,12-Tetraoxatetracosan-1-ol (CAS 5274-68-0) is an alkyl poly(ethylene glycol) ether surfactant with a long hydrophobic C24 tail and a short EO4 polyoxyethylene head. It is used as a nonionic surfactant and emulsifier in detergents and cosmetic/personal-care formulations; as a wetting agent and dispersant in paints, coatings, inks, and polymer dispersions; as a processing aid and lubricant/flow modifier in industrial manufacturing and polymer formulations; as an emulsifier and carrier in agricultural formulations to improve spray coverage; and as a synthetic intermediate for the production of other surfactants or related lubricant/additive formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.37
    methanol 13.97
    isopropanol 6.33
    water 0.31
    ethyl acetate 58.67
    n-propanol 10.99
    acetone 39.1
    n-butanol 11.33
    acetonitrile 21.36
    DMF 72.45
    toluene 25.0
    isobutanol 11.79
    1,4-dioxane 81.16
    methyl acetate 46.0
    THF 166.31
    2-butanone 49.15
    n-pentanol 13.19
    sec-butanol 12.61
    n-hexane 5.59
    ethylene glycol 3.38
    NMP 228.11
    cyclohexane 39.46
    DMSO 226.22
    n-butyl acetate 66.0
    n-octanol 22.26
    chloroform 258.29
    n-propyl acetate 74.78
    acetic acid 60.54
    dichloromethane 278.44
    cyclohexanone 183.75
    propylene glycol 5.18
    isopropyl acetate 50.98
    DMAc 154.89
    2-ethoxyethanol 48.08
    isopentanol 16.59
    n-heptane 12.22
    ethyl formate 35.85
    1,2-dichloroethane 176.67
    n-hexanol 12.96
    2-methoxyethanol 42.58
    isobutyl acetate 47.65
    tetrachloromethane 65.05
    n-pentyl acetate 102.44
    transcutol 264.53
    n-heptanol 19.85
    ethylbenzene 19.63
    MIBK 42.17
    2-propoxyethanol 42.4
    tert-butanol 17.71
    MTBE 28.71
    2-butoxyethanol 60.44
    propionic acid 40.58
    o-xylene 31.24
    formic acid 23.08
    diethyl ether 25.12
    m-xylene 21.64
    p-xylene 28.4
    chlorobenzene 48.54
    dimethyl carbonate 25.36
    n-octane 5.69
    formamide 38.23
    cyclopentanone 183.82
    2-pentanone 46.41
    anisole 40.91
    cyclopentyl methyl ether 102.22
    gamma-butyrolactone 203.45
    1-methoxy-2-propanol 38.78
    pyridine 81.36
    3-pentanone 53.8
    furfural 165.34
    n-dodecane 3.24
    diethylene glycol 25.61
    diisopropyl ether 16.39
    tert-amyl alcohol 25.09
    acetylacetone 86.06
    n-hexadecane 3.88
    acetophenone 70.42
    methyl propionate 50.79
    isopentyl acetate 63.6
    trichloroethylene 293.86
    n-nonanol 23.47
    cyclohexanol 46.31
    benzyl alcohol 31.28
    2-ethylhexanol 22.54
    isooctanol 22.52
    dipropyl ether 51.16
    1,2-dichlorobenzene 76.72
    ethyl lactate 43.31
    propylene carbonate 115.27
    n-methylformamide 33.31
    2-pentanol 11.36
    n-pentane 4.08
    1-propoxy-2-propanol 53.0
    1-methoxy-2-propyl acetate 71.35
    2-(2-methoxypropoxy) propanol 67.98
    mesitylene 20.27
    ε-caprolactone 167.95
    p-cymene 24.51
    epichlorohydrin 198.78
    1,1,1-trichloroethane 153.66
    2-aminoethanol 8.74
    morpholine-4-carbaldehyde 151.6
    sulfolane 439.99
    2,2,4-trimethylpentane 6.46
    2-methyltetrahydrofuran 111.96
    n-hexyl acetate 83.72
    isooctane 2.71
    2-(2-butoxyethoxy)ethanol 82.75
    sec-butyl acetate 55.29
    tert-butyl acetate 74.1
    decalin 14.11
    glycerin 16.03
    diglyme 225.89
    acrylic acid 36.91
    isopropyl myristate 29.39
    n-butyric acid 64.39
    acetyl acetate 64.66
    di(2-ethylhexyl) phthalate 29.94
    ethyl propionate 66.4
    nitromethane 126.6
    1,2-diethoxyethane 93.69
    benzonitrile 44.66
    trioctyl phosphate 22.95
    1-bromopropane 64.32
    gamma-valerolactone 242.39
    n-decanol 15.22
    triethyl phosphate 68.3
    4-methyl-2-pentanol 10.76
    propionitrile 20.76
    vinylene carbonate 102.49
    1,1,2-trichlorotrifluoroethane 201.29
    DMS 61.14
    cumene 17.8
    2-octanol 17.08
    2-hexanone 52.8
    octyl acetate 37.67
    limonene 41.71
    1,2-dimethoxyethane 108.65
    ethyl orthosilicate 66.85
    tributyl phosphate 33.88
    diacetone alcohol 66.53
    N,N-dimethylaniline 39.01
    acrylonitrile 28.04
    aniline 30.18
    1,3-propanediol 13.65
    bromobenzene 58.74
    dibromomethane 164.0
    1,1,2,2-tetrachloroethane 303.6
    2-methyl-cyclohexyl acetate 77.91
    tetrabutyl urea 48.84
    diisobutyl methanol 18.93
    2-phenylethanol 28.84
    styrene 21.72
    dioctyl adipate 62.96
    dimethyl sulfate 81.73
    ethyl butyrate 86.36
    methyl lactate 30.65
    butyl lactate 73.21
    diethyl carbonate 56.92
    propanediol butyl ether 44.53
    triethyl orthoformate 88.31
    p-tert-butyltoluene 22.36
    methyl 4-tert-butylbenzoate 89.02
    morpholine 99.67
    tert-butylamine 13.17
    n-dodecanol 11.11
    dimethoxymethane 48.0
    ethylene carbonate 92.71
    cyrene 86.2
    2-ethoxyethyl acetate 113.67
    2-ethylhexyl acetate 62.34
    1,2,4-trichlorobenzene 93.88
    4-methylpyridine 60.43
    dibutyl ether 53.26
    2,6-dimethyl-4-heptanol 18.93
    DEF 88.57
    dimethyl isosorbide 155.67
    tetrachloroethylene 210.75
    eugenol 70.61
    triacetin 145.77
    span 80 57.89
    1,4-butanediol 8.09
    1,1-dichloroethane 95.27
    2-methyl-1-pentanol 18.09
    methyl formate 28.9
    2-methyl-1-butanol 17.34
    n-decane 7.33
    butyronitrile 21.2
    3,7-dimethyl-1-octanol 24.62
    1-chlorooctane 30.39
    1-chlorotetradecane 9.54
    n-nonane 7.28
    undecane 4.5
    tert-butylcyclohexane 8.63
    cyclooctane 12.99
    cyclopentanol 42.9
    tetrahydropyran 100.03
    tert-amyl methyl ether 37.52
    2,5,8-trioxanonane 137.4
    1-hexene 11.44
    2-isopropoxyethanol 38.67
    2,2,2-trifluoroethanol 46.41
    methyl butyrate 91.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction